Mitochondrial carnitine carrier (Q12289)

Identification
NameMitochondrial carnitine carrier
SynonymsNot Available
Gene NameCRC1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in binding
Specific FunctionTransports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long- chain acylcarnitines
Cellular LocationMitochondrion inner membrane; Multi-pass membrane protein (Potential)
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00616(R)-CarnitineShow
YMDB00617O-acetylcarnitiniumShow
GO Classification
Component
cell part
membrane
Function
binding
Process
transmembrane transport
establishment of localization
transport
Gene Properties
Chromosome Locationchromosome 15
LocusYOR100C
Gene Sequence>984 bp ATGTCTTCAGACACTTCATTATCAGAATCTTCATTATTGAAAGAAGAGAGTGGGAGCTTG ACCAAGTCTCGTCCACCTATAAAATCAAACCCTGTACGCGAAAATATCAAATCATTTGTG GCCGGTGGAGTTGGCGGGGTATGTGCGGTGTTTACGGGTCATCCCTTCGATTTGATTAAA GTGAGATGTCAAAATGGACAAGCGAATTCCACGGTACATGCCATTACAAATATTATAAAA GAAGCAAAAACTCAAGTAAAGGGCACATTATTTACCAATTCCGTAAAGGGGTTCTATAAA GGTGTTATCCCGCCCTTATTAGGTGTTACTCCCATATTCGCTGTTTCTTTCTGGGGTTAC GATGTGGGTAAGAAACTGGTTACTTTTAATAACAAGCAAGGAGGCAGTAACGAGTTAACT ATGGGACAAATGGCTGCAGCAGGATTTATCAGCGCTATTCCTACCACTTTAGTGACTGCG CCAACGGAAAGAGTAAAGGTTGTCCTGCAAACATCTTCTAAGGGCTCTTTCATTCAGGCG GCTAAAACCATTGTTAAAGAAGGTGGCATAGCTTCTTTATTTAAAGGTTCATTAGCCACT TTAGCAAGAGATGGGCCTGGCTCAGCTCTATATTTTGCATCTTATGAAATTTCAAAAAAT TACTTGAATAGTAGGCAACCTCGTCAAGATGCGGGCAAAGATGAACCGGTCAATATCTTG AACGTGTGTCTTGCTGGTGGTATTGCTGGTATGTCGATGTGGCTAGCTGTTTTCCCCATA GACACTATAAAGACAAAATTGCAGGCTTCCTCCACGAGGCAGAATATGCTTTCCGCCACA AAGGAAATTTATCTACAAAGAGGTGGTATCAAGGGATTTTTCCCTGGTTTAGGTCCTGCT TTACTAAGATCTTTCCCAGCCAATGCGGCCACATTTTTAGGTGTGGAGATGACTCATTCA CTGTTCAAGAAGTATGGCATATGA
Protein Properties
Pfam Domain Function
Protein Residues327
Protein Molecular Weight34753.89844
Protein Theoretical pI10.46
Signalling Regions
  • None
Transmembrane Regions
  • 33-49
  • 107-123
  • 141-162
  • 196-212
  • 244-260
  • 293-313
Protein Sequence>Mitochondrial carnitine carrier MSSDTSLSESSLLKEESGSLTKSRPPIKSNPVRENIKSFVAGGVGGVCAVFTGHPFDLIK VRCQNGQANSTVHAITNIIKEAKTQVKGTLFTNSVKGFYKGVIPPLLGVTPIFAVSFWGY DVGKKLVTFNNKQGGSNELTMGQMAAAGFISAIPTTLVTAPTERVKVVLQTSSKGSFIQA AKTIVKEGGIASLFKGSLATLARDGPGSALYFASYEISKNYLNSRQPRQDAGKDEPVNIL NVCLAGGIAGMSMWLAVFPIDTIKTKLQASSTRQNMLSATKEIYLQRGGIKGFFPGLGPA LLRSFPANAATFLGVEMTHSLFKKYGI
References
External Links
ResourceLink
Saccharomyces Genome Database CRC1
Uniprot IDQ12289
Uniprot NameCRC1_YEAST
GenBank Gene IDAJ250124
Genebank Protein ID6634541
General Reference
  • Palmieri, L., Lasorsa, F. M., Iacobazzi, V., Runswick, M. J., Palmieri, F., Walker, J. E. (1999). "Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae." FEBS Lett 462:472-476.10622748
  • Voss, H., Benes, V., Andrade, M. A., Valencia, A., Rechmann, S., Teodoru, C., Schwager, C., Paces, V., Sander, C., Ansorge, W. (1997). "DNA sequencing and analysis of 130 kb from yeast chromosome XV." Yeast 13:655-672.9200815
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • van Roermund, C. W., Hettema, E. H., van den Berg, M., Tabak, H. F., Wanders, R. J. (1999). "Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p." EMBO J 18:5843-5852.10545096