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Identification
NameFAD-linked sulfhydryl oxidase ERV2
SynonymsNot Available
Gene NameERV2
Enzyme Class
Biological Properties
General FunctionInvolved in thiol oxidase activity
Specific FunctionFAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1
Cellular LocationEndoplasmic reticulum membrane; Single-pass type III membrane protein; Lumenal side
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00888Hydrogen peroxideShow
YMDB00900oxygenShow
GO Classification
Component
Not Available
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors
oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
thiol oxidase activity
Process
metabolic process
oxidation reduction
Gene Properties
Chromosome Locationchromosome 16
LocusYPR037C
Gene Sequence>591 bp ATGAAACAGATAGTCAAAAGAAGCCATGCCATCAGAATAGTTGCAGCATTAGGAATCATA GGCCTGTGGATGTTTTTCTCGTCTAATGAACTATCCATCGCTACGCCGGGCCTAATCAAG GCGAAGTCTGGTATAGATGAAGTGCAAGGGGCGGCTGCTGAGAAGAACGACGCTCGGTTG AAAGAGATCGAGAAGCAAACCATTATGCCATTGATGGGCGATGACAAGGTGAAGAAGGAA GTGGGCAGGGCGTCGTGGAAGTACTTCCATACCCTGCTGGCCCGTTTTCCGGACGAGCCT ACTCCTGAAGAAAGAGAGAAACTGCACACGTTTATTGGGTTGTATGCAGAACTCTATCCA TGCGGGGAATGTTCATATCACTTTGTAAAGTTGATTGAGAAGTATCCCGTACAGACATCT AGCAGGACGGCTGCCGCAATGTGGGGATGCCACATTCACAACAAGGTGAACGAATACCTA AAGAAAGACATATATGACTGTGCTACCATCCTGGAGGACTACGATTGTGGATGTAGTGAC AGCGACGGTAAACGCGTGTCTCTCGAGAAGGAGGCTAAACAGCACGGTTGA
Protein Properties
Pfam Domain Function
Protein Residues196
Protein Molecular Weight22141.30078
Protein Theoretical pI7.5
PDB Fileshow
Signalling Regions
  • None
Transmembrane Regions
  • 13-35
Protein Sequence>FAD-linked sulfhydryl oxidase ERV2 MKQIVKRSHAIRIVAALGIIGLWMFFSSNELSIATPGLIKAKSGIDEVQGAAAEKNDARL KEIEKQTIMPLMGDDKVKKEVGRASWKYFHTLLARFPDEPTPEEREKLHTFIGLYAELYP CGECSYHFVKLIEKYPVQTSSRTAAAMWGCHIHNKVNEYLKKDIYDCATILEDYDCGCSD SDGKRVSLEKEAKQHG
References
External Links
ResourceLink
Saccharomyces Genome Database ERV2
Uniprot IDQ12284
Uniprot NameERV2_YEAST
GenBank Gene IDZ68111
Genebank Protein ID1072405
PDB ID
1JRA
General Reference
  • Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
  • Stein, G., Lisowsky, T. (1998). "Functional comparison of the yeast scERV1 and scERV2 genes." Yeast 14:171-180.9483805
  • Gerber, J., Muhlenhoff, U., Hofhaus, G., Lill, R., Lisowsky, T. (2001). "Yeast ERV2p is the first microsomal FAD-linked sulfhydryl oxidase of the Erv1p/Alrp protein family." J Biol Chem 276:23486-23491.11313344
  • Sevier, C. S., Cuozzo, J. W., Vala, A., Aslund, F., Kaiser, C. A. (2001). "A flavoprotein oxidase defines a new endoplasmic reticulum pathway for biosynthetic disulphide bond formation." Nat Cell Biol 3:874-882.11584268
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Gross, E., Sevier, C. S., Vala, A., Kaiser, C. A., Fass, D. (2002). "A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p." Nat Struct Biol 9:61-67.11740506