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Identification
NameAccumulation of dyads protein 2
Synonyms
  • Ammonia transport outward protein 1
Gene NameADY2
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in acetate transmembrane transporter activity
Specific FunctionTransporter protein required for ammonia export and acetate uptake and resistance. Necessary for up-regulation and down-regulation of meiotic plaque (MP) component levels in a dependency on external acetate. Has a role in ascus formation
Cellular LocationCell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00056Acetic acidShow
GO Classification
Component
cell part
membrane
Function
Not Available
Process
Not Available
Gene Properties
Chromosome Locationchromosome 3
LocusYCR010C
Gene Sequence>852 bp ATGTCTGACAAGGAACAAACGAGCGGAAACACAGATTTGGAGAATGCACCAGCAGGATAC TATAGTTCCCATGATAACGACGTTAATGGCGTTGCAGAAGATGAACGTCCATCTCATGAT TCGTTGGGCAAGATTTACACTGGAGGTGATAACAATGAATATATCTATATTGGGCGTCAA AAGTTTTTGAAGAGCGACTTATACCAAGCCTTTGGTGGTACCTTGAATCCAGGGTTAGCT CCTGCTCCAGTGCACAAATTTGCTAATCCTGCGCCCTTAGGTCTTTCAGCCTTCGCGTTG ACGACATTTGTGCTGTCCATGTTCAATGCGAGAGCGCAAGGGATCACTGTTCCTAATGTT GTCGTCGGTTGTGCTATGTTTTATGGTGGTTTGGTGCAATTGATTGCTGGTATTTGGGAG ATAGCTTTGGAAAATACTTTTGGTGGTACCGCATTATGTTCTTACGGTGGGTTTTGGTTG AGTTTCGCTGCAATTTACATTCCTTGGTTTGGTATCTTGGAAGCTTACGAAGACAATGAA TCTGATTTGAATAATGCTTTAGGATTTTATTTGTTGGGGTGGGCCATCTTTACGTTTGGT TTAACCGTTTGTACCATGAAATCCACTGTTATGTTCTTTTTGTTGTTCTTCTTACTAGCA TTAACTTTCCTACTGTTGTCTATTGGTCACTTTGCTAATAGACTTGGTGTCACAAGAGCT GGTGGTGTCCTGGGAGTTGTTGTTGCTTTCATTGCTTGGTACAACGCATATGCAGGTGTT GCTACAAAGCAGAATTCATATGTACTGGCTCGTCCATTCCCATTACCATCTACTGAAAGG GTAATCTTTTAA
Protein Properties
Pfam Domain Function
Protein Residues283
Protein Molecular Weight30725.90039
Protein Theoretical pI4.79
Signalling Regions
  • None
Transmembrane Regions
  • 90-110
  • 121-141
  • 152-172
  • 186-206
  • 209-229
  • 241-261
Protein Sequence>Accumulation of dyads protein 2 MSDKEQTSGNTDLENAPAGYYSSHDNDVNGVAEDERPSHDSLGKIYTGGDNNEYIYIGRQ KFLKSDLYQAFGGTLNPGLAPAPVHKFANPAPLGLSAFALTTFVLSMFNARAQGITVPNV VVGCAMFYGGLVQLIAGIWEIALENTFGGTALCSYGGFWLSFAAIYIPWFGILEAYEDNE SDLNNALGFYLLGWAIFTFGLTVCTMKSTVMFFLLFFLLALTFLLLSIGHFANRLGVTRA GGVLGVVVAFIAWYNAYAGVATKQNSYVLARPFPLPSTERVIF
References
External Links
ResourceLink
Saccharomyces Genome Database ADY2
Uniprot IDP25613
Uniprot NameADY2_YEAST
GenBank Gene IDX59720
Genebank Protein ID1907153
General Reference
  • Skala, J., Purnelle, B., Goffeau, A. (1992). "The complete sequence of a 10.8 kb segment distal of SUF2 on the right arm of chromosome III from Saccharomyces cerevisiae reveals seven open reading frames including the RVS161, ADP1 and PGK genes." Yeast 8:409-417.1626432
  • Oliver, S. G., van der Aart, Q. J., Agostoni-Carbone, M. L., Aigle, M., Alberghina, L., Alexandraki, D., Antoine, G., Anwar, R., Ballesta, J. P., Benit, P., et, a. l. .. (1992). "The complete DNA sequence of yeast chromosome III." Nature 357:38-46.1574125
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
  • Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666
  • Rabitsch, K. P., Toth, A., Galova, M., Schleiffer, A., Schaffner, G., Aigner, E., Rupp, C., Penkner, A. M., Moreno-Borchart, A. C., Primig, M., Esposito, R. E., Klein, F., Knop, M., Nasmyth, K. (2001). "A screen for genes required for meiosis and spore formation based on whole-genome expression." Curr Biol 11:1001-1009.11470404
  • Palkova, Z., Devaux, F., Icicova, M., Minarikova, L., Le Crom, S., Jacq, C. (2002). "Ammonia pulses and metabolic oscillations guide yeast colony development." Mol Biol Cell 13:3901-3914.12429834
  • Paiva, S., Devaux, F., Barbosa, S., Jacq, C., Casal, M. (2004). "Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae." Yeast 21:201-210.14968426
  • Taxis, C., Keller, P., Kavagiou, Z., Jensen, L. J., Colombelli, J., Bork, P., Stelzer, E. H., Knop, M. (2005). "Spore number control and breeding in Saccharomyces cerevisiae: a key role for a self-organizing system." J Cell Biol 171:627-640.16286509
  • Ricicova, M., Kucerova, H., Vachova, L., Palkova, Z. (2007). "Association of putative ammonium exporters Ato with detergent-resistant compartments of plasma membrane during yeast colony development: pH affects Ato1p localisation in patches." Biochim Biophys Acta 1768:1170-1178.17395151
  • Gentsch, M., Kuschel, M., Schlegel, S., Barth, G. (2007). "Mutations at different sites in members of the Gpr1/Fun34/YaaH protein family cause hypersensitivity to acetic acid in Saccharomyces cerevisiae as well as in Yarrowia lipolytica." FEMS Yeast Res 7:380-390.17233767