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3-Isopropylmalate + S-Adenosylmethionine → S-Adenosylhomocysteine + 3-hydroxy-2-isopropyl-4-methoxy-4-oxobutanoate
Alpha-Ketoisovaleric acid + water + 5,10-Methylene-THF → 2-Dehydropantoic acid + 5,6,7,8-Tetrahydrofolic acid
Phosphoenolpyruvic acid + 3-Phosphoshikimic acid → phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimic acid
5-Aminoimidazole ribonucleotide + hydron → Glycolaldehyde + phosphate + 4-amino-5-hydroxymethyl-2-methylpyrimidine
NAD + water + 4-Coumaroyl-CoA + Coenzyme A → NADH + Acetyl-CoA + hydron + 4-hydroxybenzoyl-CoA
water + 4-Diphospho-1D-myo-inositol pentakisphosphate ↔ Myo-Inositol hexakisphosphate + phosphate + hydron