Glycerol 3-phosphate (YMDB00073)

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Identification

YMDB ID

YMDB00073

Name

Glycerol 3-phosphate

Species

Saccharomyces cerevisiae

Strain

Baker's yeast

Description

Glycerol 3-phosphate is produced from glycerol, the triose sugar backbone of triglycerides and glycerophospholipids, by the enzyme glycerol kinase. Glycerol 3-phosphate may then be converted by dehydrogenation to dihydroxyacetone phosphate (DHAP) by the enzyme glycerol-3-phosphate dehydrogenase. DHAP can then be rearranged into glyceraldehyde 3-phosphate(GA3P) by triose phosphate isomerase(TIM), and feed into glycolysis. [Wikipedia]

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

(R)-glycerol 1-phosphate
1-(dihydrogen phosphate) Glycerol
1-Glycerophosphate
1-Glycerophosphorate
1-Glycerophosphoric acid
1-phosphoglycerol
1,2,3-propanetriol, 1-(dihydrogen phosphate)
2,3-dihydroxypropyl dihydrogen phosphate
2,3-hydroxy-1-propyl dihydrogen phosphate
3-Glycerophosphate
a-Glycerophosphate
a-Glycerophosphorate
a-Glycerophosphoric acid
a-Phosphoglycerol
alpha-Glycerophosphate
alpha-Glycerophosphorate
alpha-Glycerophosphoric acid
alpha-Phosphoglycerol
D-(glycerol 1-phosphate)
D-Glycerol 1-phosphate
dihydrogen a-glycerophosphate
DL-a-Glycerol phosphate
DL-a-Glycerophosphate
DL-a-Glycerophosphorate
DL-a-Glycerophosphoric acid
DL-a-Glyceryl phosphate
DL-alpha-Glycerol phosphate
DL-alpha-Glycerophosphate
DL-alpha-Glycerophosphorate
DL-alpha-Glycerophosphoric acid
DL-alpha-Glyceryl phosphate
DL-Glycerol 1-phosphate
DL-Glycerol 3-phosphate
Glycerol 1-phosphate
Glycerol a-phosphate
glycerol alpha-phosphate
Glycerol monophosphate
Glycerol-3-phosphate
Glycerophosphate
Glycerophosphorate
Glycerophosphoric acid
Glycerophosphoric acid I
Glyceryl phosphate
Glyceryl phosphic acid
L-(glycerol 3-phosphate)
PG
phosphatidyl glycerol
phosphoric acid mono-((R)-2,3-dihydroxy-propyl) ester
Phosphorsaeure-mono-((R)-2,3-dihydroxy-propylester)
sn-glycerol 3-phosphate
SN-GLYCEROL-3-PHOSPHATE
sn-Gro-1-P
(R)-Glycerol 1-phosphoric acid
D-(Glycerol 1-phosphoric acid)
D-Glycerol 1-phosphoric acid
Glycerol-3-phosphoric acid
L-(Glycerol 3-phosphoric acid)
Phosphate mono-((R)-2,3-dihydroxy-propyl) ester
sn-GLYCEROL-3-phosphoric acid
Glycerol 3-phosphoric acid
alpha-Glycerophosphoric acid, (DL)-isomer
alpha-Glycerophosphoric acid, (R)-isomer
alpha-Glycerophosphoric acid, (S)-isomer
alpha-Glycerophosphoric acid, 1,2,3-propanetriol-1-(18)O,3-(dihydrogen phosphate)-labeled
alpha-Glycerophosphoric acid, 1,2,3-propanetriol-2-(18)O,3-(dihydrogen phosphate)-labeled
alpha-Glycerophosphoric acid, fe salt
alpha-Glycerophosphoric acid, fe(+3) salt (3:2)
alpha-Glycerophosphoric acid, calcium salt
alpha-Glycerophosphoric acid, disodium salt
alpha-Glycerophosphoric acid, disodium salt (+-)-isomer
alpha-Glycerophosphoric acid, disodium salt hexahydrate(+-)-isomer
alpha-Glycerophosphoric acid, monocalcium salt
alpha-Glycerophosphoric acid, monocalcium salt (S)-isomer
alpha-Glycerophosphoric acid, monomagnesium salt
alpha-Glycerophosphoric acid, sodium salt
Disodium glycerophosphate
Sodium glycerophosphate

CAS number

17989-41-2

Weight

Average: 172.0737
Monoisotopic: 172.013674532

InChI Key

AWUCVROLDVIAJX-GSVOUGTGSA-N

InChI

InChI=1S/C3H9O6P/c4-1-3(5)2-9-10(6,7)8/h3-5H,1-2H2,(H2,6,7,8)/t3-/m1/s1

IUPAC Name

[(2R)-2,3-dihydroxypropoxy]phosphonic acid

Traditional IUPAC Name

3-phosphoglycerol

Chemical Formula

C₃H₉O₆P

SMILES

[H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OP(=O)(O[H])O[H]

Chemical Taxonomy

Description

belongs to the class of organic compounds known as glycerophosphates. Glycerophosphates are compounds containing a glycerol linked to a phosphate group.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Glycerophospholipids

Sub Class

Glycerophosphates

Direct Parent

Glycerophosphates

Alternative Parents

Substituents

Sn-glycerol-3-phosphate
Monoalkyl phosphate
Alkyl phosphate
Phosphoric acid ester
Organic phosphoric acid derivative
Secondary alcohol
1,2-diol
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Primary alcohol
Organooxygen compound
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

sn-glycerol 3-phosphates (CHEBI:15978 )
glycerol 1-phosphate (CHEBI:15978 )

Physical Properties

State

Solid

Charge

Melting point

102-104 °C

Experimental Properties

Property	Value	Reference
Water Solubility	1000 mg/mL [MERCK INDEX (1996); readily soluble]	PhysProp
LogP	Not Available	PhysProp

Predicted Properties

Property	Value	Source
Water Solubility	30.6 g/L	ALOGPS
logP	-1.8	ALOGPS
logP	-2	ChemAxon
logS	-0.75	ALOGPS
pKa (Strongest Acidic)	1.51	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	107.22 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	31.39 m³·mol⁻¹	ChemAxon
Polarizability	13.58 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Biological Properties

Cellular Locations

mitochondrion
lipid particle
endoplasmic reticulum
cytoplasm

Organoleptic Properties

Not Available

SMPDB Pathways

Cardiolipin Biosynthesis CL(10:0/10:0/15:0/27:1(9Z))	PW003534
Cardiolipin Biosynthesis CL(10:0/10:0/15:0/29:0)	PW003535
Cardiolipin Biosynthesis CL(10:0/10:0/15:1(11Z)/25:0)	PW003536
Cardiolipin Biosynthesis CL(10:0/10:0/15:1(11Z)/25:1(11Z))	PW003537
Cardiolipin Biosynthesis CL(10:0/10:0/15:1(11Z)/25:1(9Z))	PW003538

KEGG Pathways

Glycerolipid metabolism	ec00561
Glycerophospholipid metabolism	ec00564

SMPDB Reactions

KEGG Reactions

Adenosine triphosphate + Glycerol → Glycerol 3-phosphate + hydron + ADP

Glycerol 3-phosphate + water → Glycerol + phosphate

Glycerol 3-phosphate + FAD → FADH2 + Dihydroxyacetone phosphate

NADH + Dihydroxyacetone phosphate + hydron → NAD + Glycerol 3-phosphate

acyl-CoA + Glycerol 3-phosphate ↔ PA(18:1(9Z)/0:0) + Coenzyme A + hydron

Concentrations

Intracellular Concentrations

Intracellular Concentration	Substrate	Growth Conditions	Strain	Citation
0.0 ± 0.0 µM	Minimal medium supplemented with ammonia salts and glucose	aerobic;resting cells	Baker's yeast	PMID: 4578278
Conversion Details Here

Extracellular Concentrations

Not Available

Spectra

Spectrum Type	Description	Splash Key	View
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-0uea-0932000000-726f422c76a193edf232	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-0uea-0932000000-726f422c76a193edf232	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-MS (4 TMS)	splash10-0zgj-1976000000-019de1fa6314b95ef7fe	JSpectraViewer \| MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-01ot-9300000000-a435ec7fb966f8ddc1a2	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive	splash10-0230-9080000000-9f48133c7a08fb549acd	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_3) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_2) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_3) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_4) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_2) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_3) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_2_1) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_2_2) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_2_3) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_2_4) - 70eV, Positive	Not Available	JSpectraViewer
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0002-9200000000-bf06c1d1e56cb8853243	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-00kr-9200000000-ffce45222cab00a0c302	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-001j-9000000000-7689cca8f9c9a12d9e75	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0902000000-00e3a7e1ee10fbd8b03e	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-1a40c90fd2eb656ddf5c	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-9000000000-f9bc5f552db38767c437	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0920000000-72f8b96355726dd3a5b1	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0901000000-2c3a8ed438d7ca0fa049	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-a3549fb5ec2675fbf615	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-9000000000-096e2ba9a6ef6fd20d88	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0930000000-171708905bad289d6031	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-0925110000-c1ced10d34f533b3fa1f	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0900000000-4ee8a36492a451beda75	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-9000000000-de2aacfb81476c7755e5	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-0900000000-dd342482ade09e9ce749	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0fkc-0917520000-d61e6034525ac5f7588d	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-9000000000-d537d3f23f3d9a789c20	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-0900000000-2f1ca45b50402f6e62df	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0009000000-5606781224d6ab5caed3	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0pi0-1900000000-75b6ed57a4c9cd6378b4	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-0a59-6900000000-1c46fbda1468f6fd803c	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-0a5c-9400000000-305e9a2554d8c3274f32	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-007o-9000000000-d11ad04a048c3dca25de	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-00mo-9000000000-7b779b4be184b5b26b6a	JSpectraViewer \| MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00di-5900000000-297dbde751110233eca5	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
2D NMR	[1H,1H] 2D NMR Spectrum	Not Available	JSpectraViewer
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available	JSpectraViewer

References

References:

UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). "BRENDA, the enzyme information system in 2011." Nucleic Acids Res 39:D670-D676.21062828
Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
Norbeck, J., Pahlman, A. K., Akhtar, N., Blomberg, A., Adler, L. (1996). "Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway." J Biol Chem 271:13875-13881.8662716
Andre, L., Hemming, A., Adler, L. (1991). "Osmoregulation in Saccharomyces cerevisiae. Studies on the osmotic induction of glycerol production and glycerol-3-phosphate dehydrogenase (NAD+)" FEBS Lett 286:13-17.1864360
Fernandez-Murray, J. P., McMaster, C. R. (2005). "Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway." J Biol Chem 280:38290-38296.16172116
Athenstaedt, K., Weys, S., Paltauf, F., Daum, G. (1999). "Redundant systems of phosphatidic acid biosynthesis via acylation of glycerol-3-phosphate or dihydroxyacetone phosphate in the yeast Saccharomyces cerevisiae." J Bacteriol 181:1458-1463.10049376
Fisher, E., Almaguer, C., Holic, R., Griac, P., Patton-Vogt, J. (2005). "Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae." J Biol Chem 280:36110-36117.16141200
Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
Zheng, Z., Zou, J. (2001). "The initial step of the glycerolipid pathway: identification of glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate acyltransferases in Saccharomyces cerevisiae." J Biol Chem 276:41710-41716.11544256
Albertyn, J., Hohmann, S., Thevelein, J. M., Prior, B. A. (1994). "GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway." Mol Cell Biol 14:4135-4144.8196651
Gancedo, J. M., Gancedo, C. (1973). "Concentrations of intermediary metabolites in yeast." Biochimie 55:205-211.4578278

Synthesis Reference:

Rios-Mercadillo, Victor M.; Whitesides, George M. Enzymic synthesis of sn-glycerol 3-phosphate. Journal of the American Chemical Society (1979), 101(19), 5828-9.

External Links:

Resource	Link
CHEBI ID	15978
HMDB ID	HMDB00126
Pubchem Compound ID	439162
Kegg ID	C00093
ChemSpider ID	388308
FOODB ID	FDB031180
Wikipedia	Glycerol_3-phosphate
BioCyc ID	GLYCEROL-3P

Enzymes

Protein Details

1. Enolase-phosphatase E1

General function:: Involved in catalytic activity
Specific function:: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)
Gene Name:: UTR4
Uniprot ID:: P32626
Molecular weight:: 25187.19922

Reactions

5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O → 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.
2-Phosphoglycolate + H2O → glycolate + phosphate

Protein Details

2. Glycerol-3-phosphate O-acyltransferase 1

General function:: Involved in acyltransferase activity
Specific function:: G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase
Gene Name:: GPT1
Uniprot ID:: P32784
Molecular weight:: 85693.5

Reactions

Acyl-CoA + sn-glycerol 3-phosphate → CoA + 1-acyl-sn-glycerol 3-phosphate.
Acyl-CoA + glycerone phosphate → CoA + acylglycerone phosphate.

Protein Details

3. Glycerol-3-phosphate O-acyltransferase 2

General function:: Involved in acyltransferase activity
Specific function:: G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase
Gene Name:: GPT2
Uniprot ID:: P36148
Molecular weight:: 83644.0

Reactions

Acyl-CoA + sn-glycerol 3-phosphate → CoA + 1-acyl-sn-glycerol 3-phosphate.
Acyl-CoA + glycerone phosphate → CoA + acylglycerone phosphate.

Protein Details

4. Glycerol-3-phosphate dehydrogenase [NAD+] 1

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells
Gene Name:: GPD1
Uniprot ID:: Q00055
Molecular weight:: 42868.5

Reactions

sn-glycerol 3-phosphate + NAD(+) → glycerone phosphate + NADH.

Protein Details

5. Glycerophosphodiester phosphodiesterase GDE1

General function:: Involved in protein binding
Specific function:: Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source
Gene Name:: GDE1
Uniprot ID:: Q02979
Molecular weight:: 138013.0

Reactions

A glycerophosphodiester + H(2)O → an alcohol + sn-glycerol 3-phosphate.

Protein Details

6. (DL)-glycerol-3-phosphatase 2

General function:: Involved in catalytic activity
Specific function:: Glycerol 3-phosphate + H(2)O = glycerol + phosphate
Gene Name:: HOR2
Uniprot ID:: P40106
Molecular weight:: 27813.5

Reactions

Glycerol 3-phosphate + H(2)O → glycerol + phosphate.
glycerol 1-phosphate + H2O → glycerol + phosphate

Protein Details

7. Glycerol-3-phosphate dehydrogenase [NAD+] 2, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the production of glycerol under anaerobic growth conditions. Glycerol production serves as a redox sink by consuming the excess cytosolic NADH during anaerobic metabolism
Gene Name:: GPD2
Uniprot ID:: P41911
Molecular weight:: 49421.30078

Reactions

sn-glycerol 3-phosphate + NAD(+) → glycerone phosphate + NADH.

Protein Details

8. Probable glycerophosphodiester phosphodiesterase YPL206C

General function:: Involved in glycerophosphodiester phosphodiesterase activity
Specific function:: Probable glycerophosphocholine glycerophosphodiesterase which may be responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis
Gene Name:: Not Available
Uniprot ID:: Q08959
Molecular weight:: 37069.39844

Reactions

A glycerophosphodiester + H(2)O → an alcohol + sn-glycerol 3-phosphate.

Protein Details

9. Glycerol kinase

General function:: Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:: ATP + glycerol = ADP + sn-glycerol 3- phosphate
Gene Name:: GUT1
Uniprot ID:: P32190
Molecular weight:: 79823.60156

Reactions

ATP + glycerol → ADP + sn-glycerol 3-phosphate.

Protein Details

10. Glycerol-3-phosphate dehydrogenase, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol
Gene Name:: GUT2
Uniprot ID:: P32191
Molecular weight:: 72388.29688

Reactions

sn-glycerol 3-phosphate + a quinone → glycerone phosphate + a quinol.

Protein Details

11. (DL)-glycerol-3-phosphatase 1

General function:: Involved in catalytic activity
Specific function:: Glycerol 3-phosphate + H(2)O = glycerol + phosphate
Gene Name:: RHR2
Uniprot ID:: P41277
Molecular weight:: 27946.59961

Reactions

Glycerol 3-phosphate + H(2)O → glycerol + phosphate.
glycerol 1-phosphate + H2O → glycerol + phosphate

Protein Details

12. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

General function:: Involved in phosphotransferase activity, for other substituted phosphate groups
Specific function:: Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids
Gene Name:: PGS1
Uniprot ID:: P25578
Molecular weight:: 59369.69922

Reactions

CDP-diacylglycerol + sn-glycerol 3-phosphate → CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Protein Details

13. Putative uncharacterized hydrolase YOR131C

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: Not Available
Uniprot ID:: Q12486
Molecular weight:: 24839.80078

Reactions

2-Phosphoglycolate + H2O → glycolate + phosphate

Protein Details

14. Uncharacterized protein YMR130W

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: Not Available
Uniprot ID:: Q04223
Molecular weight:: 35278.10156

Reactions

2-Phosphoglycolate + H2O → glycolate + phosphate

Structure for #<Compound:0xb1710640>

Enzymes

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