{"ymdb_id":"YMDB00031","created_at":"2011-05-29T15:50:09.000Z","updated_at":"2016-09-08T18:34:55.000Z","name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid","cas":"2627-73-8","state":null,"melting_point":null,"description":"7-Phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid is an intermediate in phenylalanine, tyrosine and tryptophan biosynthesis pathway. [KEGG]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion;cytoplasm","synthesis_reference":null,"chebi_id":"18150","hmdb_id":null,"kegg_id":"C04691","pubchem_id":"160647","cs_id":"24785546","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(4R,5S,6R)-4,5,6-trihydroxy-2-oxo-7-(phosphonooxy)heptanoic acid","traditional_iupac":"DAHP","logp":"-2.5289322136666668","pka":"2.9174480444633493","alogps_solubility":"1.41e+01 g/l","alogps_logp":"-2.47","alogps_logs":"-1.31","acceptor_count":"9","donor_count":"6","rotatable_bond_count":"8","polar_surface_area":"181.82","refractivity":"53.151700000000005","polarizability":"22.367783841238907","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":"-3.271766798649698","pka_strongest_acidic":"1.4688872906407804","bioavailability":"1","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-Dahp","2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate","2-dehydro-3-Deoxy-D-arabino-heptonic acid 7-phosphoric acid","2-dehydro-3-Deoxy-D-arabino-heptulosonic acid-7-phosphate","3-Deoxy-arabino-heptulonate 7-phosphate","3-Deoxy-arabino-heptulonic acid 7-phosphoric acid","3-Deoxy-D-arabino-2-heptulosonate 7-(dihydrogen phosphate)","3-Deoxy-D-arabino-2-heptulosonic acid","3-deoxy-D-arabino-2-heptulosonic acid 7-(dihydrogen phosphate)","3-Deoxy-D-arabino-2-heptulosonic acid 7-(dihydrogen phosphoric acid)","3-Deoxy-D-arabino-hept-2-ulosonate 7-phosphate","3-Deoxy-D-arabino-hept-2-ulosonic acid 7-phosphoric acid","3-Deoxy-D-arabino-heptulosonate 7-phosphate","3-deoxy-D-arabino-heptulosonate-7-phosphate","3-Deoxy-D-arabino-heptulosonic acid 7-phosphate","3-Deoxy-D-arabino-heptulosonic acid 7-phosphoric acid","3-Deoxy-D-arabino-heptulosonic acid-7-phosphoric acid","3-Deoxyarabinoheptulosonate-7-phosphate","7-phospho-2-keto-3-Deoxy-D-arabinoheptonate","DAHP"],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":15019786,"citation":"Konig, V., Pfeil, A., Braus, G. H., Schneider, T. R. (2004). \"Substrate and metal complexes of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae provide new insights into the catalytic mechanism.\" J Mol Biol 337:675-690."},{"pubmed_id":6355828,"citation":"Larimer, F. W., Morse, C. C., Beck, A. K., Cole, K. W., Gaertner, F. H. (1983). \"Isolation of the ARO1 cluster gene of Saccharomyces cerevisiae.\" Mol Cell Biol 3:1609-1614."},{"pubmed_id":2880280,"citation":"Teshiba, S., Furter, R., Niederberger, P., Braus, G., Paravicini, G., Hutter, R. (1986). \"Cloning of the ARO3 gene of Saccharomyces cerevisiae and its regulation.\" Mol Gen Genet 205:353-357."}],"proteins":[{"created_at":"2011-05-24T20:47:22.000Z","updated_at":"2011-07-22T17:53:48.000Z","name":"Pentafunctional AROM polypeptide","uniprot_id":"P08566","uniprot_name":"ARO1_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO1","num_residues":1588,"molecular_weight":"174754.0","theoretical_pi":"6.22","general_function":"Involved in 3-dehydroquinate dehydratase activity","specific_function":"The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis","reactions":[{"id":1162,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1163,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1187,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1965,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1966,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2343,"direction":"\u003e","locations":"Cytoplasm","altext":"3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2344,"direction":"\u003e","locations":"Cytoplasm","altext":"3-dehydroquinate = 3-dehydroshikimate + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2345,"direction":"\u003e","locations":"Cytoplasm","altext":"Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2346,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + shikimate = ADP + shikimate 3-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2347,"direction":"\u003e","locations":"Cytoplasm","altext":"Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X06077","genbank_protein_id":"3381","gene_card_id":"ARO1","chromosome_location":"chromosome 4","locus":"YDR127W","synonyms":["3-dehydroquinate synthase","3-phosphoshikimate 1-carboxyvinyltransferase","5-enolpyruvylshikimate-3-phosphate synthase","EPSP 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binding"},{"category":"Function","description":" shikimate kinase activity"},{"category":"Function","description":" shikimate 5-dehydrogenase activity"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" 3-phosphoshikimate 1-carboxyvinyltransferase activity"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" carbon-oxygen lyase activity, acting on phosphates"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" 3-dehydroquinate synthase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" 3-dehydroquinate dehydratase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" aromatic amino acid family biosynthetic process"}],"pfams":[{"name":"DHQ_synthase","identifier":"PF01761"},{"name":"DHquinase_I","identifier":"PF01487"},{"name":"EPSP_synthase","identifier":"PF00275"},{"name":"Shikimate_DH","identifier":"PF01488"},{"name":"Shikimate_dh_N","identifier":"PF08501"},{"name":"SKI","identifier":"PF01202"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"}],"gene_sequence":"ATGGTGCAGTTAGCCAAAGTCCCAATTCTAGGAAATGATATTATCCACGTTGGGTATAACATTCATGACCATTTGGTTGAAACCATAATTAAACATTGTCCTTCTTCGACATACGTTATTTGCAATGATACGAACTTGAGTAAAGTTCCATACTACCAGCAATTAGTCCTGGAATTCAAGGCTTCTTTGCCAGAAGGCTCTCGTTTACTTACTTATGTTGTTAAACCAGGTGAGACAAGTAAAAGTAGAGAAACCAAAGCGCAGCTAGAAGATTATCTTTTAGTGGAAGGATGTACTCGTGATACGGTTATGGTAGCGATCGGTGGTGGTGTTATTGGTGACATGATTGGGTTCGTTGCATCTACATTTATGAGAGGTGTTCGTGTTGTCCAAGTACCAACATCCTTATTGGCAATGGTCGATTCCTCCATTGGTGGTAAAACTGCTATTGACACTCCTCTAGGTAAAAACTTTATTGGTGCATTTTGGCAACCAAAATTTGTCCTTGTAGATATTAAATGGCTAGAAACGTTAGCCAAGAGAGAGTTTATCAATGGGATGGCAGAAGTTATCAAGACTGCTTGTATTTGGAACGCTGACGAATTTACTAGATTAGAATCAAACGCTTCGTTGTTCTTAAATGTTGTTAATGGGGCAAAAAATGTCAAGGTTACCAATCAATTGACAAACGAGATTGACGAGATATCGAATACAGATATTGAAGCTATGTTGGATCATACATATAAGTTAGTTCTTGAGAGTATTAAGGTCAAAGCGGAAGTTGTCTCTTCGGATGAACGTGAATCCAGTCTAAGAAACCTTTTGAACTTCGGACATTCTATTGGTCATGCTTATGAAGCTATACTAACCCCACAAGCATTACATGGTGAATGTGTGTCCATTGGTATGGTTAAAGAGGCGGAATTATCCCGTTATTTCGGTATTCTCTCCCCTACCCAAGTTGCACGTCTATCCAAGATTTTGGTTGCCTACGGGTTGCCTGTTTCGCCTGATGAGAAATGGTTTAAAGAGCTAACCTTACATAAGAAAACACCATTGGATATCTTATTGAAGAAAATGAGTATTGACAAGAAAAACGAGGGTTCCAAAAAGAAGGTGGTCATTTTAGAAAGTATTGGTAAGTGCTATGGTGACTCCGCTCAATTTGTTAGCGATGAAGACCTGAGATTTATTCTAACAGATGAAACCCTCGTTTACCCCTTCAAGGACATCCCTGCTGATCAACAGAAAGTTGTTATCCCCCCTGGTTCTAAGTCCATCTCCAATCGTGCTTTAATTCTTGCTGCCCTCGGTGAAGGTCAATGTAAAATCAAGAACTTATTACATTCTGATGATACTAAACATATGTTAACCGCTGTTCATGAATTGAAAGGTGCTACGATATCATGGGAAGATAATGGTGAGACGGTAGTGGTGGAAGGACATGGTGGTTCCACATTGTCAGCTTGTGCTGACCCCTTATATCTAGGTAATGCAGGTACTGCATCTAGATTTTTGACTTCCTTGGCTGCCTTGGTCAATTCTACTTCAAGCCAAAAGTATATCGTTTTAACTGGTAACGCAAGAATGCAACAAAGACCAATTGCTCCTTTGGTCGATTCTTTGCGTGCTAATGGTACTAAAATTGAGTACTTGAATAATGAAGGTTCCCTGCCAATCAAAGTTTATACTGATTCGGTATTCAAAGGTGGTAGAATTGAATTAGCTGCTACAGTTTCTTCTCAGTACGTATCCTCTATCTTGATGTGTGCCCCATACGCTGAAGAACCTGTAACTTTGGCTCTTGTTGGTGGTAAGCCAATCTCTAAATTGTACGTCGATATGACAATAAAAATGATGGAAAAATTCGGTATCAATGTTGAAACTTCTACTACAGAACCTTACACTTATTATATTCCAAAGGGACATTATATTAACCCATCAGAATACGTCATTGAAAGTGATGCCTCAAGTGCTACATACCCATTGGCCTTCGCCGCAATGACTGGTACTACCGTAACGGTTCCAAACATTGGTTTTGAGTCGTTACAAGGTGATGCCAGATTTGCAAGAGATGTCTTGAAACCTATGGGTTGTAAAATAACTCAAACGGCAACTTCAACTACTGTTTCGGGTCCTCCTGTAGGTACTTTAAAGCCATTAAAACATGTTGATATGGAGCCAATGACTGATGCGTTCTTAACTGCATGTGTTGTTGCCGCTATTTCGCACGACAGTGATCCAAATTCTGCAAATACAACCACCATTGAAGGTATTGCAAACCAGCGTGTCAAAGAGTGTAACAGAATTTTGGCCATGGCTACAGAGCTCGCCAAATTTGGCGTCAAAACTACAGAATTACCAGATGGTATTCAAGTCCATGGTTTAAACTCGATAAAAGATTTGAAGGTTCCTTCCGACTCTTCTGGACCTGTCGGTGTATGCACATATGATGATCATCGTGTGGCCATGAGTTTCTCGCTTCTTGCAGGAATGGTAAATTCTCAAAATGAACGTGACGAAGTTGCTAATCCTGTAAGAATACTTGAAAGACATTGTACTGGTAAAACCTGGCCTGGCTGGTGGGATGTGTTACATTCCGAACTAGGTGCCAAATTAGATGGTGCAGAACCTTTAGAGTGCACATCCAAAAAGAACTCAAAGAAAAGCGTTGTCATTATTGGCATGAGAGCAGCTGGCAAAACTACTATAAGTAAATGGTGCGCATCCGCTCTGGGTTACAAATTAGTTGACCTAGACGAGCTGTTTGAGCAACAGCATAACAATCAAAGTGTTAAACAATTTGTTGTGGAGAACGGTTGGGAGAAGTTCCGTGAGGAAGAAACAAGAATTTTCAAGGAAGTTATTCAAAATTACGGCGATGATGGATATGTTTTCTCAACAGGTGGCGGTATTGTTGAAAGCGCTGAGTCTAGAAAAGCCTTAAAAGATTTTGCCTCATCAGGTGGATACGTTTTACACTTACATAGGGATATTGAGGAGACAATTGTCTTTTTACAAAGTGATCCTTCAAGACCTGCCTATGTGGAAGAAATTCGTGAAGTTTGGAACAGAAGGGAGGGGTGGTATAAAGAATGCTCAAATTTCTCTTTCTTTGCTCCTCATTGCTCCGCAGAAGCTGAGTTCCAAGCTCTAAGAAGATCGTTTAGTAAGTACATTGCAACCATTACAGGTGTCAGAGAAATAGAAATTCCAAGCGGAAGATCTGCCTTTGTGTGTTTAACCTTTGATGACTTAACTGAACAAACTGAGAATTTGACTCCAATCTGTTATGGTTGTGAGGCTGTAGAGGTCAGAGTAGACCATTTGGCTAATTACTCTGCTGATTTCGTGAGTAAACAGTTATCTATATTGCGTAAAGCCACTGACAGTATTCCTATCATTTTTACTGTGCGAACCATGAAGCAAGGTGGCAACTTTCCTGATGAAGAGTTCAAAACCTTGAGAGAGCTATACGATATTGCCTTGAAGAATGGTGTTGAATTCCTTGACTTAGAACTAACTTTACCTACTGATATCCAATATGAGGTTATTAACAAAAGGGGCAACACCAAGATCATTGGTTCCCATCATGACTTCCAAGGATTATACTCCTGGGACGACGCTGAATGGGAAAACAGATTCAATCAAGCGTTAACTCTTGATGTGGATGTTGTAAAATTTGTGGGTACGGCTGTTAATTTCGAAGATAATTTGAGACTGGAACACTTTAGGGATACACACAAGAATAAGCCTTTAATTGCAGTTAATATGACTTCTAAAGGTAGCATTTCTCGTGTTTTGAATAATGTTTTAACACCTGTGACATCAGATTTATTGCCTAACTCCGCTGCCCCTGGCCAATTGACAGTAGCACAAATTAACAAGATGTATACATCTATGGGAGGTATCGAGCCTAAGGAACTGTTTGTTGTTGGAAAGCCAATTGGCCACTCTAGATCGCCAATTTTACATAACACTGGCTATGAAATTTTAGGTTTACCTCACAAGTTCGATAAATTTGAAACTGAATCCGCACAATTGGTGAAAGAAAAACTTTTGGACGGAAACAAGAACTTTGGCGGTGCTGCAGTCACAATTCCTCTGAAATTAGATATAATGCAGTACATGGATGAATTGACTGATGCTGCTAAAGTTATTGGTGCTGTAAACACAGTTATACCATTGGGTAACAAGAAGTTTAAGGGTGATAATACCGACTGGTTAGGTATCCGTAATGCCTTAATTAACAATGGCGTTCCCGAATATGTTGGTCATACCGCTGGTTTGGTTATCGGTGCAGGTGGCACTTCTAGAGCCGCCCTTTACGCCTTGCACAGTTTAGGTTGCAAAAAGATCTTCATAATCAACAGGACAACTTCGAAATTGAAGCCATTAATAGAGTCACTTCCATCTGAATTCAACATTATTGGAATAGAGTCCACTAAATCTATAGAAGAGATTAAGGAACACGTTGGCGTTGCTGTCAGCTGTGTACCAGCCGACAAACCATTAGATGACGAACTTTTAAGTAAGCTGGAGAGATTCCTTGTGAAAGGTGCCCATGCTGCTTTTGTACCAACCTTATTGGAAGCCGCATACAAACCAAGCGTTACTCCCGTTATGACAATTTCACAAGACAAATATCAATGGCACGTTGTCCCTGGATCACAAATGTTAGTACACCAAGGTGTAGCTCAGTTTGAAAAGTGGACAGGATTCAAGGGCCCTTTCAAGGCCATTTTTGATGCCGTTACGAAAGAGTAG","protein_sequence":"MVQLAKVPILGNDIIHVGYNIHDHLVETIIKHCPSSTYVICNDTNLSKVPYYQQLVLEFKASLPEGSRLLTYVVKPGETSKSRETKAQLEDYLLVEGCTRDTVMVAIGGGVIGDMIGFVASTFMRGVRVVQVPTSLLAMVDSSIGGKTAIDTPLGKNFIGAFWQPKFVLVDIKWLETLAKREFINGMAEVIKTACIWNADEFTRLESNASLFLNVVNGAKNVKVTNQLTNEIDEISNTDIEAMLDHTYKLVLESIKVKAEVVSSDERESSLRNLLNFGHSIGHAYEAILTPQALHGECVSIGMVKEAELSRYFGILSPTQVARLSKILVAYGLPVSPDEKWFKELTLHKKTPLDILLKKMSIDKKNEGSKKKVVILESIGKCYGDSAQFVSDEDLRFILTDETLVYPFKDIPADQQKVVIPPGSKSISNRALILAALGEGQCKIKNLLHSDDTKHMLTAVHELKGATISWEDNGETVVVEGHGGSTLSACADPLYLGNAGTASRFLTSLAALVNSTSSQKYIVLTGNARMQQRPIAPLVDSLRANGTKIEYLNNEGSLPIKVYTDSVFKGGRIELAATVSSQYVSSILMCAPYAEEPVTLALVGGKPISKLYVDMTIKMMEKFGINVETSTTEPYTYYIPKGHYINPSEYVIESDASSATYPLAFAAMTGTTVTVPNIGFESLQGDARFARDVLKPMGCKITQTATSTTVSGPPVGTLKPLKHVDMEPMTDAFLTACVVAAISHDSDPNSANTTTIEGIANQRVKECNRILAMATELAKFGVKTTELPDGIQVHGLNSIKDLKVPSDSSGPVGVCTYDDHRVAMSFSLLAGMVNSQNERDEVANPVRILERHCTGKTWPGWWDVLHSELGAKLDGAEPLECTSKKNSKKSVVIIGMRAAGKTTISKWCASALGYKLVDLDELFEQQHNNQSVKQFVVENGWEKFREEETRIFKEVIQNYGDDGYVFSTGGGIVESAESRKALKDFASSGGYVLHLHRDIEETIVFLQSDPSRPAYVEEIREVWNRREGWYKECSNFSFFAPHCSAEAEFQALRRSFSKYIATITGVREIEIPSGRSAFVCLTFDDLTEQTENLTPICYGCEAVEVRVDHLANYSADFVSKQLSILRKATDSIPIIFTVRTMKQGGNFPDEEFKTLRELYDIALKNGVEFLDLELTLPTDIQYEVINKRGNTKIIGSHHDFQGLYSWDDAEWENRFNQALTLDVDVVKFVGTAVNFEDNLRLEHFRDTHKNKPLIAVNMTSKGSISRVLNNVLTPVTSDLLPNSAAPGQLTVAQINKMYTSMGGIEPKELFVVGKPIGHSRSPILHNTGYEILGLPHKFDKFETESAQLVKEKLLDGNKNFGGAAVTIPLKLDIMQYMDELTDAAKVIGAVNTVIPLGNKKFKGDNTDWLGIRNALINNGVPEYVGHTAGLVIGAGGTSRAALYALHSLGCKKIFIINRTTSKLKPLIESLPSEFNIIGIESTKSIEEIKEHVGVAVSCVPADKPLDDELLSKLERFLVKGAHAAFVPTLLEAAYKPSVTPVMTISQDKYQWHVVPGSQMLVHQGVAQFEKWTGFKGPFKAIFDAVTKE"},{"created_at":"2011-05-24T20:48:15.000Z","updated_at":"2011-07-22T17:53:45.000Z","name":"Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited","uniprot_id":"P32449","uniprot_name":"AROG_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO4","num_residues":370,"molecular_weight":"39748.80078","theoretical_pi":"6.94","general_function":"Involved in catalytic activity","specific_function":"Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)","reactions":[{"id":1143,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2348,"direction":"\u003e","locations":"","altext":"Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1OF6","cellular_location":null,"genbank_gene_id":"X61107","genbank_protein_id":"433966","gene_card_id":"ARO4","chromosome_location":"chromosome 2","locus":"YBR249C","synonyms":["3-deoxy-D-arabino-heptulosonate 7-phosphate synthase","DAHP synthase","Phospho-2-keto-3-deoxyheptonate aldolase"],"enzyme_classes":["2.5.1.54"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" 3-deoxy-7-phosphoheptulonate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" aromatic amino acid family biosynthetic process"}],"pfams":[{"name":"DAHP_synth_1","identifier":"PF00793"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"}],"gene_sequence":"ATGAGTGAATCTCCAATGTTCGCTGCCAACGGCATGCCAAAGGTAAATCAAGGTGCTGAAGAAGATGTCAGAATTTTAGGTTACGACCCATTAGCTTCTCCAGCTCTCCTTCAAGTGCAAATCCCAGCCACACCAACTTCTTTGGAAACTGCCAAGAGAGGTAGAAGAGAAGCTATAGATATTATTACCGGTAAAGACGACAGAGTTCTTGTCATTGTCGGTCCTTGTTCCATCCATGATCTAGAAGCCGCTCAAGAATACGCTTTGAGATTAAAGAAATTGTCAGATGAATTAAAAGGTGATTTATCCATCATTATGAGAGCATACTTGGAGAAGCCAAGAACAACCGTCGGCTGGAAAGGTCTAATTAATGACCCTGATGTTAACAACACTTTCAACATCAACAAGGGTTTGCAATCCGCTAGACAATTGTTTGTCAACTTGACAAATATCGGTTTGCCAATTGGTTCTGAAATGCTTGATACCATTTCTCCTCAATACTTGGCTGATTTGGTCTCCTTCGGTGCCATTGGTGCCAGAACCACCGAATCTCAACTGCACAGAGAATTGGCCTCCGGTTTGTCTTTCCCAGTTGGTTTCAAGAACGGTACCGATGGTACCTTAAATGTTGCTGTGGATGCTTGTCAAGCCGCTGCTCATTCTCACCATTTCATGGGTGTTACTAAGCATGGTGTTGCTGCTATCACCACTACTAAGGGTAACGAACACTGCTTCGTTATTCTAAGAGGTGGTAAAAAGGGTACCAACTACGACGCTAAGTCCGTTGCAGAAGCTAAGGCTCAATTGCCTGCCGGTTCCAACGGTCTAATGATTGACTACTCTCACGGTAACTCCAATAAGGATTTCAGAAACCAACCAAAGGTCAATGACGTTGTTTGTGAGCAAATCGCTAACGGTGAAAACGCCATTACCGGTGTCATGATTGAATCAAACATCAACGAAGGTAACCAAGGCATCCCAGCCGAAGGTAAAGCCGGCTTGAAATATGGTGTTTCCATCACTGATGCTTGTATAGGTTGGGAAACTACTGAAGACGTCTTGAGGAAATTGGCTGCTGCTGTCAGACAAAGAAGAGAAGTTAACAAGAAATAG","protein_sequence":"MSESPMFAANGMPKVNQGAEEDVRILGYDPLASPALLQVQIPATPTSLETAKRGRREAIDIITGKDDRVLVIVGPCSIHDLEAAQEYALRLKKLSDELKGDLSIIMRAYLEKPRTTVGWKGLINDPDVNNTFNINKGLQSARQLFVNLTNIGLPIGSEMLDTISPQYLADLVSFGAIGARTTESQLHRELASGLSFPVGFKNGTDGTLNVAVDACQAAAHSHHFMGVTKHGVAAITTTKGNEHCFVILRGGKKGTNYDAKSVAEAKAQLPAGSNGLMIDYSHGNSNKDFRNQPKVNDVVCEQIANGENAITGVMIESNINEGNQGIPAEGKAGLKYGVSITDACIGWETTEDVLRKLAAAVRQRREVNKK"},{"created_at":"2011-05-24T20:48:53.000Z","updated_at":"2011-07-22T17:53:45.000Z","name":"Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited","uniprot_id":"P14843","uniprot_name":"AROF_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO3","num_residues":370,"molecular_weight":"41069.5","theoretical_pi":"7.44","general_function":"Involved in catalytic activity","specific_function":"Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)","reactions":[{"id":1143,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2348,"direction":"\u003e","locations":"","altext":"Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557657","genbank_protein_id":"45269207","gene_card_id":"ARO3","chromosome_location":"chromosome 4","locus":"YDR035W","synonyms":["3-deoxy-D-arabino-heptulosonate 7-phosphate synthase","DAHP synthase","Phospho-2-keto-3-deoxyheptonate aldolase"],"enzyme_classes":["2.5.1.54"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" 3-deoxy-7-phosphoheptulonate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" aromatic amino acid family biosynthetic process"}],"pfams":[{"name":"DAHP_synth_1","identifier":"PF00793"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"}],"gene_sequence":"ATGTTCATTAAAAACGATCACGCCGGTGACAGGAAACGCTTGGAAGACTGGAGAATCAAAGGTTATGATCCATTAACCCCTCCAGATCTGCTTCAACATGAATTTCCAATTTCAGCCAAAGGTGAGGAAAACATTATCAAGGCAAGAGACTCCGTCTGTGATATTTTGAATGGTAAAGATGATCGTTTAGTTATCGTGATCGGGCCATGTTCCCTACATGACCCCAAAGCCGCTTACGATTACGCTGACAGATTGGCTAAAATTTCAGAAAAGTTGTCAAAAGACTTATTGATTATTATGAGAGCGTATTTAGAAAAACCAAGGACTACTGTTGGCTGGAAAGGGTTGATTAACGACCCTGATATGAATAACTCTTTTCAAATCAATAAAGGTCTACGGATTTCGAGAGAAATGTTCATAAAACTGGTTGAAAAATTACCCATTGCTGGTGAGATGTTGGATACCATTTCTCCGCAGTTTTTGAGTGATTGTTTCTCCTTGGGTGCCATCGGCGCCAGAACTACTGAATCCCAACTGCACAGAGAATTAGCATCCGGTCTATCTTTCCCTATTGGATTTAAGAACGGTACTGATGGTGGTTTGCAAGTCGCCATCGACGCTATGAGAGCCGCTGCACATGAACATTACTTCCTTTCTGTCACAAAGCCAGGTGTCACTGCTATCGTGGGCACTGAAGGTAACAAGGATACCTTCCTGATCTTGAGAGGTGGTAAGAACGGTACTAACTTTGACAAAGAAAGTGTTCAAAATACTAAGAAACAGTTAGAAAAGGCCGGTTTGACTGATGATTCCCAGAAAAGAATTATGATCGATTGTTCCCACGGCAACAGTAATAAAGATTTCAAGAACCAACCAAAGGTTGCCAAATGTATTTATGACCAGCTGACGGAGGGTGAGAATAGTCTCTGTGGTGTTATGATTGAGTCCAACATAAATGAAGGTAGACAAGATATTCCCAAAGAAGGTGGCAGAGAGGGATTGAAGTATGGTTGTTCTGTTACGGATGCTTGTATTGGCTGGGAGTCCACCGAACAGGTATTGGAGCTATTGGCAGAAGGTGTTAGAAACAGAAGAAAGGCCTTGAAAAAATAG","protein_sequence":"MFIKNDHAGDRKRLEDWRIKGYDPLTPPDLLQHEFPISAKGEENIIKARDSVCDILNGKDDRLVIVIGPCSLHDPKAAYDYADRLAKISEKLSKDLLIIMRAYLEKPRTTVGWKGLINDPDMNNSFQINKGLRISREMFIKLVEKLPIAGEMLDTISPQFLSDCFSLGAIGARTTESQLHRELASGLSFPIGFKNGTDGGLQVAIDAMRAAAHEHYFLSVTKPGVTAIVGTEGNKDTFLILRGGKNGTNFDKESVQNTKKQLEKAGLTDDSQKRIMIDCSHGNSNKDFKNQPKVAKCIYDQLTEGENSLCGVMIESNINEGRQDIPKEGGREGLKYGCSVTDACIGWESTEQVLELLAEGVRNRRKALKK"}]}