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Identification
NameV-type proton ATPase subunit H
Synonyms
  • V-ATPase subunit H
  • V-ATPase 54 kDa subunit
  • Vacuolar proton pump subunit H
Gene NameVMA13
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in identical protein binding
Specific FunctionVacuolar ATPases regulate the organelle acidity. This subunit is essential for activity, but not assembly, of the enzyme complex
Cellular LocationVacuole membrane; Peripheral membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
macromolecular complex
protein complex
proton-transporting two-sector ATPase complex, catalytic domain
proton-transporting V-type ATPase, V1 domain
vacuolar proton-transporting V-type ATPase, V1 domain
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
hydrolase activity
inorganic cation transmembrane transporter activity
hydrolase activity, acting on acid anhydrides
monovalent inorganic cation transmembrane transporter activity
proton-transporting ATPase activity, rotational mechanism
hydrogen ion transmembrane transporter activity
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
binding
catalytic activity
Process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
ATP biosynthetic process
ATP synthesis coupled proton transport
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
metabolic process
nucleotide metabolic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>1437 bp ATGGGCGCAACCAAAATTTTAATGGACAGTACTCATTTCAATGAGATCCGTAGTATAATC CGTTCGAGGTCAGTGGCATGGGACGCCTTAGCCAGATCTGAGGAATTGAGCGAAATTGAT GCGTCTACTGCAAAAGCGTTAGAATCCATTCTGGTGAAGAAGAACATTGGTGACGGTTTA TCATCTTCGAACAATGCACATTCCGGGTTCAAAGTGAATGGCAAGACGTTGATACCATTA ATTCACTTACTTTCCACCTCAGACAACGAAGACTGCAAAAAATCTGTGCAGAACCTAATA GCTGAATTGTTATCGTCTGACAAGTATGGAGACGATACCGTGAAGTTTTTCCAAGAAGAC CCCAAGCAATTGGAACAATTATTTGATGTGTCACTCAAGGGAGACTTCCAGACTGTGCTA ATCTCTGGGTTCAACGTGGTCTCACTCTTAGTGCAAAATGGGTTGCACAATGTGAAACTA GTGGAAAAGCTGTTGAAAAACAACAACTTGATCAATATCTTGCAAAACATTGAGCAGATG GACACTTGTTACGTGTGCATCAGACTATTGCAAGAACTGGCCGTGATACCAGAGTATCGT GACGTGATATGGTTGCATGAGAAGAAGTTCATGCCCACCTTATTCAAGATCCTGCAACGT GCCACGGACTCTCAATTGGCCACGCGGATAGTTGCAACAAACTCCAACCACCTGGGTATT CAATTGCAGTACCACTCTTTACTATTGATATGGTTGCTGACCTTTAACCCAGTTTTTGCA AACGAGCTAGTCCAGAAATACTTGAGTGATTTCTTGGACCTCTTGAAATTGGTTAAGATA ACCATAAAGGAGAAAGTGTCCAGATTGTGCATATCCATCATCCTGCAATGTTGCTCCACG CGCGTCAAGCAGCACAAGAAGGTGATTAAGCAACTTTTGTTGCTCGGCAACGCGTTGCCC ACCGTACAGAGCTTGAGCGAAAGAAAGTATTCCGACGAAGAATTGCGTCAAGACATCAGC AACCTCAAGGAAATCCTAGAAAACGAGTACCAAGAATTGACCTCCTTCGATGAATACGTC GCCGAATTGGACTCCAAGTTGCTGTGCTGGTCTCCACCACATGTCGACAACGGTTTCTGG TCCGATAACATTGACGAGTTCAAGAAGGACAACTACAAGATCTTTAGACAATTGATCGAA CTCTTGCAAGCAAAGGTCCGTAACGGCGACGTCAACGCGAAACAAGAAAAGATCATTATC CAAGTCGCCTTGAACGACATCACTCACGTGGTCGAGCTTCTACCAGAGAGCATCGACGTT CTCGACAAGACTGGCGGCAAAGCCGACATCATGGAGTTGCTGAACCATTCAGATTCTAGG GTGAAATACGAGGCCCTCAAGGCCACGCAGGCAATCATTGGATATACCTTCAAATAA
Protein Properties
Pfam Domain Function
Protein Residues478
Protein Molecular Weight54415.30078
Protein Theoretical pI6.3
PDB Fileshow
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>V-type proton ATPase subunit H MGATKILMDSTHFNEIRSIIRSRSVAWDALARSEELSEIDASTAKALESILVKKNIGDGL SSSNNAHSGFKVNGKTLIPLIHLLSTSDNEDCKKSVQNLIAELLSSDKYGDDTVKFFQED PKQLEQLFDVSLKGDFQTVLISGFNVVSLLVQNGLHNVKLVEKLLKNNNLINILQNIEQM DTCYVCIRLLQELAVIPEYRDVIWLHEKKFMPTLFKILQRATDSQLATRIVATNSNHLGI QLQYHSLLLIWLLTFNPVFANELVQKYLSDFLDLLKLVKITIKEKVSRLCISIILQCCST RVKQHKKVIKQLLLLGNALPTVQSLSERKYSDEELRQDISNLKEILENEYQELTSFDEYV AELDSKLLCWSPPHVDNGFWSDNIDEFKKDNYKIFRQLIELLQAKVRNGDVNAKQEKIII QVALNDITHVVELLPESIDVLDKTGGKADIMELLNHSDSRVKYEALKATQAIIGYTFK
References
External Links
ResourceLink
Saccharomyces Genome Database VMA13
Uniprot IDP41807
Uniprot NameVATH_YEAST
GenBank Gene IDD13916
Genebank Protein ID439902
PDB ID
1HO8
General Reference
  • Ho, M. N., Hirata, R., Umemoto, N., Ohya, Y., Takatsuki, A., Stevens, T. H., Anraku, Y. (1993). "VMA13 encodes a 54-kDa vacuolar H(+)-ATPase subunit required for activity but not assembly of the enzyme complex in Saccharomyces cerevisiae." J Biol Chem 268:18286-18292.8349704
  • Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
  • Zhong, X., Malhotra, R., Guidotti, G. (2000). "Regulation of yeast ectoapyrase ynd1p activity by activator subunit Vma13p of vacuolar H+-ATPase." J Biol Chem 275:35592-35599.10954728
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956
  • Sagermann, M., Stevens, T. H., Matthews, B. W. (2001). "Crystal structure of the regulatory subunit H of the V-type ATPase of Saccharomyces cerevisiae." Proc Natl Acad Sci U S A 98:7134-7139.11416198