| Identification |
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| Name | Vacuolar basic amino acid transporter 1 |
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| Synonyms | Not Available |
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| Gene Name | VBA1 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in transmembrane transport |
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| Specific Function | Transporter required for vacuolar uptake of at least histidine and lysine |
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| Cellular Location | Vacuole membrane; Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00330 | L-Lysine | Show | | YMDB00369 | L-Histidine | Show | | YMDB00862 | hydron | Show |
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| GO Classification | | Component |
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| Not Available | | Function |
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| Not Available | | Process |
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| transmembrane transport | | establishment of localization | | transport |
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| Gene Properties |
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| Chromosome Location | chromosome 13 |
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| Locus | YMR088C |
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| Gene Sequence | >1689 bp
ATGCAAACACTAGACGAGACTTCAAATCTACTCCCTCCACCTGAGGAAGCTGAAGCCCCT
CCCTTGGAACAAAAATTTCATGAATATAATTTGGCCTTACCTAAGTTTCCCATTTTGTTT
TCGCTATGGTTGGGTAGTTTTTTGAGTTCCTTGGATAGCACTATTGTCGCAAATATAATG
AATAGAGTTGCTGAGGAATTCTCTGAATCAAGTAAAAAGCAATGGATTGCGACGAGTTTT
CTTTTGACAAATACGGCTTTCCAACCACTATATGGGAAGCTTTCTGATATAACAGGGCGG
AAGTCAGCATTATTAACCGCTCAATTTTTTTTTGGCCTTGGGTGCTTATTAACATGTTTT
GCCAGAAACGTCACGGAATTCTCAATAGCAAGAGCCATATGTGGTATTGGTGCAGGAGGA
TTGAATGCTATTAGTAGCATTGCTGTTAGTGACATATGTACAGCAAGAGAAAGGGGCGTT
TACCAGGGATATGCGAATATTGTTTTCGGGTTTGGTCAATTACTAGGTGCTCCGTTGGGT
GGTGTATTTATAGAAACCATTGGATGGAGGGCTCTTTTTGGTATCCAAGTACCCGTGATA
ATGTTGTGCTCGGTATTAGCAATCAAAAACATTAATATTAAGCTATTCCATGTTCCTCCT
ATGAAAGAAAGATATACCTTAAAGAATCTGTCACGGATAGATATATTTGGCTCATTAAGC
CTGGTGGCGACCATTAGTGGAGTTTTATTTTTGTGCTCTAGCCAGTTGAACAAGTTGTAT
TTAGCATTGTTTACCATTGGTAGCTTTATTGTTTTTATCCTGGTTGAACGTTATTACGCG
ACTGAGAAAATTTTACCATTCGAACTATTGACTCGCTCATTCTGTTTGAGCTCAGCGGTA
ACGGTTATATCTTCATTTGTTGTATTTGGTGAAATCTTTAGGTCACCAATCTATTTACAA
TTGCTTCAAAATATTAGTGTAACAAAGACTGGCCTCTTTTTGATTTTCCCCTCTATATCA
GTTGCAGTCGGATCATTGGTAACAGGATGGGTATTGCGGAATACGAAAATTAACCTAGCA
CACTGTGCATATCAAATCATTTTTGGTGGTATGATAATGCAGCTATTGGGTTTGGGATTG
GGCTATTTCCTACTTTCACACTTGAATCCTGACTACACCATATATGATATGCTTGAGTCT
ATTACATTCAGATCTAACTCAATATGGTGGAAATTGATATATGTGTTTGCATCAGTCCTT
GTGTCCTTTGGTTACGCTTGTCTATTAGTGGCCACGTTAGTAAGCATCGTATTCACCGTC
GAAAAATCACAGCAAGGAACCATGACTGGTGTTTTCTATTTGTGGAGATCCATTGGTAAC
GTTCTTGGTGCCTCTTTAACTTTAGTGTCCTATGAGAATAGCCTGTCGTCCATGTTATGG
AATTATATGTTCAAAACCAAGCGTGATGACGAATATCACTTCACCAAAAAGCAGTACTAC
TCCCTTATCAATGATTCGAGTTACTTGAGAGGGCCCAATTTTCCAACGGATATATTTGTT
CGCATTCTTGATGTCTACAAAAAGGCATTCCTGATTTCCTATATTCCAAATATAGCCCTG
GCAGCAGTGGGAATTGTTTTATCGTTATATCTGGTGAAACATACTTACAAACGTAGTTCA
AGTTCTTGA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 562 |
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| Protein Molecular Weight | 62638.80078 |
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| Protein Theoretical pI | 9.02 |
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| Signalling Regions | |
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| Transmembrane Regions | - 31-51
- 101-121
- 132-152
- 167-187
- 191-211
- 233-253
- 256-276
- 293-313
- 332-352
- 366-386
- 420-440
- 449-469
- 529-549
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| Protein Sequence | >Vacuolar basic amino acid transporter 1
MQTLDETSNLLPPPEEAEAPPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIM
NRVAEEFSESSKKQWIATSFLLTNTAFQPLYGKLSDITGRKSALLTAQFFFGLGCLLTCF
ARNVTEFSIARAICGIGAGGLNAISSIAVSDICTARERGVYQGYANIVFGFGQLLGAPLG
GVFIETIGWRALFGIQVPVIMLCSVLAIKNINIKLFHVPPMKERYTLKNLSRIDIFGSLS
LVATISGVLFLCSSQLNKLYLALFTIGSFIVFILVERYYATEKILPFELLTRSFCLSSAV
TVISSFVVFGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAVGSLVTGWVLRNTKINLA
HCAYQIIFGGMIMQLLGLGLGYFLLSHLNPDYTIYDMLESITFRSNSIWWKLIYVFASVL
VSFGYACLLVATLVSIVFTVEKSQQGTMTGVFYLWRSIGNVLGASLTLVSYENSLSSMLW
NYMFKTKRDDEYHFTKKQYYSLINDSSYLRGPNFPTDIFVRILDVYKKAFLISYIPNIAL
AAVGIVLSLYLVKHTYKRSSSS |
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| References |
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| External Links | |
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| General Reference | - Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
- Shimazu, M., Sekito, T., Akiyama, K., Ohsumi, Y., Kakinuma, Y. (2005). "A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae." J Biol Chem 280:4851-4857.15572352
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
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