You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Yeast Metabolome Database.
Identification |
---|
Name | N(2),N(2)-dimethylguanosine tRNA methyltransferase, mitochondrial |
---|
Synonyms | - tRNA 2,2-dimethylguanosine-26 methyltransferase
- tRNA(guanine-26,N(2)-N(2)) methyltransferase
- tRNA(m(2,2)G26)dimethyltransferase
|
---|
Gene Name | TRM1 |
---|
Enzyme Class | |
---|
Biological Properties |
---|
General Function | Involved in RNA binding |
---|
Specific Function | Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs |
---|
Cellular Location | Mitochondrion. Nucleus. Cytoplasm. |
---|
SMPDB Pathways | Not Available |
---|
KEGG Pathways | Not Available |
---|
SMPDB Reactions | Not Available |
---|
KEGG Reactions | Not Available |
---|
Metabolites | YMDB ID | Name | View |
---|
YMDB00198 | S-Adenosylhomocysteine | Show | YMDB00297 | S-Adenosylmethionine | Show |
|
---|
GO Classification | Component |
---|
Not Available | Function |
---|
binding | nucleic acid binding | RNA binding | N-methyltransferase activity | catalytic activity | tRNA (guanine-N2-)-methyltransferase activity | transferase activity | transferase activity, transferring one-carbon groups | methyltransferase activity | Process |
---|
cellular macromolecule metabolic process | RNA metabolic process | ncRNA metabolic process | tRNA metabolic process | tRNA processing | metabolic process | macromolecule metabolic process |
|
---|
Gene Properties |
---|
Chromosome Location | chromosome 4 |
---|
Locus | YDR120C |
---|
Gene Sequence | >1713 bp
ATGGAAGGTTTCTTCAGGATACCCCTCAAGCGGGCAAATTTACACGGAATGTTGAAGGCT
GCTATATCCAAAATTAAAGCGAATTTTACCGCGTATGGTGCACCAAGAATCAATATTGAG
GATTTCAATATAGTCAAGGAAGGAAAAGCAGAAATTCTTTTCCCTAAAAAGGAAACTGTT
TTCTATAATCCCATCCAACAATTTAATAGAGATCTAAGTGTTACATGCATCAAGGCGTGG
GACAACCTATATGGTGAGGAATGTGGCCAAAAGAGAAATAATAAAAAAAGTAAGAAGAAA
AGGTGCGCGGAAACTAACGATGATTCTTCCAAGCGTCAAAAAATGGGAAACGGGTCACCA
AAAGAAGCCGTTGGTAATTCTAATCGAAACGAACCTTATATAAATATTTTGGAAGCATTG
TCAGCCACTGGGTTAAGAGCCATTAGGTATGCTCATGAAATTCCCCATGTGAGGGAAGTT
ATTGCTAACGATTTACTTCCAGAGGCTGTCGAATCTATAAAACGAAACGTTGAATATAAT
AGTGTCGAAAACATTGTCAAGCCAAACCTTGATGATGCTAATGTCTTAATGTACCGTAAC
AAAGCGACGAATAATAAGTTTCACGTCATCGACTTGGATCCTTACGGTACCGTTACACCT
TTTGTAGATGCGGCTATTCAGAGTATTGAGGAGGGTGGTCTAATGCTGGTAACTTGCACT
GATTTATCCGTTTTGGCCGGTAACGGATACCCAGAAAAGTGTTTTGCCTTATATGGTGGT
GCAAATATGGTTTCTCATGAATCAACTCACGAAAGTGCGCTGAGACTAGTATTGAACTTA
CTAAAGCAAACTGCCGCGAAATACAAGAAAACTGTGGAACCGCTTTTGTCGTTGAGCATT
GACTTTTACGTCAGAGTTTTTGTCAAAGTCAAAACAAGCCCGATTGAAGTCAAAAACGTT
ATGTCAAGTACTATGACTACTTACCATTGTTCCCGTTGCGGCTCTTACCACAATCAACCT
CTGGGCAGAATTTCTCAACGCGAAGGTAGGAACAACAAAACATTCACCAAATACTCGGTT
GCGCAAGGGCCTCCGGTTGATACTAAATGTAAGTTCTGCGAGGGGACATACCATTTAGCT
GGTCCAATGTATGCAGGACCTCTACACAACAAGGAGTTCATCGAGGAGGTGTTGAGAATT
AATAAAGAAGAGCATCGTGACCAGGATGATACATATGGAACACGTAAAAGAATTGAAGGT
ATGCTATCTCTAGCTAAGAATGAATTATCCGATTCGCCATTCTATTTCAGTCCTAACCAT
ATTGCATCGGTAATAAAATTACAAGTACCTCCCTTGAAAAAAGTAGTCGCAGGCCTAGGT
TCCCTAGGCTTTGAATGTTCATTGACACATGCCCAACCATCGTCCCTAAAGACTAACGCT
CCATGGGATGCAATCTGGTATGTGATGCAGAAATGTGATGATGAGAAGAAAGACTTAAGC
AAAATGAATCCAAATACTACGGGCTATAAGATTTTATCGGCAATGCCAGGATGGTTGAGT
GGCACTGTCAAATCAGAGTATGACTCAAAGCTGTCGTTCGCACCAAATGAACAAAGCGGT
AATATTGAAAAACTAAGGAAGCTAAAAATTGTGAGATATCAGGAAAATCCAACAAAGAAT
TGGGGCCCAAAAGCCCGTCCCAACACTTCATAA |
---|
Protein Properties |
---|
Pfam Domain Function | |
---|
Protein Residues | 570 |
---|
Protein Molecular Weight | 64051.80078 |
---|
Protein Theoretical pI | 9.49 |
---|
Signalling Regions | |
---|
Transmembrane Regions | |
---|
Protein Sequence | >N(2),N(2)-dimethylguanosine tRNA methyltransferase, mitochondrial
MEGFFRIPLKRANLHGMLKAAISKIKANFTAYGAPRINIEDFNIVKEGKAEILFPKKETV
FYNPIQQFNRDLSVTCIKAWDNLYGEECGQKRNNKKSKKKRCAETNDDSSKRQKMGNGSP
KEAVGNSNRNEPYINILEALSATGLRAIRYAHEIPHVREVIANDLLPEAVESIKRNVEYN
SVENIVKPNLDDANVLMYRNKATNNKFHVIDLDPYGTVTPFVDAAIQSIEEGGLMLVTCT
DLSVLAGNGYPEKCFALYGGANMVSHESTHESALRLVLNLLKQTAAKYKKTVEPLLSLSI
DFYVRVFVKVKTSPIEVKNVMSSTMTTYHCSRCGSYHNQPLGRISQREGRNNKTFTKYSV
AQGPPVDTKCKFCEGTYHLAGPMYAGPLHNKEFIEEVLRINKEEHRDQDDTYGTRKRIEG
MLSLAKNELSDSPFYFSPNHIASVIKLQVPPLKKVVAGLGSLGFECSLTHAQPSSLKTNA
PWDAIWYVMQKCDDEKKDLSKMNPNTTGYKILSAMPGWLSGTVKSEYDSKLSFAPNEQSG
NIEKLRKLKIVRYQENPTKNWGPKARPNTS |
---|
References |
---|
External Links | |
---|
General Reference | - Ellis, S. R., Hopper, A. K., Martin, N. C. (1987). "Amino-terminal extension generated from an upstream AUG codon is not required for mitochondrial import of yeast N2,N2-dimethylguanosine-specific tRNA methyltransferase." Proc Natl Acad Sci U S A 84:5172-5176.3299379
- Liu, J., Liu, J., Straby, K. B. (1998). "Point and deletion mutations eliminate one or both methyl group transfers catalysed by the yeast TRM1 encoded tRNA (m22G26)dimethyltransferase." Nucleic Acids Res 26:5102-5108.9801306
- Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
- Liu, J., Zhou, G. Q., Straby, K. B. (1999). "Caenorhabditis elegans ZC376.5 encodes a tRNA (m2/2G(26))dimethyltransferance in which (246)arginine is important for the enzyme activity." Gene 226:73-81.10048958
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
|
---|