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Identification
NametRNA (uracil-O(2)-)-methyltransferase
Synonyms
  • tRNA(M-2-U44)-methyltransferase
Gene NameTRM44
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in methyltransferase activity
Specific FunctiontRNA (uracil-O(2)-)-methyltransferase, which catalyzes the formation of O(2)-methyluracil at position 44 (m2U44) in tRNA(Ser)
Cellular LocationCytoplasm
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00198S-AdenosylhomocysteineShow
YMDB00297S-AdenosylmethionineShow
GO Classification
Component
Not Available
Function
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
Process
Not Available
Gene Properties
Chromosome Locationchromosome 16
LocusYPL030W
Gene Sequence>1704 bp ATGACTGGCGACGGTAGTGCACATATTTCTAAAAACAATCAAAATCAACACAAAGATCGC TTCAAGTTTATTGTGAATGATAAAAGTATTCTAGGACCTCAATGGTTAAGCCTTTACCAA ACGGATGGGAAAGTAACATTCGCAAAGTCCCACTTCGAGCAAGCAATGATGAACGTTATT AGAGAACCAAATATTAACTCTACTGTCATATTAAGAGCGGATATTTTGAAAGAGATCAAT CATGCTGCAGAAGCTGGGTCTGAGCCAAAATTTGACGAGTCCGTATTAAAAAAGTTTGAG ATCGATAATGGTAATGAAAGCGGTGAAGAAGATGTCAAGAAGATAAATATTGAAGATTTA AACATAAGGTCGTGTGAAACATCTGAGAGTTTAAAATTGTCACCCGTTCATGAATTTGTA AGAAGGATCATTCCTAGGAATTTTTACAAAGATGCTATCATAAACCAAACATGTTTAATC CTAAATAGCAAAGACCCTAATTTTCAGGAGACCTCATTGATTGTATATACGCCGCACATT AACTCTGAGAAAGACTGTCCGTTTTATATTCCAAGAACGCAAAGTGTAGGCATTTTGTTA CACCAGTCAGTTCTTTCTGTACACTACATTCCCTTCCCCGAGGATAAAACTGCCTTTACA GATGAATCTGAGCGTGTTGTAAGAACCGCTTATAGGTTATTACAAACTGCTAACAAACAC TCAAAGGGTGTGATGCAGGGTTATGAAAAGAGGGTCAATCACGATCAAGTGGTAAATAAA GTCAATTTTCAGAACACATACATTGTTTTGAAGAAAAAATACTCCAAGTTCCTGGTGGAG AATTGGGCAGAGTCTACAGACCCAAAAAAACATGTTTTTGAAGACATAGCCATTGCCGCT TTCCTGATTGAATTATGGATTAAAGTGTACGGTCCAGACTTCCGTTCAAAAATGCAATTT AGAGATTTGGGATGCGGCAATGGTGCTCTTTGTTATATTTTACTGAGTGAAAGTATTAAA GGTCTCGGCATAGATGCAAGGAAGCGCAAATCGTGGTCTATCTACCCGCCTGAAGTGCAA TCATCGTTAAAGGAGCAAGTTATAATACCTTCTATCCTTTTAAGACCCCATCCTGCTTTG AAAAGACAAGTACCTCATTTGGAACACAATGGGAGATTTTTCCCAGTCAAGGTGACGCAC GAAGTGATTGCCCCCGCAACCGTCGTGTATTCAAGTGAGGACTTACTAAAATCTCCGCAG GTCAATACAGCAGAGTTCCCACCAGATACTTTTATTATAGGTAACCACTCAGATGAGTTG ACTTGCTGGATCCCATTACTAGGTCATCCTTATATGGTTATACCTTGTTGCTCTCATAAT TTTTCTGGCCAGAGAGTTCGTTTTAACGTAAGGAAACGTTCGCCTAGGTCAAATGAAATC AAAAACCAGAATAACAGTAAGAGCACCTACTCTGGTTTGGTTGATCACGTTGAATATATT TCATCTCGTGTAGGCTGGAAAGTAGAGAAAGAGATGTTAAGGATACCAAGCACAAGAAAT GCAGCCATCATAGGTGTAGAAAATGCAACCTTAAAGCATTTTCCAACGCAAGCAGTGTAC GATATGATTTGGGAAGACGGTGGAGCTGAAGGGTGGATTCAGAACACAATGTCCTTATTG AAAAGAAACCCAAGAAACCATTAA
Protein Properties
Pfam Domain Function
Protein Residues567
Protein Molecular Weight64854.60156
Protein Theoretical pI8.79
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>tRNA (uracil-O(2)-)-methyltransferase MTGDGSAHISKNNQNQHKDRFKFIVNDKSILGPQWLSLYQTDGKVTFAKSHFEQAMMNVI REPNINSTVILRADILKEINHAAEAGSEPKFDESVLKKFEIDNGNESGEEDVKKINIEDL NIRSCETSESLKLSPVHEFVRRIIPRNFYKDAIINQTCLILNSKDPNFQETSLIVYTPHI NSEKDCPFYIPRTQSVGILLHQSVLSVHYIPFPEDKTAFTDESERVVRTAYRLLQTANKH SKGVMQGYEKRVNHDQVVNKVNFQNTYIVLKKKYSKFLVENWAESTDPKKHVFEDIAIAA FLIELWIKVYGPDFRSKMQFRDLGCGNGALCYILLSESIKGLGIDARKRKSWSIYPPEVQ SSLKEQVIIPSILLRPHPALKRQVPHLEHNGRFFPVKVTHEVIAPATVVYSSEDLLKSPQ VNTAEFPPDTFIIGNHSDELTCWIPLLGHPYMVIPCCSHNFSGQRVRFNVRKRSPRSNEI KNQNNSKSTYSGLVDHVEYISSRVGWKVEKEMLRIPSTRNAAIIGVENATLKHFPTQAVY DMIWEDGGAEGWIQNTMSLLKRNPRNH
References
External Links
ResourceLink
Saccharomyces Genome Database TRM44
Uniprot IDQ02648
Uniprot NameTRM44_YEAST
GenBank Gene IDU36624
Genebank Protein ID1039447
General Reference
  • Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Li, X., Gerber, S. A., Rudner, A. D., Beausoleil, S. A., Haas, W., Villen, J., Elias, J. E., Gygi, S. P. (2007). "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." J Proteome Res 6:1190-1197.17330950
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
  • Kotelawala, L., Grayhack, E. J., Phizicky, E. M. (2008). "Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species." RNA 14:158-169.18025252