{"ymdb_id":"YMDB00038","created_at":"2011-05-29T15:50:40.000Z","updated_at":"2016-10-18T17:11:15.000Z","name":"L-Isoleucine","cas":"73-32-5","state":"Solid","melting_point":"285.5 oC","description":"Isoleucine (abbreviated as Ile or I) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a nonpolar branched chain amino acid, because of the hydrophobic nature of the branched alkyl side chain. Together with threonine, isoleucine is one of two common amino acids that have a chiral side chain. it is synthesized via several steps, starting from pyruvic acid and alpha-ketoglutarate. Enzymes involved in this biosynthesis include: Acetolactate synthase (also known as acetohydroxy acid synthase), Acetohydroxy acid isomeroreductase, Dihydroxyacid dehydratase and Valine aminotransferase.\u003cbr\u003eS. cerevisiae degrade the branched-chain amino acids (valine, leucine, and iso-leucine) via the Ehrlich pathway.  This pathway consists of 3 steps: 1) deamination of the amino acid to the corresponding alpha-keto acid; 2) decarboxylation of the resulting alpha-keto acid to the respective aldehyde; and, 3) reduction of the aldehyde to form the corresponding long chain or complex alcohol, known as a fusel alcohol or fusel oil. Fusel alcohols are important flavor and aroma compounds in yeast-fermented food products and beverages. Each of the three steps in branched-chain amino acid degradation can be catalyzed by more than one isozyme; which enzyme is used appears to depend on the amino acid, the carbon source and the stage of growth of the culture.  The initial transamination step in isoleucine degradation can be catalyzed by either of the branched-chain amino acid transaminases BAT1 (mitochondrial) or BAT2 (cytosolic). The subsequent decarboxylation step can be catalyzed by any one of the five decarboxylases (Pdc1p, Pdc5p, Pdc6p, Thi3p, and Aro10p) and the final step can be catalyzed by any one of six alcohol dehydrogenases (Adh1p, Adh2p, Adh3p, Adh4p, Adh5p, and Sfa1p).","experimental_water_solubility":"34.4 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-1.70 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;vacuole;cytoplasm","synthesis_reference":" Marvel, C. S. L-Isoleucine. Organic Syntheses (1941), 21 60-4.","chebi_id":"17191","hmdb_id":"HMDB00172","kegg_id":"C00407","pubchem_id":"791","cs_id":"6067","foodb_id":null,"wikipedia_link":"Isoleucine","biocyc_id":"ILE","iupac":"(2S,3S)-2-amino-3-methylpentanoic acid","traditional_iupac":"L-isoleucine","logp":"-1.5084066056000942","pka":null,"alogps_solubility":"1.14e+02 g/l","alogps_logp":"-1.73","alogps_logs":"-0.06","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"3","polar_surface_area":"63.31999999999999","refractivity":"34.093900000000005","polarizability":"14.11454343235902","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.591345628135606","pka_strongest_acidic":"2.7913082723326537","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2S,3S)-2-amino-3-methyl-Pentanoate","(2S,3S)-2-amino-3-methyl-Pentanoic acid","(2S,3S)-2-Amino-3-methylpentanoate","(2S,3S)-2-Amino-3-methylpentanoic acid","(2S,3S)-a-Amino-b-methyl-n-valerate","(2S,3S)-a-Amino-b-methyl-n-valeric acid","(2S,3S)-a-Amino-b-methylvalerate","(2S,3S)-a-Amino-b-methylvaleric acid","(2S,3S)-alph-Amino-beta-methylvalerate","(2S,3S)-alph-Amino-beta-methylvaleric acid","(2S,3S)-alpha-Amino-beta-merthyl-n-valerate","(2S,3S)-alpha-Amino-beta-merthyl-n-valeric acid","(2S,3S)-alpha-Amino-beta-merthylvalerate","(2S,3S)-alpha-Amino-beta-merthylvaleric acid","(2S,3S)-alpha-Amino-beta-methyl-n-valerate","(2S,3S)-alpha-Amino-beta-methyl-n-valeric acid","(2S,3S)-alpha-Amino-beta-methylvalerate","(2S,3S)-alpha-Amino-beta-methylvaleric acid","(S,S)-Isoleucine","(S)-Isoleucine","[S-(R*,R*)]-2-Amino-3-methylpentanoate","[S-(R*,R*)]-2-Amino-3-methylpentanoic acid","2-Amino-3-methylpentanoate","2-Amino-3-methylpentanoic acid","2-Amino-3-methylvalerate","2-Amino-3-methylvaleric acid","2S,3S-Isoleucine","a-amino-b-Methylvalerate","a-amino-b-Methylvaleric acid","Alloisoleucine","alpha-amino-beta-Methylvalerate","alpha-amino-beta-Methylvaleric acid","erythro-L-Isoleucine","I","Ile","iso-leucine","Isoleucine","Isoleucine, L isomer","Isoleucine, L-isomer","L-(+)-Isoleucine","L-Ile","L-Isomer isoleucine","α-amino-β-methylvalerate","α-amino-β-methylvaleric acid"],"pathways":[{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"isoleucine biosynthesis","kegg_map_id":null}],"growth_conditions":[{"growth_media":"YPD media","concentration":"938.41026","concentration_units":"\u0026#181;M","error":"18.73846"},{"growth_media":"YPG media","concentration":"156.45128","concentration_units":"\u0026#181;M","error":"3.27179"},{"growth_media":"SD media","concentration":"234.67692","concentration_units":"\u0026#181;M","error":"4.75897"},{"growth_media":"SG media","concentration":"156.45128","concentration_units":"\u0026#181;M","error":"3.27179"},{"growth_media":"M (molasses)","concentration":"625.50769","concentration_units":"\u0026#181;M","error":"12.49231"},{"growth_media":"MA (molasses)","concentration":"4535.00513","concentration_units":"\u0026#181;M","error":"90.71795"},{"growth_media":"MB (molasses)","concentration":"1172.78974","concentration_units":"\u0026#181;M","error":"23.49744"},{"growth_media":"MAB (molasses)","concentration":"6177.14872","concentration_units":"\u0026#181;M","error":"123.4359"},{"growth_media":"YEB media with 0.5 mM glucose","concentration":"1359.0","concentration_units":"\u0026#181;M","error":"68.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"700.0","concentration_units":"\u0026#181;M","error":"67.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"1.6","concentration_units":"umol/g DW","error":"0.0"}],"references":[{"pubmed_id":7654310,"citation":"Martinez-Force, E., Benitez, T. (1995). \"Effects of varying media, temperature, and growth rates on the intracellular concentrations of yeast amino acids.\" Biotechnol Prog 11:386-392."},{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":11341309,"citation":"Eden, A., Van Nedervelde, L., Drukker, M., Benvenisty, N., Debourg, A. (2001). \"Involvement of branched-chain amino acid aminotransferases in the production of fusel alcohols during fermentation in yeast.\" Appl Microbiol Biotechnol 55:296-300."},{"pubmed_id":6281001,"citation":"Freist, W., von der Haar, F., Cramer, F. (1981). \"Isoleucyl-tRNA synthetase from Baker's yeast. Action of ATP analogs in pyrophosphate exchange and aminoacylation, two pathways of the aminoacylation depending on concentration of pyrophosphate.\" Eur J Biochem 119:151-164."},{"pubmed_id":12584756,"citation":"Hans, M. A., Heinzle, E., Wittmann, C. (2003). \"Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.\" Biotechnol Bioeng 82:143-151."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."},{"pubmed_id":17021250,"citation":"Yang, Z., Huang, J., Geng, J., Nair, U., Klionsky, D. J. (2006). \"Atg22 recycles amino acids to link the degradative and recycling functions of autophagy.\" Mol Biol Cell 17:5094-5104."},{"pubmed_id":7607232,"citation":"Tzagoloff, A., Shtanko, A. (1995). \"Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes.\" Eur J Biochem 230:582-586."},{"pubmed_id":8798704,"citation":"Kispal, G., Steiner, H., Court, D. A., Rolinski, B., Lill, R. (1996). \"Mitochondrial and cytosolic branched-chain amino acid transaminases from yeast, homologs of the myc oncogene-regulated Eca39 protein.\" J Biol Chem 271:24458-24464."},{"pubmed_id":7619074,"citation":"Harris, C. L., Kolanko, C. J. (1995). \"Aminoacyl-tRNA synthetase complex in Saccharomyces cerevisiae.\" Biochem J 309 ( Pt 1):321-324."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:32:56.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Vacuolar amino acid transporter 3","uniprot_id":"P36062","uniprot_name":"AVT3_YEAST","enzyme":false,"transporter":true,"gene_name":"AVT3","num_residues":692,"molecular_weight":"75458.70313","theoretical_pi":"8.69","general_function":"Amino acid transport and metabolism","specific_function":"Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine","reactions":[],"signal_regions":"None","transmembrane_regions":"302-322;329-349;374-394;412-432;443-463;483-503;519-539;561-581;607-627;630-650;665-685","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"Z28146","genbank_protein_id":"486252","gene_card_id":"AVT3","chromosome_location":"chromosome 11","locus":"YKL146W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"Aa_trans","identifier":"PF01490"}],"pathways":[],"gene_sequence":"ATGAATGGAAAAGAGGTTTCAAGTGGCTCTGGAAGAACGCAGAGCAACAACAACAAAAAAAATAACAACGGAGGCAGTACAGGAATCTCGCATGCGTCTGGCTCACCTTTAACGGACGGCAACGGTGGCAATAGCAACGGTAATAGTAGAAGTAGAAGCAGAAGTAGAAAATCTAGTGGAACTACAGGTGGTTTGCTAAAAAAGCCGCCGCTGCTTGTGAACAATGAAGCGGTGCATGCTAGCGTACCCGACGCGTCGCACACTTCCTGTAACAATGGCACGCTTGAAGTGAGCATAAATAACCCTGAGCCACATGTGGTAGATGCCGTGGCACGCCACTTGATAAGAAACCCGAGTAACAGCCTACAATTGCAAGGCGGAGACATTACAAGAGATCTGTATAAGTGGACAAACGACCATCCTTCATCACCATCGCAGTATCAGTACCCAAGTCAACCTGCACTTTCCACCTCAATACCTTCACAAGCGCCCTCATTCTCGAATCGTAAAAGGTCTATGAGCTTTTCTGCCGCTTCTATAGCATCTTCCTCTCACCTTAACAACAACTCGGAGGCGAATGGGAATCCTCTAGCGGCAATAGGCCTGGCGCCCGCACCGATGACGCACGAAGAAATCAGGGCTCCTGGTGGATTCAGAAGATCTTTTATAATACAGAAGCGCAGGAAACATAACGTTGATGCGCCCATACCGAATTTTTTCACCAGGAACTTTATTGAATTTTTGACCTTGTATGGCCACTTCGCTGGTGAAGATTTATCGGAAGAAGAGGAGGAGGAGGAAGAAACTGAAGAGGAGCCAGAGGAGGAAGCTTTGGAAACGGAAAGCACCCAGCTAGTTTCTCGTGAACACGGGCGCCATCCTCACAAATCATCTACGGTAAAGGCGGTGCTGCTCTTGTTAAAGTCATTTGTTGGGACAGGTGTGCTTTTCCTACCAAAGGCTTTCCATAACGGTGGTTGGGGATTTAGCGCCCTTTGTCTACTCTCGTGTGCCCTCATTTCTTATGGATGTTTCGTATCATTGATTACCACCAAGGACAAAGTAGGCGTAGATGGGTACGGTGACATGGGTCGTATACTATATGGGCCCAAAATGAAATTTGCCATTCTTTCGTCTATCGCCTTGTCACAAATCGGGTTTTCTGCTGCATACACTGTTTTCACTGCAACTAATTTGCAGGTCTTTTCTGAAAATTTCTTCCATTTGAAACCGGGCAGCATCAGTCTAGCCACCTATATCTTTGCACAAGTACTCATCTTTGTCCCACTATCTTTGACAAGAAACATAGCCAAGTTAAGTGGGACCGCGTTAATAGCAGATCTATTTATTCTACTGGGATTGGTTTATGTTTACGTTTACTCCATTTATTATATTGCTGTTAATGGTGTCGCATCCGATACAATGCTTATGTTCAATAAAGCGGACTGGTCGTTGTTCATCGGTACCGCCATATTCACCTTTGAAGGTATAGGCCTACTTATCCCCATTCAGGAGTCAATGAAACACCCGAAGCATTTCCGGCCATCGTTGTCCGCGGTGATGTGTATCGTGGCAGTGATTTTCATATCATGTGGTCTCTTATGCTATGCCGCTTTTGGATCTGACGTGAAAACTGTTGTTTTATTGAATTTTCCGCAGGACACTTCCTATACTCTCACTGTTCAATTACTGTATGCATTAGCCATTTTGTTATCCACGCCGTTGCAGCTATTTCCCGCGATACGTATTTTGGAAAACTGGACTTTTCCCTCAAATGCATCTGGTAAATACAACCCGAAAGTCAAATGGTTGAAAAACTATTTCCGTTGCGCTATTGTCGTCCTGACATCTATCCTCGCTTGGGTAGGCGCCAACGATTTGGACAAATTTGTATCACTGGTAGGCTCCTTCGCGTGTATCCCATTGATCTACATATACCCGCCATTGTTGCACTATAAGGCGTCCATCTTATCTGGAACCTCGAGAGCCAGGCTTCTTTTAGATTTAATCGTCATAGTATTTGGAGTTGCTGTCATGGCCTACACGTCATGGCAGACGATTAAAATGTGGAGCCAGTAA","protein_sequence":"MNGKEVSSGSGRTQSNNNKKNNNGGSTGISHASGSPLTDGNGGNSNGNSRSRSRSRKSSGTTGGLLKKPPLLVNNEAVHASVPDASHTSCNNGTLEVSINNPEPHVVDAVARHLIRNPSNSLQLQGGDITRDLYKWTNDHPSSPSQYQYPSQPALSTSIPSQAPSFSNRKRSMSFSAASIASSSHLNNNSEANGNPLAAIGLAPAPMTHEEIRAPGGFRRSFIIQKRRKHNVDAPIPNFFTRNFIEFLTLYGHFAGEDLSEEEEEEEETEEEPEEEALETESTQLVSREHGRHPHKSSTVKAVLLLLKSFVGTGVLFLPKAFHNGGWGFSALCLLSCALISYGCFVSLITTKDKVGVDGYGDMGRILYGPKMKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYIFAQVLIFVPLSLTRNIAKLSGTALIADLFILLGLVYVYVYSIYYIAVNGVASDTMLMFNKADWSLFIGTAIFTFEGIGLLIPIQESMKHPKHFRPSLSAVMCIVAVIFISCGLLCYAAFGSDVKTVVLLNFPQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNASGKYNPKVKWLKNYFRCAIVVLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLLHYKASILSGTSRARLLLDLIVIVFGVAVMAYTSWQTIKMWSQ"},{"created_at":"2011-05-24T19:33:19.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Vacuolar amino acid transporter 1","uniprot_id":"P47082","uniprot_name":"AVT1_YEAST","enzyme":false,"transporter":true,"gene_name":"AVT1","num_residues":602,"molecular_weight":"65345.30078","theoretical_pi":"8.2","general_function":"Amino acid transport and metabolism","specific_function":"Required for the vacuolar uptake of large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine. Requires ATP for function","reactions":[],"signal_regions":"None","transmembrane_regions":"209-231;241-261;287-307;322-342;345-365;390-410;430-450;467-487;518-538;544-564;581-601","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"X87611","genbank_protein_id":"854573","gene_card_id":"AVT1","chromosome_location":"chromosome 10","locus":"YJR001W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"Aa_trans","identifier":"PF01490"}],"pathways":[],"gene_sequence":"ATGCCTGAGCAAGAACCATTGAGTCCCAATGGCCGTAAGCGCTCTGAGGTTCACTATATCTCAATCCCATTGAACAGAGGTTCCGCATTCTCACCAGATGATTCTGTATCACAGTTTCAGTCTGACGGGTTCATGACACGTAGGCAATCCATATTGGACCATCCTGTGGGCTCATTTAAGGGAGTTAATTCTTTAAGTCGATTTGCGACTTCGTTGAGGAGAGCCAATTCGTTTCGTAATATCGAGCTAAATGCGGATAATGAAAGATCCTTTTTCAAAGAGAGTAACGATGAAACCTACGATCCGGATACTTTAGCACCAGCTTTGGACGGTAGAAGATTATCAGTAACTTTAAATAATGCTGGTCGCCCGCGCATTACTAATTTGGCTAACAACGATAGAGTTAGTACAGCCAGCATGGCTATTCACGATGATGATTATGGGTCCATCCAAAATTCAACAATTGGGGATTCTGGGTCAATATTACGCCCTACTGCCTCCTTAACAGAAATGATGAGTGGTGGAGCGGGGAGAAGGTTTACAAATAATGACATGGATTCAATTGTAGTGAAGAGAGTGGAGGGTGTAGATGGTAAGGTAGTAACTCTTCTTGCTGGTCAGTCGACCGCTCCACAGACCATATTCAACTCAATCAATGTACTGATTGGTATTGGGCTCCTGGCGTTACCTCTTGGTTTGAAATACGCCGGCTGGGTTATAGGACTTACTATGCTTGCAATCTTCGCCTTAGCGACATTTTGTACTGCTGAACTTTTGTCTAGGTGCCTAGATACAGATCCAACTTTGATATCTTACGCGGACTTGGGATATGCAGCATTTGGTACAAAAGGGCGCGCACTAATTTCTGCTCTTTTCACACTTGACCTACTGGGTAGTGGGGTGTCCTTGGTGATTCTCTTCGGAGATTCTTTAAATGCTCTATTTCCTCAATACTCCACCACTTTTTTCAAAATAGTTTCATTTTTTATCGTTACACCCCCGGTTTTTATACCATTGAGTGTTCTATCTAATATCTCGCTTCTGGGAATCCTTTCAACAACCGGAACTGTGCTAGTCATTTGCTGCTGCGGACTATACAAGTCGTCTTCTCCAGGTTCATTAGTTAATCCGATGGAAACGAGCATGTGGCCGATAGATCTAAAGCATCTCTGTTTATCTATAGGTTTATTGAGTGCCTGCTGGGGAGGACATGCGGTTTTTCCCAACTTAAAGACAGATATGAGGCATCCAGATAAATTTAAAGACTGTTTGAAAACTACCTATAAGATAACATCGGTTACGGACATAGGTACTGCAGTTATTGGCTTTTTGATGTTTGGAAATCTTGTTAAAGATGAAATTACTAAGAACGTTTTGCTGACGGAGGGATATCCAAAATTCGTTTATGGTCTGATTTCAGCGCTTATGACTATCATTCCTATCGCAAAGACCCCATTGAACGCAAGACCTATCGTTTCTGTATTGGACGTTCTGATGAATGTGCAACACATAGATGAAGCGGCCAGCGCCATAAAAAGAAGAGCTGCGAAAGGCCTTCAAGTATTCAATAGGATCTTTATTAATGTTGTCTTCGTTTTGATAGCTATTAATTTCCCTGAATTTGATAAGATTATCGCATTTCTGGGGGCCGGTTTGTGTTTTACAATTTGCCTAATTTTGCCGTGTTGGTTCTATTTAAGATTGTGCAAGACAACAATCAAACCATGGGAGAGAGTGGCTTGTCACGTAACCATATGTATTAGTGTCGTGTTGTCCACATTAGGTGTTGGTGCTGCAATTATTTCATAA","protein_sequence":"MPEQEPLSPNGRKRSEVHYISIPLNRGSAFSPDDSVSQFQSDGFMTRRQSILDHPVGSFKGVNSLSRFATSLRRANSFRNIELNADNERSFFKESNDETYDPDTLAPALDGRRLSVTLNNAGRPRITNLANNDRVSTASMAIHDDDYGSIQNSTIGDSGSILRPTASLTEMMSGGAGRRFTNNDMDSIVVKRVEGVDGKVVTLLAGQSTAPQTIFNSINVLIGIGLLALPLGLKYAGWVIGLTMLAIFALATFCTAELLSRCLDTDPTLISYADLGYAAFGTKGRALISALFTLDLLGSGVSLVILFGDSLNALFPQYSTTFFKIVSFFIVTPPVFIPLSVLSNISLLGILSTTGTVLVICCCGLYKSSSPGSLVNPMETSMWPIDLKHLCLSIGLLSACWGGHAVFPNLKTDMRHPDKFKDCLKTTYKITSVTDIGTAVIGFLMFGNLVKDEITKNVLLTEGYPKFVYGLISALMTIIPIAKTPLNARPIVSVLDVLMNVQHIDEAASAIKRRAAKGLQVFNRIFINVVFVLIAINFPEFDKIIAFLGAGLCFTICLILPCWFYLRLCKTTIKPWERVACHVTICISVVLSTLGVGAAIIS"},{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T19:39:09.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Vacuolar amino acid transporter 4","uniprot_id":"P50944","uniprot_name":"AVT4_YEAST","enzyme":false,"transporter":true,"gene_name":"AVT4","num_residues":713,"molecular_weight":"80025.0","theoretical_pi":"9.73","general_function":"Amino acid transport and metabolism","specific_function":"Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine","reactions":[],"signal_regions":"None","transmembrane_regions":"243-263;302-322;327-347;374-394;411-431;439-459;484-504;516-536;562-582;622-642;649-669;693-711","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"Z50161","genbank_protein_id":"929852","gene_card_id":"AVT4","chromosome_location":"chromosome 14","locus":"YNL101W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"Aa_trans","identifier":"PF01490"}],"pathways":[],"gene_sequence":"ATGGTCACTAACAATGGAGATGGTGAGCACCTTGGGATCCGAAGAAACGGAAATTTAAGGCATCCTTCCAATAATATGAAAATTCCCAGAAGGGCTCAATCAACAGTTCTCAATTCAAACCCATTTTATAGTAGGAAGTATTCTATGTCTACCTTAACGCCGAGGGATATATGTCGAAGCGTTGATTCTAGAGTATTTGTGGATATGTCTTCTCCCAATTTTCAGACTCTGGAGGATCCCCACAGAGATGAGATTATAAACAGTGTACGGCTTAACTACTTGAACAGTAGCAAAAGAAGTTCCGTCTCTCATGGAAATGAAGCAATCCCTAGGGTTAATCCGACTAAGAATTCTTCAGCAAGTACCATAGCTGCAGCAAATGTTGATAGTGATGACGATGAGACTAACCTGAGTAGCGCTGGAGGCGACATAACGCATGATATTTACAAGTTGGTTAAAGCAGAGGATCCTAAACGGCTCAGACGCCCTCGGTCCATGGAAAATGTAACACCTAAAATTGAGCACCATACTAAATTGTCATCAGCAAGTGGTTTAAATGTCCCCGGTGGCTTCAGAAGGGAATTTATTGTCAACAAAAAAAGGCAAGAACATCAATTAAATGATTCCGCTAGCTCAGACTTCACTTCGCATGAAAGCGATTCGATTAACCAGTCATCTCCATCTTCTAACCAAGATATCGATAAGGTCCCCTTTTTAACAAGAAACTTTTTGGAATTTCTATACGTGTTTGGACATTTTGCTGGTGAATCCTTCGAGGATGATTTTATCCCTGATAGCTCAAACATGATGATACGCGGAGAAGATGAAAGGAGTGCATTGCTGTCTCGGCCTGACCATATGAAAGTATTACCTTCAGCCAAAGGTACGACTTCGACAAAGAAGGTTTTTTTGATATTGCTTAAATCTTTCATTGGAACTGGCGTTTTATTTTTACCTAATGCCTTTCATAATGGTGGTTTGTTTTTCTCAGTAAGTATGCTGGCCTTTTTTGGAATTTATTCATACTGGTGTTACTACATATTGGTGCAGGCCAAATCTTCATGCGGTGTATCCTCCTTTGGTGATATTGGTTTAAAACTGTATGGACCTTGGATGAGAATAATAATTCTTTTCTCCCTAGTAATAACTCAAGTTGGATTCTCTGGAGCTTATATGATATTTACTGCAAAAAATTTACAAGCTTTTCTTGATAACGTATTCCATGTGGGCGTCCTACCTTTATCTTACCTGATGGTCTTTCAAACGATCATTTTTATTCCACTTTCGTTTATTAGAAACATTTCGAAATTGTCACTACCATCTTTACTAGCAAATTTTTTCATCATGGCTGGTTTAGTCATTGTCATTATTTTTACAGCCAAAAGGTTGTTTTTTGACCTGATGGGGACCCCAGCAATGGGTGTCGTCTATGGCTTAAATGCAGACCGTTGGACGCTGTTTATCGGGACGGCAATATTTGCTTTCGAAGGAATCGGGTTAATTATTCCTGTTCAAGACTCAATGAGAAATCCTGAAAAATTTCCTTTAGTACTTGCTTTGGTGATTCTAACGGCAACCATACTTTTCATTTCCATAGCTACATTGGGATATTTGGCATACGGCTCAAATGTTCAAACGGTTATACTGTTGAACTTACCTCAAAGTAACATTTTTGTAAACTTAATCCAGCTGTTCTATTCCATCGCAATTATGTTGTCCACACCTTTGCAGTTGTTTCCAGCTATTAAAATTATTGAAAATAAGTTTTTTCCAAAGTTCACTAAAATATATGTCAAGCACGATGATCTAACAACAAGAGTCGAATTACGTCCTAATTCAGGAAAGCTGAACTGGAAAATTAAATGGCTGAAGAACTTTATTCGTTCTATAATCGTAATCATTGTTGTATCAATTGCTTACTTTGGGTCTGATAATTTAGACAAGTTCGTTTCAGTTATAGGATCCCTCGCCTGTATTCCTTTGGTATATATATACCCATCGATGCTGCATTTACGGGGCAATAGCCTTCCAGAGACTAAAGGGGAATTTTGGAGATTCAAACCAATGTTAGATACCATTTTAATTTTCTTCGGTATTGCAAGCATGCTTTATACGTCTTACCAGAGTATATTCGGTGTCTAG","protein_sequence":"MVTNNGDGEHLGIRRNGNLRHPSNNMKIPRRAQSTVLNSNPFYSRKYSMSTLTPRDICRSVDSRVFVDMSSPNFQTLEDPHRDEIINSVRLNYLNSSKRSSVSHGNEAIPRVNPTKNSSASTIAAANVDSDDDETNLSSAGGDITHDIYKLVKAEDPKRLRRPRSMENVTPKIEHHTKLSSASGLNVPGGFRREFIVNKKRQEHQLNDSASSDFTSHESDSINQSSPSSNQDIDKVPFLTRNFLEFLYVFGHFAGESFEDDFIPDSSNMMIRGEDERSALLSRPDHMKVLPSAKGTTSTKKVFLILLKSFIGTGVLFLPNAFHNGGLFFSVSMLAFFGIYSYWCYYILVQAKSSCGVSSFGDIGLKLYGPWMRIIILFSLVITQVGFSGAYMIFTAKNLQAFLDNVFHVGVLPLSYLMVFQTIIFIPLSFIRNISKLSLPSLLANFFIMAGLVIVIIFTAKRLFFDLMGTPAMGVVYGLNADRWTLFIGTAIFAFEGIGLIIPVQDSMRNPEKFPLVLALVILTATILFISIATLGYLAYGSNVQTVILLNLPQSNIFVNLIQLFYSIAIMLSTPLQLFPAIKIIENKFFPKFTKIYVKHDDLTTRVELRPNSGKLNWKIKWLKNFIRSIIVIIVVSIAYFGSDNLDKFVSVIGSLACIPLVYIYPSMLHLRGNSLPETKGEFWRFKPMLDTILIFFGIASMLYTSYQSIFGV"},{"created_at":"2011-05-24T21:01:35.000Z","updated_at":"2011-07-22T17:53:43.000Z","name":"Branched-chain-amino-acid aminotransferase, cytosolic","uniprot_id":"P47176","uniprot_name":"BCA2_YEAST","enzyme":true,"transporter":false,"gene_name":"BAT2","num_residues":376,"molecular_weight":"41624.39844","theoretical_pi":"7.36","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Involved in cell cycle regulation","reactions":[{"id":1152,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1678,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1712,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2045,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2358,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2359,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":2360,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":14458,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006970","source":"Smpdb"},{"id":14459,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006974","source":"Smpdb"},{"id":14460,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006978","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z49648","genbank_protein_id":"1015897","gene_card_id":"BAT2","chromosome_location":"chromosome 10","locus":"YJR148W","synonyms":["BCAT","Protein TWT2"],"enzyme_classes":["2.6.1.42"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" branched-chain-amino-acid transaminase activity"},{"category":"Process","description":" branched chain family amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Aminotran_4","identifier":"PF01063"}],"pathways":[{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Leucine Degradation","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null}],"gene_sequence":"ATGACCTTGGCACCCCTAGACGCCTCCAAAGTTAAGATAACTACCACACAACATGCATCTAAGCCAAAACCGAACAGTGAGTTAGTGTTTGGCAAGAGCTTCACGGACCACATGTTAACTGCGGAATGGACAGCTGAAAAAGGGTGGGGTACCCCAGAGATTAAACCTTATCAAAATCTGTCTTTAGACCCTTCCGCGGTGGTTTTCCATTATGCTTTTGAGCTATTCGAAGGGATGAAGGCTTACAGAACGGTGGACAACAAAATTACAATGTTTCGTCCAGATATGAATATGAAGCGCATGAATAAGTCTGCTCAGAGAATCTGTTTGCCAACGTTCGACCCAGAAGAGTTGATTACCCTAATTGGGAAACTGATCCAGCAAGATAAGTGCTTAGTTCCTGAAGGAAAAGGTTACTCTTTATATATCAGGCCTACATTAATCGGCACTACGGCCGGTTTAGGGGTTTCCACGCCTGATAGAGCCTTGCTATATGTCATTTGCTGCCCTGTGGGTCCTTATTACAAAACTGGATTTAAGGCGGTCAGACTGGAAGCCACTGATTATGCCACAAGAGCTTGGCCAGGAGGCTGTGGTGACAAGAAACTAGGTGCAAACTACGCCCCCTGCGTCCTGCCACAATTGCAAGCTGCTTCAAGGGGTTACCAACAAAATTTATGGCTATTTGGTCCAAATAACAACATTACTGAAGTCGGCACCATGAATGCTTTTTTCGTGTTTAAAGATAGTAAAACGGGCAAGAAGGAACTAGTTACTGCTCCACTAGACGGTACCATTTTGGAAGGTGTTACTAGGGATTCCATTTTAAATCTTGCTAAAGAAAGACTCGAACCAAGTGAATGGACCATTAGTGAACGCTACTTCACTATAGGCGAAGTTACTGAGAGATCCAAGAACGGTGAACTACTTGAAGCCTTTGGTTCTGGTACTGCTGCGATTGTTTCTCCCATTAAGGAAATCGGCTGGAAAGGCGAACAAATTAATATTCCGTTGTTGCCCGGCGAACAAACCGGTCCATTGGCCAAAGAAGTTGCACAATGGATTAATGGAATCCAATATGGCGAGACTGAGCATGGCAATTGGTCAAGGGTTGTTACTGATTTGAACTGA","protein_sequence":"MTLAPLDASKVKITTTQHASKPKPNSELVFGKSFTDHMLTAEWTAEKGWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQDKCLVPEGKGYSLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATDYATRAWPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWLFGPNNNITEVGTMNAFFVFKDSKTGKKELVTAPLDGTILEGVTRDSILNLAKERLEPSEWTISERYFTIGEVTERSKNGELLEAFGSGTAAIVSPIKEIGWKGEQINIPLLPGEQTGPLAKEVAQWINGIQYGETEHGNWSRVVTDLN"},{"created_at":"2011-05-24T21:03:21.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Leu/Val/Ile 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Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan","reactions":[],"signal_regions":"None","transmembrane_regions":"100-120;124-144;174-194;211-231;236-256;290-310;329-349;375-395;428-448;452-472;501-521;537-557","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z35937","genbank_protein_id":"536316","gene_card_id":"BAP2","chromosome_location":"chromosome 2","locus":"YBR068C","synonyms":["Branched-chain amino-acid permease 2"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGCTATCTTCAGAAGATTTTGGATCTTCTGGGAAAAAGGAAACTTCTCCTGATTCGATATCGATACGTTCCTTTAGTGCCGGGAATAATTTCCAATCATCATCAAGTGAGAAAACTTATTCTAAGCAAAAATCCGGGAGTGACAAACTTATACATAGATTTGCGGATTCATTCAAAAGAGCCGAGGGTAGCACTACAAGAACTAAGCAAATAAATGAAAATACGTCTGATTTAGAGGATGGCGTTGAGTCTATCACGTCGGATTCCAAGTTGAAAAAGTCCATGAAGTCGCGCCATGTTGTCATGATGTCTTTAGGGACAGGTATTGGGACTGGTCTTTTGGTAGCTAATGCAAAAGGTCTACATTACGGTGGTCCTGCTGCGCTAATAATTGGTTACATCTTGGTTTCTTTCGAGACGTACTTCATGATCCAAGCTGCAGGTGAGATGGCGGTAACCTATCCGACTTTACCAGCAAATTTCAACGCATACTCCTCCATATTCATTTCCAAATCATTTGGATTCGCCACAGTATGGCTTTACTGTTTCCAATGGCTAACGGTTTTGCCTTTAGAGTTAATAACCGCGTCTATGACTATTCAATTTGGGAATGATAAAATAAATCCGGACATTTATATTCTTATTTTCTATGTTTTCTTAGTATTCATTCATTTCTTCGGTGTAAAAGCCTATGGTGAAACGGAATTCATCTTCAATTGCTGTAAAATTTTAATGATTGCAGGTTTCATTATTCTTTCTATTGTTATCAACTGTGGTGGGGCCGGAAATGACGGTTATATCGGGGCCACTTATTGGCATAATCCAGGTGCTTTTGCAGGTGACACATCGATTGGTAGGTTCAAAAACGTTTGCTATATTTTAGTTACTGCTTACTTCTCCTTTGGTGGTATGGAATTATTTGCACTAAGTGTTCAGGAACAGTCTAACCCTAGAAAATCTACTCCGGTGGCAGCCAAGAGAAGCATTTATCGTATCGTTGTGATTTATCTTTTGACTATGATCCTCATTGGATTCAATGTTCCATATAATGATGACCAACTAATGGGCGCAGGCGGATCCGCTACACATGCATCTCCCTATGTCTTAGCCGCTTCTATTCACGGTGTGAAAATTGTTCCACATATTATCAACGCTGTTATTTTGATTTCTGTGGTTTCAGTGGCAAATTCCTCTTTGTATGCTGGTCCAAGACTGATTTGCTCTTTGGCCCAACAAGGCTACGCACCCAAGTTTTTAGATTACGTTGACAGAGAGGGCAGGCCCTTGAGAGCTCTTATTGTGTGTTGCGTTTTCGGCGTCATTGCTTTTGTTGCAGCTTCATCAAAGGAAGAGATCGTGTTTACATGGTTAGCAGCTATCGCAGGCTTGAGTGAATTATTCACATGGACTTCCATAATGTTGTCCCATCTGCGATTCAGACAAGCAATGAAAGTACAGGGAAGGTCTCTAGACGAGTTGGGATACAAGGCCACAACAGGGATTTGGGGTTCCATATACGGTGTCTTTTTTAATATTTTAGTCTTTGTTGCCCAATTTTGGGTAGCATTGGCCCCCTTAGGTAATGGGGGCAAATGCGATGCGGAATCCTTCTTTCAAAATTATTTAGCTTTTCCAATATGGTTGGCCTTTTACTTCGGATATATGGTTTACAACCGAGATTTTACGCTATTAAATCCCCTCGACAAGATTGACCTTGACTTCCACAGACGCATTTATGATCCAGAGCTAATGAGACAAGAGGACGAAGAAAATAAAGAAAAACTAAGGAATATGTCTTTGATGAGAAAAGCTTATCATTTCTGGTGTTAA","protein_sequence":"MLSSEDFGSSGKKETSPDSISIRSFSAGNNFQSSSSEKTYSKQKSGSDKLIHRFADSFKRAEGSTTRTKQINENTSDLEDGVESITSDSKLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLHYGGPAALIIGYILVSFETYFMIQAAGEMAVTYPTLPANFNAYSSIFISKSFGFATVWLYCFQWLTVLPLELITASMTIQFGNDKINPDIYILIFYVFLVFIHFFGVKAYGETEFIFNCCKILMIAGFIILSIVINCGGAGNDGYIGATYWHNPGAFAGDTSIGRFKNVCYILVTAYFSFGGMELFALSVQEQSNPRKSTPVAAKRSIYRIVVIYLLTMILIGFNVPYNDDQLMGAGGSATHASPYVLAASIHGVKIVPHIINAVILISVVSVANSSLYAGPRLICSLAQQGYAPKFLDYVDREGRPLRALIVCCVFGVIAFVAASSKEEIVFTWLAAIAGLSELFTWTSIMLSHLRFRQAMKVQGRSLDELGYKATTGIWGSIYGVFFNILVFVAQFWVALAPLGNGGKCDAESFFQNYLAFPIWLAFYFGYMVYNRDFTLLNPLDKIDLDFHRRIYDPELMRQEDEENKEKLRNMSLMRKAYHFWC"},{"created_at":"2011-05-24T21:03:55.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Valine/tyrosine/tryptophan amino-acid permease 1","uniprot_id":"P38085","uniprot_name":"TAT1_YEAST","enzyme":false,"transporter":true,"gene_name":"TAT1","num_residues":619,"molecular_weight":"68756.89844","theoretical_pi":"7.8","general_function":"Involved in transport","specific_function":"High-affinity transport of valine and tyrosine. Low- affinity transport of tryptophan. Can also transport L-cysteine","reactions":[],"signal_regions":"None","transmembrane_regions":"100-120;123-143;173-193;205-225;234-254;282-302;321-341;369-389;423-443;447-467;500-520;530-550","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"U10503","genbank_protein_id":"558077","gene_card_id":"TAT1","chromosome_location":"chromosome 2","locus":"YBR069C","synonyms":["Tyrosine and tryptophan amino acid transporter 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGACGATAGTGTCAGTTTCATTGCCAAAGAGGCCAGTCCAGCACAATATTCGCACAGTTTGCATGAAAGAACACACAGTGAAAAACAAAAGAGAGACTTTACAATAACAGAAAAACAAGATGAGGTATCTGGACAAACAGCGGAGCCTCGAAGGACGGACAGCAAATCCATATTACAGAGGAAATGCAAAGAATTCTTCGACTCTTTTAAAAGGCAGCTGCCACCAGACCGTAATTCCGAACTAGAGTCCCAAGAAAAAAACAACCTGACAAAGTCGATCAAATCTCGTCACTTAGTCATGATCAGTCTCGGTACCGGTATAGGTACTGGTTTACTGGTCGGTAATGGTCAGGTGCTGGGAACAGCTGGTCCTGCCGGGTTAGTCCTTGGTTACGGAATAGCATCGATCATGCTTTACTGTATCATCCAAGCGGCAGGCGAGTTAGGTCTCTGTTATGCAGGACTAACCGGCAATTACACCAGATATCCTTCTATTTTAGTCGACCCTTCGTTGGGTTTTGCAGTTTCTGTGGTTTACACCATTCAATGGCTAACTGTTCTGCCCTTACAATTGGTCACTGCGGCAATGACAGTTAAGTACTGGACGAGTGTAAATGCAGACATCTTTGTTGCCGTGGTTTTCGTTTTTGTAATTATCATTAATCTATTTGGGTCCAGAGGCTATGCTGAAGCCGAGTTCATTTTCAATTCCTGTAAGATATTGATGGTAATCGGATTCGTCATTCTGGCGATTATCATCAATTGTGGGGGTGCAGGTGACAGAAGATACATCGGTGCTGAGTACTGGCACAATCCTGGTCCATTTGCCCACGGTTTCAAAGGTGTATGTACGGTTTTCTGTTATGCTGCATTCAGCTACGGTGGAATTGAAGTTCTACTTCTATCTGCCGCTGAGCAGGAAAACCCAACAAAATCTATTCCCAATGCCTGCAAAAAAGTGGTATACCGTATTCTGCTGATTTACATGCTCACCACCATTTTGGTTTGCTTTCTTGTTCCATACAACAGTGACGAATTATTAGGGTCTAGTGACTCCTCTGGATCCCATGCCTCCCCATTTGTCATTGCTGTTGCATCACATGGTGTCAAAGTTGTGCCTCACTTTATAAATGCTGTTATTTTGATTTCTGTCATTTCTGTTGCAAACTCTTCGTTATATTCTGGGCCAAGATTGTTATTATCATTGGCAGAACAAGGCGTCTTACCTAAATGCTTAGCATATGTTGATAGAAACGGCAGGCCTTTACTTTGTTTTTTTGTTTCCCTTGTCTTTGGATGCATTGGGTTTGTAGCCACTAGTGACGCTGAAGAACAGGTTTTCACCTGGTTATTGGCAATTTCTAGTCTTTCGCAATTATTTATCTGGATGTCAATGTCCTTGTCACATATAAGATTTAGAGATGCCATGGCAAAGCAAGGTCGTTCGATGAACGAAGTTGGATACAAAGCACAAACTGGCTATTGGGGTTCATGGCTTGCAGTTTTAATTGCAATCTTCTTCCTTGTGTGCCAGTTCTGGGTAGCCATCGCACCTGTTAATGAACATGGAAAACTTAACGTCAAAGTGTTTTTCCAAAATTATTTGGCAATGCCCATCGTTTTGTTTGCCTATTTTGGTCACAAGATATACTTCAAATCATGGAGCTTTTGGATTCCAGCCGAAAAAATTGATTTGGACTCACATAGAAACATATTTGTGTCTCCATCGCTTACAGAGATCGACAAAGTTGACGATAACGATGATCTTAAAGAGTATGAAAATTCAGAATCGTCGGAAAATCCAAACAGTTCGCGTTCAAGAAAGTTTTTTAAGAGGATGACCAATTTCTGGTGCTAA","protein_sequence":"MDDSVSFIAKEASPAQYSHSLHERTHSEKQKRDFTITEKQDEVSGQTAEPRRTDSKSILQRKCKEFFDSFKRQLPPDRNSELESQEKNNLTKSIKSRHLVMISLGTGIGTGLLVGNGQVLGTAGPAGLVLGYGIASIMLYCIIQAAGELGLCYAGLTGNYTRYPSILVDPSLGFAVSVVYTIQWLTVLPLQLVTAAMTVKYWTSVNADIFVAVVFVFVIIINLFGSRGYAEAEFIFNSCKILMVIGFVILAIIINCGGAGDRRYIGAEYWHNPGPFAHGFKGVCTVFCYAAFSYGGIEVLLLSAAEQENPTKSIPNACKKVVYRILLIYMLTTILVCFLVPYNSDELLGSSDSSGSHASPFVIAVASHGVKVVPHFINAVILISVISVANSSLYSGPRLLLSLAEQGVLPKCLAYVDRNGRPLLCFFVSLVFGCIGFVATSDAEEQVFTWLLAISSLSQLFIWMSMSLSHIRFRDAMAKQGRSMNEVGYKAQTGYWGSWLAVLIAIFFLVCQFWVAIAPVNEHGKLNVKVFFQNYLAMPIVLFAYFGHKIYFKSWSFWIPAEKIDLDSHRNIFVSPSLTEIDKVDDNDDLKEYENSESSENPNSSRSRKFFKRMTNFWC"},{"created_at":"2011-05-24T21:05:15.000Z","updated_at":"2011-05-29T05:06:15.000Z","name":"Isoleucyl-tRNA synthetase, mitochondrial","uniprot_id":"P48526","uniprot_name":"SYIM_YEAST","enzyme":true,"transporter":false,"gene_name":"ISM1","num_residues":1002,"molecular_weight":"115793.0","theoretical_pi":"8.29","general_function":"Involved in nucleotide binding","specific_function":"ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)","reactions":[{"id":1679,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2361,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"L38957","genbank_protein_id":"625184","gene_card_id":"ISM1","chromosome_location":"chromosome 16","locus":"YPL040C","synonyms":["Isoleucine--tRNA ligase","IleRS"],"enzyme_classes":["6.1.1.5"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" isoleucine-tRNA ligase activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" translation"},{"category":"Process","description":" isoleucyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"}],"pfams":[{"name":"Anticodon_1","identifier":"PF08264"},{"name":"tRNA-synt_1","identifier":"PF00133"}],"pathways":[{"name":"Valine, leucine and isoleucine 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amino-acid permease","uniprot_id":"P41815","uniprot_name":"BAP3_YEAST","enzyme":false,"transporter":true,"gene_name":"BAP3","num_residues":604,"molecular_weight":"67364.39844","theoretical_pi":"8.28","general_function":"Involved in transport","specific_function":"Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;120-140;170-190;207-227;239-259;285-305;324-344;378-398;424-444;450-470;503-523;532-552","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z49209","genbank_protein_id":"798899","gene_card_id":"BAP3","chromosome_location":"chromosome 4","locus":"YDR046C","synonyms":["Branched-chain amino-acid permease 3"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCAGATCCTATAGTAACGTCTTCCAAAATGGAAAAAAGTGCAGAGTTTGAAGTAACAGACTCTGCTTTATATAATAACTTCAATACATCAACAACAGCTTCACTAACTCCGGAGATTAAGGAACATTCTGAGGAATCTCGCAATGGGTTAGTTCACAGATTCGTCGACTCATTCAGAAGAGCCGAAAGCCAACGTTTAGAAGAAGACAATGACTTGGAGGATGGTACCAAATCGATGAAATCTAATAACCACTTAAAAAAGTCAATGAAATCTAGACATGTTGTAATGATGTCTTTAGGTACAGGGATAGGAACAGGTCTTCTAGTTGCCAACGCCAAAGGTTTGAGTCTTGCAGGCCCGGGGTCTTTAGTCATCGGTTACGTTATGGTGTCCTTCGTCACGTATTTTATGGTCCAAGCGGCTGGTGAGATGGGTGTCACTTATCCGACGCTTCCAGGTAACTTCAATGCATACAATTCAATCTTTATTTCAAAGTCGTTTGGGTTCGCGACCACTTGGTTATTTTGCATTCAGTGGTTAACTGTGCTACCGTTGGAATTGATTACTTCTTCCATGACCGTCAAGTACTGGAATGACACAATTAATGCTGATGTATTCATTGTCATTTTCTATGTGTTTTTATTGTTTATCCACTTTTTTGGTGTTAAGGCATACGGTGAAACGGAATTTATCTTCAATTCCTGTAAGATATTGATGGTTGCAGGATTCATTATTTTATCAGTCGTCATCAATTGTGGGGGAGCCGGTGTGGACGGCTATATTGGCGGCAAATATTGGCGCGACCCTGGTTCATTTGCAGAAGGCAGCGGTGCCACTCGTTTCAAAGGGATATGTTATATTCTAGTATCTGCATATTTCTCCTTCGGTGGTATTGAATTATTTGTTCTTTCCATCAATGAGCAGTCTAACCCTAGAAAATCCACTCCTGTAGCCGCGAAGAGAAGTGTATATCGTATTTTGATCATTTATTTGCTGACAATGATTCTAATTGGGTTCAATGTTCCTCACAATAACGATCAATTGATGGGTTCCGGTGGCTCCGCAACGCACGCTTCACCATATGTCTTGGCAGCCTCTATTCACAAGGTTAGGGTCATCCCCCATATCATTAATGCTGTTATTTTGATATCAGTCATCTCTGTTGCGAACTCTGCCCTTTATGCCGCACCGAGATTAATGTGTTCCTTGGCTCAACAGGGCTATGCTCCAAAATTTTTGAACTATATTGATAGGGAGGGAAGACCTTTAAGGGCCTTGGTAGTGTGCTCTCTTGTTGGTGTCGTTGGCTTCGTCGCCTGTTCTCCACAGGAAGAGCAAGCATTTACATGGTTGGCAGCCATTGCAGGTTTGAGTGAACTTTTCACATGGTCAGGCATTATGCTTTCACACATTCGATTCAGAAAAGCGATGAAAGTCCAAGGAAGATCACTTGATGAAGTCGGCTATAAGGCCAATACCGGTATATGGGGTTCATACTATGGGGTTTTTTTCAATATGCTTGTCTTTATGGCCCAATTTTGGGTCGCACTGTCTCCAATAGGAAATGGCGGAAAGTGTGATGCTCAGGCATTCTTCGAGAGTTATCTGGCTGCCCCGCTATGGATATTCATGTATGTTGGATACATGGTTTACAAAAGAGATTTTACCTTTTTAAACCCACTGGACAAGATCGACTTGGACTTTCATAGAAGAGTTTACGACCCTGAAATAATGAGGCAGGAGGACGAAGAAAATAAAGAAAGGTTAAAGAACTCTTCAATATTCGTCAGAGTCTACAAATTTTGGTGTTAG","protein_sequence":"MSDPIVTSSKMEKSAEFEVTDSALYNNFNTSTTASLTPEIKEHSEESRNGLVHRFVDSFRRAESQRLEEDNDLEDGTKSMKSNNHLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLSLAGPGSLVIGYVMVSFVTYFMVQAAGEMGVTYPTLPGNFNAYNSIFISKSFGFATTWLFCIQWLTVLPLELITSSMTVKYWNDTINADVFIVIFYVFLLFIHFFGVKAYGETEFIFNSCKILMVAGFIILSVVINCGGAGVDGYIGGKYWRDPGSFAEGSGATRFKGICYILVSAYFSFGGIELFVLSINEQSNPRKSTPVAAKRSVYRILIIYLLTMILIGFNVPHNNDQLMGSGGSATHASPYVLAASIHKVRVIPHIINAVILISVISVANSALYAAPRLMCSLAQQGYAPKFLNYIDREGRPLRALVVCSLVGVVGFVACSPQEEQAFTWLAAIAGLSELFTWSGIMLSHIRFRKAMKVQGRSLDEVGYKANTGIWGSYYGVFFNMLVFMAQFWVALSPIGNGGKCDAQAFFESYLAAPLWIFMYVGYMVYKRDFTFLNPLDKIDLDFHRRVYDPEIMRQEDEENKERLKNSSIFVRVYKFWC"},{"created_at":"2011-05-24T21:06:51.000Z","updated_at":"2011-07-22T17:53:43.000Z","name":"Branched-chain-amino-acid aminotransferase, mitochondrial","uniprot_id":"P38891","uniprot_name":"BCA1_YEAST","enzyme":true,"transporter":false,"gene_name":"BAT1","num_residues":393,"molecular_weight":"43595.69922","theoretical_pi":"9.27","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Appears to be involved in the regulation of the transition from G1 to S phase in the cell cycle. High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1","reactions":[{"id":1152,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1678,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1712,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2046,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2358,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2359,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":2360,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"2-oxoglutaric acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamic acid.","export":false,"pw_reaction_id":null,"source":null},{"id":14455,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006969","source":"Smpdb"},{"id":14456,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006973","source":"Smpdb"},{"id":14457,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006977","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY558111","genbank_protein_id":"45270112","gene_card_id":"BAT1","chromosome_location":"chromosome 8","locus":"YHR208W","synonyms":["BCAT","Protein ECA39","Protein TWT1"],"enzyme_classes":["2.6.1.42"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" branched-chain-amino-acid transaminase activity"},{"category":"Process","description":" branched chain family amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Aminotran_4","identifier":"PF01063"}],"pathways":[{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Leucine Degradation","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null}],"gene_sequence":"ATGTTGCAGAGACATTCCTTGAAGTTGGGGAAATTCTCCATCAGAACACTCGCTACTGGTGCCCCATTAGATGCATCCAAACTAAAAATTACTAGAAACCCAAATCCATCCAAGCCAAGACCAAATGAAGAATTAGTGTTCGGCCAGACATTCACCGATCATATGTTGACCATTCCTTGGTCAGCCAAAGAAGGGTGGGGCACTCCACACATCAAGCCTTACGGTAATCTTTCTCTTGACCCATCTGCTTGTGTATTCCATTATGCATTTGAATTATTTGAAGGTTTGAAAGCCTACAGAACTCCTCAAAATACTATCACCATGTTCCGTCCGGATAAGAACATGGCCCGTATGAACAAGTCTGCCGCTAGAATTTGTTTGCCAACTTTCGAATCTGAAGAATTGATCAAACTTACCGGGAAATTGATCGAACAAGATAAACACTTGGTTCCTCAAGGTAATGGTTACTCATTATACATCAGACCAACAATGATTGGTACATCCAAGGGTTTAGGTGTTGGCACTCCCTCCGAGGCTCTTCTTTATGTTATTACTTCTCCAGTCGGTCCTTATTATAAGACTGGTTTCAAAGCCGTACGTCTTGAAGCAACAGACTATGCTACAAGAGCTTGGCCAGGTGGTGTTGGCGACAAAAAATTGGGTGCTAACTATGCCCCATGCATCTTACCTCAACTACAAGCTGCCAAAAGAGGGTACCAACAAAATCTATGGTTGTTCGGCCCAGAAAAGAACATCACTGAGGTTGGTACTATGAACGTGTTCTTCGTTTTCCTCAACAAAGTCACTGGCAAGAAGGAATTGGTTACCGCTCCATTAGATGGTACCATTTTAGAAGGTGTTACCAGAGACTCTGTTTTAACATTGGCTCGTGACAAACTAGATCCTCAAGAATGGGACATCAACGAGCGTTATTACACTATTACTGAAGTCGCCACTAGAGCAAAACAAGGTGAACTATTAGAAGCCTTCGGTTCTGGTACTGCTGCTGTCGTTTCACCTATCAAGGAAATTGGCTGGAACAACGAAGATATTCATGTTCCACTATTGCCTGGTGAACAATGTGGTGCATTGACCAAGCAAGTTGCTCAATGGATTGCTGATATCCAATACGGTAGAGTCAATTATGGTAACTGGTCAAAAACTGTTGCCGACTTGAACTAA","protein_sequence":"MLQRHSLKLGKFSIRTLATGAPLDASKLKITRNPNPSKPRPNEELVFGQTFTDHMLTIPWSAKEGWGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYSLYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLWLFGPEKNITEVGTMNVFFVFLNKVTGKKELVTAPLDGTILEGVTRDSVLTLARDKLDPQEWDINERYYTITEVATRAKQGELLEAFGSGTAAVVSPIKEIGWNNEDIHVPLLPGEQCGALTKQVAQWIADIQYGRVNYGNWSKTVADLN"},{"created_at":"2011-05-24T21:08:07.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Isoleucyl-tRNA synthetase, cytoplasmic","uniprot_id":"P09436","uniprot_name":"SYIC_YEAST","enzyme":true,"transporter":false,"gene_name":"ILS1","num_residues":1072,"molecular_weight":"122982.0","theoretical_pi":"5.9","general_function":"Involved in nucleotide binding","specific_function":"ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)","reactions":[{"id":1679,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2361,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X07886","genbank_protein_id":"3820","gene_card_id":"ILS1","chromosome_location":"chromosome 2","locus":"YBL076C","synonyms":["Isoleucine--tRNA ligase","IleRS"],"enzyme_classes":["6.1.1.5"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" isoleucine-tRNA ligase activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related compounds"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aminoacyl-tRNA ligase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" translation"},{"category":"Process","description":" isoleucyl-tRNA aminoacylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"}],"pfams":[{"name":"Anticodon_1","identifier":"PF08264"},{"name":"tRNA-synt_1","identifier":"PF00133"}],"pathways":[{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"}],"gene_sequence":"ATGTCCGAGAGTAACGCACACTTCTCATTTCCAAAGGAGGAAGAAAAAGTTCTATCTCTTTGGGATGAAATAGATGCCTTTCATACTTCATTAGAATTAACAAAAGACAAACCGGAGTTTTCCTTCTTCGATGGGCCTCCATTTGCCACCGGTACTCCTCATTACGGTCATATTCTTGCTTCCACTATTAAGGATATTGTTCCAAGATACGCTACCATGACAGGCCACCACGTGGAAAGAAGATTCGGTTGGGATACACACGGTGTTCCAATTGAACATATCATTGACAAGAAATTAGGTATCACGGGTAAAGATGATGTCTTCAAGTATGGTCTTGAAAACTACAACAATGAGTGTAGATCCATTGTTATGACTTATGCCAGTGATTGGAGAAAAACTATTGGTCGTTTGGGTCGTTGGATTGATTTCGACAACGATTACAAGACTATGTATCCATCCTTTATGGAGTCCACATGGTGGGCTTTCAAGCAACTTCATGAAAAAGGTCAAGTTTACCGTGGATTCAAAGTTATGCCTTATTCTACTGGGCTAACCACTCCCTTAAGTAACTTTGAAGCTCAGCAAAACTATAAAGATGTCAATGACCCAGCTGTGACCATTGGTTTCAATGTTATTGGCCAGGAAAAAACTCAATTGGTCGCATGGACTACGACTCCATGGACTTTACCTTCCAATTTGTCGTTATGTGTTAACGCTGATTTCGAATATGTAAAGATTTACGACGAAACCAGAGATCGTTATTTCATCTTATTAGAATCTTTGATTAAAACCTTGTATAAGAAGCCTAAGAATGAAAAATATAAGATTGTGGAAAAAATTAAAGGTTCTGATTTGGTTGGTTTGAAGTATGAACCATTGTTCCCATATTTCGCTGAACAGTTCCATGAAACAGCTTTTAGAGTTATTTCAGATGATTATGTTACTAGTGATTCCGGTACTGGTATTGTTCATAACGCTCCCGCTTTCGGTGAAGAGGATAATGCTGCTTGTTTGAAGAACGGCGTCATATCCGAAGATTCAGTGTTACCTAACGCCATTGATGACCTTGGTAGATTCACGAAAGACGTTCCTGATTTTGAGGGTGTTTATGTCAAGGACGCTGATAAGTTGATTATTAAGTACTTAACTAATACTGGAAATTTGTTATTGGCATCCCAAATTCGCCATTCCTATCCATTCTGTTGGAGATCCGATACCCCATTGTTATACCGTTCTGTTCCAGCTTGGTTCGTTCGTGTTAAAAACATTGTCCCTCAAATGTTGGATTCTGTGATGAAATCTCACTGGGTTCCTAACACCATCAAGGAAAAGAGGTTCGCCAACTGGATCGCCAATGCCCGTGACTGGAACGTTTCCAGAAATAGATATTGGGGTACTCCAATTCCTTTATGGGTTTCAGACGATTTTGAGGAGGTCGTCTGTGTTGGTTCTATCAAAGAATTGGAAGAATTGACCGGTGTGCGTAACATCACTGACTTGCATCGTGATGTCATTGACAAATTGACAATTCCATCCAAGCAAGGTAAGGGTGACTTAAAGAGAATTGAAGAAGTTTTTGATTGTTGGTTTGAATCTGGTTCTATGCCTTATGCTTCTCAACATTATCCATTTGAAAACACAGAAAAATTTGACGAAAGAGTTCCAGCTAATTTCATCTCTGAAGGTTTAGATCAAACAAGAGGTTGGTTCTACACGTTAGCTGTCTTAGGTACCCATCTATTTGGCTCTGTTCCATACAAGAACGTCATCGTCTCTGGTATTGTCTTAGCTGCCGATGGTAGAAAGATGTCTAAATCCTTGAAAAATTACCCTGATCCATCCATTGTTCTGAACAAATATGGTGCGGATGCATTAAGATTGTACTTGATAAACTCACCTGTTTTAAAAGCTGAAAGTTTGAAATTCAAAGAAGAGGGTGTTAAGGAGGTTGTTTCAAAGGTCTTACTACCATGGTGGAACTCCTTTAAATTTTTGGACGGTCAAATTGCCTTGTTGAAAAAGATGTCTAACATCGACTTCCAATATGATGATTCTGTGAAAAGTGATAATGTCATGGACAGATGGATTTTAGCTTCTATGCAATCTCTAGTACAATTCATTCACGAAGAAATGGGTCAGTACAAATTATACACTGTCGTTCCAAAACTTTTGAACTTCATTGATGAATTGACAAACTGGTATATTAGATTTAATCGTCGTCGTTTGAAGGGTGAAAACGGTGTTGAGGACTGTTTGAAAGCATTGAATTCTTTATTCGATGCCTTATTCACATTTGTCCGTGCCATGGCTCCATTCACCCCATTTTTGTCAGAAAGCATTTATTTGAGACTGAAGGAATACATCCCAGAAGCTGTCTTAGCAAAATACGGTAAGGACGGAAGATCAGTCCATTTCTTATCTTACCCAGTGGTCAAAAAAGAATACTTTGACGAGGCCATCGAAACTGCAGTTTCTAGAATGCAATCCGTTATCGATTTGGGTAGAAACATTCGTGAAAAGAAAACTATTTCCTTAAAAACTCCATTGAAGACTTTGGTCATCCTTCACAGTGATGAATCATACTTGAAGGATGTAGAAGCCTTGAAGAACTACATTATCGAGGAATTAAATGTTCGTGATGTTGTTATCACCTCCGATGAGGCAAAATATGGTGTTGAGTATAAAGCAGTTGCTGATTGGCCTGTATTGGGTAAGAAGTTGAAAAAAGACGCAAAGAAGGTTAAAGATGCCCTACCATCAGTCACTTCTGAGCAAGTACGGGAATATTTGGAAAGCGGAAAGTTGGAGGTTGCCGGTATTGAACTGGTTAAAGGAGATTTGAATGCTATTAGAGGCTTGCCAGAATCTGCTGTCCAAGCTGGACAAGAAACCAGAACCGACCAAGACGTGTTAATCATCATGGATACAAATATTTACTCTGAACTAAAGAGTGAAGGTCTCGCAAGAGAGCTGGTCAACAGAATCCAAAAATTGAGAAAGAAGTGTGGTTTGGAAGCCACCGACGATGTTTTAGTGGAGTACGAATTAGTTAAAGATACTATCGACTTTGAAGCCATTGTCAAAGAACATTTTGATATGTTAAGCAAGACCTGTAGATCCGACATCGCCAAATATGACGGCTCAAAGACAGACCCAATTGGTGATGAAGAACAATCTATTAATGACACCATTTTCAAATTAAAAGTGTTCAAATTATGA","protein_sequence":"MSESNAHFSFPKEEEKVLSLWDEIDAFHTSLELTKDKPEFSFFDGPPFATGTPHYGHILASTIKDIVPRYATMTGHHVERRFGWDTHGVPIEHIIDKKLGITGKDDVFKYGLENYNNECRSIVMTYASDWRKTIGRLGRWIDFDNDYKTMYPSFMESTWWAFKQLHEKGQVYRGFKVMPYSTGLTTPLSNFEAQQNYKDVNDPAVTIGFNVIGQEKTQLVAWTTTPWTLPSNLSLCVNADFEYVKIYDETRDRYFILLESLIKTLYKKPKNEKYKIVEKIKGSDLVGLKYEPLFPYFAEQFHETAFRVISDDYVTSDSGTGIVHNAPAFGEEDNAACLKNGVISEDSVLPNAIDDLGRFTKDVPDFEGVYVKDADKLIIKYLTNTGNLLLASQIRHSYPFCWRSDTPLLYRSVPAWFVRVKNIVPQMLDSVMKSHWVPNTIKEKRFANWIANARDWNVSRNRYWGTPIPLWVSDDFEEVVCVGSIKELEELTGVRNITDLHRDVIDKLTIPSKQGKGDLKRIEEVFDCWFESGSMPYASQHYPFENTEKFDERVPANFISEGLDQTRGWFYTLAVLGTHLFGSVPYKNVIVSGIVLAADGRKMSKSLKNYPDPSIVLNKYGADALRLYLINSPVLKAESLKFKEEGVKEVVSKVLLPWWNSFKFLDGQIALLKKMSNIDFQYDDSVKSDNVMDRWILASMQSLVQFIHEEMGQYKLYTVVPKLLNFIDELTNWYIRFNRRRLKGENGVEDCLKALNSLFDALFTFVRAMAPFTPFLSESIYLRLKEYIPEAVLAKYGKDGRSVHFLSYPVVKKEYFDEAIETAVSRMQSVIDLGRNIREKKTISLKTPLKTLVILHSDESYLKDVEALKNYIIEELNVRDVVITSDEAKYGVEYKAVADWPVLGKKLKKDAKKVKDALPSVTSEQVREYLESGKLEVAGIELVKGDLNAIRGLPESAVQAGQETRTDQDVLIIMDTNIYSELKSEGLARELVNRIQKLRKKCGLEATDDVLVEYELVKDTIDFEAIVKEHFDMLSKTCRSDIAKYDGSKTDPIGDEEQSINDTIFKLKVFKL"},{"created_at":"2011-05-24T21:08:49.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Autophagy-related protein 22","uniprot_id":"P25568","uniprot_name":"ATG22_YEAST","enzyme":false,"transporter":true,"gene_name":"ATG22","num_residues":528,"molecular_weight":"58843.10156","theoretical_pi":"8.61","general_function":"Involved in amino acid export from vacuole","specific_function":"Required for lysis of autophagic vesicles after delivery to the vacuole","reactions":[],"signal_regions":"None","transmembrane_regions":"99-119;131-151;154-174;211-231;242-262;319-339;353-373;389-409;418-438;486-506","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein.","genbank_gene_id":"X59720","genbank_protein_id":"5325","gene_card_id":"ATG22","chromosome_location":"chromosome 3","locus":"YCL038C","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[],"pathways":[],"gene_sequence":"ATGAGCTATGGAACTATAAATGATATGAATGAATCGGTAACGAACTATCGAATAAAAAAAGCCCAAAACAATATCAAGGGATGGTACGCTTACTCATTTTCTAGCGAACCATTTGTCGTTTCTGCGGTTTCAACGTATATTCCCTTACTACTGCAGCAATTTGCGAGTATAAATGGTGTAAAAGTTCACGATCACTCCATACCCTGCCTGTCAGAAACGGGTAGTGATTCAGATAAGTGTGTTCTTGGTTTGTTCAACAATCGGATCTTCGTAGATACTTCAAGTTTTGCATTATATGTCTTTTCCCTTAGCGTTTTATTCCAAACTATAATAGTCATTTCCGTTTCAGGGATAGTAGATCTCTGGGGGAGCGTTAAATTCAAAGGCAGAATTCTGGTTTGGTTTGGTATTGTGGGCGCATTGTCGACTGTTGCGATTTCAAAATTGAATGATACCCAGATTTATTCTCTGGCTGGGCTTTATATAGTGGCCAATGGTTGTTTTGGCGTTATCAATGTTGTTGGGAATTCTCTTCTGCCCATTTTTGTCAAGGATTCTTTGAAATGTCAAAGTCAAGGAGCTTATGAACCTGATAAGGTAGACTCGTTAACTACTGTTATTAGCGGTAGAGGTGCATCTTTAGGTTATTCAAGTGCCCTCATTGTTCAGATTGTATCTATGTTCTTAGTCGCATCTAAAAAGGGCAGTAAGCAGGATGTTCAAGTGGCTGTTCTTTTCGTTGGGATTTGGTGGTTTGTGTGGCAACTGCCCATGATCTGGTTGATTGACGATGTGACAATACCGATAAGAGTTGACGATTCTACATTAGCATCCGCCCGCAGTCCGTATCCCGGTGAGCAAGACGCCTTGGGTCAACTAAACTGGAAGAATTACCTTTCATATGGTTGGGTTTCGCTTTTCGAATCGTTTAAACATGCCAGACTATTGAAAGATGTGATGATTTTTCTTATTGCGTGGTTTATTATTAGTGATTCCATTACAACTATAAATTCTACAGCGGTTTTGTTCTCCAAGGCAGAACTGCACATGAGTACCCTCAATTTAATCATGATAAGTGTTTTGACCGTTGTAAATGCAATGCTGGGTGCCTTTATGATTCCACAATTTCTTGCCACAAAGTTTCGGTGGACTTCTAGTCAAACTTTGATGTACATTATCATTTGGGCAAGTTTCATACCATTTTATGGTATTCTTGGATTTTTCTTCAATGCGTTCGGTTTAAAGCATAAGTTTGAAATGTTCTTATTGGCCATTTGGTATGGATTATCACTAGGTGGCCTGTCCGCGGTTTCAAGATCAGTTTTCAGTTTGATTGTACCTCCAGGAAAAGAATCCACGTTTTTTAGTATGTTCAGTATCACAGATAAGGGGTCGTCCATCCTGGGACCCTTCCTTGTTGGACTGCTTACCGATAAAACGCATAATATTCGCTATTCGTTTTATTTCTTCTTTTTGCTTTTGATGCTATCATTGCCTGTGCTAAACTGTTTGGATGTCAAGAGAGGTAGAAGAGAGGCTGAAGAACTCAGTCAAGTTTTACCTGAAAGTGAAAGAAGGTTGGATTAG","protein_sequence":"MSYGTINDMNESVTNYRIKKAQNNIKGWYAYSFSSEPFVVSAVSTYIPLLLQQFASINGVKVHDHSIPCLSETGSDSDKCVLGLFNNRIFVDTSSFALYVFSLSVLFQTIIVISVSGIVDLWGSVKFKGRILVWFGIVGALSTVAISKLNDTQIYSLAGLYIVANGCFGVINVVGNSLLPIFVKDSLKCQSQGAYEPDKVDSLTTVISGRGASLGYSSALIVQIVSMFLVASKKGSKQDVQVAVLFVGIWWFVWQLPMIWLIDDVTIPIRVDDSTLASARSPYPGEQDALGQLNWKNYLSYGWVSLFESFKHARLLKDVMIFLIAWFIISDSITTINSTAVLFSKAELHMSTLNLIMISVLTVVNAMLGAFMIPQFLATKFRWTSSQTLMYIIIWASFIPFYGILGFFFNAFGLKHKFEMFLLAIWYGLSLGGLSAVSRSVFSLIVPPGKESTFFSMFSITDKGSSILGPFLVGLLTDKTHNIRYSFYFFFLLLMLSLPVLNCLDVKRGRREAEELSQVLPESERRLD"},{"created_at":"2011-05-26T17:45:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"General amino acid permease AGP1","uniprot_id":"P25376","uniprot_name":"AGP1_YEAST","enzyme":false,"transporter":true,"gene_name":"AGP1","num_residues":633,"molecular_weight":"69670.70313","theoretical_pi":"6.97","general_function":"Involved in transport","specific_function":"Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source","reactions":[],"signal_regions":"None","transmembrane_regions":"125-145;149-169;198-218;232-252;261-281;314-334;353-373;403-425;453-473;478-498;532-552;561-581","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"AGP1","chromosome_location":"chromosome 3","locus":"YCL025C","synonyms":["Asparagine/glutamine permease"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCGTCGTCGAAGTCTCTATACGAACTGAAAGACTTGAAAAATAGCTCCACAGAAATACATGCCACGGGGCAGGATAATGAAATTGAATATTTCGAAACAGGCTCCAATGACCGTCCATCCTCACAACCTCATTTAGGTTACGAACAGCATAACACTTCTGCCGTGCGTAGGTTTTTCGACTCCTTTAAAAGAGCGGATCAGGGTCCACAGGATGAAGTAGAAGCAACACAAATGAACGATCTTACGTCGGCTATCTCACCTTCTTCTAGACAGGCTCAAGAACTAGAAAAAAATGAAAGTTCGGACAACATAGGCGCTAATACAGGTCATAAGTCGGACTCGCTGAAGAAAACCATTCAGCCTAGACATGTTCTGATGATTGCGTTGGGTACGGGTATCGGTACTGGGTTATTGGTCGGTAACGGTACCGCGTTGGTTCATGCGGGTCCAGCTGGACTACTTATTGGTTACGCTATTATGGGTTCTATCTTGTACTGTATTATTCAAGCATGTGGTGAAATGGCGCTAGTGTATAGTAACTTGACTGGTGGCTACAATGCATACCCCAGTTTCCTTGTGGATGATGGTTTTGGGTTTGCAGTCGCTTGGGTTTATTGTTTGCAATGGCTGTGTGTGTGTCCTCTGGAATTGGTGACCGCATCCATGACTATCAAATATTGGACGACATCTGTGAACCCGGATGTGTTCGTCATTATTTTCTATGTTTTGGTGATTACTATTAATATTTTCGGTGCTCGTGGTTATGCAGAAGCTGAGTTCTTCTTCAACTGTTGCAAAATTTTGATGATGACTGGGTTCTTCATTCTTGGTATTATCATCGATGTTGGTGGCGCTGGTAATGATGGTTTTATTGGTGGTAAATACTGGCACGATCCGGGCGCTTTCAATGGTAAACATGCCATTGACAGATTTAAAGGTGTTGCTGCAACATTAGTGACTGCTGCTTTTGCCTTTGGTGGTTCAGAGTTTATTGCCATCACCACTGCAGAACAATCTAATCCAAGAAAGGCCATTCCAGGTGCGGCCAAACAAATGATCTACAGAATCTTATTCCTATTCTTGGCTACCATTATTCTACTGGGTTTCTTGGTGCCATACAATTCCGATCAATTATTGGGTTCTACCGGTGGTGGTACTAAAGCCTCGCCATATGTCATTGCTGTTGCATCCCACGGTGTCCGTGTCGTCCCACACTTCATTAACGCCGTTATTCTACTTTCCGTGCTGTCCATGGCTAACTCCTCCTTCTACTCCAGTGCTCGTTTATTTTTAACTCTATCCGAGCAAGGTTACGCTCCTAAGGTTTTCTCCTACATCGACAGAGCCGGTAGACCATTGATTGCCATGGGTGTTTCTGCATTGTTTGCCGTTATTGCCTTCTGTGCTGCATCTCCCAAGGAAGAACAAGTTTTCACTTGGTTATTGGCCATTTCTGGTTTGTCTCAGCTTTTCACATGGACTGCCATTTGTTTATCCCATCTTAGATTTAGAAGAGCCATGAAAGTCCAAGGGAGATCTCTTGGAGAATTGGGTTTCAAATCTCAAACTGGTGTTTGGGGATCTGCCTACGCTTGCATTATGATGATTTTAATTCTTATTGCCCAATTTTGGGTCGCTATCGCCCCCATTGGTGAAGGTAAGCTGGATGCACAAGCCTTTTTCGAAAACTACTTGGCTATGCCAATCTTGATTGCACTTTATGTCGGCTACAAGGTCTGGCACAAGGATTGGAAACTGTTCATCAGGGCAGACAAGATCGACCTAGATTCTCATAGACAAATCTTTGATGAAGAATTAATCAAGCAAGAAGACGAAGAATATAGGGAACGTTTGAGGAACGGACCTTATTGGAAAAGGGTCGTTGCCTTCTGGTGTTAA","protein_sequence":"MSSSKSLYELKDLKNSSTEIHATGQDNEIEYFETGSNDRPSSQPHLGYEQHNTSAVRRFFDSFKRADQGPQDEVEATQMNDLTSAISPSSRQAQELEKNESSDNIGANTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGFIGGKYWHDPGAFNGKHAIDRFKGVAATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIILLGFLVPYNSDQLLGSTGGGTKASPYVIAVASHGVRVVPHFINAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKVFSYIDRAGRPLIAMGVSALFAVIAFCAASPKEEQVFTWLLAISGLSQLFTWTAICLSHLRFRRAMKVQGRSLGELGFKSQTGVWGSAYACIMMILILIAQFWVAIAPIGEGKLDAQAFFENYLAMPILIALYVGYKVWHKDWKLFIRADKIDLDSHRQIFDEELIKQEDEEYRERLRNGPYWKRVVAFWC"}]}