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Identification
NameCytochrome c iso-1
SynonymsNot Available
Gene NameCYC1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in iron ion binding
Specific FunctionElectron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain
Cellular LocationMitochondrion intermembrane space
SMPDB Pathways
Sulfur metabolismPW002483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Sulfur metabolismec00920 Map00920
SMPDB Reactions
ThiosulfateSulfate
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00005SulfateShow
YMDB00175Pyruvic acidShow
YMDB00247L-Lactic acidShow
YMDB00287D-Lactic acidShow
YMDB00303ThiosulfateShow
YMDB00660Ubiquinone-6Show
YMDB00862hydronShow
YMDB00888Hydrogen peroxideShow
YMDB00890waterShow
YMDB00900oxygenShow
YMDB00915Ubiquinol-6Show
GO Classification
Component
Not Available
Function
heme binding
electron carrier activity
binding
ion binding
cation binding
metal ion binding
transition metal ion binding
iron ion binding
Process
Not Available
Gene Properties
Chromosome Locationchromosome 10
LocusYJR048W
Gene Sequence>330 bp ATGACTGAATTCAAGGCCGGTTCTGCTAAGAAAGGTGCTACACTTTTCAAGACTAGATGT CTACAATGCCACACCGTGGAAAAGGGTGGCCCACATAAGGTTGGTCCAAACTTGCATGGT ATCTTTGGCAGACACTCTGGTCAAGCTGAAGGGTATTCGTACACAGATGCCAATATCAAG AAAAACGTGTTGTGGGACGAAAATAACATGTCAGAGTACTTGACTAACCCAAAGAAATAT ATTCCTGGTACCAAGATGGCCTTTGGTGGGTTGAAGAAGGAAAAAGACAGAAACGACTTA ATTACCTACTTGAAAAAAGCCTGTGAGTAA
Protein Properties
Pfam Domain Function
Protein Residues109
Protein Molecular Weight12181.90039
Protein Theoretical pI9.96
PDB Fileshow
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Cytochrome c iso-1 MTEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGRHSGQAEGYSYTDANIK KNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLITYLKKACE
References
External Links
ResourceLink
Saccharomyces Genome Database CYC1
Uniprot IDP00044
Uniprot NameCYC1_YEAST
GenBank Gene IDL26347
Genebank Protein ID695795
PDB ID
2PCC
General Reference
  • Smith, M., Leung, D. W., Gillam, S., Astell, C. R., Montgomery, D. L., Hall, B. D. (1979). "Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae." Cell 16:753-761.222467
  • Boss, J. M., Gillam, S., Zitomer, R. S., Smith, M. (1981). "Sequence of the yeast iso-1-cytochrome c mRNA." J Biol Chem 256:12958-12961.6273415
  • Melnick, L., Sherman, F. (1990). "Nucleotide sequence of the COR region: a cluster of six genes in the yeast Saccharomyces cerevisiae." Gene 87:157-166.2158927
  • Huang, M. E., Manus, V., Chuat, J. C., Galibert, F. (1994). "Revised nucleotide sequence of the COR region of yeast Saccharomyces cerevisiae chromosome X." Yeast 10:811-818.7975898
  • Galibert, F., Alexandraki, D., Baur, A., Boles, E., Chalwatzis, N., Chuat, J. C., Coster, F., Cziepluch, C., De Haan, M., Domdey, H., Durand, P., Entian, K. D., Gatius, M., Goffeau, A., Grivell, L. A., Hennemann, A., Herbert, C. J., Heumann, K., Hilger, F., Hollenberg, C. P., Huang, M. E., Jacq, C., Jauniaux, J. C., Katsoulou, C., Karpfinger-Hartl, L., et, a. l. .. (1996). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." EMBO J 15:2031-2049.8641269
  • Narita, K., Chitani, K. (1969). "The complete amino acid sequence in baker's yeast cytochrome c." J Biochem 65:259-267.5771953
  • McNeil, J. B., Smith, M. (1986). "Transcription initiation of the Saccharomyces cerevisiae iso-1-cytochrome c gene. Multiple, independent T-A-T-A sequences." J Mol Biol 187:363-378.3009831
  • Moroder, L., Marchiori, F., Borin, G., Scoffone, E. (1973). "Studies on cytochrome c. 8. Synthesis of the protected hexadecapeptide (sequence 93-108) of Baker's yeast iso-1-cytochrome c." Biopolymers 12:729-750.4348687
  • Park, K. S., Frost, B., Tuck, M., Ho, L. L., Kim, S., Paik, W. K. (1987). "Enzymatic methylation of in vitro synthesized apocytochrome c enhances its transport into mitochondria." J Biol Chem 262:14702-14708.2822698
  • Polevoda, B., Martzen, M. R., Das, B., Phizicky, E. M., Sherman, F. (2000). "Cytochrome c methyltransferase, Ctm1p, of yeast." J Biol Chem 275:20508-20513.10791961
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Louie, G. V., Hutcheon, W. L., Brayer, G. D. (1988). "Yeast iso-1-cytochrome c. A 2.8 A resolution three-dimensional structure determination." J Mol Biol 199:295-314.2832611
  • Louie, G. V., Brayer, G. D. (1990). "High-resolution refinement of yeast iso-1-cytochrome c and comparisons with other eukaryotic cytochromes c." J Mol Biol 214:527-555.2166169
  • Lange, C., Hunte, C. (2002). "Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c." Proc Natl Acad Sci U S A 99:2800-2805.11880631
  • Baistrocchi, P., Banci, L., Bertini, I., Turano, P., Bren, K. L., Gray, H. B. (1996). "Three-dimensional solution structure of Saccharomyces cerevisiae reduced iso-1-cytochrome c." Biochemistry 35:13788-13796.8901521
  • Banci, L., Bertini, I., Bren, K. L., Gray, H. B., Sompornpisut, P., Turano, P. (1997). "Solution structure of oxidized Saccharomyces cerevisiae iso-1-cytochrome c." Biochemistry 36:8992-9001.9220987