V-type proton ATPase subunit D (P32610)

Identification
NameV-type proton ATPase subunit D
Synonyms
  • V-ATPase subunit D
  • Vacuolar proton pump subunit D
Gene NameVMA8
Enzyme ClassNot Available
Biological Properties
General FunctionEnergy production and conversion
Specific FunctionSubunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system
Cellular LocationNot Available
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
macromolecular complex
protein complex
proton-transporting two-sector ATPase complex, catalytic domain
Function
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
active transmembrane transporter activity
cation transmembrane transporter activity
primary active transmembrane transporter activity
inorganic cation transmembrane transporter activity
P-P-bond-hydrolysis-driven transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
hydrogen ion transmembrane transporter activity
proton-transporting ATPase activity, rotational mechanism
transporter activity
transmembrane transporter activity
Process
ATP biosynthetic process
ATP synthesis coupled proton transport
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
metabolic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>771 bp ATGTCTGGTAATAGAGAGCAAGTCTTTCCTACGCGTATGACGCTGGGTTTGATGAAGACC AAGTTAAAAGGTGCCAACCAAGGTTATTCTTTACTAAAGCGTAAGTCTGAAGCCCTAACA AAGAGATTCAGAGATATTACCAAAAGAATTGATGATGCTAAGCAAAAGATGGGGAGAGTT ATGCAAACTGCTGCCTTTTCCTTGGCCGAAGTTTCCTATGCAACAGGTGAAAACATTGGC TATCAAGTGCAAGAAAGTGTCTCTACTGCAAGATTCAAAGTGAGAGCACGTCAAGAAAAC GTTAGTGGTGTGTATTTGTCTCAATTTGAGTCCTACATCGACCCTGAAATTAATGATTTC AGATTAACTGGTTTAGGTAGAGGTGGTCAACAGGTTCAACGAGCCAAGGAAATCTATTCA AGAGCCGTTGAAACTTTAGTTGAATTAGCCTCTTTACAGACTGCATTTATTATTTTGGAT GAAGTGATTAAAGTGACGAACAGAAGGGTTAATGCTATCGAACACGTTATTATCCCAAGA ACTGAAAACACAATTGCTTACATTAACAGTGAGTTGGATGAGTTGGACAGAGAAGAATTT TATAGATTGAAAAAGGTCCAAGAAAAGAAGCAAAATGAGACTGCAAAATTGGATGCTGAG ATGAAATTGAAGAGAGATAGAGCAGAACAAGATGCTTCAGAAGTAGCTGCTGATGAGGAA CCTCAAGGTGAAACATTGGTTGCTGATCAAGAAGACGATGTTATATTCTGA
Protein Properties
Pfam Domain Function
Protein Residues256
Protein Molecular Weight29193.80078
Protein Theoretical pI5.61
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>V-type proton ATPase subunit D MSGNREQVFPTRMTLGLMKTKLKGANQGYSLLKRKSEALTKRFRDITKRIDDAKQKMGRV MQTAAFSLAEVSYATGENIGYQVQESVSTARFKVRARQENVSGVYLSQFESYIDPEINDF RLTGLGRGGQQVQRAKEIYSRAVETLVELASLQTAFIILDEVIKVTNRRVNAIEHVIIPR TENTIAYINSELDELDREEFYRLKKVQEKKQNETAKLDAEMKLKRDRAEQDASEVAADEE PQGETLVADQEDDVIF
References
External Links
ResourceLink
Saccharomyces Genome Database VMA8
Uniprot IDP32610
Uniprot NameVATD_YEAST
GenBank Gene IDU18779
Genebank Protein ID603628
General Reference
  • Graham, L. A., Hill, K. J., Stevens, T. H. (1995). "VMA8 encodes a 32-kDa V1 subunit of the Saccharomyces cerevisiae vacuolar H(+)-ATPase required for function and assembly of the enzyme complex." J Biol Chem 270:15037-15044.7797485
  • Dietrich, F. S., Mulligan, J., Hennessy, K., Yelton, M. A., Allen, E., Araujo, R., Aviles, E., Berno, A., Brennan, T., Carpenter, J., Chen, E., Cherry, J. M., Chung, E., Duncan, M., Guzman, E., Hartzell, G., Hunicke-Smith, S., Hyman, R. W., Kayser, A., Komp, C., Lashkari, D., Lew, H., Lin, D., Mosedale, D., Davis, R. W., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Nature 387:78-81.9169868
  • Nelson, H., Mandiyan, S., Nelson, N. (1995). "A bovine cDNA and a yeast gene (VMA8) encoding the subunit D of the vacuolar H(+)-ATPase." Proc Natl Acad Sci U S A 92:497-501.7831318
  • Seol, J. H., Shevchenko, A., Shevchenko, A., Deshaies, R. J. (2001). "Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly." Nat Cell Biol 3:384-391.11283612
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106