{"ymdb_id":"YMDB00013","created_at":"2011-05-29T15:48:30.000Z","updated_at":"2016-09-08T18:34:54.000Z","name":"5-Diphosphoinositol pentakisphosphate","cas":"149714-25-0","state":"Solid","melting_point":null,"description":"5-Diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate is an inositol polyphosphate involved in the sphingolipid metabolism. [Biocyc SPHINGOLIPID-SYN-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"30164","hmdb_id":"HMDB06229","kegg_id":"C11526","pubchem_id":"443247","cs_id":"23107121","foodb_id":null,"wikipedia_link":null,"biocyc_id":"5-DIPHOSPHO-1D-MYO-INOSITOL-12346P","iupac":"{[(1R,2r,3S,4R,5s,6S)-2-{[hydroxy(phosphonooxy)phosphoryl]oxy}-3,4,5,6-tetrakis(phosphonooxy)cyclohexyl]oxy}phosphonic acid","traditional_iupac":"[(1R,2r,3S,4R,5s,6S)-2-{[hydroxy(phosphonooxy)phosphoryl]oxy}-3,4,5,6-tetrakis(phosphonooxy)cyclohexyl]oxyphosphonic acid","logp":"-4.945204319","pka":"0.5803373082352428","alogps_solubility":"1.40e+01 g/l","alogps_logp":"0.35","alogps_logs":"-1.72","acceptor_count":"20","donor_count":"13","rotatable_bond_count":"14","polar_surface_area":"447.09","refractivity":"111.88529999999992","polarizability":"46.856533321342035","formal_charge":"0","physiological_charge":"-12","pka_strongest_basic":null,"pka_strongest_acidic":"0.1432035931677449","bioavailability":"0","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(1R,2R,3S,4S,5R,6S)-2,3,4,5,6-Pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate","(1R,2R,3S,4S,5R,6S)-2,3,4,5,6-Pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphoric acid","1,2,3,4,6-pentakis-O-phosphono-1D-myo-inositol 5-(trihydrogen diphosphate)","1D-myo-Inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate","1D-myo-inositol 5-diphosphate pentakisphosphate","1D-myo-Inositol 5-diphosphoric acid 1,2,3,4,6-pentakisphosphoric acid","1D-myo-Inositol 5-diphosphoric acid pentakisphosphoric acid","5-Diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate","5-diphospho-1D-myo-inositol pentakisphosphate","5-Diphosphoinositol pentakisphosphoric acid","5-PP-InsP5","5beta 5PP-IP5","5beta-IP7","diphosphoinositol pentakisphosphate","InsP7","IP7","PP-InsP5"],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":17563356,"citation":"Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). \"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.\" Proc Natl Acad Sci U S A 104:10364-10369."},{"pubmed_id":17412958,"citation":"Mulugu, S., Bai, W., Fridy, P. C., Bastidas, R. J., Otto, J. C., Dollins, D. E., Haystead, T. A., Ribeiro, A. A., York, J. D. (2007). \"A conserved family of enzymes that phosphorylate inositol hexakisphosphate.\" Science 316:106-109."},{"pubmed_id":11956213,"citation":"Dubois, E., Scherens, B., Vierendeels, F., Ho, M. M., Messenguy, F., Shears, S. B. (2002). \"In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis.\" J Biol Chem 277:23755-23763."},{"pubmed_id":17412959,"citation":"Lee, Y. S., Mulugu, S., York, J. D., O'Shea, E. K. (2007). \"Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.\" Science 316:109-112."},{"pubmed_id":15665377,"citation":"Gruhler, A., Olsen, J. V., Mohammed, S., Mortensen, P., Faergeman, N. J., Mann, M., Jensen, O. N. (2005). \"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.\" Mol Cell Proteomics 4:310-327."},{"pubmed_id":18407956,"citation":"Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). \"A multidimensional chromatography technology for in-depth phosphoproteome analysis.\" Mol Cell Proteomics 7:1389-1396."},{"pubmed_id":14562095,"citation":"Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). \"Global analysis of protein localization in budding yeast.\" Nature 425:686-691."},{"pubmed_id":10419486,"citation":"Safrany, S. T., Ingram, S. W., Cartwright, J. L., Falck, J. R., McLennan, A. G., Barnes, L. D., Shears, S. B. (1999). \"The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein.\" J Biol Chem 274:21735-21740."},{"pubmed_id":17330950,"citation":"Li, X., Gerber, S. A., Rudner, A. D., Beausoleil, S. A., Haas, W., Villen, J., Elias, J. E., Gygi, S. P. (2007). \"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.\" J Proteome Res 6:1190-1197."}],"proteins":[{"created_at":"2011-05-24T19:50:13.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Inositol polyphosphate multikinase","uniprot_id":"P07250","uniprot_name":"IPMK_YEAST","enzyme":true,"transporter":false,"gene_name":"ARG82","num_residues":355,"molecular_weight":"40352.5","theoretical_pi":"4.33","general_function":"Involved in inositol trisphosphate 3-kinase activity","specific_function":"Has kinase activity and phosphorylates inositol-1,4,5- trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. Originally it was proposed that the ARGRI and ARGRIII proteins are more likely to be involved in the control of ARGRII activity","reactions":[{"id":1661,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1662,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1663,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1664,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2276,"direction":"\u003e","locations":null,"altext":"ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2277,"direction":"\u003e","locations":null,"altext":"ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14818,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007006","source":"Smpdb"},{"id":14819,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007031","source":"Smpdb"},{"id":14820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007032","source":"Smpdb"},{"id":14821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007033","source":"Smpdb"},{"id":14822,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007034","source":"Smpdb"},{"id":14823,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007035","source":"Smpdb"},{"id":14824,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007036","source":"Smpdb"},{"id":14825,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007037","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X05328","genbank_protein_id":"3376","gene_card_id":"ARG82","chromosome_location":"chromosome 4","locus":"YDR173C","synonyms":["IPMK","Arginine metabolism regulation protein III"],"enzyme_classes":["2.7.1.151"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" inositol trisphosphate kinase activity"},{"category":"Function","description":" inositol trisphosphate 3-kinase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IPK","identifier":"PF03770"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"gene_sequence":"ATGGATACGGTAAACAATTATAGGGTTTTAGAGCATAAAGCTGCTGGCCACGACGGTACTCTAACAGACGGTGATGGATTGCTCATCTTTAAACCGGCCTTTCCGCAGGAACTGGAATTCTACAAAGCCATACAAGTGAGAGATGTGAGTCGAAGAAAGTCTTCGGCTGATGGAGATGCTCCCTTGTGCTCTTGGATGCCCACGTATCTTGGAGTCTTGAATGAAGGGGCAAAAATCGAGCAAAGTGGCGATGCTGCGCTTCTGAAGATAGATGAGCGGTTAAGTGATTCCACTGATAATCTTGATTCAATACCTGTAAAGTCTGAGAAGTCCAAGCAATACCTCGTTTTAGAAAATCTACTATATGGATTTAGTAAACCTAATATACTTGATATAAAATTAGGCAAAACTTTGTATGATTCGAAGGCATCATTGGAAAAAAGAGAGAGAATGAAAAGAGTCAGTGAGACGACGACTTCAGGATCTTTGGGTTTCAGGATATGTGGCATGAAAATACAGAAAAATCCCTCTGTGCTGAATCAGCTTTCGCTCGAATATTACGAAGAAGAAGCAGACAGTGATTATATCTTTATAAACAAATTGTATGGTCGTTCAAGAACCGATCAAAATGTTTCAGATGCAATTGAACTTTATTTTAACAATCCTCATCTGTCGGATGCGAGAAAGCATCAACTGAAGAAAACATTTTTGAAAAGATTGCAGTTGTTTTATAATACTATGCTAGAAGAAGAAGTTAGAATGATATCAAGTAGTCTTTTGTTTATTTACGAAGGAGACCCGGAGCGATGGGAATTACTAAATGATGTTGACAAACTTATGCGAGATGATTTTATAGACGATGATGACGACGATGATGATAATGATGATGATGATGATGATGATGCCGAGGGAAGCAGCGAAGGACCAAAGGACAAAAAAACAACTGGTTCTTTGAGTTCCATGTCACTAATAGATTTTGCACATTCTGAAATAACGCCGGGGAAGGGTTATGATGAAAACGTGATTGAAGGAGTTGAAACCTTGCTAGATATTTTTATGAAATTCTAG","protein_sequence":"MDTVNNYRVLEHKAAGHDGTLTDGDGLLIFKPAFPQELEFYKAIQVRDVSRRKSSADGDAPLCSWMPTYLGVLNEGAKIEQSGDAALLKIDERLSDSTDNLDSIPVKSEKSKQYLVLENLLYGFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKIQKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNPHLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWELLNDVDKLMRDDFIDDDDDDDDNDDDDDDDAEGSSEGPKDKKTTGSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIFMKF"},{"created_at":"2011-05-24T19:59:56.000Z","updated_at":"2011-07-22T17:54:38.000Z","name":"Diphosphoinositol polyphosphate phosphohydrolase DDP1","uniprot_id":"Q99321","uniprot_name":"DDP1_YEAST","enzyme":true,"transporter":false,"gene_name":"DDP1","num_residues":188,"molecular_weight":"21572.30078","theoretical_pi":"8.32","general_function":"Involved in hydrolase activity","specific_function":"May eliminate potentially toxic dinucleoside polyphosphates during sporulation. Most active against diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A). Can also hydrolyze diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A), adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate)","reactions":[{"id":1198,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1214,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1225,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1468,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2288,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY558436","genbank_protein_id":"45270762","gene_card_id":"DDP1","chromosome_location":"chromosome 15","locus":"YOR163W","synonyms":["Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase","AP6A hydrolase","Diadenosine and diphosphoinositol polyphosphate phosphohydrolase 1"],"enzyme_classes":["3.6.1.52","3.6.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"NUDIX","identifier":"PF00293"}],"pathways":[],"gene_sequence":"ATGGGCAAAACCGCGGATAATCATGGTCCAGTACGTTCTGAGACAGCACGTGAAGGAAGAGAAAACCAGGTTTACTCACCCGTTACAGGTGCAAGATTAGTTGCTGGCTGCATATGTTTAACACCCGACAAGAAGCAAGTTCTCATGATTACTTCTTCTGCACACAAGAAAAGATGGATTGTCCCCAAAGGTGGCGTTGAGAAAGACGAGCCTAATTACGAGACGACTGCCCAACGAGAAACTTGGGAGGAAGCTGGTTGCATAGGTAAAATTGTCGCCAATTTGGGTACAGTTGAAGACATGAGACCCCCTAAGGACTGGAACAAAGACATTAAGCAATTCGAGAACTCTCGAAAAGATTCAGAAGTAGCAAAGCACCCGCCAAGAACCGAATTTCATTTTTATGAATTAGAGATTGAAAATCTCCTTGATAAATTTCCGGAATGTCACAAAAGACATAGAAAGCTATACTCTTATACAGAAGCTAAACAAAACTTGATAGACGCCAAGAGGCCTGAATTGTTGGAGGCCCTTAATAGGTCTGCTATCATTAAAGACGACAAATAG","protein_sequence":"MGKTADNHGPVRSETAREGRENQVYSPVTGARLVAGCICLTPDKKQVLMITSSAHKKRWIVPKGGVEKDEPNYETTAQRETWEEAGCIGKIVANLGTVEDMRPPKDWNKDIKQFENSRKDSEVAKHPPRTEFHFYELEIENLLDKFPECHKRHRKLYSYTEAKQNLIDAKRPELLEALNRSAIIKDDK"},{"created_at":"2011-05-24T20:00:21.000Z","updated_at":"2011-07-22T17:54:38.000Z","name":"Inositol hexakisphosphate kinase 1","uniprot_id":"Q12494","uniprot_name":"KCS1_YEAST","enzyme":true,"transporter":false,"gene_name":"KCS1","num_residues":1050,"molecular_weight":"119549.0","theoretical_pi":"6.78","general_function":"Involved in inositol trisphosphate 3-kinase activity","specific_function":"Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance","reactions":[{"id":1199,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1215,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1226,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1469,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1667,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2289,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2290,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"S81651","genbank_protein_id":"1478442","gene_card_id":"KCS1","chromosome_location":"chromosome 4","locus":"YDR017C","synonyms":["InsP6 kinase 1","InsP6 kinase KCS1","PKC1 suppressor protein 1"],"enzyme_classes":["2.7.4.21"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" inositol trisphosphate kinase activity"},{"category":"Function","description":" inositol trisphosphate 3-kinase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IPK","identifier":"PF03770"}],"pathways":[],"gene_sequence":"ATGGATACCTCTCACGAAATTCATGATAAAATACCCGATACATTAAGAGAGCAGCAGCAGCATTTGCGCCAAAAAGAGTCGGAAGGGTGCATAACAACATTGAAAGATCTTAATGTACCTGAGACGAAGAAACTTTCCTCCGTCTTACATGGCAGAAAGGCGAGTACATATTTAAGAATTTTTAGAGATGATGAATGTTTAGCCGATAACAACAATGGTGTAGATAGCAATAATGGCGGGTCCGTGACATGCGCGGACAAAATAACAAGGTCAGAAGCAACTCCCAAATCGGTACCAGAAGGACTACAAGTTTCTGAAAAAAAGAATAACCCAGATACTTTGTCCTCTTCATTGTCAAGTTTCATTTTATCTAACCACGAGGAGCCGGCAATTAAGCCCAATAAACACGTGGCGCATAGAAATAATATTACTGAGACAGGTCAAGGCTCTGGTGAGGATATCGCAAAACAACAATCACACCAACCACAGGTGTTACACCACCAGACTTCTTTAAAGCCAATTCAGAATGTTGATGAGGGATGTATTTCGCCTAAGTCCACTTATCAGGAGAGCTTACATGGAATATCGGAGGACTTAACGTTAAAGCCTGTTTCTTCTGCAACATACTATCCTCACAAAAGTAAAGCAGATTCTGGTTATGAAGAAAAGGATAAAATGGAAAATGATATTGATACTATTCAGCCTGCCACCATAAATTGTGCCTCTGGTATAGCGACACTTCCTAGTTCATATAACCGACATACTTTCAAAGTTAAGACATATTCAACTTTATCACAATCCCTAAGGCAAGAAAACGTCAACAATCGTAGTAACGAAAAAAAACCTCAACAGTTTGTGCCACATAGCGAATCAATTAAAGAAAAACCCAATACGTTTGAACAAGATAAAGAAGGCGAGCAAGCGGACGAAGAAGAGGATGAAGGTGATAATGAACATAGGGAATATCCCCTAGCAGTTGAACTAAAACCATTTACGAATAGAGTTGGAGGTCACACTGCAATATTCAGATTTTCGAAGAGAGCGGTTTGTAAGGCTCTAGTGAATAGAGAAAACAGGTGGTATGAGAATATAGAGCTGTGCCATAAAGAATTATTGCAATTCATGCCACGTTATATTGGTGTCCTGAATGTTAGGCAACATTTTCAGTCAAAAGATGACTTTTTAAGCGATTTGGATCAAGAAAACAACGGTAAAAATGATACCAGTAATGAAAACAAAGACATAGAAGTCAATCATAACAATAACGACGATATTGCGCTTAATACAGAACCCACGGGGACCCCCTTAACACACATACATTCCTTCCCCTTGGAACATTCGTCGAGACAAGTACTTGAAAAAGAGCATCCTGAAATTGAGTCTGTCCATCCACACGTGAAAAGATCACTGTCAAGTTCCAACCAACCTTCCTTGTTGCCCGAGGTTGTATTAAATGATAACAGGCATATTATACCGGAATCTCTGTGGTACAAATATTCCGATTCTCCAAACTCGGCACCGAATGATTCGTACTTTTCGTCCTCCTCTTCTCATAACTCATGTTCGTTCGGTGAGCGTGGCAATACAAATAAATTAAAAAGACGCGATTCTGGGTCCACCATGATCAATACTGAATTGAAGAACCTAGTCATAAGGGAAGTATTTGCACCGAAATGTTTTAGAAGGAAAAGAAACTCTAATACGACTACAATGGGAAACCATAATGCGCGTTTGGGTTCCAGTCCATCTTTTTTAACACAAAAATCAAGAGCCTCGTCCCATGATGCATCGAATACGTCTATGAAGACTCTTGGTGATTCATCGTCACAAGCGAGTTTACAGATGGATGACTCGAAAGTCAATCCGAATTTGCAGGATCCTTTCTTGAAAAAATCGCTTCATGAAAAAATATCTAATGCTTTAGATGGCTCGCATTCAGTAATGGATTTGAAGCAATTCCACAAAAACGAACAAATAAAACATAAAAACTCTTTCTGCAACTCTTTATCACCCATTCTCACTGCAACCAATTCTAGAGATGATGGCGAATTTGCCACCTCCCCGAATTATATCAGCAACGCACAAGATGGTGTTTTTGATATGGATGAAGATACGGGAAACGAAACTATAAATATGGATAACCACGGCTGCCATCTTGACTCTGGTAAAAACATGATTATAAAGTCATTGGCGTATAATGTTTCAAATGACTATAGTCATCATGATATTGAATCAATTACGTTTGAGGAGACGTCCCACACCATTGTTTCAAAATTTATCTTATTGGAAGATTTGACAAGAAACATGAACAAGCCTTGTGCACTGGATCTAAAGATGGGGACAAGACAATATGGCGTAGACGCCAAAAGAGCCAAGCAACTGTCACAGCGTGCAAAGTGTTTAAAGACCACTTCTAGGCGTTTAGGCGTTAGAATCTGCGGATTAAAGGTTTGGAACAAAGATTATTATATCACAAGAGATAAATACTTTGGTAGAAGGGTTAAGGTTGGTTGGCAATTTGCTAGGGTACTTGCACGTTTTTTGTATGATGGTAAGACCATTGAAAGTTTAATCAGGCAAATTCCAAGGTTGATCAAGCAACTAGATACTTTGTATTCTGAAATTTTTAATTTGAAAGGTTACAGGCTATATGGCGCGTCTTTATTACTAATGTACGATGGAGATGCTAATAAATCAAATTCTAAAAGGAAAAAAGCTGCTAATGTTAAAGTCAACTTGATCGATTTTGCACGTTGTGTTACTAAAGAAGATGCAATGGAATGTATGGATAAATTTCGTATACCCCCAAAATCGCCAAATATAGAAGATAAAGGGTTCTTACGAGGTGTGAAGAGCTTGAGGTTTTATCTGTTATTAATCTGGAATTATCTGACTTCTGATATGCCGTTAATTTTCGATGAAGTAGAGATGAATGATATGATTAGCGAAGAAGCAGATTCGAATAGTTTCACCTCCGCCACCGGTTCGAAAATCAACTTCAACAGTAAGTGGGATTGGTTAGATGAATTTGACAAAGAAGACGAAGAAATGTATAATGATCCAAATAGTAAACTAAGACAAAAATGGAGAAAATACGAGCTTATTTTCGACGCTGAACCAAGATACAATGACGATGCTCAAGTTAGTGATTGA","protein_sequence":"MDTSHEIHDKIPDTLREQQQHLRQKESEGCITTLKDLNVPETKKLSSVLHGRKASTYLRIFRDDECLADNNNGVDSNNGGSVTCADKITRSEATPKSVPEGLQVSEKKNNPDTLSSSLSSFILSNHEEPAIKPNKHVAHRNNITETGQGSGEDIAKQQSHQPQVLHHQTSLKPIQNVDEGCISPKSTYQESLHGISEDLTLKPVSSATYYPHKSKADSGYEEKDKMENDIDTIQPATINCASGIATLPSSYNRHTFKVKTYSTLSQSLRQENVNNRSNEKKPQQFVPHSESIKEKPNTFEQDKEGEQADEEEDEGDNEHREYPLAVELKPFTNRVGGHTAIFRFSKRAVCKALVNRENRWYENIELCHKELLQFMPRYIGVLNVRQHFQSKDDFLSDLDQENNGKNDTSNENKDIEVNHNNNDDIALNTEPTGTPLTHIHSFPLEHSSRQVLEKEHPEIESVHPHVKRSLSSSNQPSLLPEVVLNDNRHIIPESLWYKYSDSPNSAPNDSYFSSSSSHNSCSFGERGNTNKLKRRDSGSTMINTELKNLVIREVFAPKCFRRKRNSNTTTMGNHNARLGSSPSFLTQKSRASSHDASNTSMKTLGDSSSQASLQMDDSKVNPNLQDPFLKKSLHEKISNALDGSHSVMDLKQFHKNEQIKHKNSFCNSLSPILTATNSRDDGEFATSPNYISNAQDGVFDMDEDTGNETINMDNHGCHLDSGKNMIIKSLAYNVSNDYSHHDIESITFEETSHTIVSKFILLEDLTRNMNKPCALDLKMGTRQYGVDAKRAKQLSQRAKCLKTTSRRLGVRICGLKVWNKDYYITRDKYFGRRVKVGWQFARVLARFLYDGKTIESLIRQIPRLIKQLDTLYSEIFNLKGYRLYGASLLLMYDGDANKSNSKRKKAANVKVNLIDFARCVTKEDAMECMDKFRIPPKSPNIEDKGFLRGVKSLRFYLLLIWNYLTSDMPLIFDEVEMNDMISEEADSNSFTSATGSKINFNSKWDWLDEFDKEDEEMYNDPNSKLRQKWRKYELIFDAEPRYNDDAQVSD"},{"created_at":"2011-05-24T20:01:03.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase","uniprot_id":"Q06685","uniprot_name":"VIP1_YEAST","enzyme":true,"transporter":false,"gene_name":"VIP1","num_residues":1146,"molecular_weight":"129754.0","theoretical_pi":"9.01","general_function":"Involved in acid phosphatase activity","specific_function":"Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP- InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2- InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Required for maintaining celllular integrity, normal growth and interactions with the ARP complex. Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability. Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth","reactions":[{"id":1198,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1221,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1222,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1225,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2289,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2290,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton;Cytoplasm","altext":"ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown).","export":false,"pw_reaction_id":null,"source":null},{"id":2291,"direction":"\u003e","locations":"Cytoplasm. Cytoplasm, cytoskeleton","altext":"ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Cytoplasm, cytoskeleton","genbank_gene_id":"U20162","genbank_protein_id":"632676","gene_card_id":"VIP1","chromosome_location":"chromosome 12","locus":"YLR410W","synonyms":["InsP6 and PP-IP5 kinase"],"enzyme_classes":["2.7.4.21","2.7.4.24"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" acid phosphatase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Acid_phosphat_A","identifier":"PF00328"},{"name":"RimK","identifier":"PF08443"}],"pathways":[],"gene_sequence":"ATGAGTGGGATAAAGAAGGAACCGATTGAATCTGATGAGGTTCCTCAACAAGAGACAAAAAATAACTTACCTAGTGCACCTTCTGAGATGTCACCCCTTTTCCTAAACAAAAACACACAGAAGGCTATGCAATCTATTGCACCAATATTGGAGGGTTTCAGTCCTAAGACGTCAGCTAGCGAAAATATGTCTTTGAAATTGCCACCTCCCGGTATTCAAGATGATCACAGTGAAGAGAATCTCACCGTGCATGATACTCTGCAAAGAACCATAAGCACTGCACTAGGAAACGGAAACAACACCAATACAGTTACAACTTCCGGTTTAAAAAAGGCAGACAGTGAATCAAAGTCAGAAGCTGATCCTGAGGGGCTCAGCAATTCTAACATAGTCAATGATGCAGATAACATAAATTCCATCTCCAAGACCGGATCGCCCCATTTACCTCAAGGAACAATGGACGCTGAGCAGACTAACATGGGAACTAACTCTGTACCTACTTCATCAGCTTCTTCACGCAAATCCTCGACTAGTCATCCCAAACCTAGGCTACCCAAGGTAGGGAAGATTGGGGTATGTGCAATGGATGCAAAAGTCCTTTCAAAGCCAATGAGACACATTTTGAATCGTTTAATTGAACATGGTGAATTTGAAACTGTCATTTTTGGAGATAAGGTGATTCTAGATGAAAGAATAGAGAATTGGCCAACTTGCGACTTTTTGATATCTTTCTTTTCTTCAGGATTTCCCCTAGATAAAGCAATTAAATACGTCAAGTTACGCAAGCCTTTCATTATCAATGATTTAATAATGCAAAAGATTTTGTGGGACAGGAGATTATGTCTACAAGTATTAGAAGCCTACAACGTTCCAACACCTCCTAGACTGGAAATCAGTAGAGATGGTGGTCCCCGTGCCAACGAAGAATTAAGGGCAAAATTACGTGAGCATGGCGTAGAAGTTAAACCCGTTGAAGAACCGGAATGGAAAATGGTTGATGATGATACTTTAGAAGTTGATGGGAAAACCATGACTAAGCCCTTTGTTGAAAAGCCCGTTGATGGTGAAGACCACAACATTTATATATACTATCATTCTAAGAACGGAGGAGGCGGTCGTCGTCTATTCCGTAAAGTTGGTAACAAGTCTTCTGAGTTTGATCCTACTTTGGTTCATCCTCGTACGGAGGGGTCTTACATTTATGAGCAGTTTATGGATACCGATAATTTCGAAGATGTGAAGGCTTATACGATTGGTGAGAACTTTTGTCACGCTGAAACTAGGAAATCACCTGTGGTTGATGGTATAGTTAGAAGAAATACTCATGGTAAAGAAGTTAGATATATTACTGAGTTATCAGACGAAGAGAAAACCATTGCTGGGAAAGTTTCCAAAGCTTTTTCACAAATGATCTGTGGTTTCGATTTGCTTCGCGTTTCTGGTAAAAGTTACGTCATTGATGTTAACGGATTTTCTTTTGTAAAGGATAACAAAGCTTACTATGATTCATGCGCCAATATATTGAGAAGTACCTTCATTGAAGCCAAAAAGAAGATGGATATGGAAAAGAAGAATCTGCCCATTATTCGTGAAGAAAAGGAACAAAAGTGGGTATTCAAAGGACTGGCTATCATTATCCGTCACGCGGACAGAACACCAAAACAGAAATTCAAACATTCATTCACTTCGCCTATTTTTATATCGTTACTAAAAGGTCACAAAGAAGAAGTTGTCATTCGGAATGTAAATGATTTAAAGATTGTTCTTCAGGCCTTAAGAATTGCGTTAGATGAAAAAGCAGGAAATCCAGCTAAAATTAAAGTGTTAGCAAACGCTCTAGAAAAGAAACTGAATTTTCCCGGTACGAAAATACAATTGAAACCGGTTTTAAATAAAGAGAACGAAGTGGAAAAAGTTCAGTTTATTTTGAAATGGGGTGGTGAACCCACTCATTCTGCCAAATATCAGGCTACGGAACTCGGAGAGCAAATGAGACAAGATTTTGACCTATTGAATAAGAGCATTCTACAAAACATCAAGATATTTTCATCGTCTGAGAGACGTGTTCTTCATACGGCGCAGTACTGGACCAGAGCTCTTTTTGGGGCCGATGAATTAGGTAGCGATGAAATCAGTATTAGAAAGGATCTTTTAGATGACAGTAATGCCGCCAAAGATTTAATGGATAAGGTGAAAAAGAAGTTGAAGCCACTTTTAAGAGAGGGTAAGGAAGCTCCCCCACAATTTGCCTGGCCTTCAAAGATGCCGGAGCCATATTTAGTCATAAAGCGAGTGGTTGAATTGATGAATTACCATAAAAAAATTATGGATAACAACTTTGCTAAAAAGGATGTCAACTCGATGCAAACAAGATGGTGTACTTCTGAAGATCCTAGTTTGTTTAAGGAAAGGTGGGATAAACTTTTCAAAGAATTCAATAATGCTGAAAAAGTCGATCCTTCTAAAATTTCTGAATTGTATGATACTATGAAGTATGATGCTCTTCACAACAGGCAGTTCCTAGAGAACATATTTGACCCGGGTCTTCCAAATGAAGCTATCGCCGATGAACTCGGCAGTCATTCTTTAGTTGACCGATACCCAATTAACGTTCTCGCCAAAAATAATTTTAAGATAATAGACAGTCATAGCATGAACAATTCTGGAAAGAACAGTAGTAATAGTGTTGGGTCGTTAGGATGGGTTCTGGAAAGCGGAAAAACATCTACAGCAAGAAACCCCAAATCTTCTTCTCAATTCGATGAGCCACGCTTTATGCAGTTGCGGGAGCTGTATAAGCTGGCCAAAGTATTGTTTGATTTTATCTGCCCCAAAGAATATGGTATTTCAGATGCAGAGAAACTGGATATCGGTTTGTTAACTTCGTTGCCTTTGGCAAAGCAAATACTAAATGATATAGGAGACATGAAAAATAGAGAAACTCCAGCTTGTGTTGCGTACTTCACCAAAGAGTCCCATATTTACACTCTATTGAATATCATATACGAATCTGGTATTCCAATGAGAATCGCTAGAAATGCTTTACCAGAACTAGACTACTTGTCGCAGATCACTTTTGAACTTTATGAGAGTACGGATGCTTCTGGTCAAAAATCGCATTCCATTAGACTAAAAATGTCTCCTGGGTGTCATACTCAAGATCCGTTAGATGTTCAATTAGATGACAGGCATTATATTAGTTGTATTCCAAAGATTTCCCTGACGAAGCATTTGGATATGGACTATGTTCAACAGAAATTGAGAAACAAATTTACCAGGGTCATTATGCCTCCGAAATTTACACCAGTAAACATTACGAGCCCCAACTTGAGTTTCCAGAAACGCAAAACCAGAAGAAAGTCGGTATCTGTTGAGAAGTTGAAACGTCCTGCCTCGTCCGGATCTTCATCATCTACCTCCGTTAACAAGACATTAGATTAG","protein_sequence":"MSGIKKEPIESDEVPQQETKNNLPSAPSEMSPLFLNKNTQKAMQSIAPILEGFSPKTSASENMSLKLPPPGIQDDHSEENLTVHDTLQRTISTALGNGNNTNTVTTSGLKKADSESKSEADPEGLSNSNIVNDADNINSISKTGSPHLPQGTMDAEQTNMGTNSVPTSSASSRKSSTSHPKPRLPKVGKIGVCAMDAKVLSKPMRHILNRLIEHGEFETVIFGDKVILDERIENWPTCDFLISFFSSGFPLDKAIKYVKLRKPFIINDLIMQKILWDRRLCLQVLEAYNVPTPPRLEISRDGGPRANEELRAKLREHGVEVKPVEEPEWKMVDDDTLEVDGKTMTKPFVEKPVDGEDHNIYIYYHSKNGGGGRRLFRKVGNKSSEFDPTLVHPRTEGSYIYEQFMDTDNFEDVKAYTIGENFCHAETRKSPVVDGIVRRNTHGKEVRYITELSDEEKTIAGKVSKAFSQMICGFDLLRVSGKSYVIDVNGFSFVKDNKAYYDSCANILRSTFIEAKKKMDMEKKNLPIIREEKEQKWVFKGLAIIIRHADRTPKQKFKHSFTSPIFISLLKGHKEEVVIRNVNDLKIVLQALRIALDEKAGNPAKIKVLANALEKKLNFPGTKIQLKPVLNKENEVEKVQFILKWGGEPTHSAKYQATELGEQMRQDFDLLNKSILQNIKIFSSSERRVLHTAQYWTRALFGADELGSDEISIRKDLLDDSNAAKDLMDKVKKKLKPLLREGKEAPPQFAWPSKMPEPYLVIKRVVELMNYHKKIMDNNFAKKDVNSMQTRWCTSEDPSLFKERWDKLFKEFNNAEKVDPSKISELYDTMKYDALHNRQFLENIFDPGLPNEAIADELGSHSLVDRYPINVLAKNNFKIIDSHSMNNSGKNSSNSVGSLGWVLESGKTSTARNPKSSSQFDEPRFMQLRELYKLAKVLFDFICPKEYGISDAEKLDIGLLTSLPLAKQILNDIGDMKNRETPACVAYFTKESHIYTLLNIIYESGIPMRIARNALPELDYLSQITFELYESTDASGQKSHSIRLKMSPGCHTQDPLDVQLDDRHYISCIPKISLTKHLDMDYVQQKLRNKFTRVIMPPKFTPVNITSPNLSFQKRKTRRKSVSVEKLKRPASSGSSSSTSVNKTLD"},{"created_at":"2011-05-26T19:29:06.000Z","updated_at":"2011-05-27T15:01:06.000Z","name":"Inositol-pentakisphosphate 2-kinase","uniprot_id":"Q06667","uniprot_name":"IPK1_YEAST","enzyme":true,"transporter":false,"gene_name":"IPK1","num_residues":281,"molecular_weight":"32917.69922","theoretical_pi":"7.95","general_function":"Involved in ATP binding","specific_function":"Has kinase activity and phosphorylates inositol- 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate","reactions":[{"id":1660,"direction":"\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2570,"direction":"\u003e","locations":"Nucleus","altext":"ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14853,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007030","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"AY557740","genbank_protein_id":"45269371","gene_card_id":"IPK1","chromosome_location":"chromosome 4","locus":"YDR315C","synonyms":["Inositol-1,3,4,5,6-pentakisphosphate 2-kinase","Ins(1,3,4,5,6)P5 2-kinase","InsP5 2-kinase"],"enzyme_classes":["2.7.1.158"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" inositol or phosphatidylinositol kinase activity"},{"category":"Function","description":" inositol pentakisphosphate 2-kinase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Ins_P5_2-kin","identifier":"PF06090"}],"pathways":[{"name":"Inositol phosphate metabolism","kegg_map_id":"00562"}],"gene_sequence":"ATGCAAGTCATCGGACGTGGTGGGGCAAATATACTGATTGATTATGGGGATCCTACGTGGTTGTGGCGATGCTGCATCCGTTGGCCCGATCTGTTATCATCAAATAATTCTTATACAATCAAAAACATCAGTTATATTAAAGATTATGTAGAACCTCTTCTACATGGCTTGCTTTGCCCGATGTATCTGATTGACGTCGATATAGAAGCTATAAGGCCAATTCTCAGTGACTTTATTCTAAATTTAGACGATAAGGTAGTCAAAGTTATCAAAATTAAAAATCTCACCAATAATACCTCAAATCTGATATTAAATAACCACTTTTTAAAATCTTATTGTTCACAAAATCTGCAAACAGTTATTTTAGAATTGAAGCCTAAATGGTTATACTATGATACAGATTACTGTAGGAACTGTACTCATAATGCATTTAAGGGTAGAGGCACTAAGTACTGTTACAATCAATTACTAATGAATCCAGCACACTTGGAATTAATATTTGGAGAATGTAATATATTTCCGGTTAAGTTTAAAGATGCCATGCATGAGTACTTGCGCAATGACAATAACATTTTCAAGATCCTTTATGATTTACAGAAAAAACTTACAAAGAACACAACTCCAATAAGTGACATAAAATCAATCAACGATGTAAACGATGAGCATCTGCTACTCATGACACTCAGAGACGTGACATGTTTCATTGAATGGAACAGTGCTGAAAATGCGTTGCACGTGAATATAATAGATGTAGATCTAAAGCCGAAAGAAAAATGGACCCATTGGACAAAAACTTACAGCCAGTTGACATCAAGCCAAAAAATTTATCATACTTCAAATAAATAA","protein_sequence":"MQVIGRGGANILIDYGDPTWLWRCCIRWPDLLSSNNSYTIKNISYIKDYVEPLLHGLLCPMYLIDVDIEAIRPILSDFILNLDDKVVKVIKIKNLTNNTSNLILNNHFLKSYCSQNLQTVILELKPKWLYYDTDYCRNCTHNAFKGRGTKYCYNQLLMNPAHLELIFGECNIFPVKFKDAMHEYLRNDNNIFKILYDLQKKLTKNTTPISDIKSINDVNDEHLLLMTLRDVTCFIEWNSAENALHVNIIDVDLKPKEKWTHWTKTYSQLTSSQKIYHTSNK"}]}