Cytochrome c1, heme protein, mitochondrial (P07143)

Identification
NameCytochrome c1, heme protein, mitochondrial
Synonyms
  • Complex III subunit 4
  • Complex III subunit IV
  • Cytochrome b-c1 complex subunit 4
  • Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
  • Cytochrome c-1
Gene NameCYT1
Enzyme ClassNot Available
Biological Properties
General FunctionEnergy production and conversion
Specific FunctionHeme-containing component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c
Cellular LocationMitochondrion inner membrane; Single-pass membrane protein; Intermembrane side
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
ion binding
cation binding
metal ion binding
transition metal ion binding
heme binding
electron carrier activity
iron ion binding
binding
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>930 bp ATGTTTTCAAATCTATCTAAACGTTGGGCTCAAAGGACCCTCTCGAAAAGTTTCTACTCT ACCGCAACAGGTGCTGCTAGTAAATCTGGCAAGCTTACTCAAAAGCTAGTTACAGCGGGT GTTGCTGCCGCCGGTATCACCGCATCGACTTTACTCTATGCAGACTCATTAACTGCCGAA GCTATGACCGCAGCTGAACACGGATTGCACGCCCCAGCATATGCTTGGTCCCACAATGGG CCTTTTGAAACATTTGATCATGCATCCATTAGAAGAGGTTACCAGGTTTACCGTGAAGTT TGTGCCGCCTGCCATTCTCTTGACAGAGTTGCTTGGAGAACTTTGGTTGGTGTTTCTCAT ACCAACGAAGAGGTTCGTAATATGGCCGAAGAATTTGAATACGATGACGAACCTGATGAA CAAGGTAACCCTAAAAAGAGACCAGGTAAGTTGTCCGATTACATCCCTGGCCCATACCCA AACGAACAGGCTGCAAGAGCTGCTAATCAAGGTGCCTTGCCACCTGATCTATCTTTGATC GTGAAAGCTAGACACGGTGGTTGTGACTACATTTTCTCTTTGTTGACCGGTTATCCTGAT GAACCTCCTGCTGGTGTGGCTTTACCACCAGGTTCTAATTATAACCCTTACTTCCCAGGT GGTTCCATTGCAATGGCAAGAGTCTTGTTTGATGACATGGTTGAGTACGAAGATGGTACC CCCGCAACGACATCTCAAATGGCAAAGGACGTTACCACCTTTTTAAACTGGTGTGCCGAA CCTGAACATGACGAAAGAAAGAGATTGGGTTTGAAAACGGTGATAATCTTATCATCTTTG TATTTGCTATCTATCTGGGTGAAGAAGTTCAAATGGGCCGGTATCAAAACCAGAAAATTC GTTTTCAATCCACCAAAACCAAGAAAGTAG
Protein Properties
Pfam Domain Function
Protein Residues309
Protein Molecular Weight34054.19922
Protein Theoretical pI8.29
PDB Fileshow
Signalling Regions
  • None
Transmembrane Regions
  • 273-287
Protein Sequence>Cytochrome c1, heme protein, mitochondrial MFSNLSKRWAQRTLSKSFYSTATGAASKSGKLTQKLVTAGVAAAGITASTLLYADSLTAE AMTAAEHGLHAPAYAWSHNGPFETFDHASIRRGYQVYREVCAACHSLDRVAWRTLVGVSH TNEEVRNMAEEFEYDDEPDEQGNPKKRPGKLSDYIPGPYPNEQAARAANQGALPPDLSLI VKARHGGCDYIFSLLTGYPDEPPAGVALPPGSNYNPYFPGGSIAMARVLFDDMVEYEDGT PATTSQMAKDVTTFLNWCAEPEHDERKRLGLKTVIILSSLYLLSIWVKKFKWAGIKTRKF VFNPPKPRK
References
External Links
ResourceLink
Saccharomyces Genome Database CYT1
Uniprot IDP07143
Uniprot NameCY1_YEAST
GenBank Gene IDX00791
Genebank Protein ID3610
PDB ID
1KYO
General Reference
  • Sadler, I., Suda, K., Schatz, G., Kaudewitz, F., Haid, A. (1984). "Sequencing of the nuclear gene for the yeast cytochrome c1 precursor reveals an unusually complex amino-terminal presequence." EMBO J 3:2137-2143.6092058
  • Valens, M., Bohn, C., Daignan-Fornier, B., Dang, V. D., Bolotin-Fukuhara, M. (1997). "The sequence of a 54.7 kb fragment of yeast chromosome XV reveals the presence of two tRNAs and 24 new open reading frames." Yeast 13:379-390.9133743
  • Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Hunte, C., Koepke, J., Lange, C., Rossmanith, T., Michel, H. (2000). "Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment." Structure 8:669-684.10873857
  • Lange, C., Hunte, C. (2002). "Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c." Proc Natl Acad Sci U S A 99:2800-2805.11880631