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V-type proton ATPase subunit c' (P32842)

Identification
NameV-type proton ATPase subunit c'
Synonyms
  • V-ATPase subunit c'
  • Proteolipid protein VMA11
  • V-ATPase 16 kDa proteolipid subunit 2
  • Vacuolar proton pump c' subunit
Gene NameVMA11
Enzyme ClassNot Available
Biological Properties
General FunctionEnergy production and conversion
Specific FunctionProton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells
Cellular LocationVacuole membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
macromolecular complex
protein complex
proton-transporting two-sector ATPase complex, proton-transporting domain
proton-transporting V-type ATPase, V0 domain
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
Process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
metabolic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
ATP biosynthetic process
ATP synthesis coupled proton transport
nitrogen compound metabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>495 bp ATGTCAACGCAACTCGCAAGTAACATATATGCTCCATTGTACGCTCCCTTTTTCGGGTTC GCAGGTTGTGCAGCTGCCATGGTGCTTTCCTGTTTGGGAGCTGCCATTGGTACAGCTAAG TCAGGTATTGGTATCGCCGGTATAGGTACTTTCAAGCCGGAATTGATCATGAAGTCTTTG ATTCCTGTGGTTATGAGTGGTATCTTAGCCATTTATGGGCTTGTTGTGGCCGTTTTAATT GCAGGTAATTTATCTCCTACCGAAGACTATACTCTCTTCAATGGGTTCATGCACTTGAGT TGTGGGCTCTGTGTGGGATTTGCCTGTTTGAGTAGTGGCTACGCCATTGGTATGGTCGGT GACGTTGGTGTTAGAAAGTATATGCACCAACCAAGGCTTTTTGTCGGTATCGTTTTGATT CTAATTTTCTCTGAAGTTTTAGGGTTATATGGTATGATTGTAGCTTTGATTTTGAACACT AGAGGCTCTGAATGA
Protein Properties
Pfam Domain Function
Protein Residues164
Protein Molecular Weight17037.19922
Protein Theoretical pI7.84
Signalling Regions
  • None
Transmembrane Regions
  • 15-37
  • 60-80
  • 99-120
  • 133-158
Protein Sequence>V-type proton ATPase subunit c' MSTQLASNIYAPLYAPFFGFAGCAAAMVLSCLGAAIGTAKSGIGIAGIGTFKPELIMKSL IPVVMSGILAIYGLVVAVLIAGNLSPTEDYTLFNGFMHLSCGLCVGFACLSSGYAIGMVG DVGVRKYMHQPRLFVGIVLILIFSEVLGLYGMIVALILNTRGSE
References
External Links
ResourceLink
Saccharomyces Genome Database VMA11
Uniprot IDP32842
Uniprot NameVATL2_YEAST
GenBank Gene IDAY558058
Genebank Protein ID45270006
General Reference
  • Umemoto, N., Ohya, Y., Anraku, Y. (1991). "VMA11, a novel gene that encodes a putative proteolipid, is indispensable for expression of yeast vacuolar membrane H(+)-ATPase activity." J Biol Chem 266:24526-24532.1837023
  • Shih, C. K., Kwong, J., Montalvo, E., Neff, N. (1990). "Expression of a proteolipid gene from a high-copy-number plasmid confers trifluoperazine resistance to Saccharomyces cerevisiae." Mol Cell Biol 10:3397-3404.2192255
  • Bussey, H., Storms, R. K., Ahmed, A., Albermann, K., Allen, E., Ansorge, W., Araujo, R., Aparicio, A., Barrell, B., Badcock, K., Benes, V., Botstein, D., Bowman, S., Bruckner, M., Carpenter, J., Cherry, J. M., Chung, E., Churcher, C., Coster, F., Davis, K., Davis, R. W., Dietrich, F. S., Delius, H., DiPaolo, T., Hani, J., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature 387:103-105.9169875
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Hirata, R., Graham, L. A., Takatsuki, A., Stevens, T. H., Anraku, Y. (1997). "VMA11 and VMA16 encode second and third proteolipid subunits of the Saccharomyces cerevisiae vacuolar membrane H+-ATPase." J Biol Chem 272:4795-4803.9030535
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258