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tetrahydrofolate biosynthesis

SourceIDPathway
PathWhizPW002417 ThumbThumb?image type=greyscaleThumb?image type=simple

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB000015'-Phosphoribosyl-N-formylglycinamide
349-34-8
{[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-formamidoacetamido)oxolan-2-yl]methoxy}phosphonic acidC8H15N2O9P
314.1865
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YMDB00002L-Glutamine
56-85-9
(2S)-2-amino-4-carbamoylbutanoic acidC5H10N2O3
146.1445
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YMDB00080N10-Formyl-THF
2800-34-2
(2S)-2-[(4-{N-[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]formamido}phenyl)formamido]pentanedioic acidC20H23N7O7
473.4393
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YMDB00097Adenosine monophosphate
61-19-8
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC10H14N5O7P
347.2212
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YMDB00109Adenosine triphosphate
56-65-5
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O13P3
507.181
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YMDB00139Tetrahydrofolic acid
135-16-0
2-{[4-({[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acidC19H23N7O6
445.4292
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YMDB00148Chorismate
55508-12-8
(3R,4R)-3-[(1-carboxyeth-1-en-1-yl)oxy]-4-hydroxycyclohexa-1,5-diene-1-carboxylic acidC10H10O6
226.1828
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YMDB001492-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol
3672-03-5
2-amino-6-(hydroxymethyl)-3,4,7,8-tetrahydropteridin-4-oneC7H9N5O2
195.1787
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YMDB00175Pyruvic acid
127-17-3
2-oxopropanoic acidC3H4O3
88.0621
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YMDB001765,10-Methenyltetrahydrofolic acid
7444-29-3
C20H21N7O6
455.424
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YMDB00219Pyrophosphate
14000-31-8
(phosphonooxy)phosphonic acidH4O7P2
177.9751
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YMDB00271L-Glutamic acid
56-86-0
(2S)-2-aminopentanedioic acidC5H9NO4
147.1293
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YMDB002937,8-Dihydropteroic acid
2134-76-1
4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoic acidC14H14N6O3
314.2994
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YMDB003144-amino-4-deoxychorismic acid(3R,4R)-4-amino-3-[(1-carboxyeth-1-en-1-yl)oxy]cyclohexa-1,5-diene-1-carboxylic acidC10H11NO5
225.198
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YMDB00343Glycolaldehyde
141-46-8
2-hydroxyacetaldehydeC2H4O2
60.052
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YMDB00385Formic acid
64-18-6
formic acidCH2O2
46.0254
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YMDB00426NADPH
53-57-6
{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC21H30N7O17P3
745.4209
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YMDB00427NADP
53-59-8
1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-yliumC21H29N7O17P3
744.4129
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YMDB004835,6,7,8-Tetrahydrofolic acid
135-16-0
(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acidC19H23N7O6
445.4292
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YMDB004934-Aminobenzoic acid
150-13-0
4-aminobenzoic acidC7H7NO2
137.136
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YMDB0051710-Formyltetrahydrofolic acid
2800-34-2
(2S)-2-{[4-(N-{[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)phenyl]formamido}pentanedioic acidC20H23N7O7
473.4393
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YMDB00558GTP
86-01-1
({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O14P3
523.1804
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YMDB005787,8-dihydroneopterin 3'-triphosphate
20574-65-6
{[({[(2R,3S)-3-(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)-2,3-dihydroxypropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}phosphonic acidC9H16N5O13P3
495.1703
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YMDB005797,8-Dihydroneopterin
1218-98-0
2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-1,4,7,8-tetrahydropteridin-4-oneC9H13N5O4
255.2306
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YMDB006687,8-dihydroneopterin 3'-phosphate[(2R,3S)-3-(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)-2,3-dihydroxypropoxy]phosphonic acidC9H14N5O7P
335.2105
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YMDB00759N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
349-34-8
{[(2R,3S,4R)-3,4-dihydroxy-5-(2-formamidoacetamido)oxolan-2-yl]methoxy}phosphonic acidC8H15N2O9P
314.1865
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YMDB00862hydron
12408-02-5
hydronH
1.00794
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YMDB00890water
7732-18-5
waterH2O
18.0153
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YMDB00907phosphate
14265-44-2
phosphoric acidO4P
94.9714
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YMDB00914ADP
58-64-0
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acidC10H15N5O10P2
427.2011
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YMDB162534-amino-4-deoxychorismate2-{[(1R,6R)-6-amino-3-carboxycyclohexa-2,4-dien-1-yl]oxy}prop-2-enoateC10H10NO5
224.193
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YMDB16254(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate6-({[hydroxy(phosphonatooxy)phosphoryl]oxy}methyl)-2-imino-1,2,7,8-tetrahydropteridin-4-olateC7H8N5O8P2
352.1146
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YMDB162807,8-dihydrofolate monoglutamate(4S)-4-carboxy-4-[(4-{[(2-imino-4-oxido-1,2,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]butanoateC19H19N7O6
441.405
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Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P04161ADE8
YDR408C
Phosphoribosylglycinamide formyltransferaseEnzyme
P37254ABZ1
YNR033W
Aminodeoxychorismate synthaseEnzyme
P07807DFR1
YOR236W
Dihydrofolate reductaseEnzyme
Q12676FOL3
YMR113W
Folylpolyglutamate synthase 1Enzyme
P09440MIS1
YBR084W
C-1-tetrahydrofolate synthase, mitochondrialEnzyme
P51601FOL2
YGR267C
GTP cyclohydrolase 1Enzyme
P53848FOL1
YNL256W
Folic acid synthesis protein FOL1Enzyme
Q03266ABZ2
YMR289W
Aminodeoxychorismate lyaseEnzyme