Osmosensing histidine protein kinase SLN1 (P39928)

Identification
NameOsmosensing histidine protein kinase SLN1
Synonyms
  • Osmolarity two-component system protein SLN1
  • Tyrosine phosphatase-dependent protein 2
Gene NameSLN1
Enzyme ClassNot Available
Biological Properties
General Functionprotein autophosphorylation
Specific FunctionHistidine kinase that acts as a osmosensor at the plasma membrane. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, the histidine kinase autophosphorylates His-576. This phosphate is subsequently transferred to Asp-1144, from where it is relayed to 'His-64' of the phosphorelay intermediate protein YPD1. Under high osmolarity conditions, the histidine kinase is no longer active.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarityPW002516 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity 1469654356PW002970 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
Stress-activated signalling pathways: low osmolarityPW002515 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
negative regulation of protein kinase activity
osmosensory signaling via phosphorelay pathway
peptidyl-histidine phosphorylation
metal ion binding
ATP binding
integral component of plasma membrane
plasma membrane
protein autophosphorylation
intracellular
osmosensor activity
histidine phosphotransfer kinase activity
phosphorelay response regulator activity
phosphorelay sensor kinase activity
protein histidine kinase activity
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>3663 bp ATGCGATTTGGCCTGCCATCAAAATTGGAACTCACTCCTCCGTTTAGGATAGGCATCCGA ACTCAACTAACGGCACTAGTTAGTATAGTGGCTTTGGGCTCACTGATTATTCTGGCTGTA ACGACAGGGGTCTATTTTACCTCGAACTATAAAAATTTAAGGTCCGATAGACTGTACATT GCCGCTCAGTTAAAGTCATCACAGATTGACCAAACTCTAAACTACTTATATTACCAGGCG TACTATTTGGCATCAAGAGACGCCCTGCAAAGCTCACTAACAAGTTACGTTGCAGGTAAC AAGAGTGCAGATAATTGGGTAGATTCCTTGAGTGTGATTCAAAAATTTTTGAGCTCTTCA AACTTGTTTTATGTTGCTAAAGTTTACGATTCTTCATTTAATGCTGTTTTGAACGCTACG AATAATGGAACTGGTGATCTAATTCCAGAAGATGTTTTAGACAGTTTGTTCCCATTATCC ACCGATACACCGCTACCTTCTTCACTGGAAACTATAGGTATATTGACGGATCCAGTACTA AATAGCACCGACTATTTGATGTCTATGTCTTTACCTATTTTTGCCAATCCTTCTATTATC TTGACTGATTCAAGGGTTTACGGATACATTACTATAATAATGTCGGCAGAGGGTCTGAAA AGTGTGTTCAACGATACAACTGCTTTAGAACATTCCACAATTGCCATTATTTCTGCAGTA TATAATAGTCAAGGCAAAGCTTCAGGGTATCATTTTGTCTTTCCACCGTATGGATCACGA TCAGACCTCCCGCAAAAAGTTTTTTCTATAAAAAATGATACATTCATTAGTAGCGCATTT AGAAACGGGAAGGGAGGGTCTTTGAAACAAACCAATATCCTTTCTACACGGAATACTGCT TTAGGCTATTCACCATGTTCGTTTAACCTAGTTAATTGGGTCGCGATAGTTTCACAGCCT GAGTCGGTTTTCCTTTCTCCAGCAACGAAACTAGCAAAAATCATCACCGGCACTGTCATC GCTATTGGTGTCTTTGTCATTTTGTTAACCCTTCCTCTAGCACACTGGGCAGTGCAACCA ATTGTACGTCTACAAAAGGCAACTGAATTAATTACAGAGGGGAGAGGCCTTCGACCGAGC ACCCCAAGAACGATAAGCAGAGCCAGTTCATTCAAAAGAGGATTTAGTTCTGGATTTGCT GTTCCTTCTTCGTTATTACAATTTAATACTGCTGAAGCTGGCAGCACCACAAGCGTAAGT GGCCATGGAGGCAGTGGCCATGGCAGTGGTGCAGCTTTTTCAGCAAATAGTAGCATGAAA AGCGCTATAAACCTTGGAAATGAGAAAATGTCACCTCCAGAGGAGGAGAACAAAATACCG AATAACCACACCGATGCTAAAATATCAATGGATGGCTCGCTAAATCACGATTTGCTTGGA CCACATTCCTTGAGACATAATGACACTGACAGAAGTTCCAATAGATCTCACATTCTCACA ACTTCTGCAAATTTAACTGAAGCTAGGCTACCAGATTATAGAAGACTATTTTCTGATGAA CTTTCCGATTTAACAGAAACCTTCAATACTATGACAGACGCATTAGACCAACATTATGCT CTTCTAGAAGAAAGAGTTAGGGCGAGGACAAAACAACTCGAAGCTGCCAAGATTGAGGCA GAGGCCGCAAATGAAGCAAAAACCGTCTTTATTGCCAATATTTCGCACGAATTGAGAACG CCTTTAAATGGTATTCTGGGTATGACGGCTATTTCAATGGAAGAAACCGATGTTAACAAA ATAAGAAATAGTTTAAAACTCATTTTTAGATCAGGTGAGCTTTTGCTTCATATTCTAACG GAATTGTTAACTTTTTCCAAAAACGTTCTTCAAAGAACGAAACTGGAGAAAAGAGATTTT TGCATTACCGATGTTGCCTTACAAATAAAATCGATATTTGGTAAAGTTGCAAAGGATCAG CGTGTTCGTCTTTCAATATCATTGTTTCCTAATTTGATAAGGACAATGGTTCTTTGGGGT GATTCCAACAGAATTATTCAAATTGTGATGAATCTAGTGTCCAATGCACTAAAGTTCACC CCTGTAGATGGTACCGTTGATGTAAGAATGAAACTGTTGGGTGAATACGACAAAGAATTA AGCGAGAAGAAGCAATACAAAGAAGTGTATATCAAAAAAGGGACAGAAGTAACCGAAAAT TTAGAAACTACAGATAAATACGATCTTCCAACTTTATCGAACCATAGGAAAAGTGTCGAT TTAGAATCCAGCGCTACTTCCCTAGGAAGTAATAGAGACACTTCGACAATTCAGGAAGAG ATAACAAAAAGAAATACTGTTGCGAATGAAAGTATCTATAAGAAAGTGAATGACAGGGAA AAAGCTTCGAATGATGATGTATCTTCTATAGTATCAACAACTACCAGCTCGTATGATAAC GCTATCTTCAATAGTCAGTTCAATAAAGCACCTGGCTCAGATGATGAAGAAGGTGGTAAC CTAGGAAGACCTATCGAAAACCCCAAAACGTGGGTTATTTCTATTGAAGTGGAAGACACT GGGCCTGGTATTGACCCTTCCTTACAAGAATCTGTATTTCATCCATTTGTTCAAGGTGAT CAAACATTGTCCAGGCAATATGGTGGTACTGGCTTAGGTCTATCAATCTGTAGACAGTTA GCAAATATGATGCATGGAACGATGAAATTAGAGTCGAAAGTAGGTGTTGGTAGTAAATTC ACTTTTACCTTGCCATTAAATCAAACTAAAGAGATCAGTTTTGCAGATATGGAGTTTCCT TTTGAGGACGAATTTAATCCTGAGAGTAGAAAGAACAGAAGAGTCAAGTTTAGTGTTGCT AAAAGCATCAAGAGCCGACAATCCACATCATCTGTTGCAACACCAGCTACAAATAGAAGT AGCCTAACCAACGACGTGCTACCGGAGGTAAGAAGTAAAGGTAAGCATGAGACGAAAGAT GTTGGAAATCCTAACATGGGAAGAGAAGAAAAAAACGACAATGGAGGGCTTGAACAACTG CAGGAAAAAAATATTAAACCTTCTATATGTCTTACAGGTGCTGAAGTTAACGAACAAAAT TCCTTGTCTTCTAAGCATCGTTCTCGACATGAAGGTCTAGGTTCTGTCAATCTTGATAGA CCATTTTTGCAAAGTACTGGTACAGCCACATCAAGTAGAAACATCCCCACAGTCAAAGAC GACGATAAAAATGAAACAAGTGTCAAAATTTTGGTTGTAGAAGATAATCATGTAAATCAG GAAGTTATCAAAAGAATGTTGAACTTGGAGGGCATTGAAAATATTGAACTGGCTTGCGAT GGCCAAGAAGCATTCGACAAAGTTAAAGAATTGACATCTAAGGGCGAAAATTATAATATG ATTTTCATGGATGTCCAGATGCCTAAAGTGGATGGTTTACTTTCTACCAAGATGATAAGG CGCGATTTAGGTTATACCTCACCTATTGTCGCTCTAACCGCTTTTGCTGACGATAGCAAC ATTAAAGAATGTTTGGAATCAGGAATGAACGGATTTTTATCGAAACCAATCAAAAGACCA AAATTGAAAACTATTCTTACTGAGTTTTGTGCAGCATATCAGGGAAAGAAAAATAACAAA TGA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues1220
Protein Molecular Weight134433.845
Protein Theoretical pINot Available
PDB Fileshow
Signalling RegionsNot Available
Transmembrane Regions
  • 23-46
  • 334-354
Protein Sequence>Osmosensing histidine protein kinase SLN1 MRFGLPSKLELTPPFRIGIRTQLTALVSIVALGSLIILAVTTGVYFTSNYKNLRSDRLYI AAQLKSSQIDQTLNYLYYQAYYLASRDALQSSLTSYVAGNKSADNWVDSLSVIQKFLSSS NLFYVAKVYDSSFNAVLNATNNGTGDLIPEDVLDSLFPLSTDTPLPSSLETIGILTDPVL NSTDYLMSMSLPIFANPSIILTDSRVYGYITIIMSAEGLKSVFNDTTALEHSTIAIISAV YNSQGKASGYHFVFPPYGSRSDLPQKVFSIKNDTFISSAFRNGKGGSLKQTNILSTRNTA LGYSPCSFNLVNWVAIVSQPESVFLSPATKLAKIITGTVIAIGVFVILLTLPLAHWAVQP IVRLQKATELITEGRGLRPSTPRTISRASSFKRGFSSGFAVPSSLLQFNTAEAGSTTSVS GHGGSGHGSGAAFSANSSMKSAINLGNEKMSPPEEENKIPNNHTDAKISMDGSLNHDLLG PHSLRHNDTDRSSNRSHILTTSANLTEARLPDYRRLFSDELSDLTETFNTMTDALDQHYA LLEERVRARTKQLEAAKIEAEAANEAKTVFIANISHELRTPLNGILGMTAISMEETDVNK IRNSLKLIFRSGELLLHILTELLTFSKNVLQRTKLEKRDFCITDVALQIKSIFGKVAKDQ RVRLSISLFPNLIRTMVLWGDSNRIIQIVMNLVSNALKFTPVDGTVDVRMKLLGEYDKEL SEKKQYKEVYIKKGTEVTENLETTDKYDLPTLSNHRKSVDLESSATSLGSNRDTSTIQEE ITKRNTVANESIYKKVNDREKASNDDVSSIVSTTTSSYDNAIFNSQFNKAPGSDDEEGGN LGRPIENPKTWVISIEVEDTGPGIDPSLQESVFHPFVQGDQTLSRQYGGTGLGLSICRQL ANMMHGTMKLESKVGVGSKFTFTLPLNQTKEISFADMEFPFEDEFNPESRKNRRVKFSVA KSIKSRQSTSSVATPATNRSSLTNDVLPEVRSKGKHETKDVGNPNMGREEKNDNGGLEQL QEKNIKPSICLTGAEVNEQNSLSSKHRSRHEGLGSVNLDRPFLQSTGTATSSRNIPTVKD DDKNETSVKILVVEDNHVNQEVIKRMLNLEGIENIELACDGQEAFDKVKELTSKGENYNM IFMDVQMPKVDGLLSTKMIRRDLGYTSPIVALTAFADDSNIKECLESGMNGFLSKPIKRP KLKTILTEFCAAYQGKKNNK
References
External Links
ResourceLink
Saccharomyces Genome Database SLN1
Uniprot IDP39928
Uniprot NameSLN1
PDB ID
1OXB
General ReferenceNot Available