ATP synthase subunit delta, mitochondrial (Q12165)

Identification
NameATP synthase subunit delta, mitochondrial
Synonyms
  • F-ATPase delta subunit
Gene NameATP16
Enzyme ClassNot Available
Biological Properties
General FunctionEnergy production and conversion
Specific FunctionMitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits
Cellular LocationMitochondrion. Mitochondrion inner membrane
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
proton-transporting ATP synthase complex, catalytic core F(1)
macromolecular complex
protein complex
proton-transporting two-sector ATPase complex, catalytic domain
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
proton-transporting ATPase activity, rotational mechanism
inorganic cation transmembrane transporter activity
hydrogen ion transporting ATP synthase activity, rotational mechanism
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
Process
nucleotide metabolic process
purine nucleotide metabolic process
metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
ATP biosynthetic process
ATP synthesis coupled proton transport
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>483 bp ATGTTACGTTCAATTATTGGAAAGAGTGCATCAAGATCATTGAATTTCGTCGCTAAGCGT TCATATGCAGAAGCTGCTGCCGCATCATCAGGTTTGAAGTTACAATTTGCTCTACCACAC GAAACTTTATATAGTGGCTCCGAAGTTACTCAAGTGAACCTGCCTGCTAAGTCAGGACGT ATTGGTGTATTGGCCAACCATGTTCCCACCGTTGAACAATTACTACCAGGTGTCGTTGAA GTTATGGAAGGCTCTAACTCTAAAAAATTCTTTATATCAGGTGGATTTGCAACAGTTCAA CCAGACTCGCAGTTATGTGTAACTGCAATTGAAGCTTTTCCATTGGAATCCTTTTCACAA GAAAATATAAAAAATTTGTTGGCAGAAGCTAAGAAGAACGTTAGTTCATCTGATGCCAGG GAAGCCGCAGAAGCTGCAATTCAAGTAGAAGTTTTAGAAAACCTACAATCCGTATTGAAA TAG
Protein Properties
Pfam Domain Function
Protein Residues160
Protein Molecular Weight17020.19922
Protein Theoretical pI6.53
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>ATP synthase subunit delta, mitochondrial MLRSIIGKSASRSLNFVAKRSYAEAAAASSGLKLQFALPHETLYSGSEVTQVNLPAKSGR IGVLANHVPTVEQLLPGVVEVMEGSNSKKFFISGGFATVQPDSQLCVTAIEAFPLESFSQ ENIKNLLAEAKKNVSSSDAREAAEAAIQVEVLENLQSVLK
References
External Links
ResourceLink
Saccharomyces Genome Database ATP16
Uniprot IDQ12165
Uniprot NameATPD_YEAST
GenBank Gene IDAY558155
Genebank Protein ID45270200
General Reference
  • Giraud, M. F., Velours, J. (1994). "ATP synthase of yeast mitochondria. Isolation of the F1 delta subunit, sequence and disruption of the structural gene." Eur J Biochem 222:851-859.8026496
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666
  • Stock, D., Leslie, A. G., Walker, J. E. (1999). "Molecular architecture of the rotary motor in ATP synthase." Science 286:1700-1705.10576729