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Identification
NamePhosphoglucomutase-2
Synonyms
  • PGM 2
  • Glucose phosphomutase 2
Gene NamePGM2
Enzyme Class
Biological Properties
General FunctionInvolved in intramolecular transferase activity, phosphotransferases
Specific FunctionThis enzyme participates in both the breakdown and synthesis of glucose. Can also act on mannose
Cellular LocationCytoplasm
SMPDB Pathways
Amino sugar and nucleotide sugar metabolismPW002413 ThumbThumb?image type=greyscaleThumb?image type=simple
Leloir PathwayPW002397 ThumbThumb?image type=greyscaleThumb?image type=simple
Starch and sucrose metabolismPW002481 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Amino sugar and nucleotide sugar metabolismec00520 Map00520
Galactose metabolismec00052 Map00052
Glycolysis / Gluconeogenesisec00010 Map00010
Pentose phosphate pathwayec00030 Map00030
Purine metabolismec00230 Map00230
SMPDB Reactions
Glucose 1-phosphateGlucose 6-phosphate
Beta-D-Glucose 6-phosphateGlucose 1-phosphate
KEGG Reactions
Glucose 1-phosphatealdehydo-D-glucose 6-phosphate
Ribose 1-phosphatealpha-D-ribose 5-phosphate
Metabolites
YMDB IDNameView
YMDB00061Ribose 1-phosphateShow
YMDB00288Glucose 1-phosphateShow
YMDB00311Beta-D-Glucose 6-phosphateShow
YMDB00582aldehydo-D-glucose 6-phosphateShow
YMDB00650alpha-D-ribose 5-phosphateShow
YMDB00947Glucose 6-phosphateShow
GO Classification
Component
Not Available
Function
ion binding
cation binding
metal ion binding
magnesium ion binding
isomerase activity
catalytic activity
intramolecular transferase activity
intramolecular transferase activity, phosphotransferases
binding
Process
primary metabolic process
carbohydrate metabolic process
metabolic process
Gene Properties
Chromosome Locationchromosome 13
LocusYMR105C
Gene Sequence>1710 bp ATGTCATTTCAAATTGAAACGGTTCCCACCAAACCATATGAAGACCAAAAGCCTGGTACC TCTGGTTTGCGTAAGAAGACAAAGGTGTTTAAAGACGAACCTAACTACACAGAAAATTTC ATTCAATCGATCATGGAAGCTATTCCAGAGGGTTCTAAAGGTGCCACTCTTGTTGTCGGT GGTGATGGGCGTTACTACAATGATGTCATTCTTCATAAGATTGCCGCTATCGGTGCTGCC AACGGTATTAAAAAGTTAGTTATTGGCCAGCATGGTCTTCTGTCTACGCCAGCCGCTTCT CACATCATGAGAACCTACGAGGAAAAATGTACTGGTGGTATTATCTTAACCGCCTCACAT AATCCAGGTGGTCCAGAAAATGACATGGGTATTAAGTATAACTTATCCAATGGGGGTCCT GCTCCTGAATCCGTCACAAATGCTATTTGGGAGATTTCCAAAAAGCTTACCAGCTATAAG ATTATCAAAGACTTCCCAGAACTAGACTTGGGTACGATAGGCAAGAACAAGAAATACGGT CCATTACTCGTTGACATTATCGATATTACAAAAGATTATGTCAACTTCTTGAAGGAAATC TTCGATTTCGACTTAATCAAGAAATTCATCGATAATCAACGTTCTACTAAGAATTGGAAG TTACTGTTTGACAGTATGAACGGTGTAACTGGACCATACGGTAAGGCTATTTTCGTTGAT GAATTTGGTTTACCGGCGGATGAGGTTTTACAAAACTGGCATCCTTCTCCGGATTTTGGT GGTATGCATCCAGATCCAAACTTAACCTATGCCAGTTCGTTAGTGAAAAGAGTAGATCGT GAAAAGATTGAGTTTGGTGCTGCATCCGATGGTGATGGTGATAGAAATATGATTTACGGT TACGGCCCATCTTTCGTTTCTCCAGGTGACTCCGTCGCAATTATTGCCGAATATGCAGCT GAAATCCCATATTTCGCCAAGCAAGGTATATATGGTCTGGCCCGTTCATTCCCTACCTCA GGAGCCATAGACCGTGTTGCCAAGGCCCATGGTCTAAACTGTTATGAGGTCCCAACTGGC TGGAAATTTTTCTGTGCTTTGTTCGACGCTAAAAAATTATCTATTTGTGGTGAAGAATCG TTTGGTACTGGTTCCAACCACGTAAGGGAAAAGGACGGTGTTTGGGCCATTATGGCGTGG TTGAACATCTTGGCCATTTACAACAAGCATCATCCGGAGAACGAAGCTTCTATTAAGACG ATACAGAATGAATTCTGGGCAAAGTACGGCCGTACTTTCTTCACTCGTTATGATTTTGAA AAAGTTGAAACAGAAAAAGCTAACAAGATTGTCGATCAATTGAGAGCATATGTTACCAAA TCGGGTGTTGTTAATTCCGCCTTCCCAGCCGATGAGTCTCTTAAGGTCACCGATTGTGGT GATTTTTCATACACAGATTTGGACGGTTCTGTTTCTGACCATCAAGGTTTATATGTCAAG CTTTCCAATGGTGCAAGATTCGTTCTAAGATTGTCAGGTACAGGTTCTTCAGGTGCTACC ATTAGATTGTACATTGAAAAATACTGCGATGATAAATCACAATACCAAAAGACAGCTGAA GAATACTTGAAGCCAATTATTAACTCGGTCATCAAGTTCTTGAACTTTAAACAAGTTCTA GGAACTGAAGAACCCACGGTTCGTACTTAA
Protein Properties
Pfam Domain Function
Protein Residues569
Protein Molecular Weight63088.0
Protein Theoretical pI6.59
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Phosphoglucomutase-2 MSFQIETVPTKPYEDQKPGTSGLRKKTKVFKDEPNYTENFIQSIMEAIPEGSKGATLVVG GDGRYYNDVILHKIAAIGAANGIKKLVIGQHGLLSTPAASHIMRTYEEKCTGGIILTASH NPGGPENDMGIKYNLSNGGPAPESVTNAIWEISKKLTSYKIIKDFPELDLGTIGKNKKYG PLLVDIIDITKDYVNFLKEIFDFDLIKKFIDNQRSTKNWKLLFDSMNGVTGPYGKAIFVD EFGLPADEVLQNWHPSPDFGGMHPDPNLTYASSLVKRVDREKIEFGAASDGDGDRNMIYG YGPSFVSPGDSVAIIAEYAAEIPYFAKQGIYGLARSFPTSGAIDRVAKAHGLNCYEVPTG WKFFCALFDAKKLSICGEESFGTGSNHVREKDGVWAIMAWLNILAIYNKHHPENEASIKT IQNEFWAKYGRTFFTRYDFEKVETEKANKIVDQLRAYVTKSGVVNSAFPADESLKVTDCG DFSYTDLDGSVSDHQGLYVKLSNGARFVLRLSGTGSSGATIRLYIEKYCDDKSQYQKTAE EYLKPIINSVIKFLNFKQVLGTEEPTVRT
References
External Links
ResourceLink
Saccharomyces Genome Database PGM2
Uniprot IDP37012
Uniprot NamePGM2_YEAST
GenBank Gene IDAY723853
Genebank Protein ID51830486
General Reference
  • Boles, E., Liebetrau, W., Hofmann, M., Zimmermann, F. K. (1994). "A family of hexosephosphate mutases in Saccharomyces cerevisiae." Eur J Biochem 220:83-96.8119301
  • Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Gruhler, A., Olsen, J. V., Mohammed, S., Mortensen, P., Faergeman, N. J., Mann, M., Jensen, O. N. (2005). "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Mol Cell Proteomics 4:310-327.15665377
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956