| Identification |
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| Name | Low-affinity Fe(2+) transport protein |
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| Synonyms | - Low-affinity Fe(II) transport protein
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| Gene Name | FET4 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in transmembrane transport |
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| Specific Function | Required for Fe(2+) ion low affinity uptake |
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| Cellular Location | Membrane; Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00379 | Iron(2+) | Show |
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| GO Classification | | Component |
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| Not Available | | Function |
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| Not Available | | Process |
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| transmembrane transport | | establishment of localization | | transport |
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| Gene Properties |
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| Chromosome Location | chromosome 13 |
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| Locus | YMR319C |
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| Gene Sequence | >1659 bp
ATGGGTAAAATTGCAGAGTTTCTCGGGAATCCAGGTGCTAGGCCTGACGTTCATCATAGA
GCACCTACTGTTGACTGCAAACAGTACGAAGAATTCGGTGATTCTAACGATTACAAAAAT
GATGATGTGGTCAGAGTAGTCAGCCATAGCGATGAGAGTACTGATGACGAACTTTGTAAT
GTGAATTTAACAGAAACAGGGGCAATCTTCACGAGTAAAGGTTTTACCGGGTTAAGCAAA
GGTTTCACAGATAAGACCCTGGATTTCCTGGTACGAGTGGCCGGTTCGCAGGCGGTTTTT
TTTATTGTTTGGATCATCCTCATAATTTGGGTGGTTATTGGTATTGTTTATAACGCACCT
TTCAATTGGCAAGTTGTTATGCAGGACGGACAGTCCATTCAAAGTTATGTTTGGGACACA
CTGTTGATGAGACAACAGTTGATGAGTACGCATGAACAAATTTTGATCTGCGGTAGATTG
AAGTCGAGATTGGCTTCCTTCAAAAACTATCTAACAAGAAGCACCCCAGAGGAAGAAAAA
GCAGACTGCACAGTTGAAGCTAATGAAGTCAGCTCTGTTGAAAATCATATAGACCCATCT
GCCATTAACGGAGAACTGCCTGTGGAAAATTGGTACGACCGTTTATCTAATGTAGCAAGT
AGGTATATGGGTTCAATTGCAGCAATGGTGATATTTTGGATAGGTATTTTCGTTTGGATT
GGTTGCGGTGCTATCCCAAAAGATGCGGGCAACACTCCACCTTACACCGGAGAAACTACA
GGTAGTAATCCAAGATTGAAAAAGTTCAGTGACGCTTGGCAGATGTATATTAACACTGCA
GTTGCAATTTCCCTTCTAATTTGCACTACTTTCTTACAAAATATAAGGGCCAGACATGAT
TATTTCACGGGGAGGTTTTTAGTTGATATCTTTGATATGGACGAGAAAATCGACTATCGT
ATAAGAAAGCATTTTAACGATTTTGAAACACCTCACCCAGTTGTTACCATTGAGTCTAAA
AAAAGGTCGACAGGGAGAAAGATGATTGATTGGTATGCTGATATTATTGGTACTGGTATT
GGTGTCCTGATCGGTGTGGCAGTGTTCGCTACATGGATTGGTATTGGTTCGCCAATGAAG
TGGGATGATAATTGGTGGTTGATTATCGGTACATACACAGGTTTAATTGGGTTTTTGGAC
GGTTTCGTTTTGAGAGAAGTGTACTTCCGAATCGTTCAACATGAAGAGAAAAATTATTCT
GATGTGGCTAAAGAAGACCTTGAATTATTCCAAGAATTAGGTATTGAATGTCCCGAAGAA
CTTAGTGGTAAAGCTCCTGAAATTAACATTATTGGTTACAGAACATCCCAATATATTAAT
AGGATCTGCTCAACTCCATGGAGTGTTCTTGTATCCGTCATCATCATCATTGGTTTAATT
TGTATTGCTTCCGGTTTGCGTTGGAGTACAACAGGTCAATTGATTGCTAACACGCCAACT
ATGATTATCGAAGAATTTTTCTTGCTAGTTTTGTTGCAAGCACATAATTGGGCCGATCGT
CAAAGAAGAGTGGAGGTTACCGCTTTGTACGCACGTAGGCGCATACTTCTATCATACGTA
GAAAAGCGTTTCCCAGAGGTTATGATGTTGGAAAAATAG |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 552 |
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| Protein Molecular Weight | 62791.5 |
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| Protein Theoretical pI | 5.16 |
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| Signalling Regions | |
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| Transmembrane Regions | - 98-118
- 226-246
- 272-292
- 355-375
- 384-404
- 466-486
- 494-514
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| Protein Sequence | >Low-affinity Fe(2+) transport protein
MGKIAEFLGNPGARPDVHHRAPTVDCKQYEEFGDSNDYKNDDVVRVVSHSDESTDDELCN
VNLTETGAIFTSKGFTGLSKGFTDKTLDFLVRVAGSQAVFFIVWIILIIWVVIGIVYNAP
FNWQVVMQDGQSIQSYVWDTLLMRQQLMSTHEQILICGRLKSRLASFKNYLTRSTPEEEK
ADCTVEANEVSSVENHIDPSAINGELPVENWYDRLSNVASRYMGSIAAMVIFWIGIFVWI
GCGAIPKDAGNTPPYTGETTGSNPRLKKFSDAWQMYINTAVAVSLLICTTFLQNIRARHD
YFTGRFLVDIFDMDEKIDYRIRKHFNDFETPHPVVTIESKKRSTGRKMIDWYADIIGTGI
GVLIGVAVFATWIGIGSPMKWDDNWWLIIGTYTGLIGFLDGFVLREVYFRIVQHEEKNYS
DVAKEDLELFQELGIECPEEFSGKAPEINTIGYRTSQYINRICSTPWSVLVSVIIIIGLI
CIASGLRWSTTGQLIANTPTMIIEEFFLLVLLQAHNWADRQRRVEVTALYARRRILLSYV
EKRFPEVMMLEK |
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| References |
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| External Links | |
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| General Reference | - Dix, D. R., Bridgham, J. T., Broderius, M. A., Byersdorfer, C. A., Eide, D. J. (1994). "The FET4 gene encodes the low affinity Fe(II) transport protein of Saccharomyces cerevisiae." J Biol Chem 269:26092-26099.7929320
- Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
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