| Identification |
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| Name | V-type proton ATPase subunit d _ |
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| Synonyms | - V-ATPase subunit d
- V-ATPase 39 kDa subunit
- V-ATPase subunit M39
- Vacuolar proton pump subunit d
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| Gene Name | VMA6 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Energy production and conversion |
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| Specific Function | Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores |
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| Cellular Location | Vacuole membrane; Peripheral membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | |
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| GO Classification | | Component |
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| macromolecular complex | | protein complex | | proton-transporting two-sector ATPase complex, proton-transporting domain | | proton-transporting V-type ATPase, V0 domain | | Function |
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| transporter activity | | transmembrane transporter activity | | substrate-specific transmembrane transporter activity | | ion transmembrane transporter activity | | cation transmembrane transporter activity | | inorganic cation transmembrane transporter activity | | monovalent inorganic cation transmembrane transporter activity | | hydrogen ion transmembrane transporter activity | | Process |
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| purine nucleotide metabolic process | | metabolic process | | purine nucleotide biosynthetic process | | purine nucleoside triphosphate biosynthetic process | | purine ribonucleoside triphosphate biosynthetic process | | ATP biosynthetic process | | ATP synthesis coupled proton transport | | nitrogen compound metabolic process | | cellular nitrogen compound metabolic process | | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | | nucleobase, nucleoside and nucleotide metabolic process | | nucleoside phosphate metabolic process | | nucleotide metabolic process |
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| Gene Properties |
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| Chromosome Location | Not Available |
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| Locus | |
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| Gene Sequence | >1038 bp
ATGGAAGGCGTGTATTTCAATATTGACAATGGGTTTATTGAAGGTGTAGTGAGAGGCTAC
AGAAATGGGTTGTTATCTAATAACCAATACATCACCTTAACACAATGTGACACGTTGGAA
GATCTAAAATTACAATTATCATCAACTGATTATGGTAATTTTCTTTCCTCTGTTTCCTCA
GAGTCTTTGACCACGTCATTGATTCAAGAATATGCTTCTAGCAAGTTGTACCACGAATTC
AACTACATAAGAGACCAATCCAGTGGATCCACGAGAAAGTTCATGGACTATATCACTTAT
GGTTACATGATCGACAATGTAGCATTGATGATTACAGGTACTATTCATGATCGTGATAAG
GGTGAAATTTTACAACGTTGTCATCCGCTAGGTTGGTTTGATACTTTGCCTACGTTGAGT
GTTGCTACTGATCTTGAATCCCTATACGAAACCGTATTGGTGGATACCCCACTGGCACCT
TACTTCAAAAACTGTTTTGACACGGCAGAGGAGCTAGACGATATGAACATTGAAATTATT
AGAAATAAGCTGTACAAGGCTTATTTAGAAGACTTTTACAATTTTGTCACTGAAGAAATT
CCGGAACCTGCTAAAGAATGTATGCAAACATTACTAGGGTTTGAAGCTGACAGAAGAAGT
ATCAATATTGCACTCAACTCTTTGCAAAGTTCAGATATTGACCCAGATTTGAAAAGTGAC
TTGTTACCTAACATAGGTAAGTTGTACCCTCTTGCAACGTTTCACTTGGCGCAAGCCCAA
GATTTCGAAGGAGTTAGAGCTGCTTTAGCTAACGTCTATGAGTATAGGGGATTTTTGGAG
ACTGGTAACTTAGAAGATCACTTTTACCAATTGGAAATGGAACTATGTAGAGATGCTTTC
ACGCAACAATTTGCCATCAGCACTGTTTGGGCCTGGATGAAATCCAAGGAACAAGAAGTT
AGGAATATTACCTGGATTGCAGAATGTATCGCACAAAACCAAAGAGAAAGAATCAACAAT
TATATTTCCGTTTATTAG |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 345 |
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| Protein Molecular Weight | 39790.30078 |
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| Protein Theoretical pI | 4.22 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >V-type proton ATPase subunit d
MEGVYFNIDNGFIEGVVRGYRNGLLSNNQYINLTQCDTLEDLKLQLSSTDYGNFLSSVSS
ESLTTSLIQEYASSKLYHEFNYIRDQSSGSTRKFMDYITYGYMIDNVALMITGTIHDRDK
GEILQRCHPLGWFDTLPTLSVATDLESLYETVLVDTPLAPYFKNCFDTAEELDDMNIEII
RNKLYKAYLEDFYNFVTEEIPEPAKECMQTLLGFEADRRSINIALNSLQSSDIDPDLKSD
LLPNIGKLYPLATFHLAQAQDFEGVRAALANVYEYRGFLETGNLEDHFYQLEMELCRDAF
TQQFAISTVWAWMKSKEQEVRNITWIAECIAQNQRERINNYISVY |
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| References |
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| External Links | |
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| General Reference | - Bauerle, C., Ho, M. N., Lindorfer, M. A., Stevens, T. H. (1993). "The Saccharomyces cerevisiae VMA6 gene encodes the 36-kDa subunit of the vacuolar H(+)-ATPase membrane sector." J Biol Chem 268:12749-12757.8509410
- Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
- Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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