{"ymdb_id":"YMDB00087","created_at":"2011-05-29T15:55:26.000Z","updated_at":"2016-09-08T18:35:00.000Z","name":"L-Iditol","cas":"488-45-9","state":"Solid","melting_point":null,"description":"L-Iditol is a sweet six-carbon sugar alcohol. It can be produced through fermentation by the reduction of idose or sorbose.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Mitochondrion","synthesis_reference":null,"chebi_id":"18202","hmdb_id":"HMDB11632","kegg_id":"C01507","pubchem_id":"453","cs_id":"24533858","foodb_id":null,"wikipedia_link":"Iditol","biocyc_id":"CPD-369","iupac":"(2S,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol","traditional_iupac":"L-iditol","logp":"-3.7300188486666666","pka":"13.37874915684328","alogps_solubility":"2.29e+02 g/l","alogps_logp":"-2.68","alogps_logs":"0.10","acceptor_count":"6","donor_count":"6","rotatable_bond_count":"5","polar_surface_area":"121.38000000000001","refractivity":"38.4036","polarizability":"17.143868562582828","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-2.974211614825128","pka_strongest_acidic":"12.585200956788803","bioavailability":"1","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Cordycepic acid","D-Dulcitol","D-Galactitol","dulcite","dulcitol","dulcose","galactitol","glucitol","Hexahydric alcohol","Hexahydroxyhexane","Hexitol","iso-sorbide","Isotol","Karion","L-Gulitol","Manna sugar","Mannit","Mannite","meglumine","mitobronitol","Sionit","Sionon","Siosan","Sorbo","Sorbol"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":5854586,"citation":"Wilkins, P. O., Cirillo, V. P. (1965). \"Sorbose counterflow as a measure of intracellular glucose in baker's yeast.\" J Bacteriol 90:1605-1610."}],"proteins":[{"created_at":"2011-05-26T18:00:48.000Z","updated_at":"2011-07-22T17:54:34.000Z","name":"Sorbitol dehydrogenase 1","uniprot_id":"P35497","uniprot_name":"DHSO1_YEAST","enzyme":true,"transporter":false,"gene_name":"SOR1","num_residues":357,"molecular_weight":"38165.39844","theoretical_pi":"6.94","general_function":"Involved in zinc ion binding","specific_function":"L-iditol + NAD(+) = L-sorbose + NADH","reactions":[{"id":1435,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1705,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2503,"direction":"\u003e","locations":"","altext":"L-iditol + NAD(+) = L-sorbose + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":3819,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006333","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY693012","genbank_protein_id":"51013475","gene_card_id":"SOR1","chromosome_location":"chromosome 10","locus":"YJR159W","synonyms":["L-iditol 2-dehydrogenase 1"],"enzyme_classes":["1.1.1.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" zinc ion binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"ADH_N","identifier":"PF08240"},{"name":"ADH_zinc_N","identifier":"PF00107"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Fructose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTCAAAATAGTAACCCTGCAGTAGTTCTAGAGAAAGTCGGCGATATTGCCATCGAGCAAAGACCAATCCCTACCATTAAGGACCCCCATTATGTCAAGTTAGCTATTAAAGCCACTGGTATCTGCGGCTCTGATATTCATTATTATAGAAGCGGTGGTATTGGTAAGTACATATTGAAGGCGCCAATGGTTTTAGGTCATGAATCAAGCGGACAGGTTGTGGAAGTTGGTGATGCCGTCACAAGGGTCAAAGTTGGTGACCGTGTTGCTATTGAACCTGGTGTTCCTAGCCGTTACTCTGATGAGACCAAAGAAGGGAGGTATAACCTTTGCCCACATATGGCATTTGCTGCAACTCCTCCAATTGATGGTACTCTTGTGAAGTACTATTTATCTCCAGAAGATTTCCTTGTGAAATTGCCAGAAGGCGTCAGTTATGAAGAGGGCGCTTGTGTCGAACCCTTATCAGTCGGTGTACACTCTAATAAATTGGCTGGGGTCCGCTTTGGTACCAAAGTTGTTGTATTTGGTGCAGGTCCTGTGGGGCTTTTAACTGGCGCAGTCGCCCGCGCTTTTGGTGCCACCGACGTCATTTTCGTCGATGTATTCGACAACAAGCTACAGAGAGCAAAAGATTTCGGAGCCACAAACACTTTCAATTCTTCCCAGTTTTCCACCGATAAAGCCCAAGACTTGGCCGATGGGGTCCAAAAGCTTTTGGGCGGAAATCACGCAGATGTGGTGTTTGAGTGTTCAGGTGCTGATGTTTGCATTGATGCCGCTGTCAAAACAACTAAGGTTGGAGGTACCATGGTGCAAGTCGGTATGGGTAAAAACTACACTAATTTTCCAATTGCTGAAGTTAGTGGAAAGGAAATGAAATTGATTGGATGTTTCCGTTATTCATTCGGTGATTATCGTGACGCTGTGAACTTGGTTGCCACAGGAAAAGTCAATGTCAAGCCATTGATAACCCACAAATTTAAATTTGAAGATGCAGCCAAGGCTTACGACTACAACATTGCCCATGGTGGAGAGGTAGTCAAGACTATTATCTTTGGTCCTGAATGA","protein_sequence":"MSQNSNPAVVLEKVGDIAIEQRPIPTIKDPHYVKLAIKATGICGSDIHYYRSGGIGKYILKAPMVLGHESSGQVVEVGDAVTRVKVGDRVAIEPGVPSRYSDETKEGRYNLCPHMAFAATPPIDGTLVKYYLSPEDFLVKLPEGVSYEEGACVEPLSVGVHSNKLAGVRFGTKVVVFGAGPVGLLTGAVARAFGATDVIFVDVFDNKLQRAKDFGATNTFNSSQFSTDKAQDLADGVQKLLGGNHADVVFECSGADVCIDAAVKTTKVGGTMVQVGMGKNYTNFPIAEVSGKEMKLIGCFRYSFGDYRDAVNLVATGKVNVKPLITHKFKFEDAAKAYDYNIAHGGEVVKTIIFGPE"},{"created_at":"2011-05-26T18:01:23.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Sorbitol dehydrogenase 2","uniprot_id":"Q07786","uniprot_name":"DHSO2_YEAST","enzyme":true,"transporter":false,"gene_name":"SOR2","num_residues":357,"molecular_weight":"38096.30078","theoretical_pi":"6.71","general_function":"Involved in zinc ion binding","specific_function":"L-iditol + NAD(+) = L-sorbose + NADH","reactions":[{"id":2503,"direction":"\u003e","locations":"","altext":"L-iditol + NAD(+) = L-sorbose + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z74294","genbank_protein_id":"1431420","gene_card_id":"SOR2","chromosome_location":"chromosome 4","locus":"YDL246C","synonyms":["L-iditol 2-dehydrogenase 2"],"enzyme_classes":["1.1.1.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" zinc ion binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"ADH_N","identifier":"PF08240"},{"name":"ADH_zinc_N","identifier":"PF00107"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"}],"gene_sequence":"ATGTCTCAAAATAGTAACCCTGCAGTAGTTCTAGAGAAAGTCGGCGATATTGCCATCGAGCAAAGACCAATCCCTACCATTAAGGACCCCCATTATGTCAAGTTAGCTATTAAAGCCACTGGTATCTGCGGCTCTGATATTCATTATTATAGAAGCGGTGGTATTGGTAAGTACATATTGAAGGCGCCAATGGTTTTAGGTCATGAATCAAGCGGACAGGTTGTGGAAGTTGGTGATGCCGTCACAAGGGTCAAAGTTGGTGACCGTGTTGCTATTGAACCTGGTGTTCCTAGCCGTTACTCTGATGAGACCAAAGAAGGGAGCTATAACCTTTGCCCACATATGGCATTTGCTGCAACTCCTCCAATTGATGGTACTCTTGTGAAGTACTATTTATCTCCAGAAGATTTCCTTGTGAAATTGCCAGAAGGCGTCAGTTATGAAGAGGGCGCTTGTGTCGAACCCTTATCAGTCGGTGTACACTCTAATAAATTGGCTGGGGTCCGCTTTGGTACCAAAGTTGTTGTATTTGGTGCAGGTCCTGTGGGGCTTTTAACTGGCGCAGTCGCCCGCGCTTTTGGTGCCACCGACGTCATTTTCGTCGATGTATTCGACAACAAGCTACAGAGAGCAAAAGATTTCGGAGCCACAAACACTTTCAATTCTTCCCAGTTTTCCACCGATAAAGCCCAAGACTTGGCCGATGGGGTCCAAAAGCTTTTGGGCGGAAATCACGCAGATGTGGTGTTTGAGTGTTCAGGTGCTGATGTTTGCATTGATGCCGCTGTCAAAACAACTAAGGTTGGAGGTACCATGGTGCAAGTCGGTATGGGTAAAAACTACACTAATTTTCCAATTGCTGAAGTTAGTGGAAAGGAAATGAAATTGATTGGATGTTTCCGTTATTCATTCGGTGATTATCGTGACGCTGTGAACTTGGTTGCCACAGGAAAAGTCAATGTCAAGCCATTGATAACCCACAAATTTAAATTTGAAGATGCAGCCAAGGCTTACGACTACAACATTGCCCATGGTGGAGAGGTAGTCAAGACTATTATCTTTGGTCCTGAATGA","protein_sequence":"MSQNSNPAVVLEKVGDIAIEQRPIPTIKDPHYVKLAIKATGICGSDIHYYRSGGIGKYILKAPMVLGHESSGQVVEVGDAVTRVKVGDRVAIEPGVPSRYSDETKEGSYNLCPHMAFAATPPIDGTLVKYYLSPEDFLVKLPEGVSYEEGACVEPLSVGVHSNKLAGVRFGTKVVVFGAGPVGLLTGAVARAFGATDVIFVDVFDNKLQRAKDFGATNTFNSSQFSTDKAQDLADGVQKLLGGNHADVVFECSGADVCIDAAVKTTKVGGTMVQVGMGKNYTNFPIAEVSGKEMKLIGCFRYSFGDYRDAVNLVATGKVNVKPLITHKFKFEDAAKAYDYNIAHGGEVVKTIIFGPE"}]}