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Identification
NameDolichyl-phosphate-mannose--protein mannosyltransferase 4
SynonymsNot Available
Gene NamePMT4
Enzyme Class
Biological Properties
General FunctionInvolved in mannosyltransferase activity
Specific FunctionTransfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Seems to be active on GAS1
Cellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG Pathways
O-Mannosyl glycan biosynthesisec00514 Map00514
SMPDB ReactionsNot Available
KEGG Reactions
dolichyl D-mannosyl phosphatedolichyl phosphate + hydron + mannan
Metabolites
YMDB IDNameView
YMDB00937dolichyl D-mannosyl phosphateShow
GO Classification
Component
cell part
membrane
Function
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
mannosyltransferase activity
Process
protein amino acid O-linked glycosylation
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation
Gene Properties
Chromosome Locationchromosome 10
LocusYJR143C
Gene Sequence>2289 bp ATGTCTGTGCCCAAAAAACGTAACCATGGGAAGTTACCACCTTCCACTAAGGACGTAGAC GATCCTTCGTTGAAGTACACGAAGGCCGCGCCTAAATGTGAACAAGTTGCTGAACATTGG CTCTTGCAGCCACTACCGGAACCGGAATCACGTTATAGCTTTTGGGTAACAATTGTTACC TTATTAGCGTTTGCTGCTAGATTTTATAAGATCTGGTATCCAAAAGAAGTTGTTTTTGAT GAGGTACATTTCGGGAAATTTGCATCGTATTACTTAGAAAGGTCTTATTTCTTTGACGTT CATCCCCCTTTTGCTAAGATGATGATTGCCTTCATTGGTTGGTTATGTGGCTATGATGGT TCCTTTAAGTTTGATGAGATTGGGTATTCTTATGAAACTCATCCAGCTCCATATATCGCG TACCGTTCTTTCAACGCGATATTGGGCACATTGACTGTACCAATTATGTTCAACACTTTG AAGGAACTGAATTTCAGGGCTATTACATGTGCGTTTGCATCTCTCTTGGTTGCAATCGAT ACTGCGCATGTTACAGAAACTAGGCTGATTTTACTGGATGCCATCTTGATTATTTCTATT GCTGCTACTATGTATTGTTACGTTCGTTTCTACAAGTGCCAATTGCGTCAACCTTTTACA TGGAGTTGGTATATTTGGTTACACGCTACTGGTTTGTCTTTATCCTTCGTGATTTCCACA AAATATGTTGGTGTTATGACATATTCCGCTATTGGTTTTGCTGCTGTGGTCAACTTATGG CAATTACTGGACATCAAGGCGGGTTTGTCCTTGAGGCAGTTCATGAGACATTTTAGTAAA AGGCTGAATGGTTTAGTTTTGATTCCATTTGTGATTTACTTGTTTTGGTTCTGGGTTCAT TTCACCGTTTTGAATACTTCAGGTCCTGGCGACGCATTTATGTCTGCTGAATTTCAAGAA ACACTTAAGGACTCTCCCTTAAGTGTTGACTCTAAAACCGTCAATTATTTTGATATTATC ACTATCAAACATCAAGATACTGACGCATTCTTACATTCTCACTTGGCACGTTACCCACAA CGGTATGAAGATGGTCGTATCTCATCCGCTGGTCAACAAGTTACTGGTTACACGCATCCT GACTTCAACAATCAATGGGAAGTGTTACCACCCCATGGCAGTGATGTCGGTAAAGGACAA GCTGTTCTATTGAACCAGCATATAAGATTGAGACATGTAGCCACCGATACCTACTTGTTA GCCCATGATGTCGCCTCCCCATTTTACCCTACCAATGAAGAAATCACTACAGTAACTTTA GAAGAAGGTGATGGGGAATTATATCCTGAAACACTTTTTGCATTCCAACCACTGAAAAAA TCAGATGAAGGTCACGTTTTAAAGAGTAAAACGGTTTCTTTCCGTCTTTTCCACGTTGAT ACCTCCGTAGCTTTGTGGACTCACAACGACGAGTTGTTACCGGATTGGGGGTTCCAACAA CAAGAAATTAATGGTAACAAAAAAGTTATTGATCCTTCAAATAACTGGGTTGTTGATGAA ATTGTTAACCTGGACGAGGTTCGGAAGGTATATATTCCGAAGGTTGTTAAGCCATTACCA TTCTTGAAGAAATGGATTGAAACTCAAAAATCTATGTTCGAACATAACAATAAACTATCA TCAGAGCATCCATTTGCCTCTGAACCTTACAGTTGGCCCGGTAGTTTAAGTGGTGTTTCG TTCTGGACCAACGGTGACGAAAAGAAGCAAATATATTTCATTGGTAACATCATTGGGTGG TGGTTCCAAGTCATATCATTGGCTGTTTTTGTTGGCATTATCGTGGCCGATTTAATTACT AGACATCGTGGCTATTATGCCCTAAACAAGATGACCAGAGAAAAGCTGTATGGCCCATTG ATGTTTTTCTTCGTCTCCTGGTGCTGTCATTATTTTCCATTCTTTTTAATGGCGCGTCAA AAGTTTTTGCATCATTACTTACCAGCTCATTTAATCGCGTGCTTATTCTCAGGAGCACTA TGGGAAGTAATTTTCAGTGATTGCAAATCATTGGATTTGGAGAAAGACGAGGATATTTCA GGTGCATCATATGAACGGAACCCTAAGGTCTACGTTAAACCCTATACCGTCTTCTTGGTG TGTGTCTCCTGTGCTGTTGCGTGGTTTTTTGTATACTTTTCACCACTAGTGTATGGAGAT GTCAGCTTGTCACCATCGGAAGTTGTTTCTAGAGAGTGGTTTGACATAGAATTAAATTTC TCCAAGTAA
Protein Properties
Pfam Domain Function
Protein Residues762
Protein Molecular Weight87965.5
Protein Theoretical pI6.93
Signalling Regions
  • None
Transmembrane Regions
  • 54-74
  • 137-157
  • 167-187
  • 190-210
  • 218-238
  • 243-263
  • 284-304
  • 594-614
  • 636-656
  • 717-737
Protein Sequence>Dolichyl-phosphate-mannose--protein mannosyltransferase 4 MSVPKKRNHGKLPPSTKDVDDPSLKYTKAAPKCEQVAEHWLLQPLPEPESRYSFWVTIVT LLAFAARFYKIWYPKEVVFDEVHFGKFASYYLERSYFFDVHPPFAKMMIAFIGWLCGYDG SFKFDEIGYSYETHPAPYIAYRSFNAILGTLTVPIMFNTLKELNFRAITCAFASLLVAID TAHVTETRLILLDAILIISIAATMYCYVRFYKCQLRQPFTWSWYIWLHATGLSLSFVIST KYVGVMTYSAIGFAAVVNLWQLLDIKAGLSLRQFMRHFSKRLNGLVLIPFVIYLFWFWVH FTVLNTSGPGDAFMSAEFQETLKDSPLSVDSKTVNYFDIITIKHQDTDAFLHSHLARYPQ RYEDGRISSAGQQVTGYTHPDFNNQWEVLPPHGSDVGKGQAVLLNQHIRLRHVATDTYLL AHDVASPFYPTNEEITTVTLEEGDGELYPETLFAFQPLKKSDEGHVLKSKTVSFRLFHVD TSVALWTHNDELLPDWGFQQQEINGNKKVIDPSNNWVVDEIVNLDEVRKVYIPKVVKPLP FLKKWIETQKSMFEHNNKLSSEHPFASEPYSWPGSLSGVSFWTNGDEKKQIYFIGNIIGW WFQVISLAVFVGIIVADLITRHRGYYALNKMTREKLYGPLMFFFVSWCCHYFPFFLMARQ KFLHHYLPAHLIACLFSGALWEVIFSDCKSLDLEKDEDISGASYERNPKVYVKPYTVFLV CVSCAVAWFFVYFSPLVYGDVSLSPSEVVSREWFDIELNFSK
References
External Links
ResourceLink
Saccharomyces Genome Database PMT4
Uniprot IDP46971
Uniprot NamePMT4_YEAST
GenBank Gene IDX83798
Genebank Protein ID633654
General Reference
  • Immervoll, T., Gentzsch, M., Tanner, W. (1995). "PMT3 and PMT4, two new members of the protein-O-mannosyltransferase gene family of Saccharomyces cerevisiae." Yeast 11:1345-1351.8585318
  • Galibert, F., Alexandraki, D., Baur, A., Boles, E., Chalwatzis, N., Chuat, J. C., Coster, F., Cziepluch, C., De Haan, M., Domdey, H., Durand, P., Entian, K. D., Gatius, M., Goffeau, A., Grivell, L. A., Hennemann, A., Herbert, C. J., Heumann, K., Hilger, F., Hollenberg, C. P., Huang, M. E., Jacq, C., Jauniaux, J. C., Katsoulou, C., Karpfinger-Hartl, L., et, a. l. .. (1996). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." EMBO J 15:2031-2049.8641269
  • Gentzsch, M., Tanner, W. (1996). "The PMT gene family: protein O-glycosylation in Saccharomyces cerevisiae is vital." EMBO J 15:5752-5759.8918452
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
  • Imai, K., Noda, Y., Adachi, H., Yoda, K. (2007). "Peculiar protein-protein interactions of the novel endoplasmic reticulum membrane protein Rcr1 and ubiquitin ligase Rsp5." Biosci Biotechnol Biochem 71:249-252.17213653