{"ymdb_id":"YMDB00076","created_at":"2011-05-29T15:54:18.000Z","updated_at":"2016-09-08T18:34:59.000Z","name":"DL-O-Phosphoserine","cas":"17885-08-4","state":"Solid","melting_point":"228 oC","description":"Phosphoserine is an ester of serine and phosphoric acid. Phosphoserine is a component of many proteins as the result of posttranslational modifications. The phosphorylation of the alcohol functional group in serine to produce phosphoserine is catalyzed by various types of kinases. [Wikipedia]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm","synthesis_reference":"Lacombe J M; Andriamanampisoa F; Pavia A A  Solid-phase synthesis of peptides containing phosphoserine using phosphate tert.-butyl protecting group.    International journal of peptide and protein research  (1990),  36(3),  275-80.","chebi_id":"37712","hmdb_id":"HMDB01721","kegg_id":"C01005","pubchem_id":"106","cs_id":"104","foodb_id":null,"wikipedia_link":"Phosphoserine","biocyc_id":"3-P-SERINE","iupac":"2-amino-3-(phosphonooxy)propanoic acid","traditional_iupac":"P-serine","logp":"-3.180275047030002","pka":"2.0667419682108834","alogps_solubility":"1.99e+01 g/l","alogps_logp":"-2.32","alogps_logs":"-0.97","acceptor_count":"6","donor_count":"4","rotatable_bond_count":"4","polar_surface_area":"130.08","refractivity":"32.913900000000005","polarizability":"14.008769274759121","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"9.39423622748354","pka_strongest_acidic":"1.1985006020847053","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["3-phospho-1-serine","3-phospho-serine","3-phosphoserine","DL-O-Phosphorylserine","DL-O-Phosphoserine","DL-O-Serine phosphate","DL-Serine dihydrogen phosphate","DL-Serine monophosphorate","DL-Serine monophosphoric acid","Energoserina","O-Phospho-DL-serine","O-phospho-L-serine","o-Phosphonoserine","P-serine","phosphorylserine","phosphoserine","serine phosphate","serine-3-phosphate","Serophen"],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":3933486,"citation":"Takada, Y., Noguchi, T. (1985). \"Characteristics of alanine: glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates.\" Biochem J 231:157-163."}],"proteins":[{"created_at":"2011-05-26T17:20:37.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Phosphoserine aminotransferase","uniprot_id":"P33330","uniprot_name":"SERC_YEAST","enzyme":true,"transporter":false,"gene_name":"SER1","num_residues":395,"molecular_weight":"43415.19922","theoretical_pi":"6.52","general_function":"Involved in metabolic process","specific_function":"Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine","reactions":[{"id":1800,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1894,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2474,"direction":"\u003e","locations":null,"altext":"O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2475,"direction":"\u003e","locations":null,"altext":"4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3842,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006365","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"L20917","genbank_protein_id":"311153","gene_card_id":"SER1","chromosome_location":"chromosome 15","locus":"YOR184W","synonyms":["PSAT","Phosphohydroxythreonine aminotransferase"],"enzyme_classes":["2.6.1.52"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" L-serine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" serine family amino acid metabolic process"}],"pfams":[{"name":"Aminotran_5","identifier":"PF00266"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCTTTGGAAAGAGAGGAACCACAACATTTCGGAGCAGGGCCAGCTCAAATGCCTACACCAGTTTTGCAACAAGCTGCTAAAGACTTAATCAATTTCAATGACATAGGTTTGGGTATCGGTGAAATTTCTCACCGTTCGAAGGATGCCACCAAAGTGATTGAAGACTCTAAGAAGCACTTAATCGAACTGCTAAATATTCCTGACACTCATGAAGTGTTCTACTTGCAAGGTGGTGGCACTACTGGTTTTTCTTCCGTTGCTACTAATTTGGCAGCTGCATATGTGGGTAAGCATGGGAAGATTGCACCTGCCGGTTATTTAGTCACCGGTAGTTGGTCTCAGAAATCTTTTGAAGAGGCAAAGAGATTGCACGTTCCTGCTGAAGTTATCTTCAACGCTAAAGATTATAACAATGGCAAATTTGGTAAAATTCCGGATGAATCCCTTTGGGAAGATAAAATCAAAGGTAAGGCTTTCTCATACGTGTACCTATGTGAGAATGAAACTGTTCATGGTGTTGAATGGCCAGAATTACCAAAATGTTTAGTAAACGACCCCAACATCGAAATTGTTGCTGACTTATCCAGCGACATTTTGTCTCGTAAGATTGACGTTTCTCAATACGGTGTCATCATGGCAGGCGCCCAAAAAAACATTGGTTTAGCAGGCTTAACCCTATACATTATCAAGAAATCCATCCTTAAGAATATTTCTGGCGCTTCTGATGAAACATTACATGAATTGGGAGTACCAATCACCCCTATTGCATTCGACTATCCAACGGTGGTGAAGAACAACTCAGCCTATAATACAATTCCAATTTTCACTTTACATGTTATGGATCTCGTGTTCCAACATATTTTGAAGAAGGGTGGTGTTGAAGCGCAACAGGCTGAAAATGAAGAAAAGGCCAAGATATTATATGAGGCATTGGATGCAAATTCAGATTTTTACAACGTTCCAGTGGATCCAAAGTGTAGATCAAAAATGAATGTCGTTTTCACCCTTAAAAAGGACGGCCTTGATGACCAGTTTCTAAAAGAGGCAGCTGCTCGTCATTTAACCGGTTTGAAAGGACATCGTTCAGTTGGTGGGTTCAGAGCCTCCATCTATAACGCGCTTTCAGTGAAAGCTGTACAAAACTTGGTAGATTTTATCAAGGAATTTGCTGAGAAAAACGCTTAA","protein_sequence":"MSLEREEPQHFGAGPAQMPTPVLQQAAKDLINFNDIGLGIGEISHRSKDATKVIEDSKKHLIELLNIPDTHEVFYLQGGGTTGFSSVATNLAAAYVGKHGKIAPAGYLVTGSWSQKSFEEAKRLHVPAEVIFNAKDYNNGKFGKIPDESLWEDKIKGKAFSYVYLCENETVHGVEWPELPKCLVNDPNIEIVADLSSDILSRKIDVSQYGVIMAGAQKNIGLAGLTLYIIKKSILKNISGASDETLHELGVPITPIAFDYPTVVKNNSAYNTIPIFTLHVMDLVFQHILKKGGVEAQQAENEEKAKILYEALDANSDFYNVPVDPKCRSKMNVVFTLKKDGLDDQFLKEAAARHLTGLKGHRSVGGFRASIYNALSVKAVQNLVDFIKEFAEKNA"},{"created_at":"2011-05-27T01:59:56.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"Phosphoserine phosphatase","uniprot_id":"P42941","uniprot_name":"SERB_YEAST","enzyme":true,"transporter":false,"gene_name":"SER2","num_residues":309,"molecular_weight":"34207.0","theoretical_pi":"4.83","general_function":"Involved in catalytic activity","specific_function":"O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate","reactions":[{"id":1893,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2654,"direction":"\u003e","locations":"Cytoplasmic","altext":"O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3843,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006366","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"U36473","genbank_protein_id":"1015428","gene_card_id":"SER2","chromosome_location":"chromosome 7","locus":"YGR208W","synonyms":["PSP","PSPase","O-phosphoserine phosphohydrolase"],"enzyme_classes":["3.1.3.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" phosphoserine phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" L-serine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Hydrolase","identifier":"PF00702"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCAAAGTTTGTTATCACCTGCATAGCTCATGGAGAAAATCTCCCAAAAGAAACCATCGACCAGATTGCGAAAGAAATTACTGAAAGCTCGGCGAAAGATGTATCAATCAATGGTACCAAGAAACTATCGGCCAGAGCTACCGATATATTCATTGAAGTCGCAGGATCGATTGTTCAAAAAGACCTCAAGAATAAGCTGACGAACGTCATTGACAGTCATAATGATGTTGATGTTATTGTTTCTGTCGACAATGAATATCGTCAAGCCAAAAAGCTCTTTGTCTTTGACATGGATTCAACATTAATCTACCAAGAGGTCATCGAATTGATTGCCGCTTATGCTGGTGTTGAAGAACAAGTGCACGAGATCACAGAAAGAGCCATGAACAATGAACTTGATTTCAAAGAGTCTTTAAGAGAACGCGTTAAATTATTGCAAGGCCTCCAAGTCGATACACTATATGATGAAATAAAACAAAAGCTAGAGGTCACCAAGGGTGTGCCAGAACTATGCAAGTTCCTTCACAAAAAAAATTGCAAGCTCGCTGTTTTAAGCGGTGGTTTTATTCAGTTTGCCGGTTTTATCAAGGATCAGTTAGGTTTAGATTTTTGTAAGGCAAACTTGTTGGAAGTTGACACTGATGGAAAATTAACCGGTAAAACACTGGGTCCTATCGTAGACGGACAGTGCAAGAGTGAAACCCTTCTGCAACTATGTAATGACTACAATGTTCCAGTTGAAGCAAGTTGTATGGTGGGTGACGGTGGTAACGACCTGCCAGCCATGGCTACCGCCGGGTTTGGGATCGCATGGAACGCCAAGCCAAAGGTGCAGAAAGCTGCACCTTGTAAGTTGAATACCAAGAGCATGACTGACATTTTATACATTCTTGGTTACACCGATGATGAAATATACAATAGACAATGA","protein_sequence":"MSKFVITCIAHGENLPKETIDQIAKEITESSAKDVSINGTKKLSARATDIFIEVAGSIVQKDLKNKLTNVIDSHNDVDVIVSVDNEYRQAKKLFVFDMDSTLIYQEVIELIAAYAGVEEQVHEITERAMNNELDFKESLRERVKLLQGLQVDTLYDEIKQKLEVTKGVPELCKFLHKKNCKLAVLSGGFIQFAGFIKDQLGLDFCKANLLEVDTDGKLTGKTLGPIVDGQCKSETLLQLCNDYNVPVEASCMVGDGGNDLPAMATAGFGIAWNAKPKVQKAAPCKLNTKSMTDILYILGYTDDEIYNRQ"}]}