Probable undecaprenyl pyrophosphate synthase (Q12063)

Identification
NameProbable undecaprenyl pyrophosphate synthase
Synonyms
  • UPP synthase
  • Di-trans,poly-cis-decaprenylcistransferase
  • Nuclear undecaprenyl pyrophosphate synthase 1
  • Undecaprenyl diphosphate synthase
  • UDS
Gene NameNUS1
Enzyme Class
Biological Properties
General FunctionInvolved in transferase activity, transferring alkyl or aryl (other than methyl) groups
Specific FunctionGenerates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP)
Cellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein (Potential). Lipid droplet. Nucleus membrane; Single-pass membrane protein (Potential)
SMPDB Pathways
Terpenoid backbone biosynthesisPW002485 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Terpenoid backbone biosynthesisec00900 Map00900
SMPDB Reactions
Farnesyl pyrophosphate + Isopentenyl pyrophosphate → di-trans, poly-cis-polyprenyl diphosphate (C80) + Pyrophosphate
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00184di-trans,poly-cis-Decaprenyl diphosphateShow
YMDB00200Isopentenyl pyrophosphateShow
YMDB00219PyrophosphateShow
YMDB00222di-trans,poly-cis-undecaprenyl diphosphateShow
YMDB00229Farnesyl pyrophosphateShow
YMDB16322di-trans, poly-cis-polyprenyl diphosphate (C80)Show
GO Classification
Component
Not Available
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Process
Not Available
Gene Properties
Chromosome Locationchromosome 4
LocusYDL193W
Gene Sequence>1128 bp ATGCCCACGATGATCAAAAAGGATGATAAAGCAATGGAGCCCCCTAATGAAAAACCGCAT AGAAAGATCGAAAGAGATGATGTTCCAGAATCTTCCAATCACATCCCACCTCCAGAATCT GGTGTTTTAAAGGGCGGTAAAGTTAATTCAAAAACCAGAGCTTTAAAGGCCGTTACAAGT ATCATTGCAGACGCCGATGAGAACCCTCAGAAGAAAGTGAACAATGAGACGAATGGAGTC CAAAAGCAAAAGACAGAAGATTTGAGTAAAAGAATAGGTAAATTTGAATACCTTTTTTAC AAGTTTTTACTTGTGTTGTTATACATCTGCTTCGGGTTGTTTCGGTACGGTCAATACCAA TATAATAAAATGAAACTAAGAATATTCAGTATCATCTACAACCATGCATATACACCACAG TTGATTAGACAGGACGTTATTCCTCTGAAAAAAATTCCTAAAAGGTTGGCCGCTATCTTG GAAGTCAAGCCAGTTGGCGACGTTGGCGGCGGTGTGACAGGTTTATTAAATGACGCGAGT GAAATTGTTTGCTGGACTGTTTCAGCTGGTATAAAACATTTGATGTTGTACGATTACGAT GGAATATTACAAAGAAATGTTCCAGAGCTGAGAATGGAAATTCATTCCAACCTGGCTAAA TATTTTGGGCCAGCTCATGTTCCAAACTACGCTGTTAAAATACCTCATTCTAACAAGATA TTCTACAATCTAGACGGAATTGAAACCGAGACTGATGTAGGCAATGAGATAGAAGCTAAC CAAGAAAAGGACAAAATTGCTATTGAAATTTCTTTATTGTCTAACAGAGATGGTAGAGAA ACGATTGTCGATCTGACCAAAACTATGGCTGAGTTATGTGCGGTTAACGAATTGAGCGTT TCTGACATCACAATGGATTTAGTTGATTCAGAACTGAAACAACTAGTTGGACCCGAACCA GATTTACTGTTATACTTCGGGCCTTCGTTGGATTTACAAGGGTTCCCACCTTGGCATATT AGATTAACCGAATTTTATTGGGAAAAAGATAACAACGAAGTCATATATTCGGTTTTCATC CGCGGCCTAAGACAGTACGCAGGATGTAAAGTGAATGTTGGTAAATGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues375
Protein Molecular Weight42556.69922
Protein Theoretical pI6.95
Signalling Regions
  • None
Transmembrane Regions
  • 97-119
Protein Sequence>Probable undecaprenyl pyrophosphate synthase MPTMIKKDDKAMEPPNEKPHRKIERDDVPESSNHIPPPESGVLKGGKVNSKTRALKAVTS IIADADENPQKKVNNETNGVQKQKTEDLSKRIGKFEYLFYKFLLVLLYICFGLFRYGQYQ YNKMKLRIFSIIYNHAYTPQLIRQDVIPLKKIPKRLAAILEVKPVGDVGGGVTGLLNDAS EIVCWTVSAGIKHLMLYDYDGILQRNVPELRMEIHSNLAKYFGPAHVPNYAVKIPHSNKI FYNLDGIETETDVGNEIEANQEKDKIAIEISLLSNRDGRETIVDLTKTMAELCAVNELSV SDITMDLVDSELKQLVGPEPDLLLYFGPSLDLQGFPPWHIRLTEFYWEKDNNEVIYSVFI RGLRQYAGCKVNVGK
References
External Links
ResourceLink
Saccharomyces Genome Database NUS1
Uniprot IDQ12063
Uniprot NameUPPS_YEAST
GenBank Gene IDX83276
Genebank Protein ID1004302
General Reference
  • Verhasselt, P., Voet, M., Volckaert, G. (1995). "New open reading frames, one of which is similar to the nifV gene of Azotobacter vinelandii, found on a 12.5 kbp fragment of chromosome IV of Saccharomyces cerevisiae." Yeast 11:961-966.8533471
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Athenstaedt, K., Zweytick, D., Jandrositz, A., Kohlwein, S. D., Daum, G. (1999). "Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae." J Bacteriol 181:6441-6448.10515935
  • Prein, B., Natter, K., Kohlwein, S. D. (2000). "A novel strategy for constructing N-terminal chromosomal fusions to green fluorescent protein in the yeast Saccharomyces cerevisiae." FEBS Lett 485:29-34.11086160
  • Hazbun, T. R., Malmstrom, L., Anderson, S., Graczyk, B. J., Fox, B., Riffle, M., Sundin, B. A., Aranda, J. D., McDonald, W. H., Chiu, C. H., Snydsman, B. E., Bradley, P., Muller, E. G., Fields, S., Baker, D., Yates, J. R. 3rd, Davis, T. N. (2003). "Assigning function to yeast proteins by integration of technologies." Mol Cell 12:1353-1365.14690591
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Peng, J., Schwartz, D., Elias, J. E., Thoreen, C. C., Cheng, D., Marsischky, G., Roelofs, J., Finley, D., Gygi, S. P. (2003). "A proteomics approach to understanding protein ubiquitination." Nat Biotechnol 21:921-926.12872131
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956