| Identification |
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| Name | Threonyl-tRNA synthetase, mitochondrial |
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| Synonyms | - Threonine--tRNA ligase
- ThrRS
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| Gene Name | MST1 |
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| Enzyme Class | |
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| Biological Properties |
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| General Function | Involved in nucleotide binding |
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| Specific Function | ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr) |
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| Cellular Location | Mitochondrion matrix |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00097 | Adenosine monophosphate | Show | | YMDB00109 | Adenosine triphosphate | Show | | YMDB00214 | L-Threonine | Show | | YMDB00219 | Pyrophosphate | Show |
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| GO Classification | | Component |
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| cell part | | intracellular part | | cytoplasm | | Function |
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| threonine-tRNA ligase activity | | adenyl nucleotide binding | | adenyl ribonucleotide binding | | ATP binding | | ligase activity, forming carbon-oxygen bonds | | ligase activity, forming aminoacyl-tRNA and related compounds | | catalytic activity | | aminoacyl-tRNA ligase activity | | nucleotide binding | | ligase activity | | binding | | nucleoside binding | | purine nucleoside binding | | Process |
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| threonyl-tRNA aminoacylation | | metabolic process | | cellular macromolecule metabolic process | | macromolecule metabolic process | | RNA metabolic process | | ncRNA metabolic process | | tRNA metabolic process | | biosynthetic process | | tRNA aminoacylation | | tRNA aminoacylation for protein translation | | macromolecule biosynthetic process | | cellular macromolecule biosynthetic process | | translation |
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| Gene Properties |
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| Chromosome Location | chromosome 11 |
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| Locus | YKL194C |
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| Gene Sequence | >1389 bp
ATGAAAATACAACTTGTAAGATGGCATTGTTCTCGCAATGCTCTTTGGAATCGTGCTTTC
TACTCTACGAGAAAGGCCACTAAGAACGCTTCGTCGGCGACTCCAGCTACTATGACATCC
ATGGTATCTCAGAGGCAAGATCTTTTCATGACAGATCCACTATCTCCTGGATCCATGTTC
TTTCTTCCAAATGGTGCTAAGATTTTCAACAAATTGATAGAGTTTATGAAGTTACAACAA
AAGTTCAAATTTGGTTTTAATGAAGTTGTGACGCCTTTGATTTACAAAAAGACTCTTTGG
GAAAAGTCTGGTCACTGGGAAAATTATGCTGATGACATGTTTAAGGTGGAAACTACGGAT
GAAGAAAAGGAGGAATACGGTTTAAAACCGATGAATTGCCCAGGCCATTGTCTGATCTTC
GGTAAAAAGGATAGATCGTATAACGAACTTCCCCTACGCTTCTCTGATTTTTCACCACTA
CATAGAAATGAAGCTTCTGGTGCACTGTCGGGATTGACTAGACTAAGGAAGTTCCATCAA
GACGATGGTCATATCTTTTGCACTCCTTCCCAAGTGAAATCAGAAATTTTCAACTCTTTA
AAATTAATCGACATAGTTTACAACAAAATTTTCCCCTTTGTTAAAGGAGGTTCTGGAGCA
GAGAGCAATTATTTTATAAACTTTTCTACAAGACCGGATCACTTCATTGGAGACCTCAAA
GTTTGGAATCATGCTGAGCAAGTACTCAAGGAAATCTTGGAAGAATCAGGCAAACCGTGG
AAACTGAACCCTAGTGATGGTGCGTTCTATGGTCCAAAGTTGGATATAATGGTTACGGAC
CATTTACGCAAAACTCATCAAGTCGCTACTATTCAGTTGGACTTTCAGCTACCTGAGAGG
TTCGATTTGAAATTCAAGGATCAAGACAACTCGTACAAGAGGCCAATTATGATTCATAGA
GCTACTTTTGGTTCTATCGAAAGATTTATGGCTTTACTGATAGATTCTAATGAGGGCCGT
TGGCCGTTTTGGTTGAATCCTTACCAAGCTGTAATTATTCCCGTCAATACGAAAAATGTG
CAACAGCTAGACATGTGCACTGCCTTGCAGAAAAAACTACGTAATGAACTGGAAGCCGAC
GACATGGAACCAGTTCCTTTAAATGATTGGCATTTCAATGTTGATCTCGACATAAGAAAC
GAACCCGTAGGGTATAGGATCAAGTCGGCCATTTTGAAAAACTATTCCTATTTAATTATC
GTGGGTGATGAGGAAGTACAGTTACAGAAATACAACATTCGAGAACGTGATAATAGAAAG
AGTTTCGAGAAACTTACAATGTCTCAAATTTGGGAAAAATTTATTGAGCTGGAAAAAAAC
TACAAGTAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 462 |
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| Protein Molecular Weight | 54091.60156 |
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| Protein Theoretical pI | 8.8 |
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| Signalling Regions | |
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| Transmembrane Regions | |
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| Protein Sequence | >Threonyl-tRNA synthetase, mitochondrial
MKIQLVRWHCSRNALWNRAFYSTRKATKNASSATPATMTSMVSQRQDLFMTDPLSPGSMF
FLPNGAKIFNKLIEFMKLQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMFKVETTD
EEKEEYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDFSPLHRNEASGALSGLTRLRKFHQ
DDGHIFCTPSQVKSEIFNSLKLIDIVYNKIFPFVKGGSGAESNYFINFSTRPDHFIGDLK
VWNHAEQVLKEILEESGKPWKLNPGDGAFYGPKLDIMVTDHLRKTHQVATIQLDFQLPER
FDLKFKDQDNSYKRPIMIHRATFGSIERFMALLIDSNEGRWPFWLNPYQAVIIPVNTKNV
QQLDMCTALQKKLRNELEADDMEPVPLNDWHFNVDLDIRNEPVGYRIKSAILKNYSYLII
VGDEEVQLQKYNIRERDNRKSFEKLTMSQIWEKFIELEKNYK |
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| References |
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| External Links | |
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| General Reference | - Pape, L. K., Koerner, T. J., Tzagoloff, A. (1985). "Characterization of a yeast nuclear gene (MST1) coding for the mitochondrial threonyl-tRNA1 synthetase." J Biol Chem 260:15362-15370.2999113
- Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
- MacKelvie, S. H., Andrews, P. D., Stark, M. J. (1995). "The Saccharomyces cerevisiae gene SDS22 encodes a potential regulator of the mitotic function of yeast type 1 protein phosphatase." Mol Cell Biol 15:3777-3785.7791785
- Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
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