Inositolphosphotransferase 1 (P38954)

Identification
NameInositolphosphotransferase 1
Synonyms
  • Mannosyl diphosphorylinositol ceramide synthase
Gene NameIPT1
Enzyme Class
Biological Properties
General FunctionInvolved in catalytic activity
Specific FunctionCatalyzes the addition of a phosphorylinositol group onto mannosyl phosphorylinositol ceramide to form mannosyl diphosphorylinositol ceramide
Cellular LocationMembrane; Multi-pass membrane protein (Potential)
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
mannosylinositol phosphorylceramide + 1D-myo-inositol 1-phosphate ↔ inositol phosphomannosylinositol phosphoceramide
Metabolites
YMDB IDNameView
YMDB00713inositol phosphomannosylinositol phosphoceramideShow
YMDB007141D-myo-inositol 1-phosphateShow
GO Classification
Component
cell part
membrane
Function
catalytic activity
Process
Not Available
Gene Properties
Chromosome Locationchromosome 4
LocusYDR072C
Gene Sequence>1584 bp ATGAATGTCATATTTTCTTTGGCGAGTTTCGTCAAAAACATGTATAATGCAAGTTTGAAC CAACGTAATCTAATAAGCCTGCCGTTCAACTTCATGCTTAATTTTGCGCCAGTGTTTATT TGGCTGTCTATATTCAAGCGCGCTGGTCTGATACCCATAAGGCTCAGACCTGACATTCAT AGCAAGTTTGCTTTTTTTGCTGATCAATTCCTCTTTGGGGACTATTGGCATGAACTTACT GTACAATTGCCCGATAATACTTCGAAGCTATTTTTCTGGTCATTCATATCATCTTCTGCA TTTCTCTTAGTATTTCTGATATGTATTCCCTTTGCCATTTGGTACTACATCTATTACATT AAGCACGTTAACTATAATCTGTTAGAGTGGTTCGCAAATATTTTTCATTACCCCTGCAAG CGCAAGCAGCGGCCGATCCAAAAGAGATTTCGGACAATTTTCATACCGTTTGCCTTGCCC CTGTTTACATTTGTTATACTCAACATTGATCATTTCTTTGCTTACCAGTCGGATGCAAAC TTTACTAAGACCAAGGATTTACTGGCTTGGTTCTCCTATGTCATCCTGCACTTGACAGCT CCAATTTTAACAGCTGTATACTTATACGTCTTCCAACCACCGGGGACTTTAAAATGCTTT AGTTTTGCCCTAGGATTACAAAATATAGCGGGGGTCCTTACCCATCTGCTTGTTCCAATG GCCTCCCCATGGTTTACTCATCTGTACGGTATTGATGACACCGAACATGTTAATTACACC CAGGAAGGGTTTGCTGCCGGTTTGATAAGAGTAGATAGCCATTTGGGTACTCATTTGAAC ACTAAAGGATTTCACATGTCTCCTATTGTGTTTGGTGCTGTTCCTTCACTACACTCCGCC ATTGCATTTCAATGTTTCTTGTTTTTGGTTTCAAGGTCCACCAGCTTAAAACACAGATTT TCCAATGCTGGAGGTTTCACAATGCACAATAATGATTCTTCCACTTTCAAGTTGAGTGAG GAAGACAGCGAAGATGAAGGTGACAATAGCATACCGCCCACGATTGGCCCTAACGACTTA GAGATGGAACCATTGGGTACCGTTGAGCCTGTAGATATTTCAAATGAGCGGTCCTCCTCC CCTTCATCTTCATTCACCGTATCCAGTAATGAAAGAAGCACCGGCGGCGGCGACGGCAGC ATTATTAACAGCAATGGCAATAAGAAACCTCTCCAGTTTGTCCATTTATATGATGAAGAC ACGAACTTCACAAACAAATGGATTTTTAAAATAGTCAACGATGGGTTTATACCAAAATTC TGGGCTATCCTATATATAATACTACAATGGTGGGCTACCATGTATCTGGACCACCATTAT AGATTTGACCTTTTCGTTGGTGTTTTATATGCAATGACAAGTTTCATCATCATAAACTGG TTTGTTTTACAACCAAAAGTTTTAAAAAAGTGGATTCATATAAGGTTAGGCGACAAAGTG GATACAAGAAACGAAGCTCGCACTTTTGGCATGAGAGTATTTTGTGGCACCAAGATGGAA TGGTTTTTTGATCCGCTTGCATAG
Protein Properties
Pfam Domain Function
Protein Residues527
Protein Molecular Weight60872.69922
Protein Theoretical pI8.0
Signalling Regions
  • None
Transmembrane Regions
  • 25-45
  • 100-120
  • 153-173
  • 191-211
  • 220-240
  • 289-309
  • 436-456
  • 462-482
Protein Sequence>Inositolphosphotransferase 1 MNVIFSLASFVKNMYNASLNQRNLISLPFNFMLNFAPVFIWLSIFKRAGLIPIRLRPDIH SKFAFFADQFLFGDYWHELTVQLPDNTSKLFFWSFISSSAFLLVFLICIPFAIWYYIYYI KHVNYNLLEWFANIFHYPCKRKQRPIQKRFRTIFIPFALPLFTFVILNIDHFFAYQSDAN FTKTKDLLAWFSYVILHLTAPILTAVYLYVFQPPGTLKCFSFALGLQNIAGVLTHLLVPM ASPWFTHLYGIDDTEHVNYTQEGFAAGLIRVDSHLGTHLNTKGFHMSPIVFGAVPSLHSA IAFQCFLFLVSRSTSLKHRFSNAGGFTMHNNDSSTFKLSEEDSEDEGDNSIPPTIGPNDL EMEPLGTVEPVDISNERSSSPSSSFTVSSNERSTGGGDGSIINSNGNKKPLQFVHLYDED TNFTNKWIFKIVNDGFIPKFWAILYIILQWWATMYLDHHYRFDLFVGVLYAMTSFIIINW FVLQPKVLKKWIHIRLGDKVDTRNEARTFGMRVFCGTKMEWFFDPLA
References
External Links
ResourceLink
Saccharomyces Genome Database IPT1
Uniprot IDP38954
Uniprot NameIPT1_YEAST
GenBank Gene IDAF022365
Genebank Protein ID2465787
General Reference
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956