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Identification
NameTransposon Ty2-OR1 Gag-Pol polyprotein
Synonyms
  • TY2A-TY2B
  • Transposon Ty2 TYA-TYB polyprotein
  • Capsid protein
  • CA
  • Ty2 protease
  • PR
  • Integrase
  • IN
  • Reverse transcriptase/ribonuclease H
  • RT
  • RT-RH
Gene NameTY2B-OR1
Enzyme Class
Biological Properties
General FunctionInvolved in DNA binding
Specific FunctionIntegrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome
Cellular LocationCytoplasm. Nucleus
SMPDB Pathways
Pyrimidine metabolismPW002469 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Purine metabolismec00230 Map00230
Pyrimidine metabolismec00240 Map00240
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00219PyrophosphateShow
YMDB00220ThiamineShow
YMDB00862hydronShow
YMDB00890waterShow
GO Classification
Component
cytoplasm
cell part
intracellular part
Function
nucleic acid binding
RNA binding
DNA binding
binding
Process
cellular macromolecule metabolic process
DNA metabolic process
DNA integration
metabolic process
macromolecule metabolic process
Gene Properties
Chromosome LocationNot Available
LocusYOR192C-B
Gene Sequence>5313 bp ATGGAATCCCAACAATTATCTCAAAATTCACCCACTTTTCATGGTAGCGCCTATGCTTCG GTTACTTCTAAGGAAGTCCCATCAAATCAAGATCCGTTAGCCGTTTCAGCTTCCAATTTA CCGGAATTTGATAGAGATTCCACTAAGGTTAATTCTCAACAAGAGACAACACCTGGGACA TCAGCTGTTCCAGAGAACCATCATCATGTCTCTCCTCAACCTGCTTCAGTACCACCTCCA CAGAATGGACAGTACCAACAGCACGGCATGATGACCCCAAACAAAGCTATGGCTTCTAAC TGGGCACATTACCAACAACCATCTATGATGACGTGTTCACATTATCAAACGTCACCTGCG TATTATCAACCGGACCCACACTATCCGCTGCCACAGTATATCCCACCGCTGAGTACTTCC TCACCTGATCCAATCGGTTCACAGGATCAACACTCTGAAGTACCTCAAGCTAAGACAAAG GTGAGAAATAATGTCTTACCACCACACACTTTAACATCAGAAGAAAACTTTTCTACATGG GTTAAATTTTACATCAGATTTTTGAAGAACTCTAATCTCGGTGACATTATTCCAAATGAC CAGGGTGAAATCAAAAGACAAATGACTTATGAAGAACATGCGTATATATACAATACCTTC CAAGCATTTGCCCCATTTCATTTATTGCCAACATGGGTAAAACAAATTTTAGAAATTAAT TATTCTGACATCCTTACAGTCCTTTGTAAAAGTGTGTCCAAAATGCAAACTAACAATCAA GAATTAAAAGATTGGATAGCTCTTGCCAACCTTGAGTACAACGGAAGTACATCTGCTGAT ACATTTGAAATTACAGTCAGCACGATCATTCAAAGGCTAAAAGAAAACAATATCAATGTT AGCGACAGATTGGCCTGTCAACTAATACTTAAAGGTCTATCCGGTGACTTCAAATACCTA CGTAATCAATATCGTACCAAAACGAACATGAAACTTTCCCAATTATTCGCTGAAATTCAA TTAATATATGACGAAAATAAAATCATGAATCTAAATAAACCGTCCCAATACAAACAACAC AGCGAATACAAAAATGTTTCTCGCACATCTCCAAACACGACTAACACGAAGGTTACAACT CGTAATTATCATAGAACAAATAGTTCAAAACCAAGAGCAGCAAAAGCTCACAATATTGCT ACATCCAGTAAATTCTCAAGGGTGAACAATGATCACATTAATGAATCAACCGTTTCATCA CAATACTTAAGCGATGACAACGAACTTAGTCTTGGCCAGCAACAGAAAGAATCTAAGCCA ACACGCACAATAGACTCGAATGACGAACTACCTGATCACCTTCTTATTGATTCAGGAGCT TCGCAAACGCTTGTCAGATCAGCCCATTATTTACACCATGCAACACCCAATTCTGAAATA AACATAGTCGATGCTCAAAAACAAGACATTCCTATAAATGCCATTGGTAATCTTCACTTC AACTTTCAGAACGGCACCAAAACATCAATAAAAGCACTACACACACCAAACATAGCCTAT GATCTATTAAGTTTGAGTGAGCTGGCTAACCAAAATATTACTGCCTGCTTTACCAGAAAC ACTTTAGAAAGATCGGATGGTACAGTACTAGCTCCCATAGTCAAACATGGAGACTTTTAC TGGTTATCTAAAAAATACCTAATTCCTTCGCACATTTCAAAGCTAACAATAAACAACGTC AACAAAAGCAAAAGCGTAAATAAATATCCATATCCGTTAATACATCGAATGCTTGGACAT GCTAACTTCCGAAGTATTCAGAAGTCTCTTAAGAAGAATGCAGTTACATATTTGAAAGAA TCGGATATTGAATGGTCTAACGCTAGCACATATCAATGTCCTGACTGTCTAATCGGCAAA AGCACGAAACATAGGCATGTCAAAGGATCACGACTAAAGTACCAAGAATCATATGAGCCT TTTCAGTACTTGCATACCGATATATTTGGTCCTGTACATCACTTACCGAAAAGTGCACCT TCTTACTTTATATCGTTTACAGATGAGAAAACCAGATTCCAATGGGTGTACCCATTACAC GACCGTCGTGAAGAATCTATCCTCAATGTTTTTACATCGATATTAGCATTTATTAAGAAC CAATTCAATGCTCGCGTTCTAGTTATCCAGATGGATCGTGGCTCCGAGTACACTAACAAA ACTCTTCATAAGTTCTTTACGAACAGAGGTATTACTGCATGCTATACAACCACGGCAGAT TCTAGAGCACACGGTGTCGCTGAACGATTAAATCGTACTTTATTAAACGATTGTCGCACA CTGCTTCATTGCAGTGGTCTACCAAATCATCTATGGTTCTCAGCAGTCGAATTTTCTACT ATAATCAGAAATTCATTAGTCTCACCAAAAAACGATAAATCTGCAAGACAACATGCAGGT TTAGCTGGACTGGACATTACTACTATACTACCTTTCGGTCAACCGGTTATAGTTAACAAC CATAATCCCGACTCGAAAATACATCCTCGTGGCATTCCAGGTTACGCCTTACATCCATCA CGAAACTCTTATGGCTATATTATCTATCTTCCATCCTTAAAAAAGACAGTAGATACTACC AATTACGTTATATTACAAAACAAGCAAACGAAATTGGACCAGTTCGACTACGATACACTC ACTTTTGATGATGATCTCAATCGTTTAACAGCCCATAACCAATCTTTTATTGAACAAAAT GAAACGGAGCAGTCATATGATCAAAATACAGAATCTGATCATGACTATCAATCGGAGATT GAAATAAACTCTGATCCTCTAGTGAACGATTTCTCGTCCCAATCATTGAACCCTTTACAA TTAGACAAGGAACCAGTCCAAAAGGTACGTGCACCAAAAGAAGTTGATGCCGACATATCT GAATACAATATTCTTCCATCTACTATACGATCTCGTACACCCCATATCATTAATAAAGAG AGTACCGAAATGGGTGGTACCATTGAATCAGATACTACTTCACCTAGACACTCGTCTACC TTCACTGCACGAAACCAAAAGCGACCTGGTAGTCCCAACGATATGATTGATTTGACCTCA CAGGATAGAGTTAATTATGGACTTGAAAACATCAAAACTACACGTTTGGGTGGTACGGAG GAACCATATATTCAACGAAATAGTGATACAAATATCAAATACAGGACTACAAATAGTACG CCCTCAATAGATGACCGTTCGTCCAACAGTGAATCCACTACTCCCATCATCTCCATAGAA ACAAAGGCTGCATGTGATAATACACCCTCCATTGATACGGATCCGCCAGAATATCGATCT TCTGACCATGCGACTCCTAATATAATGCCTGACAAATCCTCAAAAAATGTTACGGCTGAT TCTATTCTTGACGACCTCCCACTTCCTGACTTAACCCATCAATCTCCTACGGACACTTCT GATGTTTCAAAAGATATTCCACACATACACTCTCGTCAGACTAATTCCAGTTTGGGTGGT ATGGATGATTCTAATGTTCTGACTACTACCAAAAGTAAGAAAAGATCATTAGAAGATAAT GAAACTGAAATTGAGGTATCCCGAGACACATGGAATAATAAGAATATGAGAAGTCTGGAA CCACCAAGATCGAAGAAACGCATAAATTTAATTGCAGCAATAAAAGGAGTGAAATCGATC AAACCAGTTCGAACGACCTTAAGATATGATGAAGCAATTACTTATAATAAAGACAACAAA GAAAAAGACAGATATGTTGAAGCTTATCATAAAGAAATTAGCCAACTATTGAAAATGAAC ACTTGGGATACAAACAAATATTATGATAGAAATGACATAGATCCTAAAAAAGTAATAAAC TCAATGTTTATATTTAACAAGAAACGTGATGGTACACACAAAGCTAGATTTGTTGCAAGA GGCGACATTCAACACCCCGATACATATGATTCTGATATGCAATCCAATACCGTACATCAC TATGCACTGATGACGTCACTGTCAATCGCATTAGACAACGACTATTATATCACACAGCTG GACATATCCTCTGCTTACTTATATGCTGATATCAAAGAAGAATTATACATAAGACCTCCA CCACATTTAGGTTTGAATGATAAATTACTACGTTTGAGAAAATCACTCTATGGTTTGAAA CAAAGTGGTGCAAACTGGTATGAAACCATTAAATCATATTTAATAAATTGTTGCGACATG CAAGAAGTTCGCGGATGGTCATGCGTATTTAAGAATAGTCAAGTAACAATTTGCTTATTC GTTGACGACATGATTTTATTTAGCAAAGACTTAAATGCAAATAAGAAAATCATAACAACA CTCAAGAAACAATACGATACAAAGATAATAAATCTGGGTGAAGGTGATAACGAAATTCAG TACGACATACTTGGATTAGAGATCAAATATCAAAGAAGCAAGTACATGAAATTAGGTATG GAAAAATCCTTGACAGAAAAATTACCCAAACTAAACGTACCTTTGAACCCAAAAGGAAAG AAACTTAGAGCTCCAGGTCAACCAGGTCATTATATAGACCAGGATGAACTAGAAATAGAT GAAGATGAATACAAAGAGAAAGTGCATGAAATGCAAAAGTTGATTGGTCTAGCTTCATAT GTTGGATATAAATTTAGATTTGACTTACTATACTACATCAACACACTTGCTCAACATATA CTATTCCCCTCTAGGCAAGTTTTAGACATGACATATGAGTTAATACAATTCATGTGGGAC ACTAGAGATAAACAATTAATATGGCACAAAAACAAACCTACCAAGCCAGATAATAAACTA GTCGCAATAAGCGATGCTTCATATGGTAACCAACCATATTACAAGTCACAAATTGGTAAC ATTTTCCTACTCAACGGAAAAGTGATTGGAGGAAAGTCGACAAAGGCTTCGTTAACATGC ACTTCAACTACAGAAGCAGAAATACACGCAGTCAGTGAAGCTATACCGCTATTGAATAAC CTCAGTCACCTTGTGCAAGAACTTAACAAGAAACCAATTATTAAAGGCTTACTTACTGAT AGTAGATCAACGATCAGTATAATTAAGTCTACAAATGAAGAGAAATTTAGAAACAGATTT TTTGGCACGAAGGCAATGAGACTTAGAGATGAAGTATCAGGTAATAATTTATACGTATAC TACATCGAGACCAATAAGAACATTGCTGATGTGATGACAAAACCTCTTCCGATAAAAACA TTTAAACTATTAACTAACAAATGGATTCATTAG
Protein Properties
Pfam Domain Function
Protein Residues1770
Protein Molecular Weight201982.0
Protein Theoretical pI8.44
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Transposon Ty2-OR1 Gag-Pol polyprotein MESQQLSQNSPTFHGSAYASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGT SAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPA YYQPDPHYPLPQYIPPLSTSSPDPIGSQDQHSEVPQAKTKVRNNVLPPHTLTSEENFSTW VKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEIN YSDILTVLCKSVSKMQTNNQELKDWIALANLEYNGSTSADTFEITVSTIIQRLKENNINV SDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQH SEYKNVSRTSPNTTNTKVTTRNYHRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSS QYLSDDNELSLGQQQKESKPTRTIDSNDELPDHLLIDSGASQTLVRSAHYLHHATPNSEI NIVDAQKQDIPINAIGNLHFNFQNGTKTSIKALHTPNIAYDLLSLSELANQNITACFTRN TLERSDGTVLAPIVKHGDFYWLSKKYLIPSHISKLTINNVNKSKSVNKYPYPLIHRMLGH ANFRSIQKSLKKNAVTYLKESDIEWSNASTYQCPDCLIGKSTKHRHVKGSRLKYQESYEP FQYLHTDIFGPVHHLPKSAPSYFISFTDEKTRFQWVYPLHDRREESILNVFTSILAFIKN QFNARVLVIQMDRGSEYTNKTLHKFFTNRGITACYTTTADSRAHGVAERLNRTLLNDCRT LLHCSGLPNHLWFSAVEFSTIIRNSLVSPKNDKSARQHAGLAGLDITTILPFGQPVIVNN HNPDSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQNKQTKLDQFDYDTL TFDDDLNRLTAHNQSFIEQNETEQSYDQNTESDHDYQSEIEINSDPLVNDFSSQSLNPLQ LDKEPVQKVRAPKEVDADISEYNILPSTIRSRTPHIINKESTEMGGTIESDTTSPRHSST FTARNQKRPGSPNDMIDLTSQDRVNYGLENIKTTRLGGTEEPYIQRNSDTNIKYRTTNST PSIDDRSSNSESTTPIISIETKAACDNTPSIDTDPPEYRSSDHATPNIMPDKSSKNVTAD SILDDLPLPDLTHQSPTDTSDVSKDIPHIHSRQTNSSLGGMDDSNVLTTTKSKKRSLEDN ETEIEVSRDTWNNKNMRSLEPPRSKKRINLIAAIKGVKSIKPVRTTLRYDEAITYNKDNK EKDRYVEAYHKEISQLLKMNTWDTNKYYDRNDIDPKKVINSMFIFNKKRDGTHKARFVAR GDIQHPDTYDSDMQSNTVHHYALMTSLSIALDNDYYITQLDISSAYLYADIKEELYIRPP PHLGLNDKLLRLRKSLYGLKQSGANWYETIKSYLINCCDMQEVRGWSCVFKNSQVTICLF VDDMILFSKDLNANKKIITTLKKQYDTKIINLGEGDNEIQYDILGLEIKYQRSKYMKLGM EKSLTEKLPKLNVPLNPKGKKLRAPGQPGHYIDQDELEIDEDEYKEKVHEMQKLIGLASY VGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKL VAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNN LSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVY YIETNKNIADVMTKPLPIKTFKLLTNKWIH
References
External Links
ResourceLink
Saccharomyces Genome Database TY2B-OR1
Uniprot IDQ12113
Uniprot NameYO21B_YEAST
GenBank Gene IDZ75100
Genebank Protein ID1420460
General Reference
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • Kim, J. M., Vanguri, S., Boeke, J. D., Gabriel, A., Voytas, D. F. (1998). "Transposable elements and genome organization: a comprehensive survey of retrotransposons revealed by the complete Saccharomyces cerevisiae genome sequence." Genome Res 8:464-478.9582191
  • Lesage, P., Todeschini, A. L. (2005). "Happy together: the life and times of Ty retrotransposons and their hosts." Cytogenet Genome Res 110:70-90.16093660