{"ymdb_id":"YMDB00023","created_at":"2011-05-29T15:49:24.000Z","updated_at":"2016-10-18T17:11:15.000Z","name":"3',5'-cyclic AMP","cas":"60-92-4","state":"Solid","melting_point":"219-220 oC","description":"Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is derived from adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway.","experimental_water_solubility":"4 mg/mL [HMP experimental]","experimental_logp_hydrophobicity":"-2.96 [HANSCH,C ET AL. (1995)]","location":"cytoplasm","synthesis_reference":"Genieser, H. G.; Butt, E.; Bottin, U.; Dostmann, W.; Jastorff, B. Synthesis of the 3',5'-cyclic phosphates from unprotected nucleosides. Synthesis  (1989),   (1),  53-4.","chebi_id":"17489","hmdb_id":"HMDB00058","kegg_id":"C00575","pubchem_id":"6076","cs_id":"5851","foodb_id":null,"wikipedia_link":"Cyclic_adenosine_monophosphate","biocyc_id":"CAMP","iupac":"(4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one","traditional_iupac":"(4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2,7-dihydroxy-tetrahydro-4H-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one","logp":"-3.3924794780069596","pka":"12.588619397066793","alogps_solubility":"3.58e+00 g/l","alogps_logp":"-2.29","alogps_logs":"-1.96","acceptor_count":"8","donor_count":"3","rotatable_bond_count":"1","polar_surface_area":"154.84","refractivity":"70.2895","polarizability":"28.42295790219419","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"3.9248049140967343","pka_strongest_acidic":"1.8292367774944256","bioavailability":"1","number_of_rings":"4","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["3,5-cyclic amp","3'-5'-cyclic adenosine monophosphate","3',5'-Cyclic AMP","3',5'-Monophosphate, adenosine cyclic","3'5'-cyclic AMP","6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide","Acrasin","Adenosine 3,5'-cyclic monophosphorate","Adenosine 3,5'-cyclic monophosphoric acid","Adenosine 3', 5'-phosphate","Adenosine 3',5'-cyclic monophosphate","Adenosine 3',5'-cyclic monophosphoric acid","Adenosine 3',5'-cyclic phosphate","Adenosine 3',5'-cyclic phosphoric acid","Adenosine 3',5'-cyclophosphate","Adenosine 3',5'-monophosphate","Adenosine 3',5'-phosphate","adenosine 3',5'-phosphate monohydrate","Adenosine 3',5'-phosphoric acid","Adenosine 3':5'-cyclic monophosphate","adenosine 3[-,5[-cyclic monophosphate","Adenosine cyclic 3,5 monophosphate","Adenosine cyclic 3',5' monophosphate","Adenosine cyclic 3',5'-monophosphate","Adenosine cyclic 3',5'-phosphate","Adenosine cyclic monophosphate","Adenosine cyclic-3',5'-monophosphate","adenosine cyclic-monophosphate","Adenosine-3',5'-cyclic phosphate","ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE","ADENOSINE-3',5'-cyclic-monophosphoric acid","adenosine-cyclic-phosphate","adenosine-cyclic-phosphoric-acid","Adenosine, 3',5'-cyclic-monophosphoric acid","Adenosine, cyclic 3',5'-(hydrogen phosphate)","AMP, Cyclic","cAMP","CMP","Cyclic 3',5'-adenylate","Cyclic 3',5'-adenylic acid","Cyclic 3',5'-AMP","Cyclic 3',5'-monophosphate, adenosine","Cyclic adenosine 3',5'-monophosphate","Cyclic adenosine 3',5'-phosphate","Cyclic adenylate","cyclic adenylic acid","Cyclic AMP","Cyclic AMP, (R)-isomer","Cyclic AMP, disodium salt","Cyclic AMP, monoammonium salt","Cyclic AMP, monopotassium salt","Cyclic AMP, monosodium salt","Cyclic AMP, sodium salt","Cyclic monophosphate, adenosine","Cyclic-3',5'-monophosphate, adenosine","Monophosphate, adenosine cyclic"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"growth_conditions":[{"growth_media":"Minimal medium  supplemented with ammonia salts and glucose","concentration":"0.04","concentration_units":"\u0026#181;M","error":"0.0"},{"growth_media":"Minimal medium supplemented with ammonia salts and (Maltose or galactose)","concentration":"0.0285","concentration_units":"\u0026#181;M","error":"0.0035"},{"growth_media":"Synthetic medium with 1% glucose and 0.1% yeast extract","concentration":"3.5","concentration_units":"\u0026#181;M","error":"1.5"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":10791726,"citation":"Dumortier, F., Vanhalewyn, M., Debast, G., Colombo, S., Ma, P., Winderickx, J., Van Dijck, P., Thevelein, J. M. (2000). \"A specific mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1K176M, eliminates glucose- and acidification-induced cAMP signalling and delays glucose-induced loss of stress resistance.\" Int J Food Microbiol 55:103-107."},{"pubmed_id":4363744,"citation":"van der Plaat, J. B. (1974). \"Cyclic 3',5'-adenosine monophosphate stimulates trehalose degradation in baker's yeast.\" Biochem Biophys Res Commun 56:580-587."},{"pubmed_id":4578278,"citation":"Gancedo, J. M., Gancedo, C. (1973). \"Concentrations of intermediary metabolites in yeast.\" Biochimie 55:205-211."},{"pubmed_id":16623706,"citation":"Xu, Z., Tsurugi, K. (2006). \"A potential mechanism of energy-metabolism oscillation in an aerobic chemostat culture of the yeast Saccharomyces cerevisiae.\" FEBS J 273:1696-1709."}],"proteins":[{"created_at":"2011-05-24T20:33:35.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"Adenylate cyclase","uniprot_id":"P08678","uniprot_name":"CYAA_YEAST","enzyme":true,"transporter":false,"gene_name":"CYR1","num_residues":2026,"molecular_weight":"227832.0","theoretical_pi":"7.32","general_function":"Involved in phosphorus-oxygen lyase activity","specific_function":"Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP","reactions":[{"id":1275,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2326,"direction":"\u003e","locations":null,"altext":"ATP = 3',5'-cyclic AMP + diphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M12057","genbank_protein_id":"171360","gene_card_id":"CYR1","chromosome_location":"chromosome 10","locus":"YJL005W","synonyms":["ATP pyrophosphate-lyase","Adenylyl cyclase"],"enzyme_classes":["4.6.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenylate cyclase activity"},{"category":"Function","description":" phosphorus-oxygen lyase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" protein binding"},{"category":"Function","description":" cyclase activity"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" signal transduction"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" cAMP biosynthetic process"},{"category":"Process","description":" signaling"},{"category":"Process","description":" signaling pathway"},{"category":"Process","description":" intracellular signaling pathway"},{"category":"Process","description":" nucleoside monophosphate metabolic process"},{"category":"Process","description":" nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" cyclic nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"}],"pfams":[{"name":"Ad_cyc_g-alpha","identifier":"PF08509"},{"name":"Guanylate_cyc","identifier":"PF00211"},{"name":"LRR_1","identifier":"PF00560"},{"name":"PP2C","identifier":"PF00481"},{"name":"RA","identifier":"PF00788"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGTCATCAAAACCTGATACTGGTTCGGAAATTTCTGGCCCTCAGCGACAGGAAGAACAAGAACAACAGATAGAGCAGAGCTCACCTACGGAAGCAAACGATAGAAGCATTCATGATGAGGTACCAAAAGTGAAGAAGCGTCACGAACAAAATAGTGGTCACAAATCAAGAAGGAATAGCGCATATAGTTATTACAGCCCACGGTCGCTTTCTATGACCAAAAGCAGGGAGAGTATCACTCCAAATGGTATGGATGATGTAAGTATTTCGAACGTGGAACATCCAAGGCCGACAGAACCGAAAATCAAAAGGGGTCCATATTTACTGAAGAAAACATTGAGCAGTCTTTCAATGACGAGCGCGAATAGTACTCATGATGATAATAAAGACCACGGTTACGCTTTGAATTCATCCAAGACGCACAACTACACATCTACTCATAACCATCATGACGGTCATCATGATCATCATCATGTTCAGTTTTTTCCCAATAGGAAGCCATCATTAGCGGAAACCCTATTCAAAAGGTTTTCAGGGTCAAACAGTCACGATGGCAATAAGTCAGGAAAGGAAAGTAAAGTTGCTAACCTTTCCCTTTCAACGGTAAATCCTGCACCTGCTAATAGGAAACCTTCTAAAGACTCCACTTTATCTAATCACTTGGCTGATAACGTGCCAAGCACTTTACGAAGGAAAGTGTCCTCATTGGTACGTGGTTCTTCCGTCCATGATATAAATAATGGTATTGCAGATAAACAGATTAGACCAAAGGCTGTTGCGCAATTAGAAAATACATTACATTCATCTGATGTTCCCAATAGCAAACGCTCGCACAGAAAAAGCTTTCTGCTAGGCTCCACATCTTCTTCAAGCAGTAGAAGAGGTTCAAATGTCAGTTCAATGACTAACAGTGACAGTGCAAGTATGGCGACGTCGGGTAGTCATGTTCTCCAACATAACGTATCTAATGTTTCTCCAACTACTAAAAGTAAGGACAGCGTTAACAGCGAATCCGCCGATCACACTAATAATAAATCCGAGAAAGTGACTCCAGAATATAATGAGAACATTCCGGAAAATTCTAACTCTGACAACAAACGCGAAGCCACAACGCCTACTATAGAAACACCCATTTCATGTAAACCATCCCTTTTCAGGCTAGATACAAACCTTGAGGATGTTACTGATATTACAAAGACGGTGCCACCCACCGCTGTCAATTCTACACTAAATTCTACACACGGGACTGAGACTGCCTCACCCAAAACGGTGATCATGCCTGAAGGTCCTAGGAAGTCGGTGTCAATGGCTGATCTCTCCGTCGCTGCCGCAGCACCTAATGGTGAATTCACATCAACTTCCAATGATAGATCACAATGGGTAGCACCTCAAAGCTGGGATGTGGAAACCAAAAGGAAAAAAACAAAACCTAAAGGGAGATCGAAATCAAGAAGGTCAAGTATAGATGCTGATGAACTTGATCCCATGTCACCGGGGCCACCTTCAAAAAAAGACTCTCGTCATCATCACGATCGAAAGGATAACGAATCAATGGTCACTGCGGGTGACAGTAACTCAAGTTTTGTTGATATATGTAAAGAAAACGTTCCGAATGATAGCAAGACCGCACTCGATACTAAACTTGTGAACCGCTTAAAAAGTAATTTGGCTATGAGTCCCCCAAGTATACGATATGCTCCATCAAATTTAGATGGGGACTACGACACGTCTTCCACTTCCTCATCTTTACCGTCCTCATCTATTAGTTCAGAACATACATCTTCCTGCAGCGATTCCTCTTCGTACACTAACGCGTATATGGAGGCCAACCGAGAGCAGGATAATAAAACACCGATCCTGAATAAAACGAAATCGTATACCAAGAAATTTACATCCTCTTCGGTAAATATGAATTCACCAGATGGTGCCCAGAGTTCTGGATTATTACTACAAGATGAGAAGGACGATGAGGTCGAGTGCCAACTGGAACATTACTATAAAGATTTCAGTGATTTAGATCCAAAGAGGCACTATGCTATTCGTATATTCAATACTGATGACACTTTTACGACTCTCTCATGTACTCCAGCGACTACCGTCGAAGAGATAATACCTGCACTTAAAATAAAATTTAACATTACAGCGCAAGGGAATTTTCAAATTTCCCTGAAGGTGGGAAAGTTGTCAAAAATTTTGAGACCAACTTCGAAACCTATTTTAATTGAAAGAAAACTTTTACTTTTGAATGGTTATCGAAAGTCAGACCCACTTCATATTATGGGTATAGAGGATTTAAGTTTTGTTTTTAAGTTTCTTTTCCATCCTGTCACACCTTCTCACTTTACTCCTGAACAAGAACAAAGAATAATGAGAAGCGAATTTGTTCACGTAGATTTAAGGAATATGGATCTCACTACACCTCCCATCATTTTTTACCAGCATACGTCAGAAATAGAAAGTTTAGACGTTTCTAATAACGCAAATATATTCCTACCTCTGGAGTTCATTGAAAGCTCGATTAAATTATTAAGTTTGAGAATGGTTAATATTAGAGCATCTAAATTTCCTTCCAATATCACTAAGGCGTATAAACTAGTATCTTTGGAATTACAGAGAAACTTCATAAGAAAAGTACCGAACTCAATCATGAAACTGAGTAATTTAACGATATTAAACCTTCAATGTAATGAGCTTGAAAGCCTACCGGCTGGATTTGTTGAACTGAAAAATCTGCAATTGCTAGACTTGTCTTCAAACAAGTTCATGCACTACCCAGAAGTTATTAACTACTGCACCAATCTTTTACAAATAGACCTATCATATAATAAAATCCAAAGCTTACCACAGTCCACTAAGTACCTAGTAAAGCTTGCGAAGATGAACCCTTCTCATAACAAACTAAATTTTATAGGCGACTTATCGGAAATGACAGATTTGAGGACGCTGAACCTAAGATATAACAGAATATCATCAATTAAGACAAATGCGTCTAACTTGCAGAACCTTTTTTTAACAGATAATAGAATTTCGAACTTTGAAGACACTTTGCCGAAACTAAGAGCCCTTGAAATTCAAGAGAATCCAATCACTTCTATATCCTTCAAAGATTTTTATCCAAAAAACATGACAAGTTTGACGTTGAACAAGGCACAGTTATCGAGTATTCCTGGAGAATTACTCACCAAACTATCTTTCCTCGAGAAACTTGAACTTAATCAGAATAATTTGACTAGACTGCCACAGGAGATATCCAAGTTGACTAAATTAGTTTTCCTTTCAGTGGCGAGAAACAAACTAGAGTATATTCCACCCGAGCTATCTCAACTGAAAAGTTTGAGGACATTAGATCTACATTCTAACAACATAAGGGACTTTGTTGACGGTATGGAAAACCTTGAACTAACATCGCTAAATATTTCATCGAATGCATTCGGTAACTCTAGCTTAGAAAATTCTTTTTACCATAACATGTCATATGGGTCAAAGTTATCTAAAAGCCTGATGTTTTTTATTGCTGCAGACAATCAATTTGATGATGCTATGTGGCCTCTTTTCAATTGCTTTGTCAATCTGAAAGTGCTAAATCTTTCTTACAACAATTTTTCAGATGTATCGCACATGAAACTTGAGAGCATTACCGAATTGTACCTCTCCGGTAATAAGCTCACGACATTGTCGGGTGATACAGTTTTGAAATGGAGCTCTTTAAAGACTTTAATGTTGAATAGTAACCAAATGTTATCTCTGCCTGCAGAATTATCAAATCTCTCACAGCTAAGTGTATTTGATGTTGGAGCAAATCAATTAAAGTATAATATATCAAACTATCATTACGATTGGAACTGGAGGAATAATAAAGAACTAAAATATTTGAATTTTTCAGGAAATCGAAGGTTTGAAATAAAGTCATTTATAAGTCACGATATTGATGCTGATTTGTCAGATCTGACAGTATTACCTCAGTTAAAGGTACTAGGTTTAATGGACGTAACTTTAAATACTACCAAAGTACCGGATGAAAATGTCAATTTCCGTTTAAGGACAACTGCATCAATAATAAATGGGATGCGCTACGGTGTTGCTGATACATTAGGTCAAAGAGACTATGTGTCATCTCGTGATGTTACCTTTGAAAGATTCCGCGGAAATGACGACGAATGCTCACTATGTCTTCATGATAGTAAAAACCAAAATGCAGATTATGGCCACAATATATCAAGAATTGTTAGAGATATTTACGATAAAATACTGATCAGACAACTGGAAAGGTATGGAGACGAAACAGATGATAATATAAAAACTGCACTTCGTTTCAGTTTTTTGCAACTGAATAAGGAGATTAACGGAATGCTAAATTCTGTTGATAATGGTGCCGATGTTGCCAATCTTTCATATGCAGACTTGCTAAGTGGCGCTTGCTCTACTGTGATATATATCAGAGGGAAGAAACTCTTCGCTGCAAATTTAGGTGACTGTATGGCTATTTTATCCAAAAACAATGGTGACTACCAAACGCTAACCAAACAACATCTCCCAACAAAGCGGGAAGAATACGAGAGGATCAGAATATCTGGCGGGTATGTCAACAATGGAAAATTAGATGGTGTTGTAGATGTGTCTAGAGCAGTGGGTTTTTTTGATTTGCTTCCCCACATTCATGCTTCTCCCGACATATCTGTCGTGACATTAACAAAATCAGACGAGATGCTTATTGTAGCAACGCATAAGTTATGGGAATACATGGACGTGGATACAGTTTGTGATATCGCGCGTGAGAATAGTACTGATCCACTCCGTGCCGCAGCTGAGTTGAAGGATCATGCCATGGCTTACGGCTGTACAGAGAATATTACAATTTTGTGCCTTGCTCTTTACGAGAACATTCAGCAACAAAATCGGTTCACTTTAAATAAAAACTCTTTAATGACTAGAAGAAGTACTTTCGAGGATACTACATTAAGAAGACTTCAACCTGAGATTTCTCCGCCAACAGGTAACCTAGCAATGGTCTTCACTGATATCAAAAGCTCAACCTTCTTATGGGAGCTATTCCCTAACGCAATGAGGACCGCAATAAAAACTCACAATGACATTATGCGTCGTCAACTACGAATTTACGGTGGTTACGAAGTAAAGACAGAAGGAGACGCCTTTATGGTGGCATTTCCTACGCCAACTAGTGGTCTGACATGGTGCTTAAGTGGTCAATTAAAACTCTTGGATGCACAATGGCCGGAGGAAATTACCTCAGTTCAAGACGGCTGCCAAGTTACGGATAGAAATGGTAACATTATCTATCAAGGCCTATCAGTTAGAATGGGTATTCATTGGGGCTGCCCAGTTCCAGAGCTTGATTTAGTGACTCAAAGAATGGACTATTTGGGGCCGATGGTCAATAAGGCAGCAAGGGTCCAGGGCGTCGCTGACGGTGGTCAGATTGCAATGAGTAGTGATTTTTACTCTGAATTCAACAAGATAATGAAGTATCATGAGCGAGTAGTGAAGGGCAAGGAATCTCTCAAGGAAGTTTATGGTGAAGAAATTATCGGAGAGGTTCTTGAAAGAGAAATTGCCATGCTGGAAAGTATTGGTTGGGCATTTTTTGACTTTGGCGAGCATAAGCTAAAGGGACTCGAAACCAAAGAACTCGTTACTATTGCGTATCCTAAGATTCTTGCTTCCAGACACGAATTTGCATCTGAAGATGAGCAGTCAAAATTAATCAATGAAACGATGTTGTTTCGTTTAAGAGTCATTTCAAACAGACTGGAATCTATAATGTCAGCTTTAAGCGGCGGATTTATTGAACTAGACTCTCGGACGGAGGGAAGTTATATTAAATTTAACCCTAAAGTTGAAAATGGTATTATGCAATCGATTTCTGAGAAGGATGCGTTGTTATTTTTTGATCATGTAATTACTAGAATCGAATCCAGTGTGGCATTATTACATTTACGACAACAGAGGTGTTCAGGACTGGAAATTTTCAGAAACGATAAAACATCTGCTCGAAGCAATATTTTCAATGTTGTTGACGAACTTTTACAAATGGTTAAGAACGCAAAGGATTTATCAACTTGA","protein_sequence":"MSSKPDTGSEISGPQRQEEQEQQIEQSSPTEANDRSIHDEVPKVKKRHEQNSGHKSRRNSAYSYYSPRSLSMTKSRESITPNGMDDVSISNVEHPRPTEPKIKRGPYLLKKTLSSLSMTSANSTHDDNKDHGYALNSSKTHNYTSTHNHHDGHHDHHHVQFFPNRKPSLAETLFKRFSGSNSHDGNKSGKESKVANLSLSTVNPAPANRKPSKDSTLSNHLADNVPSTLRRKVSSLVRGSSVHDINNGIADKQIRPKAVAQSENTLHSSDVPNSKRSHRKSFLLGSTSSSSSRRGSNVSSMTNSDSASMATSGSHVLQHNVSNVSPTTKSKDSVNSESADHTNNKSEKVTPEYNENIPENSNSDNKREATTPTIETPISCKPSLFRLDTNLEDVTDITKTVPPTAVNSTLNSTHGTETASPKTVIMPEGPRKSVSMADLSVAAAAPNGEFTSTSNDRSQWVAPQSWDVETKRKKTKPKGRSKSRRSSIDADELDPMSPGPPSKKDSRHHHDRKDNESMVTAGDSNSSFVDICKENVPNDSKTALDTKSVNRLKSNLAMSPPSIRYAPSNLDGDYDTSSTSSSLPSSSISSEDTSSCSDSSSYTNAYMEANREQDNKTPILNKTKSYTKKFTSSSVNMNSPDGAQSSGLLLQDEKDDEVECQLEHYYKDFSDLDPKRHYAIRIFNTDDTFTTLSCTPATTVEEIIPALKRKFNITAQGNFQISLKVGKLSKILRPTSKPILIERKLLLLNGYRKSDPLHIMGIEDLSFVFKFLFHPVTPSHFTPEQEQRIMRSEFVHVDLRNMDLTTPPIIFYQHTSEIESLDVSNNANIFLPLEFIESSIKLLSLRMVNIRASKFPSNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTILNLQCNELESLPAGFVELKNLQLLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQSTKYLVKLAKMNLSHNKLNFIGDLSEMTDLRTLNLRYNRISSIKTNASNLQNLFLTDNRISNFEDTLPKLRALEIQENPITSISFKDFYPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDFVDGMENLELTSLNISSNAFGNSSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVNLKVLNLSYNNFSDVSHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSVFDVGANQLKYNISNYHYDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLTVLPQLKVLGLMDVTLNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMAYGCTENITILCLALYENIQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPEISPPTGNLAMVFTDIKSSTFLWELFPNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTPTSGLTWCLSVQLKLLDAQWPEEITSVQDGCQVTDRNGNIIYQGLSVRMGIHWGCPVPELDLVTQRMDYLGPMVNKAARVQGVADGGQIAMSSDFYSEFNKIMKYHERVVKGKESLKEVYGEEIIGEVLEREIAMLESIGWAFFDFGEHKLKGLETKELVTIAYPKILASRHEFASEDEQSKLINETMLFRLRVISNRLESIMSALSGGFIELDSRTEGSYIKFNPKVENGIMQSISEKDALLFFDHVITRIESSVALLHLRQQRCSGLEICRNDKTSARSNIFNVVDELLQMVKNAKDLST"},{"created_at":"2011-05-26T19:20:47.000Z","updated_at":"2011-07-22T17:53:44.000Z","name":"3',5'-cyclic-nucleotide phosphodiesterase 2","uniprot_id":"P06776","uniprot_name":"PDE2_YEAST","enzyme":true,"transporter":false,"gene_name":"PDE2","num_residues":526,"molecular_weight":"60999.19922","theoretical_pi":"6.6","general_function":"Involved in catalytic activity","specific_function":"Controls the level of cAMP in yeast cells, together with the low-affinity cAMP phosphodiesterase (PDE1)","reactions":[{"id":1155,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1156,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1157,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1158,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1159,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2564,"direction":"\u003e","locations":"Cytoplasmic","altext":"Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"M14563","genbank_protein_id":"172106","gene_card_id":"PDE2","chromosome_location":"chromosome 15","locus":"YOR360C","synonyms":["PDEase 2","High-affinity cAMP phosphodiesterase"],"enzyme_classes":["3.1.4.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphoric diester hydrolase activity"},{"category":"Function","description":" cyclic-nucleotide phosphodiesterase activity"},{"category":"Function","description":" 3',5'-cyclic-nucleotide phosphodiesterase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"},{"category":"Process","description":" regulation of cellular process"},{"category":"Process","description":" signal transduction"}],"pfams":[{"name":"PDEase_I","identifier":"PF00233"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGTCCACCCTTTTTCTGATTGGAATACACGAGATTGAGAAATCTCAAACAATTGTACAGAATGAACACTATTTTGATAGAGTGATTGAGCTTCAAGATTTGGATTCTCTGATGGTAGCATTGTATAAGGACAGAGTTTCGCCTTTTCCAAACGTCCATAACTTTGAAACGGGCGTATCTATAGTTCTTTATGACCCTTCAAAATTTCAATTATCTGTGCGACAATTGGATGTTCTATTCAAGGGATTTTTCCCATCTTTCAATATTTCTGCGATAGATCATACACGAGAGGAAAACCTGCAACGTCTGGAATGTGTTGAGCGTGAAAATAGCATCTGTCGTAATAGAATAACGAGAATTAACCACTGGATGTATCACCATCATGATGATACTCCAGACGGTATTAACAAAAACAGCTATGGTACTGTAAATGGGAATTCTGTCCCCACTCAAGCATGTGAAGCAAACATTTACACTTTATTATTGCATTTGAATGATTCCAAGGCACAACATTTACGAAAGGCATCAGTGCCAAGGCTAATTCGCAACATCGAGTTTATGTCTTTTTTGTCAGATCCAATAGAAAAAATTTCTCAAGAGGGATCACATTATTGGAACATTCTATCAACTTGGGACTTTTGTGCTTTATCATTAAGCACTCAAGAATTGATTTGGTGCGGGTTCACGCTTATCAAAAAATTATCTAAGGATGCAAAAGTACTCATTGCAGATAATAAGTTACTGCTACTACTATTTACTTTAGAATCATCCTATCATCAAGTTAACAAATTTCACAATTTTAGGCATGCCATCGATGTCATGCAAGCCACATGGCGATTGTGTACATATCTTCTTAAAGATAATCCTGTACAAACATTACTGTTGTGTATGGCTGCCATAGGTCATGATGTCGGTCATCCTGGGACTAACAATCAACTATTGTGCAACTGTGAATCAGAGGTTGCTCAAAATTTCAAAAATGTCTCTATCTTGGAGAATTTTCACAGGGAATTATTTCAACAATTGCTATCAGAGCATTGGCCTCTTAAGCTCTCTATCTCCAAAAAAAAATTTGATTTTATTTCCGAGGCTATTCTGGCCACAGATATGGCATTGCATTCTCAGTATGAGGATAGATTAATGCATGAAAACCCAATGAAACAAATCACTTTGATATCTCTAATTATTAAAGCTGCAGACATCTCTAATGTGACGAGAACCTTGTCAATATCAGCACGTTGGGCATACCTCATTACTCTCGAATTTAATGATTGCGCTCTTTTGGAAACATTTCATAAAGCTCACCGCCCAGAACAAGACTGTTTTGGCGATTCATACAAGAATGTTGATTCTCCGAAAGAAGATTTGGAATCAATTCAAAATATTTTGGTGAACGTAACAGACCCTGATGATATTATCAAAGACCATCCGCATATTCCAAACGGTCAAATATTTTTCATTAATACGTTTGCTGAAGTATTTTTCAACGCATTAAGTCAAAAATTCTCAGGATTAAAATTTTTAAGCGATAATGTCAAAATCAATAAAGAATACTGGATGAAACACAAGAAACCACAATAG","protein_sequence":"MSTLFLIGIHEIEKSQTIVQNEHYFDRVIELQDLDSLMVALYKDRVSPFPNVHNFETGVSIVLYDPSKFQLSVRQLDVLFKRFFPSFNISAIDHTREENLQRLECVERENSICRNRITRINHWMYHHHDDTPDGINKNSYGTVNGNSVPTQACEANIYTLLLHLNDSKAQHLRKASVPRLIRNIEFMSFLSDPIEKISQEGSHYWNILSTWDFCALSLSTQELIWCGFTLIKKLSKDAKVLIADNKLLLLLFTLESSYHQVNKFHNFRHAIDVMQATWRLCTYLLKDNPVQTLLLCMAAIGHDVGHPGTNNQLLCNCESEVAQNFKNVSILENFHRELFQQLLSEHWPQLLSISKKKFDFISEAILATDMALHSQYEDRLMHENPMKQITLISLIIKAADISNVTRTLSISARWAYLITLEFNDCALLETFHKAHRPEQDCFGDSYKNVDSPKEDLESIQNILVNVTDPDDIIKDHPHIPNGQIFFINTFAEVFFNALSQKFSGLKFLSDNVKINKEYWMKHKKPQ"}]}