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Identification
NameProbable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TEP1
SynonymsNot Available
Gene NameTEP1
Enzyme Class
Biological Properties
General FunctionInvolved in protein tyrosine/serine/threonine phosphatase activity
Specific FunctionMay act as a phosphoinositide 3-phosphatase by regulating PtdIns(3,4,5)P3 levels
Cellular LocationCytoplasmic
SMPDB Pathways
Inositol phosphate metabolismPW002495 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Inositol phosphate metabolismec00562 Map00562
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00133Phosphatidylinositol 4,5-bisphosphateShow
YMDB00907phosphateShow
GO Classification
Component
Not Available
Function
hydrolase activity
hydrolase activity, acting on ester bonds
phosphoric ester hydrolase activity
phosphatase activity
protein tyrosine phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
catalytic activity
Process
metabolic process
cellular metabolic process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
Gene Properties
Chromosome Locationchromosome 14
LocusYNL128W
Gene Sequence>1305 bp ATGAGAGAGGAGGGGAGTGAATTAGAAATGGAAAAAGGCTTCCTTAAATGGAAACCAGTC AACTTGATGAAGAAAATATTGTCTTTACCAATGAAAAAAACTAAAAACGATATAGGTTTG AGATTAGATATATCATATATTTTAGTTAATCTAATAGTCTGCTCATACCCGGTAAACACG TATCCAAAACTGCTTTATAGGAATAGCTTGGATGACTTAATATTGTTTCTAACAGTGTAC CATGGCAAGGGAAATTTTAGAATTTTTAATTTTAGAGGTGAGAAAGAAGACAGCGATTAT AAAGATAATGATCTTATTGGTATCGCTGCCAAGTTTGAGAGCAAAGATTTTGAAATTCAA GAATTACGTTCGACGCTGATTAATGATGGAAAGATACCAATATCACCCATTGATCTCGAA ACAAGGACCTTGGTCGAAGAAGAAACCAATAATGTAATTTGTGAAAGGATCGGTTGGCTA GATCATTTTCCACCGCCATTTGAACTGCTGGAAGAGATTGTAGATGGTATAGAAAATTAC CTGTCCGTTTCGAAGAATAGAGTGGCTGTTTTACATTGTCGAATGGGGAAAGGCCGATCT GGTATGATAACAGTAGCATACCTCATGAAATACTTGCAGTGTCCTCTTGGAGAAGCAAGA TTGATATTCATGCAGGCTAGATTCAAGTATGGTATGACGAATGGCGTCACCATACCCTCT CAATTAAGATACTTAAGGTACCATGAGTTTTTTATTACCCATGAAAAAGCAGCCCAAGAA GGAATTTCTAATGAGGCGGTAAAATTCAAATTTAAATTCAGGCTTGCTAAAATGACGTTC CTCCGCCCATCAAGCTTAATCACTTCCGAGTCTGCTATTGTAACTACTAAGATTCAACAC TACAACGATGATAGAAATGCCCTCCTAACCCGAAAAGTAGTATATTCAGATATCATGGCG CATGAATGCGGTGGTAATATGACCTTCATTTTTGGTAGGGACTACTTAACACTGGAAAAT GATTGTCGTATAGAATTTACCCTGGGGACCAGCAAGTCCAAAGCCGCCAGTAGCATAATA TCTTGGACTTCATGCGCCAGCTGTTGGCTGAATATATACCTTGAGACTTTGATGCACATA ATTAAAGACGATTCTTCGCCAGATTACTTTCAAGTAGAGAGGTTAAAGAGAGACGAAATG CTTGGAACAACCATAAGCTGGCAAGAGCTGGACGGTTTTGGGGAGCTCAGCACTCACGGC TTGAAATTATTTCAGGCACTGAAATTGGAATGGGAAATTATATAG
Protein Properties
Pfam Domain Function
Protein Residues434
Protein Molecular Weight50151.5
Protein Theoretical pI6.79
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Probable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TEP1 MREEGSELEMEKGFLKWKPVNLMKKILSLPMKKTKNDIGLRLDISYILVNLIVCSYPVNT YPKLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGIAAKFESKDFEIQ ELRSTLINDGKIPISPIDLETRTLVEEETNNVICERIGWLDHFPPPFELLEEIVDGIENY LSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKYGMTNGVTIPS QLRYLRYHEFFITHEKAAQEGISNEAVKFKFKFRLAKMTFLRPSSLITSESAIVTTKIQH YNDDRNALLTRKVVYSDIMAHECGGNMTFIFGRDYLTLENDCRIEFTLGTSKSKAASSII SWTSCASCWLNIYLETLMHIIKDDSSPDYFQVERLKRDEMLGTTISWQELDGFGELSTHG LKLFQALKLEWEII
References
External Links
ResourceLink
Saccharomyces Genome Database TEP1
Uniprot IDP53916
Uniprot NameTEP1_YEAST
GenBank Gene IDZ46843
Genebank Protein ID854509
General Reference
  • Mallet, L., Bussereau, F., Jacquet, M. (1995). "A 43.5 kb segment of yeast chromosome XIV, which contains MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1, predicts an adenosine deaminase gene and 14 new open reading frames." Yeast 11:1195-1209.8619318
  • Philippsen, P., Kleine, K., Pohlmann, R., Dusterhoft, A., Hamberg, K., Hegemann, J. H., Obermaier, B., Urrestarazu, L. A., Aert, R., Albermann, K., Altmann, R., Andre, B., Baladron, V., Ballesta, J. P., Becam, A. M., Beinhauer, J., Boskovic, J., Buitrago, M. J., Bussereau, F., Coster, F., Crouzet, M., D'Angelo, M., Dal Pero, F., De Antoni, A., Del Rey, F., Doignon, F., Domdey, H., Dubois, E., Fiedler, T., Fleig, U., Floeth, M., Fritz, C., Gaillardin, C., Garcia-Cantalejo, J. M., Glansdorff, N. N., Goffeau, A., Gueldener, U., Herbert, C., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hinni, K., Iraqui Houssaini, I., Jacquet, M., Jimenez, A., Jonniaux, J. L., Karpfinger, L., Lanfranchi, G., Lepingle, A., Levesque, H., Lyck, R., Maftahi, M., Mallet, L., Maurer, K. C., Messenguy, F., Mewes, H. W., Mosti, D., Nasr, F., Nicaud, J. M., Niedenthal, R. K., Pandolfo, D., Pierard, A., Piravandi, E., Planta, R. J., Pohl, T. M., Purnelle, B., Rebischung, C., Remacha, M., Revuelta, J. L., Rinke, M., Saiz, J. E., Sartorello, F., Scherens, B., Sen-Gupta, M., Soler-Mira, A., Urbanus, J. H., Valle, G., Van Dyck, L., Verhasselt, P., Vierendeels, F., Vissers, S., Voet, M., Volckaert, G., Wach, A., Wambutt, R., Wedler, H., Zollner, A., Hani, J. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Nature 387:93-98.9169873
  • Heymont, J., Berenfeld, L., Collins, J., Kaganovich, A., Maynes, B., Moulin, A., Ratskovskaya, I., Poon, P. P., Johnston, G. C., Kamenetsky, M., DeSilva, J., Sun, H., Petsko, G. A., Engebrecht, J. (2000). "TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation." Proc Natl Acad Sci U S A 97:12672-12677.11070083