{"ymdb_id":"YMDB00054","created_at":"2011-05-29T15:52:22.000Z","updated_at":"2016-09-08T18:34:57.000Z","name":"N-(5-phospho-beta-D-ribosyl)anthranilic acid","cas":null,"state":null,"melting_point":null,"description":"N-(5'-Phosphoribosyl)-anthranilate is an intermediate in tryptophan biosynthesis pathway. [Biocyc TRPSYN-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm","synthesis_reference":null,"chebi_id":"7091","hmdb_id":null,"kegg_id":"C04302","pubchem_id":"440289","cs_id":"389264","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"2-{[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]amino}benzoic acid","traditional_iupac":"nprat","logp":"-0.15358638733333307","pka":"4.479601137460891","alogps_solubility":"3.50e+00 g/l","alogps_logp":"-1.00","alogps_logs":"-2.00","acceptor_count":"9","donor_count":"6","rotatable_bond_count":"6","polar_surface_area":"165.77999999999997","refractivity":"76.08050000000001","polarizability":"30.590674563134687","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":"-2.1194422626628873","pka_strongest_acidic":"1.2253408707793971","bioavailability":"1","number_of_rings":"2","rule_of_five":"0","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["N-(2-carboxylatophenyl)-5-O-phosphonato-beta-D-ribofuranosylamine","N-(5-Phospho-beta-D-ribosyl)anthranilate","N-(5-Phospho-D-ribosyl)anthranilate","N-(5-Phosphoribosyl)anthranilate","N-(5-Phosphoribosyl)anthranilic acid","N-(5'-Phosphoribosyl)anthranilate","N-(5'-Phosphoribosyl)anthranilic acid","NPRAT"],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":2651124,"citation":"Hommel, U., Lustig, A., Kirschner, K. (1989). \"Purification and characterization of yeast anthranilate phosphoribosyltransferase.\" Eur J Biochem 180:33-40."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":348687,"citation":"Miozzari, G., Niederberger, P., Hutter, R. (1978). \"Tryptophan biosynthesis in Saccharomyces cerevisiae: control of the flux through the pathway.\" J Bacteriol 134:48-59."}],"proteins":[{"created_at":"2011-05-26T16:44:50.000Z","updated_at":"2011-07-22T17:54:11.000Z","name":"Anthranilate phosphoribosyltransferase","uniprot_id":"P07285","uniprot_name":"TRPD_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP4","num_residues":380,"molecular_weight":"41374.0","theoretical_pi":"6.66","general_function":"Involved in anthranilate phosphoribosyltransferase activity","specific_function":"N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1- diphosphate","reactions":[{"id":1322,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2442,"direction":"\u003e","locations":null,"altext":"N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14104,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006528","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U28372","genbank_protein_id":"849174","gene_card_id":"TRP4","chromosome_location":"chromosome 4","locus":"YDR354W","synonyms":[],"enzyme_classes":["2.4.2.18"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" anthranilate phosphoribosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" tryptophan biosynthetic process"}],"pfams":[{"name":"Glycos_trans_3N","identifier":"PF02885"},{"name":"Glycos_transf_3","identifier":"PF00591"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGTCCGAGGCGACTTTGCTATCTTACACCAAGAAATTATTGGCTTCTCCGCCGCAATTGAGTAGCACAGACCTACACGATGCGTTGCTGGTTATATTAAGTCTTTTGCAAAAATGTGATACAAATAGCGATGAGAGTCTTTCCATCTATACCAAAGTTTCGAGTTTTCTCACGGCCTTGAGAGTTACTAAACTTGATCACAAGGCTGAATACATTGCGGAAGCTGCAAAGGCTGTGCTCAGACATTCCGACCTTGTTGATCTACCTTTACCCAAGAAGGACGAATTACACCCGGAAGATGGACCAGTAATCTTAGATATTGTAGGTACTGGTGGTGACGGACAGAATACTTTTAATGTTTCCACGTCTGCTGCTATCGTTGCCTCCGGAATTCAGGGCCTAAAAATTTGTAAGCACGGTGGTAAAGCTTCTACATCCAATAGTGGAGCTGGTGACCTAATTGGAACTTTAGGCTGTGACATGTTCAAGGTTAATTCATCGACAGTGCCCAAACTTTGGCCTGATAATACGTTCATGTTTCTACTTGCTCCTTTTTTTCATCATGGAATGGGCCACGTTTCTAAGATACGCAAATTTCTTGGAATTCCGACTGTTTTCAACGTACTGGGACCACTTCTACATCCAGTTAGCCACGTAAACAAGAGAATATTGGGCGTTTACTCAAAGGAACTTGCGCCTGAATATGCCAAGGCAGCCGCTTTGGTATATCCAGGAAGCGAAACTTTTATAGTTTGGGGACATGTTGGGTTAGACGAAGTATCACCTATAGGCAAAACTACTGTCTGGCATATTGATCCGACATCGTCCGAACTTAAATTGAAGACCTTCCAATTAGAACCTTCTATGTTTGGTTTAGAAGAACACGAGTTGTCGAAGTGTGCTTCATACGGCCCTAAAGAGAATGCGAGAATTCTAAAAGAAGAAGTCTTGTCCGGCAAGTACCACCTTGGCGACAATAATCCTATTTATGACTACATCTTGATGAACACCGCCGTGTTATATTGTTTAAGCCAAGGTCACCAGAACTGGAAGGAAGGGATCATTAAGGCAGAAGAAAGCATACATTCTGGTAATGCATTACGTTCTTTAGAACACTTTATAGATAGTGTGAGCTCCTTGTAG","protein_sequence":"MSEATLLSYTKKLLASPPQLSSTDLHDALLVILSLLQKCDTNSDESLSIYTKVSSFLTALRVTKLDHKAEYIAEAAKAVLRHSDLVDLPLPKKDELHPEDGPVILDIVGTGGDGQNTFNVSTSAAIVASGIQGLKICKHGGKASTSNSGAGDLIGTLGCDMFKVNSSTVPKLWPDNTFMFLLAPFFHHGMGHVSKIRKFLGIPTVFNVLGPLLHPVSHVNKRILGVYSKELAPEYAKAAALVYPGSETFIVWGHVGLDEVSPIGKTTVWHIDPTSSELKLKTFQLEPSMFGLEEHELSKCASYGPKENARILKEEVLSGKYHLGDNNPIYDYILMNTAVLYCLSQGHQNWKEGIIKAEESIHSGNALRSLEHFIDSVSSL"},{"created_at":"2011-05-27T04:04:57.000Z","updated_at":"2011-05-27T15:01:22.000Z","name":"N-(5'-phosphoribosyl)anthranilate isomerase","uniprot_id":"P00912","uniprot_name":"TRPF_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP1","num_residues":224,"molecular_weight":"24144.30078","theoretical_pi":"5.08","general_function":"Involved in catalytic activity","specific_function":"N-(5-phospho-beta-D-ribosyl)anthranilate = 1- (2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate","reactions":[{"id":1888,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2757,"direction":"\u003e","locations":null,"altext":"N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14105,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006529","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AJ585667","genbank_protein_id":"45719938","gene_card_id":"TRP1","chromosome_location":"chromosome 4","locus":"YDR007W","synonyms":["PRAI"],"enzyme_classes":["5.3.1.24"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular oxidoreductase activity"},{"category":"Function","description":" intramolecular oxidoreductase activity, interconverting aldoses and ketoses"},{"category":"Function","description":" phosphoribosylanthranilate isomerase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"}],"pfams":[{"name":"PRAI","identifier":"PF00697"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGTCTGTTATTAATTTCACAGGTAGTTCTGGTCCATTGGTGAAAGTTTGCGGCTTGCAGAGCACAGAGGCCGCAGAATGTGCTCTAGATTCCGATGCTGACTTGCTGGGTATTATATGTGTGCCCAATAGAAAGAGAACAATTGACCCGGTTATTGCAAGGAAAATTTCAAGTCTTGTAAAAGCATATAAAAATAGTTCAGGCACTCCGAAATACTTGGTTGGCGTGTTTCGTAATCAACCTAAGGAGGATGTTTTGGCTCTGGTCAATGATTACGGCATTGATATCGTCCAACTGCATGGAGATGAGTCGTGGCAAGAATACCAAGAGTTCCTCGGTTTGCCAGTTATTAAAAGACTCGTATTTCCAAAAGACTGCAACATACTACTCAGTGCAGCTTCACAGAAACCTCATTCGTTTATTCCCTTGTTTGATTCAGAAGCAGGTGGGACAGGTGAACTTTTGGATTGGAACTCGATTTCTGACTGGGTTGGAAGGCAAGAGAGCCCCGAAAGCTTACATTTTATGTTAGCTGGTGGACTGACGCCAGAAAATGTTGGTGATGCGCTTAGATTAAATGGCGTTATTGGTGTTGATGTAAGCGGAGGTGTGGAGACAAATGGTGTAAAAGACTCTAACAAAATAGCAAATTTCGTCAAAAATGCTAAGAAATAG","protein_sequence":"MSVINFTGSSGPLVKVCGLQSTEAAECALDSDADLLGIICVPNRKRTIDPVIARKISSLVKAYKNSSGTPKYLVGVFRNQPKEDVLALVNDYGIDIVQLHGDESWQEYQEFLGLPVIKRLVFPKDCNILLSAASQKPHSFIPLFDSEAGGTGELLDWNSISDWVGRQESPESLHFMLAGGLTPENVGDALRLNGVIGVDVSGGVETNGVKDSNKIANFVKNAKK"}]}