NAD-dependent histone deacetylase HST4 (P53688)

Identification
NameNAD-dependent histone deacetylase HST4
Synonyms
  • Homologous to SIR2 protein 4
Gene NameHST4
Enzyme ClassNot Available
Biological Properties
General FunctionTranscription
Specific FunctionNAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance
Cellular LocationNucleus
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
NAD + water ↔ hydron + Niacinamide + Adenosine diphosphate ribose
Metabolites
YMDB IDNameView
GO Classification
Function
metal ion binding
transition metal ion binding
zinc ion binding
catalytic activity
NAD binding
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
nucleotide binding
NAD or NADH binding
hydrolase activity
binding
ion binding
cation binding
Process
regulation of transcription
cellular process
gene silencing
chromatin silencing
macromolecule metabolic process
macromolecule modification
protein modification process
post-translational protein modification
protein amino acid deacetylation
biological regulation
regulation of biological process
metabolic process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1113 bp ATGAAGCAAAAATTTGTACTACCGATCACCCCACCAAGTACGGCGGAAAAGAAGCCTCAA ACAGAAAACCGTTGCAATGAGAATTTGAAGCCTAGAAGATTGCTACCGCAATTGAAAAAA AGTGTCCGTAACAGGAAACCTAGACTGTCATATAGGCCTGAGTTAAACTCTGTGTTTGAT CTGGATGCGTACGTGGATTCGACACACTTGTCCAAATCCCAACGCCATCATATGGACCGC GACGCCGGTTTTATTAGCTATGCTCTGAATTATAGCAAAAGAATGGTTGTAGTCAGCGGG GCAGGTATATCTGTTGCCGCTGGTATACCGGATTTTAGATCCAGTGAAGGGATTTTCTCT ACTGTGAACGGCGGCTCTGGGAAAGATTTGTTTGACTACAATCGTGTGTATGGCGACGAA TCAATGAGTTTGAAATTTAATCAGTTAATGGTGTCATTGTTCAGATTATCCAAGAATTGC CAACCTACAAAATTTCATGAAATGCTCAATGAGTTTGCTAGGGATGGCAGGCTATTGAGA CTGTACACGCAGAATATTGACGGTTTAGATACACAATTACCTCATTTATCAACTAATGTG CCTCTGGCGAAGCCAATACCCAGTACAGTACAATTACACGGAAGCATAAAACACATGGAA TGCAATAAATGTCTGAATATCAAACCTTTTGACCCTGAACTGTTCAAATGCGACGACAAA TTTGATTCTCGGACTGAAATCATACCGTCATGTCCACAATGTGAAGAATATGAAACAGTT AGAAAAATGGCAGGCTTAAGATCTACTGGTGTGGGCAAGTTGCGTCCAAGAGTAATTTTA TACAATGAGGTCCACCCTGAAGGTGATTTTATCGGTGAAATTGCCAATAATGACTTAAAG AAAAGAATTGATTGTTTGATTATTGTTGGAACGAGTTTGAAGATTCCCGGAGTGAAAAAT ATTTGCAGGCAGTTTGCGGCCAAAGTCCATGCAAACAGGGGTATTGTGTTATATTTAAAC ACCAGTATGCCGCCTAAGAATGTGCTAGACTCTTTGAAATTTGTAGACCTAGTTGTACTG GGAGATTGTCAGCATGTTACCTCATTATTATAG
Protein Properties
Pfam Domain Function
Protein Residues370
Protein Molecular Weight41764.89844
Protein Theoretical pI9.57
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>NAD-dependent histone deacetylase HST4 MKQKFVLPITPPSTAEKKPQTENRCNENLKPRRLLPQLKKSVRNRKPRLSYRPELNSVFD LDAYVDSTHLSKSQRHHMDRDAGFISYALNYSKRMVVVSGAGISVAAGIPDFRSSEGIFS TVNGGSGKDLFDYNRVYGDESMSLKFNQLMVSLFRLSKNCQPTKFHEMLNEFARDGRLLR LYTQNIDGLDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKPFDPELFKCDDK FDSRTEIIPSCPQCEEYETVRKMAGLRSTGVGKLRPRVILYNEVHPEGDFIGEIANNDLK KRIDCLIIVGTSLKIPGVKNICRQFAAKVHANRGIVLYLNTSMPPKNVLDSLKFVDLVVL GDCQHVTSLL
References
External Links
ResourceLink
Saccharomyces Genome Database HST4
Uniprot IDP53688
Uniprot NameHST4_YEAST
GenBank Gene IDAY557699
Genebank Protein ID45269291
General Reference
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Derbyshire, M. K., Weinstock, K. G., Strathern, J. N. (1996). "HST1, a new member of the SIR2 family of genes." Yeast 12:631-640.8810037
  • Brachmann, C. B., Sherman, J. M., Devine, S. E., Cameron, E. E., Pillus, L., Boeke, J. D. (1995). "The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability." Genes Dev 9:2888-2902.7498786
  • Smith, J. S., Brachmann, C. B., Celic, I., Kenna, M. A., Muhammad, S., Starai, V. J., Avalos, J. L., Escalante-Semerena, J. C., Grubmeyer, C., Wolberger, C., Boeke, J. D. (2000). "A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family." Proc Natl Acad Sci U S A 97:6658-6663.10841563
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Pan, X., Ye, P., Yuan, D. S., Wang, X., Bader, J. S., Boeke, J. D. (2006). "A DNA integrity network in the yeast Saccharomyces cerevisiae." Cell 124:1069-1081.16487579
  • Miller, K. M., Maas, N. L., Toczyski, D. P. (2006). "Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4." Cell Cycle 5:2561-2565.17106263
  • Celic, I., Masumoto, H., Griffith, W. P., Meluh, P., Cotter, R. J., Boeke, J. D., Verreault, A. (2006). "The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation." Curr Biol 16:1280-1289.16815704