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NameCytochrome c oxidase subunit 7A
  • Cytochrome c oxidase polypeptide VIIA
Gene NameCOX9
Enzyme Class
Biological Properties
General FunctionInvolved in cytochrome-c oxidase activity
Specific FunctionThis small integral protein plays a role in holoenzyme assembly or stability
Cellular LocationMitochondrion inner membrane
SMPDB Pathways
Oxidative phosphorylationPW002461 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Oxidative phosphorylationec00190 Map00190
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
GO Classification
mitochondrial membrane part
mitochondrial respiratory chain
cell part
membrane part
catalytic activity
oxidoreductase activity
heme-copper terminal oxidase activity
cytochrome-c oxidase activity
respiratory electron transport chain
metabolic process
cellular metabolic process
oxidation reduction
generation of precursor metabolites and energy
electron transport chain
Gene Properties
Chromosome Locationchromosome 4
Protein Properties
Pfam Domain Function
Protein Residues59
Protein Molecular Weight6963.2002
Protein Theoretical pI10.39
Signalling Regions
  • None
Transmembrane Regions
  • 16-34
External Links
Saccharomyces Genome Database COX9
Uniprot IDP07255
Uniprot NameCOX9_YEAST
GenBank Gene IDAY558525
Genebank Protein ID45270940
General Reference
  • Wright, R. M., Dircks, L. K., Poyton, R. O. (1986). "Characterization of COX9, the nuclear gene encoding the yeast mitochondrial protein cytochrome c oxidase subunit VIIa. Subunit VIIa lacks a leader peptide and is an essential component of the holoenzyme." J Biol Chem 261:17183-17191.3023385
  • Duhl, D. M., Powell, T., Poyton, R. O. (1990). "Mitochondrial import of cytochrome c oxidase subunit VIIa in Saccharomyces cerevisiae. Identification of sequences required for mitochondrial localization in vivo." J Biol Chem 265:7273-7277.2158998
  • Forsbach, V., Pillar, T., Gottenof, T., Rodel, G. (1989). "Chromosomal localization and expression of CBS1, a translational activator of cytochrome b in yeast." Mol Gen Genet 218:57-63.2550765
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Power, S. D., Lochrie, M. A., Poyton, R. O. (1986). "The nuclear-coded subunits of yeast cytochrome c oxidase. The amino acid sequences of subunits VII and VIIa, structural similarities between the three smallest polypeptides of the holoenzyme, and implications for biogenesis." J Biol Chem 261:9206-9209.3013877
  • Geier, B. M., Schagger, H., Ortwein, C., Link, T. A., Hagen, W. R., Brandt, U., Von Jagow, G. (1995). "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method." Eur J Biochem 227:296-302.7851399
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106