Ras modification protein ERF4 (P41912)

Identification
NameRas modification protein ERF4
Synonyms
  • Hyperactive Ras suppressor protein 5
Gene NameSHR5
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in protein binding
Specific FunctionThe ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization
Cellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO ClassificationNot Available
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>714 bp ATGTGCGATAGCCATCAAAAGGAAGAAGATAACGCAAATACGAGCGAAAGGGCGTTATTT TTTAATTACCATGAGTTTTCGTATTCATTCTACGAAGACCTCGGTTCCGAAGACGCTAAA CCCACAGAGCACGACGAAGACCACAAATTGTGTATTACACATTTCCCGAATGTGTATGCT GCTCGGGGCTCTGCCGAGTTCCAGGTGACCCGGGTGGTACGAGTGCCCCGGCGGTTCGAT GAGTCTCGCAGCAGCCTTGAAACGCCACAATTTAGTACACAGCTTCCCGGTAGCGAGCCG GCGGCAATCGTGGGCGACGATGGCACTAGCTTTGTGCGGTGCGGGCGTTACGACATTGGG GATCACGTGTTTGGCTGCTCCTCCGTCTCGCCTCTGTCAGAATATCTTAGTGCGGCAGAG CTCGCGGAGGTTGTGCACCGGGTAAACGGATTCTTGCTGCGTGAAGAAGGTGAGGTGTTC GGGTGGCGTAACTTAAGTGGCCTGTTGCTCGATATGCTTACGGGCGGTCTGTGGAGCTGG GTTTTGGGGCCCCTTCTTTCTAGACCTGTGTTTCAGGAGTCTCTCGCGTTAGAGCAGTAC GTGGCGCAGCTAAACTCGCCGGGAGGTCTGCTTCACGAGCGCGGTGTGCGCCTAGTATTG CCCCGACGGTCCGGGTGCCTATCCCTAGATTTCGTCGTGCCCCGACCCAAATAG
Protein Properties
Pfam Domain Function
Protein Residues237
Protein Molecular Weight26541.40039
Protein Theoretical pI4.89
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Ras modification protein ERF4 MCDSHQKEEDNANTSERALFFNYHEFSYSFYEDLGSEDAKPTEHDEDHKLCITHFPNVYA ARGSAEFQVTRVVRVPRRFDESRSSLETPQFSTQLPGSEPAAIVGDDGTSFVRCGRYDIG DHVFGCSSVSPLSEYLSAAELAEVVHRVNGFLLREEGEVFGWRNLSGLLLDMLTGGLWSW VLGPLLSRPVFQESLALEQYVAQLNSPGGLLHERGVRLVLPRRSGCLSLDFVVPRPK
References
External Links
ResourceLink
Saccharomyces Genome Database SHR5
Uniprot IDP41912
Uniprot NameERFD_YEAST
GenBank Gene IDU18313
Genebank Protein ID604431
General Reference
  • Jung, V., Chen, L., Hofmann, S. L., Wigler, M., Powers, S. (1995). "Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins." Mol Cell Biol 15:1333-1342.7532279
  • Vandenbol, M., Durand, P., Portetelle, D., Hilger, F. (1995). "Sequence analysis of a 44 kb DNA fragment of yeast chromosome XV including the Tyl-H3 retrotransposon, the suf1(+) frameshift suppressor gene for tRNA-Gly, the yeast transfer RNA-Thr-1a and a delta element." Yeast 11:1069-1075.7502582
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • Lobo, S., Greentree, W. K., Linder, M. E., Deschenes, R. J. (2002). "Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae." J Biol Chem 277:41268-41273.12193598
  • Zhao, L., Lobo, S., Dong, X., Ault, A. D., Deschenes, R. J. (2002). "Erf4p and Erf2p form an endoplasmic reticulum-associated complex involved in the plasma membrane localization of yeast Ras proteins." J Biol Chem 277:49352-49359.12379641
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106