General transcriptional corepressor CYC8 (P14922)

Identification
NameGeneral transcriptional corepressor CYC8
Synonyms
  • Glucose repression mediator protein CYC8
Gene NameCYC8
Enzyme ClassNot Available
Biological Properties
General Functionregulation of response to DNA damage stimulus
Specific FunctionActs as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
Cellular LocationNot Available
SMPDB Pathways
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
transcriptional repressor activity, RNA polymerase II transcription factor binding
chromatin remodeling
negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter
nucleosome positioning
regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter
regulation of response to DNA damage stimulus
nucleus
negative regulation of transcription from RNA polymerase II promoter during mitosis
negative regulation of transcription from RNA polymerase II promoter
transcriptional repressor complex
histone deacetylase binding
transcriptional activator activity, RNA polymerase II transcription factor binding
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2901 bp ATGAATCCGGGCGGTGAACAAACAATAATGGAACAACCCGCTCAACAGCAACAACAACAG CAACAACAACAGCAGCAACAGCAACAGCAGGCAGCAGTTCCTCAGCAGCCACTCGACCCA TTAACACAATCAACTGCGGAAACTTGGCTCTCCATTGCTTCTTTGGCAGAAACCCTTGGT GATGGCGACAGGGCCGCAATGGCATATGACGCCACTTTACAGTTCAATCCCTCATCTGCA AAGGCTTTAACATCTTTGGCTCACTTGTACCGTTCCAGAGACATGTTCCAAAGAGCTGCA GAATTATATGAAAGAGCACTTTTGGTAAATCCCGAACTATCAGATGTGTGGGCTACTTTA GGTCATTGTTATCTGATGCTGGATGATCTGCAAAGAGCTTACAATGCCTATCAACAGGCT CTCTACCACCTCAGTAATCCCAACGTACCGAAATTATGGCATGGAATCGGCATTCTTTAT GACAGATATGGTTCGCTCGACTATGCCGAAGAAGCTTTTGCCAAAGTTTTGGAATTGGAC CCTCATTTTGAAAAGGCAAACGAAATTTACTTCAGACTAGGTATTATTTATAAACATCAG GGTAAATGGTCTCAAGCTTTGGAATGCTTCAGATACATTCTCCCTCAACCTCCTGCTCCC TTGCAGGAGTGGGACATATGGTTTCAGTTGGGTAGTGTTTTGGAGAGTATGGGAGAGTGG CAAGGTGCGAAGGAAGCCTACGAGCATGTCTTGGCTCAAAATCAACATCATGCCAAAGTA TTACAACAATTAGGTTGTCTTTACGGTATGAGTAACGTACAATTTTATGACCCTCAAAAG GCATTGGATTATCTTCTAAAGTCGTTAGAAGCAGATCCCTCCGATGCCACTACATGGTAC CATCTCGGTAGAGTGCATATGATTAGAACAGATTATACTGCCGCATATGATGCTTTCCAA CAAGCTGTTAATAGAGATTCAAGAAACCCTATCTTTTGGTGCTCAATCGGTGTTTTATAT TACCAAATTTCTCAATACAGAGACGCCTTAGACGCGTACACAAGAGCCATAAGATTAAAT CCTTATATTAGTGAAGTTTGGTACGATCTAGGTACTCTTTACGAAACTTGTAACAACCAA TTATCTGACGCCCTTGATGCGTATAAGCAAGCTGCAAGACTGGACGTAAATAATGTTCAC ATAAGAGAAAGATTAGAAGCTTTAACAAAGCAGTTAGAAAACCCAGGCAATATAAACAAA TCGAACGGTGCGCCAACGAATGCCTCTCCTGCCCCACCTCCTGTGATTTTACAACCTACC TTACAACCTAATGATCAAGGAAATCCTTTGAACACTAGAATTTCAGCCCAATCTGCCAAT GCTACTGCTTCAATGGTACAACAACAGCATCCTGCTCAACAAACGCCTATTAACTCTTCT GCAACAATGTACAGTAATGGAGCTTCCCCTCAATTACAAGCTCAAGCTCAAGCTCAAGCT CAAGCACAAGCTCAAGCACAAGCACAAGCTCAAGCACAAGCACAAGCACAAGCGCAAGCA CAAGCACAAGCACAGGCGCAAGCACAGGCACAAGCACAAGCACAAGCACATGCACAAGCG CAAGCACAAGCACAAGCACAGGCACAAGCACAAGCACAGGCGCAGGCACAACAACAACAA CAACAACAGCAACAACAACAACAACAACAACAACAACAACAACAACAACAACAACAACAA CAACAACAACAGCAGCAGCAATTACAGCCCCTACCAAGACAACAGCTGCAGCAAAAGGGA GTTTCTGTGCAAATGTTAAATCCTCAACAAGGGCAACCATATATCACACAGCCAACAGTC ATACAAGCTCACCAACTGCAACCATTTTCTACACAAGCTATGGAACATCCGCAAAGCTCT CAACTGCCACCTCAACAGCAACAACTACAATCTGTTCAACATCCACAACAACTTCAAGGC CAGCCTCAAGCCCAAGCTCCCCAACCTTTAATCCAGCATAACGTGGAACAGAACGTTTTA CCTCAAAAGAGATACATGGAAGGTGCAATCCACACTTTAGTAGATGCCGCCGTATCCAGT AGCACCCACACAGAGAATAACACAAAGTCTCCTCGTCAACCAACCCATGCCATTCCAACG CAAGCTCCCGCAACAGGAATAACGAACGCTGAACCACAGGTAAAGAAGCAAAAGTTGAAC TCTCCAAATTCAAACATCAACAAATTAGTAAATACTGCTACTTCCATTGAAGAAAATGCA AAATCTGAGGTGAGCAACCAATCGCCAGCAGTAGTGGAGTCTAATACCAATAATACTTCA CAAGAAGAAAAACCTGTAAAAGCAAACTCAATACCTTCAGTAATTGGCGCACAGGAACCT CCACAGGAAGCTAGTCCTGCTGAAGAAGCTACCAAAGCAGCTTCTGTTTCTCCTTCTACA AAACCGCTTAATACGGAACCAGAGTCATCTAGTGTCCAACCAACTGTATCATCAGAAAGT TCAACAACAAAAGCAAATGACCAAAGCACTGCTGAGACCATAGAACTTTCTACTGCTACT GTTCCTGCAGAAGCAAGCCCTGTAGAAGACGAAGTAAGACAGCATTCTAAAGAGGAAAAC GGCACAACTGAAGCATCTGCACCTTCTACTGAAGAGGCGGAGCCAGCAGCTTCCAGAGAT GCTGAAAAACAACAAGATGAAACCGCTGCTACAACGATAACTGTAATCAAACCTACTTTG GAAACAATGGAAACAGTGAAAGAGGAGGCCAAAATGCGTGAGGAAGAGCAAACATCTCAA GAAAAATCCCCACAGGAGAACACACTTCCAAGAGAAAATGTAGTAAGGCAAGTGGAAGAA GATGAAAACTACGACGACTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues966
Protein Molecular Weight107201.375
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>General transcriptional corepressor CYC8 MNPGGEQTIMEQPAQQQQQQQQQQQQQQQQAAVPQQPLDPLTQSTAETWLSIASLAETLG DGDRAAMAYDATLQFNPSSAKALTSLAHLYRSRDMFQRAAELYERALLVNPELSDVWATL GHCYLMLDDLQRAYNAYQQALYHLSNPNVPKLWHGIGILYDRYGSLDYAEEAFAKVLELD PHFEKANEIYFRLGIIYKHQGKWSQALECFRYILPQPPAPLQEWDIWFQLGSVLESMGEW QGAKEAYEHVLAQNQHHAKVLQQLGCLYGMSNVQFYDPQKALDYLLKSLEADPSDATTWY HLGRVHMIRTDYTAAYDAFQQAVNRDSRNPIFWCSIGVLYYQISQYRDALDAYTRAIRLN PYISEVWYDLGTLYETCNNQLSDALDAYKQAARLDVNNVHIRERLEALTKQLENPGNINK SNGAPTNASPAPPPVILQPTLQPNDQGNPLNTRISAQSANATASMVQQQHPAQQTPINSS ATMYSNGASPQLQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAHAQA QAQAQAQAQAQAQAQAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQPLPRQQLQQKG VSVQMLNPQQGQPYITQPTVIQAHQLQPFSTQAMEHPQSSQLPPQQQQLQSVQHPQQLQG QPQAQAPQPLIQHNVEQNVLPQKRYMEGAIHTLVDAAVSSSTHTENNTKSPRQPTHAIPT QAPATGITNAEPQVKKQKLNSPNSNINKLVNTATSIEENAKSEVSNQSPAVVESNTNNTS QEEKPVKANSIPSVIGAQEPPQEASPAEEATKAASVSPSTKPLNTEPESSSVQPTVSSES STTKANDQSTAETIELSTATVPAEASPVEDEVRQHSKEENGTTEASAPSTEEAEPAASRD AEKQQDETAATTITVIKPTLETMETVKEEAKMREEEQTSQEKSPQENTLPRENVVRQVEE DENYDD
References
External Links
ResourceLink
Saccharomyces Genome Database CYC8
Uniprot IDP14922
Uniprot NameCYC8
General ReferenceNot Available