V-type proton ATPase subunit c'' (P23968)

Identification
NameV-type proton ATPase subunit c''
Synonyms
  • V-ATPase subunit c''
  • V-ATPase 22 kDa proteolipid subunit
  • Vacuolar proton pump c'' subunit
Gene NamePPA1
Enzyme ClassNot Available
Biological Properties
General FunctionEnergy production and conversion
Specific FunctionProton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells
Cellular LocationMembrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
macromolecular complex
protein complex
proton-transporting two-sector ATPase complex, proton-transporting domain
proton-transporting V-type ATPase, V0 domain
Function
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
Process
nucleotide metabolic process
purine nucleotide metabolic process
metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
ATP biosynthetic process
ATP synthesis coupled proton transport
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>642 bp ATGAACAAGGAATCTAAAGATGATGATATGTCCTTGGGGAAGTTTTCCTTCTCCCACTTC CTATATTACTTGGTGCTAATAGTAGTAATAGTGTACGGTTTGTACAAGCTTTTCACTGGA CATGGATCCGACATTAATTTCGGGAAGTTCTTGTTAAGGACATCCCCTTATATGTGGGCC AATCTTGGTATTGCCCTTTGTGTAGGCTTAAGTGTCGTGGGGGCAGCATGGGGTATTTTC ATTACTGGTTCATCCATGATTGGTGCCGGTGTGCGTGCTCCAAGGATTACCACCAAGAAT TTAATTTCCATTATTTTCTGTGAAGTGGTTGCCATTTACGGTCTGATTATTGCCATTGTC TTTTCTTCGAAATTGACTGTGGCTACTGCTGAGAACATGTACTCGAAATCAAACCTGTAC ACTGGTTATTCTCTTTTCTGGGCAGGTATCACTGTCGGTGCTTCCAATTTGATTTGTGGT ATCGCTGTCGGTATCACCGGTGCGACTGCTGCCATTTCCGATGCTGCTGATTCCGCATTG TTTGTTAAAATTTTGGTCATTGAAATTTTCGGGTCCATTTTAGGTTTATTAGGTTTGATT GTTGGTTTATTGATGGCCGGTAAAGCTTCTGAATTTCAGTAA
Protein Properties
Pfam Domain Function
Protein Residues213
Protein Molecular Weight22595.5
Protein Theoretical pI8.43
Signalling Regions
  • None
Transmembrane Regions
  • 15-35
  • 62-82
  • 101-121
  • 146-167
  • 180-205
Protein Sequence>V-type proton ATPase subunit c'' MNKESKDDDMSLGKFSFSHFLYYLVLIVVIVYGLYKLFTGHGSDINFGKFLLRTSPYMWA NLGIALCVGLSVVGAAWGIFITGSSMIGAGVRAPRITTKNLISIIFCEVVAIYGLIIAIV FSSKLTVATAENMYSKSNLYTGYSLFWAGITVGASNLICGIAVGITGATAAISDAADSAL FVKILVIEIFGSILGLLGLIVGLLMAGKASEFQ
References
External Links
ResourceLink
Saccharomyces Genome Database PPA1
Uniprot IDP23968
Uniprot NameVATO_YEAST
GenBank Gene IDAY692797
Genebank Protein ID51013045
General Reference
  • Apperson, M., Jensen, R. E., Suda, K., Witte, C., Yaffe, M. P. (1990). "A yeast protein, homologous to the proteolipid of the chromaffin granule proton-ATPase, is important for cell growth." Biochem Biophys Res Commun 168:574-579.2139779
  • Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Hirata, R., Graham, L. A., Takatsuki, A., Stevens, T. H., Anraku, Y. (1997). "VMA11 and VMA16 encode second and third proteolipid subunits of the Saccharomyces cerevisiae vacuolar membrane H+-ATPase." J Biol Chem 272:4795-4803.9030535
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258