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Identification
NameSuccinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial
Synonyms
  • Succinyl-CoA synthetase subunit alpha
  • SCS-alpha
Gene NameLSC1
Enzyme Class
Biological Properties
General FunctionInvolved in catalytic activity
Specific FunctionATP + succinate + CoA = ADP + phosphate + succinyl-CoA
Cellular LocationMitochondrion
SMPDB Pathways
Citric Acid Cycle 1434561204PW000970 ThumbThumb?image type=greyscaleThumb?image type=simple
TCA CyclePW002377 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Citrate cycle (TCA cycle)ec00020 Map00020
Propanoate metabolismec00640 Map00640
SMPDB Reactions
Succinyl-CoA + phosphate + Guanosine diphosphateSuccinic acid + Coenzyme A + GTP
Adenosine triphosphate + itaconic acid + Coenzyme AADP + phosphate + itaconyl-CoA
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00045Coenzyme AShow
YMDB00109Adenosine triphosphateShow
YMDB00257Guanosine diphosphateShow
YMDB00338Succinic acidShow
YMDB00514Succinyl-CoAShow
YMDB00558GTPShow
YMDB00716itaconic acidShow
YMDB00717itaconyl-CoAShow
YMDB00907phosphateShow
YMDB00914ADPShow
GO Classification
Component
Not Available
Function
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
ligase activity, forming carbon-sulfur bonds
CoA-ligase activity
succinate-CoA ligase activity
succinate-CoA ligase (ADP-forming) activity
ATP citrate synthase activity
catalytic activity
transferase activity
ligase activity
binding
transferase activity, transferring acyl groups
Process
metabolic process
Gene Properties
Chromosome Locationchromosome 15
LocusYOR142W
Gene Sequence>990 bp ATGTTAAGATCTACCGTTTCAAAAGCTTCTCTCAAAATTTGTCGTCACTTTCACAGAGAA TCTATTCCTTACGATAAGACGATCAAAAATTTGCTGCTTCCCAAGGACACCAAGGTGATC TTTCAGGGGTTCACAGGTAAACAAGGTACTTTTCATGCCAGCATCTCTCAAGAATATGGT ACAAATGTTGTGGGTGGTACGAACCCAAAAAAGGCGGGTCAAACACATTTAGGCCAACCT GTCTTTGCCTCTGTGAAGGACGCGATTAAGGAGACTGGAGCCACTGCCAGTGCCATCTTT GTTCCTCCACCGATCGCAGCTGCTGCCATTAAAGAATCTATTGAAGCTGAAATTCCGTTA GCTGTATGTATCACTGAAGGTATTCCTCAACATGACATGTTATACATTGCAGAAATGTTG CAGACACAAGATAAAACAAGATTAGTTGGGCCCAACTGCCCTGGTATCATTAACCCAGCA ACAAAGGTAAGAATTGGTATCCAGCCCCCAAAAATTTTTCAAGCTGGTAAAATCGGTATT ATTTCCAGATCGGGAACTTTGACATACGAAGCTGTTCAGCAAACTACAAAAACTGACCTT GGTCAATCACTGGTTATTGGTATGGGTGGTGATGCTTTTCCCGGTACTGATTTTATTGAC GCCTTGAAATTATTTCTAGAAGATGAAACTACAGAAGGTATTATTATGTTAGGTGAAATA GGTGGTAAGGCCGAAATCGAAGCTGCTCAATTTCTCAAAGAATACAACTTTAGCAGGAGT AAGCCGATGCCGGTGGCATCTTTCATCGCAGGAACTGTTGCTGGTCAAATGAAAGGTGTT AGAATGGGTCACTCCGGTGCAATTGTAGAAGGATCTGGAACTGATGCAGAATCCAAAAAA CAAGCTTTGAGAGATGTTGGTGTTGCCGTCGTTGAATCTCCAGGTTACTTAGGTCAAGCT TTACTGGATCAATTTGCCAAATTTAAATGA
Protein Properties
Pfam Domain Function
Protein Residues329
Protein Molecular Weight35032.19922
Protein Theoretical pI8.76
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial MLRSTVSKASLKICRHFHRESIPYDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYG TNVVGGTNPKKAGQTHLGQPVFASVKDAIKETGATASAIFVPPPIAAAAIKESIEAEIPL AVCITEGIPQHDMLYIAEMLQTQDKTRLVGPNCPGIINPATKVRIGIQPPKIFQAGKIGI ISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAFPGTDFIDALKLFLEDETTEGIIMLGEI GGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMKGVRMGHSGAIVEGSGTDAESKK QALRDVGVAVVESPGYLGQALLDQFAKFK
References
External Links
ResourceLink
Saccharomyces Genome Database LSC1
Uniprot IDP53598
Uniprot NameSUCA_YEAST
GenBank Gene IDX94335
Genebank Protein ID1164984
General Reference
  • Voss, H., Benes, V., Andrade, M. A., Valencia, A., Rechmann, S., Teodoru, C., Schwager, C., Paces, V., Sander, C., Ansorge, W. (1997). "DNA sequencing and analysis of 130 kb from yeast chromosome XV." Yeast 13:655-672.9200815
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • Przybyla-Zawislak, B., Dennis, R. A., Zakharkin, S. O., McCammon, M. T. (1998). "Genes of succinyl-CoA ligase from Saccharomyces cerevisiae." Eur J Biochem 258:736-743.9874242
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Peng, J., Schwartz, D., Elias, J. E., Thoreen, C. C., Cheng, D., Marsischky, G., Roelofs, J., Finley, D., Gygi, S. P. (2003). "A proteomics approach to understanding protein ubiquitination." Nat Biotechnol 21:921-926.12872131
  • Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H. E., Schonfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., Meisinger, C. (2003). "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A 100:13207-13212.14576278
  • Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956