{"ymdb_id":"YMDB00028","created_at":"2011-05-29T15:49:49.000Z","updated_at":"2016-09-08T18:34:55.000Z","name":"N-Acetylornithine","cas":"6205-08-9","state":"Solid","melting_point":"","description":"N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"-0.896","location":"mitochondrion","synthesis_reference":null,"chebi_id":"16543","hmdb_id":"HMDB03357","kegg_id":"C00437","pubchem_id":"439232","cs_id":"388369","foodb_id":null,"wikipedia_link":null,"biocyc_id":"N-ALPHA-ACETYLORNITHINE","iupac":"(2S)-5-amino-2-acetamidopentanoic acid","traditional_iupac":"N(2)-acetyl-L-ornithine","logp":"-3.5996013357873164","pka":"15.840829091959762","alogps_solubility":"3.78e+01 g/l","alogps_logp":"-2.73","alogps_logs":"-0.66","acceptor_count":"4","donor_count":"3","rotatable_bond_count":"5","polar_surface_area":"92.41999999999999","refractivity":"42.652300000000004","polarizability":"17.93686154192374","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.904255219393407","pka_strongest_acidic":"3.8153807321669744","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2S)-2-acetamido-5-aminopentanoate","(2S)-2-acetamido-5-aminopentanoic acid","Acetyl-ornithine","AOR","delta-N-Acetylornithine","N(2)-acetyl-L-ornithine","N(delta)-Acetylornithine","N(delta)-Acetylornithine, (DL)-isomer","N2-Acetyl-L-ornithine"],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":7705341,"citation":"Liu, Y., Van Heeswijck, R., Hoj, P., Hoogenraad, N. (1995). \"Purification and characterization of ornithine acetyltransferase from Saccharomyces cerevisiae.\" Eur J Biochem 228:291-296."},{"pubmed_id":9428669,"citation":"Crabeel, M., Abadjieva, A., Hilven, P., Desimpelaere, J., Soetens, O. (1997). \"Characterization of the Saccharomyces cerevisiae ARG7 gene encoding ornithine acetyltransferase, an enzyme also endowed with acetylglutamate synthase activity.\" Eur J Biochem 250:232-241."}],"proteins":[{"created_at":"2011-05-24T20:44:30.000Z","updated_at":"2011-07-22T17:53:56.000Z","name":"Acetylornithine aminotransferase, mitochondrial","uniprot_id":"P18544","uniprot_name":"ARGD_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG8","num_residues":423,"molecular_weight":"46681.10156","theoretical_pi":"7.62","general_function":"Involved in transaminase activity","specific_function":"N(2)-acetyl-L-ornithine + 2-oxoglutarate = N- acetyl-L-glutamate 5-semialdehyde + L-glutamate","reactions":[{"id":1247,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2338,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3773,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006295","source":"Smpdb"},{"id":3773,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006295","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"M32795","genbank_protein_id":"171083","gene_card_id":"ARG8","chromosome_location":"chromosome 15","locus":"YOL140W","synonyms":["ACOAT"],"enzyme_classes":["2.6.1.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" arginine metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"4-aminobutanoate degradation","kegg_map_id":null}],"gene_sequence":"ATGTTTAAAAGATATTTATCCAGTACGTCATCAAGAAGATTTACAAGCATTTTAGAGGAAAAGGCCTTTCAAGTGACCACTTACTCTAGACCTGAAGATCTATGTATAACTAGAGGTAAAAATGCAAAGCTGTATGATGACGTGAATGGTAAAGAATATATCGATTTCACCGCAGGTATTGCGGTGACCGCATTAGGCCATGCAAATCCTAAAGTGGCAGAAATTCTGCACCATCAGGCTAACAAACTGGTTCATTCCTCCAACCTTTACTTCACTAAGGAATGTTTGGATTTAAGTGAAAAGATTGTTGAAAAGACCAAGCAATTCGGTGGTCAACACGACGCCTCAAGAGTATTTTTATGTAATTCTGGTACGGAAGCAAATGAAGCTGCTTTGAAGTTTGCAAAGAAACATGGTATAATGAAAAATCCTAGCAAGCAAGGCATTGTTGCATTTGAGAACTCTTTTCATGGCCGTACTATGGGCGCTTTATCTGTCACTTGGAATAGTAAATATAGAACTCCTTTTGGGGATTTGGTTCCCCATGTCTCATTCTTAAATTTGAATGACGAAATGACCAAACTACAAAGTTATATCGAGACCAAAAAGGACGAGATTGCTGGTTTAATTGTCGAGCCCATACAAGGTGAAGGTGGGGTTTTTCCCGTAGAAGTTGAAAAGCTAACCGGATTGAAGAAAATATGTCAAGATAATGATGTGATTGTCATTCATGATGAAATTCAATGCGGTTTGGGCCGTTCAGGTAAACTATGGGCTCATGCTTATTTACCAAGTGAGGCTCATCCGGATATTTTTACATCTGCCAAAGCATTGGGAAATGGCTTCCCCATCGCTGCCACCATCGTCAATGAAAAAGTTAATAATGCTTTGAGAGTTGGTGACCACGGCACCACGTATGGTGGTAATCCGCTGGCCTGTTCTGTAAGCAACTATGTTTTGGATACCATAGCAGACGAAGCTTTTTTGAAACAAGTCTCTAAGAAGAGTGATATCTTACAAAAGCGCTTGCGCGAAATTCAAGCCAAATATCCAAATCAAATAAAGACTATCAGAGGAAAAGGTTTGATGCTTGGTGCTGAGTTCGTCGAACCACCCACCGAGGTCATCAAAAAGGCCAGAGAATTGGGACTTTTGATCATTACCGCTGGTAAGAGTACCGTTAGATTTGTTCCCGCATTAACGATTGAAGACGAACTAATCGAAGAAGGGATGGATGCTTTTGAAAAGGCTATTGAAGCGGTTTACGCTTAA","protein_sequence":"MFKRYLSSTSSRRFTSILEEKAFQVTTYSRPEDLCITRGKNAKLYDDVNGKEYIDFTAGIAVTALGHANPKVAEILHHQANKLVHSSNLYFTKECLDLSEKIVEKTKQFGGQHDASRVFLCNSGTEANEAALKFAKKHGIMKNPSKQGIVAFENSFHGRTMGALSVTWNSKYRTPFGDLVPHVSFLNLNDEMTKLQSYIETKKDEIAGLIVEPIQGEGGVFPVEVEKLTGLKKICQDNDVIVIHDEIQCGLGRSGKLWAHAYLPSEAHPDIFTSAKALGNGFPIAATIVNEKVNNALRVGDHGTTYGGNPLACSVSNYVLDTIADEAFLKQVSKKSDILQKRLREIQAKYPNQIKTIRGKGLMLGAEFVEPPTEVIKKARELGLLIITAGKSTVRFVPALTIEDELIEEGMDAFEKAIEAVYA"},{"created_at":"2011-05-24T20:44:57.000Z","updated_at":"2011-05-27T14:56:01.000Z","name":"Arginine biosynthesis bifunctional protein ArgJ, mitochondrial","uniprot_id":"Q04728","uniprot_name":"ARGJ_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG7","num_residues":441,"molecular_weight":"47848.30078","theoretical_pi":"7.18","general_function":"Involved in glutamate N-acetyltransferase activity","specific_function":"Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate","reactions":[{"id":1755,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1806,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2339,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"N(2)-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2340,"direction":"\u003e","locations":"Mitochondrion matrix;Mitochondrion","altext":"Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"U90438","genbank_protein_id":"1895091","gene_card_id":"ARG7","chromosome_location":"chromosome 13","locus":"YMR062C","synonyms":["Extracellular mutant protein 40","Glutamate N-acetyltransferase","GAT","Ornithine acetyltransferase","OATase","Ornithine transacetylase","Amino-acid acetyltransferase","N-acetylglutamate synthase","AGS","Arginine biosynthesis bifunctional protein ArgJ alpha chain","Arginine biosynthesis bifunctional protein ArgJ beta chain"],"enzyme_classes":["2.3.1.35","2.3.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" acetyl-CoA:L-glutamate N-acetyltransferase activity"},{"category":"Function","description":" acetyltransferase activity"},{"category":"Function","description":" N-acetyltransferase activity"},{"category":"Function","description":" glutamate N-acetyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" arginine metabolic process"},{"category":"Process","description":" arginine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"}],"pfams":[{"name":"ArgJ","identifier":"PF01960"}],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"}],"gene_sequence":"ATGAGAATATCATCAACATTGCTTCAACGCTCGAAGCAGCTTATAGATAAGTATGCATTATACGTGCCCAAGACGGGCTCTTTTCCTAAAGGATTTGAAGTAGGCTACACTGCATCTGGAGTCAAAAAAAACGGGAGCCTGGACCTGGGTGTAATCTTGAATACCAATAAATCTCGTCCTTCAACCGCAGCAGCTGTTTTCACGACCAATAAATTCAAAGCTGCGCCAGTTTTGACATCGAAAAAAGTCCTTGAAACTGCTCGTGGTAAAAACATCAACGCTATTGTAGTCAATTCCGGTTGTGCTAACTCGGTCACAGGTGATCTTGGTATGAAAGATGCCCAAGTAATGATTGATTTGGTTAACGATAAAATTGGTCAAAAAAATTCTACCCTAGTCATGTCTACAGGCGTTATTGGACAACGACTACAGATGGACAAGATCAGCACTGGTATCAATAAAATTTTTGGAGAAGAAAAGTTCGGCAGTGATTTTAACTCTTGGTTGAACGTAGCCAAATCAATCTGTACTACTGATACTTTCCCAAAATTAGTTACATCTAGATTCAAATTACCTAGTGGTACTGAGTATACTTTGACAGGTATGGCAAAGGGCGCGGGTATGATTTGTCCGAATATGGCTACCTTATTAGGTTTCATAGTTACAGATCTTCCTATTGAAAGCAAGGCGTTGCAGAAGATGCTGACTTTCGCTACTACCCGTTCATTTAATTGTATATCGGTGGACGGTGATATGAGCACCAATGACACAATTTGCATGTTGGCCAACGGTGCTATTGACACCAAAGAAATTAACGAAGACTCTAAAGATTTTGAACAAGTAAAATTGCAGGTCACAGAATTTGCTCAGCGCTTGGCCCAGTTAGTCGTTCGCGATGGTGAAGGTTCGACAAAGTTTGTTACTGTTAACGTTAAAAATGCTTTGCATTTTGAAGACGCCAAAATAATTGCTGAATCAATCTCAAACTCTATGTTGGTCAAAACCGCACTATATGGGCAAGATGCCAATTGGGGAAGAATATTGTGCGCGATCGGGTATGCAAAGCTGAATGACTTAAAATCTCTAGATGTCAACAAAATTAATGTTAGCTTTATTGCTACCGACAATTCAGAACCTCGTGAGCTGAAGCTTGTCGCTAATGGTGTGCCACAATTGGAGATCGATGAAACAAGGGCTTCTGAAATATTGGCTTTGAATGATTTGGAAGTGTCTGTCGACTTGGGAACCGGTGATCAGGCAGCACAATTTTGGACTTGTGATTTATCACATGAATATGTAACAATTAACGGTGATTACCGTTCATAA","protein_sequence":"MRISSTLLQRSKQLIDKYALYVPKTGSFPKGFEVGYTASGVKKNGSLDLGVILNTNKSRPSTAAAVFTTNKFKAAPVLTSKKVLETARGKNINAIVVNSGCANSVTGDLGMKDAQVMIDLVNDKIGQKNSTLVMSTGVIGQRLQMDKISTGINKIFGEEKFGSDFNSWLNVAKSICTTDTFPKLVTSRFKLPSGTEYTLTGMAKGAGMICPNMATLLGFIVTDLPIESKALQKMLTFATTRSFNCISVDGDMSTNDTICMLANGAIDTKEINEDSKDFEQVKLQVTEFAQRLAQLVVRDGEGSTKFVTVNVKNALHFEDAKIIAESISNSMLVKTALYGQDANWGRILCAIGYAKLNDLKSLDVNKINVSFIATDNSEPRELKLVANGVPQLEIDETRASEILALNDLEVSVDLGTGDQAAQFWTCDLSHEYVTINGDYRS"}]}