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Identification
NameCytochrome c oxidase polypeptide 5A, mitochondrial
Synonyms
  • Cytochrome c oxidase polypeptide Va
Gene NameCOX5A
Enzyme Class
Biological Properties
General FunctionInvolved in cytochrome-c oxidase activity
Specific Function4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O
Cellular LocationMitochondrion inner membrane
SMPDB Pathways
Oxidative phosphorylationPW002461 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Oxidative phosphorylationec00190 Map00190
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00862hydronShow
GO Classification
Component
Not Available
Function
cytochrome-c oxidase activity
catalytic activity
oxidoreductase activity
heme-copper terminal oxidase activity
Process
Not Available
Gene Properties
Chromosome Locationchromosome 14
LocusYNL052W
Gene Sequence>462 bp ATGTTACGTAACACTTTTACTAGAGCTGGTGGACTATCACGTATTACATCCGTAAGATTC GCTCAAACACATGCTCTTTCCAACGCTGCTGTAATGGATCTGCAATCCAGATGGGAGAAC ATGCCCTCCACTGAGCAGCAGGATATTGTCAGTAAGTTGAGTGAACGTCAAAAATTACCA TGGGCACAGCTTACTGAGCCTGAAAAGCAAGCTGTGTGGTACATTTCTTACGGAGAATGG GGCCCAAGAAGACCTGTATTGAATAAGGGTGATTCCAGTTTTATTGCCAAAGGTGTTGCT GCAGGCCTACTATTTTCAGTGGGACTTTTTGCTGTCGTCAGGATGGCGGGTGGCCAAGAC GCAAAGACCATGAATAAGGAGTGGCAGCTAAAGAGTGACGAATATTTGAAGTCGAAGAAT GCTAATCCTTGGGGTGGTTATTCTCAGGTCCAATCTAAATGA
Protein Properties
Pfam Domain Function
Protein Residues153
Protein Molecular Weight17140.40039
Protein Theoretical pI10.42
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Cytochrome c oxidase polypeptide 5A, mitochondrial MLRNTFTRAGGLSRITSVRFAQTHALSNAAVMDLQSRWENMPSTEQQDIVSKLSERQKLP WAQLTEPEKQAVWYISYGEWGPRRPVLNKGDSSFIAKGVAAGLLFSVGLFAVVRMAGGQD AKTMNKEWQLKSDEYLKSKNANPWGGYSQVQSK
References
External Links
ResourceLink
Saccharomyces Genome Database COX5A
Uniprot IDP00424
Uniprot NameCOX5A_YEAST
GenBank Gene IDAY558131
Genebank Protein ID45270152
General Reference
  • Seraphin, B., Simon, M., Faye, G. (1985). "Primary structure of a gene for subunit V of the cytochrome c oxidase from Saccharomyces cerevisiae." Curr Genet 9:435-439.2836092
  • Koerner, T. J., Hill, J., Tzagoloff, A. (1985). "Cloning and characterization of the yeast nuclear gene for subunit 5 of cytochrome oxidase." J Biol Chem 260:9513-9515.2991248
  • Cumsky, M. G., Trueblood, C. E., Ko, C., Poyton, R. O. (1987). "Structural analysis of two genes encoding divergent forms of yeast cytochrome c oxidase subunit V." Mol Cell Biol 7:3511-3519.2824989
  • Bergez, P., Doignon, F., Crouzet, M. (1995). "The sequence of a 44 420 bp fragment located on the left arm of chromosome XIV from Saccharomyces cerevisiae." Yeast 11:967-974.8533472
  • Bergez, P., Doignon, F., Crouzet, M. (1996). "Corrigendum to: the sequence of a 44 458 bp fragment located on the left arm of chromosome XIV from Saccharomyces cervisiae." Yeast 12:297.8904343
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  • Cumsky, M. G., Ko, C., Trueblood, C. E., Poyton, R. O. (1985). "Two nonidentical forms of subunit V are functional in yeast cytochrome c oxidase." Proc Natl Acad Sci U S A 82:2235-2239.2986105
  • Power, S. D., Lochrie, M. A., Poyton, R. O. (1984). "The nuclear-coded subunits of yeast cytochrome c oxidase. III. Identification of homologous subunits in yeast, bovine heart, and Neurospora crassa cytochrome c oxidases." J Biol Chem 259:6575-6578.6327686
  • Cerletti, N., Bohni, P. C., Suda, K. (1983). "Import of proteins into mitochondria. Isolated yeast mitochondria and a solubilized matrix protease correctly process cytochrome c oxidase subunit V precursor at the NH2 terminus." J Biol Chem 258:4944-4949.6300105
  • Geier, B. M., Schagger, H., Ortwein, C., Link, T. A., Hagen, W. R., Brandt, U., Von Jagow, G. (1995). "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method." Eur J Biochem 227:296-302.7851399
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106