{"ymdb_id":"YMDB00047","created_at":"2011-05-29T15:51:38.000Z","updated_at":"2016-09-08T18:34:57.000Z","name":"N-Acetyl-L-glutamyl 5-phosphate","cas":"15383-57-0","state":"Solid","melting_point":"","description":"N-Acetyl-L-glutamyl 5-phosphate is an intermediate in urea cycle and metabolism of amino groups.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"mitochondrion","synthesis_reference":"Kuramitsu, Shigenori; Masui, Ryoji.  Cloning of thermostable acetylglutamate kinase gene from Sulfolobus tokodaii and use for N-acetyl-L-glutamate-5-phosphate biosynthesis.    Jpn. Kokai Tokkyo Koho  (2004),     12 pp.  CODEN: JKXXAF  JP  2004298187  A  2","chebi_id":"16878","hmdb_id":"HMDB06456","kegg_id":"C04133","pubchem_id":"440236","cs_id":"389220","foodb_id":null,"wikipedia_link":null,"biocyc_id":"N-ACETYL-GLUTAMYL-P","iupac":"(2S)-2-acetamido-5-oxo-5-(phosphonooxy)pentanoic acid","traditional_iupac":"(2S)-2-acetamido-5-oxo-5-(phosphonooxy)pentanoic acid","logp":"-1.766880562333333","pka":"3.564886066603254","alogps_solubility":"3.64e+00 g/l","alogps_logp":"-1.92","alogps_logs":"-1.87","acceptor_count":"7","donor_count":"4","rotatable_bond_count":"7","polar_surface_area":"150.23000000000002","refractivity":"51.89120000000001","polarizability":"21.947659100936963","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":"-1.8012284694004794","pka_strongest_acidic":"1.2321518301617242","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2S)-2-acetamido-5-oxo-5-(phosphonooxy)pentanoate","(2S)-2-acetamido-5-oxo-5-(phosphonooxy)pentanoic acid","N-acetyl-5-glutamyl phosphate","N-Acetyl-5-glutamyl phosphoric acid","N-acetyl-5-oxo-5-(phosphonooxy)-L-norvaline","N-acetyl-gamma-l-glutamyl phosphate","N-acetyl-L-glutamate 5-phosphate","N-Acetyl-L-glutamic acid 5-phosphoric acid","N-Acetyl-L-glutamyl 5-phosphoric acid"],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":205532,"citation":"Jauniaux, J. C., Urrestarazu, L. A., Wiame, J. M. (1978). \"Arginine metabolism in Saccharomyces cerevisiae: subcellular localization of the enzymes.\" J Bacteriol 133:1096-1107."},{"pubmed_id":11553611,"citation":"Abadjieva, A., Pauwels, K., Hilven, P., Crabeel, M. (2001). \"A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase.\" J Biol Chem 276:42869-42880."}],"proteins":[{"created_at":"2011-05-26T16:34:45.000Z","updated_at":"2011-07-22T17:53:55.000Z","name":"Protein ARG5,6, mitochondrial","uniprot_id":"Q01217","uniprot_name":"ARG56_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG5","num_residues":863,"molecular_weight":"94868.39844","theoretical_pi":"8.45","general_function":"Involved in acetylglutamate kinase activity","specific_function":"N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH","reactions":[{"id":1244,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1752,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2427,"direction":"\u003e","locations":"Mitochondrion","altext":"N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2428,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"U18813","genbank_protein_id":"603305","gene_card_id":"ARG5","chromosome_location":null,"locus":"YER069W","synonyms":["N-acetyl-gamma-glutamyl-phosphate reductase","N-acetyl-glutamate semialdehyde dehydrogenase","NAGSA dehydrogenase","Acetylglutamate kinase","N-acetyl-L-glutamate 5-phosphotransferase","NAG kinase","AGK"],"enzyme_classes":["1.2.1.38","2.7.2.8"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" mitochondrion"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" protein dimerization activity"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" N-acetyl-gamma-glutamyl-phosphate reductase activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" acetylglutamate kinase activity"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" protein binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" arginine biosynthetic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" arginine metabolic process"}],"pfams":[{"name":"Semialdhyde_dh","identifier":"PF01118"},{"name":"Semialdhyde_dhC","identifier":"PF02774"},{"name":"DUF619","identifier":"PF04768"},{"name":"AA_kinase","identifier":"PF00696"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGCCATCTGCTAGCTTACTCGTCTCGACAAAGAGACTTAACGCTTCCAAATTCCAAAAATTTGTGTCTTCATTAAACAAATCCACCATAGCAGGATTTGCATCTGTACCCTTGAGAGCTCCACCATCCGTTGCATTTACGAGAAAGAAAGTCGGATACTCAAAGAGGTATGTTTCATCTACTAACGGCTTTTCAGCTACTAGATCCACTGTGATCCAACTGTTGAACAATATCAGCACAAAAAGAGAGGTTGAACAATATTTGAAATATTTCACTTCCGTCTCACAACAACAATTTGCTGTGATCAAGGTGGGTGGTGCCATTATCAGCGACAATCTACACGAACTCGCTTCCTGCTTGGCATTTTTGTATCATGTTGGTCTATATCCAATAGTTTTACATGGTACCGGTCCTCAGGTTAATGGAAGGCTAGAAGCGCAGGGAATTGAGCCAGACTATATTGATGGTATTAGAATCACGGATGAGCACACAATGGCCGTAGTTAGAAAATGTTTTTTGGAACAAAATCTTAAGCTAGTTACTGCATTAGAACAGCTAGGGGTCCGTGCAAGACCCATTACTTCTGGTGTTTTTACTGCTGACTATTTGGATAAGGACAAATACAAGCTAGTGGGCAATATTAAAAGTGTCACAAAAGAGCCAATTGAAGCATCTATTAAGGCAGGTGCCCTACCAATCTTGACCTCTTTAGCCGAAACTGCTTCTGGTCAAATGTTGAACGTCAACGCCGACGTAGCTGCTGGTGAATTAGCCCGTGTTTTTGAGCCTTTGAAGATCGTTTACCTGAATGAGAAAGGGGGTATTATCAATGGCTCCACGGGAGAAAAAATTTCGATGATCAATTTGGATGAAGAGTATGACGATTTAATGAAGCAAAGTTGGGTGAAGTATGGTACCAAATTAAAAATTAGAGAAATTAAAGAGCTTTTGGACTATCTTCCTCGTTCTTCTTCAGTTGCAATCATTAACGTTCAAGATCTACAAAAAGAACTGTTCACTGATTCTGGTGCGGGTACTATGATCAGGAGAGGTTACAAATTAGTGAAGAGATCCTCCATTGGCGAATTTCCATCCGCTGATGCTCTAAGAAAAGCTCTTCAAAGGGACGCTGGCATTAGTTCCGGTAAAGAATCTGTTGCTTCTTATTTAAGATATTTGGAAAACTCTGATTTTGTCTCTTATGCTGATGAACCTCTTGAAGCAGTGGCCATTGTAAAGAAAGATACGAACGTTCCCACACTAGACAAATTTGTCTGTTCTGACGCAGCCTGGTTGAATAACGTCACAGATAATGTATTCAATGTTTTGCGCCGTGATTTTCCTGCTTTACAATGGGTAGTCAGTGAAAATGATGCTAACATTGCATGGCATTTTGATAAGTCTCAAGGTTCATATCTAAAAGGCGGAAAAGTTTTGTTCTGGTATGGTATCGATGATATAAATACAATATCCGAGCTCGTTGAAAATTTTGTGAAGTCGTGTGACACTGCTTCTACCCTCAACTCATCAGCAAGTAGTGGAGTATTTGCTAACAAAAAATCAGCTAGGTCGTACTCAACTAGATCCACTCCTCGTCCCGAGGGAGTTAACACCAACCCTGGTCGTGTCGCGCTTATTGGTGCTAGAGGTTACACAGGTAAAAATTTGGTATCTTTGATCAACGGCCACCCATATTTAGAAGTGGCCCATGTTTCTTCTCGTGAATTGAAAGGTCAAAAGTTGCAAGATTATACAAAATCCGAAATTATATATGAAAGTTTGCAAATACAGGATATTAGGAAACTGGAAGAACAAAATGCTGTGGACTTTTGGGTTATGGCATTACCCAACAAAGTCTGTGAACCTTTCGTTGAGACAATCCAAAGTGTTCATGGTAAGTCTAAAATTATTGATCTGTCCGCTGATCACAGGTTTGTATCAGAATCAGACTGGGCTTACGGTTTGCCAGAATTGAATGATAGAGCAAAAATTGCAAACGCTGCCAAAATTGCTAATCCCGGTTGTTATGCTACTGGTTCGCAATTAACTATTTCTCCGTTAACAAAGTATATCAATGGTCTTCCAACTGTGTTTGGTGTTTCAGGGTATTCAGGCGCGGGGACGAAGCCTTCTCCAAAAAACGATCCCAAATTCTTGAACAATAACTTAATTCCTTACGCTTTAAGTGATCATATACACGAACGCGAAATCTCAGCTCGCATTGGGCACAATGTTGCATTCATGCCCCATGTTGGGCAGTGGTTTCAAGGTATCTCTTTGACCGTCTCTATTCCAATAAAAAAAGGTTCCTTGTCTATTGATGAGATCAGGAAATTATACAGAAATTTTTACGAAGACGAAAAGCTAGTACATGTCATCGATGATATCCCACTGGTTAAAGATATTGAGGGCACCCATGGTGTAGTTATTGGTGGTTTCAAGCTGAATGATGCTGAAGATCGTGTAGTTGTTTGCGCAACCATCGATAACTTACTTAAAGGCGCCGCTACTCAATGTCTGCAAAATATTAATCTTGCTATGGGTTATGGAGAGTATGCTGGTATCCCTGAAAATAAAATTATTGGTGTCTGA","protein_sequence":"MPSASLLVSTKRLNASKFQKFVSSLNKSTIAGFASVPLRAPPSVAFTRKKVGYSKRYVSSTNGFSATRSTVIQLLNNISTKREVEQYLKYFTSVSQQQFAVIKVGGAIISDNLHELASCLAFLYHVGLYPIVLHGTGPQVNGRLEAQGIEPDYIDGIRITDEHTMAVVRKCFLEQNLKLVTALEQLGVRARPITSGVFTADYLDKDKYKLVGNIKSVTKEPIEASIKAGALPILTSLAETASGQMLNVNADVAAGELARVFEPLKIVYLNEKGGIINGSTGEKISMINLDEEYDDLMKQSWVKYGTKLKIREIKELLDYLPRSSSVAIINVQDLQKELFTDSGAGTMIRRGYKLVKRSSIGEFPSADALRKALQRDAGISSGKESVASYLRYLENSDFVSYADEPLEAVAIVKKDTNVPTLDKFVCSDAAWLNNVTDNVFNVLRRDFPALQWVVSENDANIAWHFDKSQGSYLKGGKVLFWYGIDDINTISELVENFVKSCDTASTLNSSASSGVFANKKSARSYSTRSTPRPEGVNTNPGRVALIGARGYTGKNLVSLINGHPYLEVAHVSSRELKGQKLQDYTKSEIIYESLQIQDIRKLEEQNAVDFWVMALPNKVCEPFVETIQSVHGKSKIIDLSADHRFVSESDWAYGLPELNDRAKIANAAKIANPGCYATGSQLTISPLTKYINGLPTVFGVSGYSGAGTKPSPKNDPKFLNNNLIPYALSDHIHEREISARIGHNVAFMPHVGQWFQGISLTVSIPIKKGSLSIDEIRKLYRNFYEDEKLVHVIDDIPLVKDIEGTHGVVIGGFKLNDAEDRVVVCATIDNLLKGAATQCLQNINLAMGYGEYAGIPENKIIGV"}]}