General alpha-glucoside permease (P53048)

Identification
NameGeneral alpha-glucoside permease
Synonyms
  • Maltose permease MAL11
  • Maltose transport protein MAL11
Gene NameMAL11
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in transmembrane transporter activity
Specific FunctionHigh-affinity uptake of alpha-glucosides such as maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose, melezitose and glucose. Acts with the concomitant transport of protons into the cell (symport system)
Cellular LocationMembrane; Multi-pass membrane protein
SMPDB Pathways
Glycolysis IPW002386 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00584MaltoseShow
YMDB00862hydronShow
GO Classification
Component
integral to membrane
cell part
membrane
membrane part
intrinsic to membrane
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
Process
transmembrane transport
establishment of localization
transport
Gene Properties
Chromosome Locationchromosome 7
LocusYGR289C
Gene Sequence>1851 bp ATGAAAAATATCATTTCATTGGTAAGCAAGAAGAAGGCTGCCTCAAAAAATGAGGATAAA AACATTTCTGAGTCTTCAAGAGATATTGTAAACCAACAGGAGGTTTTCAATACTGAAGAT TTTGAAGAAGGGAAAAAGGATAGTGCCTTTGAGCTAGACCACTTAGAGTTCACCACCAAT TCAGCCCAGTTAGGAGATTCTGACGAAGATAACGAGAATGTGATTAATGAGATGAACGCT ACTGATGATGCAAATGAAGCTAACAGCGAGGAAAAAAGCATGACTTTGAAGCAGGCGTTG CTAAAATATCCAAAAGCAGCCCTGTGGTCCATATTAGTGTCTACTACCCTGGTTATGGAA GGTTATGATACCGCACTACTGAGCGCACTGTATGCCCTGCCAGTTTTTCAGAGAAAATTC GGTACTTTGAACGGGGAGGGTTCTTACGAAATTACTTCCCAATGGCAGATTGGTTTAAAC ATGTGTGTCCTTTGTGGTGAGATGATTGGTTTGCAAATCACGACTTATATGGTTGAATTT ATGGGGAATCGTTATACGATGATTACAGCACTTGGTTTGTTAACTGCTTATATCTTTATC CTCTACTACTGTAAAAGTTTAGCTATGATTGCTGTGGGACAAATTCTCTCAGCTATACCA TGGGGTTGTTTCCAAAGTTTGGCTGTTACTTATGCTTCGGAAGTTTGCCCTTTAGCATTA AGATATTACATGACCAGTTACTCCAACATTTGTTGGTTATTTGGTCAAATCTTCGCCTCT GGTATTATGAAAAACTCACAAGAGAATTTAGGGAACTCCGACTTGGGCTATAAATTGCCA TTTGCTTTACAATGGATTTGGCCTGCTCCTTTAATGATCGGTATCTTTTTCGCTCCTGAG TCGCCCTGGTGGTTGGTGAGAAAGGATAGGGTCGCTGAGGCAAGAAAATCTTTAAGCAGA ATTTTGAGTGGTAAAGGCGCCGAGAAGGACATTCAAGTTGATCTTACTTTAAAGCAGATT GAATTGACTATTGAAAAAGAAAGACTTTTAGCATCTAAATCAGGATCATTCTTTAATTGT TTCAAGGGAGTTAATGGAAGAAGAACGAGACTTGCATGTTTAACTTGGGTAGCTCAAAAT AGTAGCGGTGCCGTTTTACTTGGTTACTCGACATATTTTTTTGAAAGAGCAGGTATGGCC ACCGACAAGGCGTTTACTTTTTCTCTAATTCAGTACTGTCTTGGGTTAGCGGGTACACTT TGCTCCTGGGTAATATCTGGCCGTGTTGGTAGATGGACAATACTGACCTATGGTCTTGCA TTTCAAATGGTCTGCTTATTTATTATTGGTGGAATGGGTTTTGGTTCTGGAAGCAGCGCT AGTAATGGTGCCGGTGGTTTATTGCTGGCTTTATCATTCTTTTACAATGCTGGTATCGGT GCAGTTGTTTACTGTATCGTTGCTGAAATTCCATCAGCGGAGTTGAGAACTAAGACTATA GTGCTGGCCCGTATTTGCTACAATCTCATGGCCGTTATTAACGCTATATTAACGCCCTAT ATGCTAAACGTGAGCGATTGGAACTGGGGTGCCAAAACTGGTCTATACTGGGGTGGTTTC ACAGCAGTCACTTTAGCTTGGGTCATCATCGATCTGCCTGAGACAACTGGTAGAACCTTC AGTGAAATTAATGAACTTTTCAACCAAGGGGTTCCTGCCAGAAAATTTGCATCTACTGTG GTTGATCCATTCGGAAAGGGAAAAACTCAACATGATTCGCTAGCTGATGAGAGTATCAGT CAGTCCTCAAGCATAAAACAGCGAGAATTAAATGCAGCTGATAAATGTTAA
Protein Properties
Pfam Domain Function
Protein Residues616
Protein Molecular Weight67979.60156
Protein Theoretical pI5.27
Signalling Regions
  • None
Transmembrane Regions
  • 116-136
  • 151-171
  • 187-207
  • 209-229
  • 243-263
  • 279-299
  • 371-391
  • 405-425
  • 434-454
  • 467-487
  • 500-520
  • 533-553
Protein Sequence>General alpha-glucoside permease MKNIISLVSKKKAASKNEDKNISESSRDIVNQQEVFNTEDFEEGKKDSAFELDHLEFTTN SAQLGDSDEDNENVINEMNATDDANEANSEEKSMTLKQALLKYPKAALWSILVSTTLVME GYDTALLSALYALPVFQRKFGTLNGEGSYEITSQWQIGLNMCVLCGEMIGLQITTYMVEF MGNRYTMITALGLLTAYIFILYYCKSLAMIAVGQILSAIPWGCFQSLAVTYASEVCPLAL RYYMTSYSNICWLFGQIFASGIMKNSQENLGNSDLGYKLPFALQWIWPAPLMIGIFFAPE SPWWLVRKDRVAEARKSLSRILSGKGAEKDIQVDLTLKQIELTIEKERLLASKSGSFFNC FKGVNGRRTRLACLTWVAQNSSGAVLLGYSTYFFERAGMATDKAFTFSLIQYCLGLAGTL CSWVISGRVGRWTILTYGLAFQMVCLFIIGGMGFGSGSSASNGAGGLLLALSFFYNAGIG AVVYCIVAEIPSAELRTKTIVLARICYNLMAVINAILTPYMLNVSDWNWGAKTGLYWGGF TAVTLAWVIIDLPETTGRTFSEINELFNQGVPARKFASTVVDPFGKGKTQHDSLADESIS QSSSIKQRELNAADKC
References
External Links
ResourceLink
Saccharomyces Genome Database MAL11
Uniprot IDP53048
Uniprot NameMAL11_YEAST
GenBank Gene IDZ73074
Genebank Protein ID1323529
General Reference
  • Han, E. K., Cotty, F., Sottas, C., Jiang, H., Michels, C. A. (1995). "Characterization of AGT1 encoding a general alpha-glucoside transporter from Saccharomyces." Mol Microbiol 17:1093-1107.8594329
  • Volckaert, G., Voet, M., Robben, J. (1997). "Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2 genes and an ABC transporter gene." Yeast 13:251-259.9090054
  • Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
  • Wieczorke, R., Krampe, S., Weierstall, T., Freidel, K., Hollenberg, C. P., Boles, E. (1999). "Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae." FEBS Lett 464:123-128.10618490
  • Day, R. E., Higgins, V. J., Rogers, P. J., Dawes, I. W. (2002). "Characterization of the putative maltose transporters encoded by YDL247w and YJR160c." Yeast 19:1015-1027.12210897
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258