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ATP synthase subunit 5, mitochondrial (P09457)

Identification
NameATP synthase subunit 5, mitochondrial
Synonyms
  • ATP synthase chain 5
  • Oligomycin sensitivity conferral protein
  • OSCP
Gene NameATP5
Enzyme ClassNot Available
Biological Properties
General FunctionEnergy production and conversion
Specific FunctionMitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements
Cellular LocationMitochondrion. Mitochondrion inner membrane
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Component
protein complex
proton-transporting two-sector ATPase complex, catalytic domain
plasma membrane
cell part
membrane
proton-transporting ATP synthase complex, catalytic core F(1)
macromolecular complex
Function
hydrogen ion transmembrane transporter activity
transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
hydrogen ion transporting ATP synthase activity, rotational mechanism
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
Process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
metabolic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
ATP biosynthetic process
ATP synthesis coupled proton transport
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>639 bp ATGTTTAATAGAGTCTTTACCAGGTCATTTGCATCAAGCTTAAGAGCTGCTGCTTCCAAA GCTGCTGCTCCCCCACCGGTGAGATTGTTCGGTGTTGAGGGCACTTACGCAACAGCTTTA TATCAGGCCGCTGCAAAGAACTCCTCTATTGATGCTGCCTTTCAATCTTTGCAAAAAGTT GAAAGCACAGTCAAAAAGAATCCAAAATTAGGTCACTTATTACTGAATCCTGCATTGTCA TTGAAGGACAGAAATTCTGTCATTGATGCCATCGTGGAGACTCACAAGAATTTGGATGGT TATGTCGTTAACCTATTGAAGGTTCTTTCCGAAAATAACAGACTGGGATGTTTTGAAAAA ATTGCGTCTGACTTTGGCGTTTTAAACGATGCTCACAACGGGTTACTTAAAGGTACAGTG ACTAGTGCTGAACCATTGGATCCTAAATCTTTCAAGAGGATTGAAAAAGCTTTGAGCGCC TCCAAATTGGTGGGGCAAGGTAAATCTTTGAAGCTGGAAAACGTGGTTAAGCCAGAGATT AAGGGTGGTTTGATTGTAGAACTTGGTGACAAGACTGTTGACTTAAGCATTTCTACAAAG ATTCAAAAACTGAATAAGGTCTTAGAGGACAGCATTTAA
Protein Properties
Pfam Domain Function
Protein Residues212
Protein Molecular Weight22814.19922
Protein Theoretical pI10.27
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>ATP synthase subunit 5, mitochondrial MFNRVFTRSFASSLRAAASKAAAPPPVRLFGVEGTYATALYQAAAKNSSIDAAFQSLQKV ESTVKKNPKLGHLLLNPALSLKDRNSVIDAIVETHKNLDGYVVNLLKVLSENNRLGCFEK IASDFGVLNDAHNGLLKGTVTSAEPLDPKSFKRIEKALSASKLVGQGKSLKLENVVKPEI KGGLIVELGDKTVDLSISTKIQKLNKVLEDSI
References
External Links
ResourceLink
Saccharomyces Genome Database ATP5
Uniprot IDP09457
Uniprot NameATPO_YEAST
GenBank Gene IDAY557732
Genebank Protein ID45269355
General Reference
  • Lee, M., Jones, D., Mueller, D. M. (1988). "The sequence of the yeast ATP5 gene." Nucleic Acids Res 16:8181.2971156
  • Uh, M., Jones, D., Mueller, D. M. (1990). "The gene coding for the yeast oligomycin sensitivity-conferring protein." J Biol Chem 265:19047-19052.2146269
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Reinders, J., Wagner, K., Zahedi, R. P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., Meisinger, C. (2007). "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase." Mol Cell Proteomics 6:1896-1906.17761666