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purine nucleotides de novo biosynthesis

SourceIDPathway
PathWhizPW002478 ThumbThumb?image type=greyscaleThumb?image type=simple

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB000015'-Phosphoribosyl-N-formylglycinamide
349-34-8
{[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-formamidoacetamido)oxolan-2-yl]methoxy}phosphonic acidC8H15N2O9P
314.1865
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YMDB00002L-Glutamine
56-85-9
(2S)-2-amino-4-carbamoylbutanoic acidC5H10N2O3
146.1445
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YMDB00016Glycine
56-40-6
2-aminoacetic acidC2H5NO2
75.0666
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YMDB00045Coenzyme A
85-61-0
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acidC21H36N7O16P3S
767.534
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YMDB000655-Aminoimidazole ribonucleotide
25635-88-5
{[(2R,3S,4R,5R)-5-(5-amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC8H14N3O7P
295.1864
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YMDB000675-Phosphoribosylamine
14050-66-9
{[(2R,3S,4R,5R)-5-amino-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC5H12NO7P
229.125
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YMDB000775-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
6001-14-5
5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazole-4-carboxylic acidC9H14N3O9P
339.1959
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YMDB00080N10-Formyl-THF
2800-34-2
(2S)-2-[(4-{N-[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]formamido}phenyl)formamido]pentanedioic acidC20H23N7O7
473.4393
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YMDB00097Adenosine monophosphate
61-19-8
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC10H14N5O7P
347.2212
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YMDB00101Fumaric acid
110-17-8
(2E)-but-2-enedioic acidC4H4O4
116.0722
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YMDB00109Adenosine triphosphate
56-65-5
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O13P3
507.181
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YMDB00110NAD
53-84-9
1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-yliumC21H28N7O14P2
664.433
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YMDB00139Tetrahydrofolic acid
135-16-0
2-{[4-({[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acidC19H23N7O6
445.4292
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YMDB00143NADH
58-68-4
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acidC21H29N7O14P2
665.441
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YMDB00219Pyrophosphate
14000-31-8
(phosphonooxy)phosphonic acidH4O7P2
177.9751
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YMDB00257Guanosine diphosphate
146-91-8
[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acidC10H15N5O11P2
443.2005
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YMDB00261Guanosine monophosphate
85-32-5
{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC10H14N5O8P
363.2206
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YMDB00271L-Glutamic acid
56-86-0
(2S)-2-aminopentanedioic acidC5H9NO4
147.1293
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YMDB00289Xanthylic acid
523-98-8
{[(2R,3S,4R,5R)-5-(2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC10H13N4O9P
364.2054
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YMDB00350SAICAR
3031-95-6
(2S)-2-({5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazol-4-yl}formamido)butanedioic acidC13H19N4O12P
454.2833
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YMDB00352Inosinic acid
131-99-7
{[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acidC10H13N4O8P
348.206
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YMDB00385Formic acid
64-18-6
formic acidCH2O2
46.0254
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YMDB003982-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
6157-85-3
{[(2R,3S,4R,5R)-3,4-dihydroxy-5-[(formamidomethanimidoyl)amino]oxolan-2-yl]oxy}phosphonic acidC6H12N3O8P
285.1485
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YMDB00402Phosphoribosyl pyrophosphate
7540-64-9
[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acidC5H13O14P3
390.0696
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YMDB004835,6,7,8-Tetrahydrofolic acid
135-16-0
(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acidC19H23N7O6
445.4292
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YMDB004925-Amino-1-(5-phospho-D-ribosyl)imidazole
25635-88-5
{[(2R,3S,4R)-5-(5-amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC8H14N3O7P
295.1864
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YMDB005032'-Deoxyadenosine(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-olC10H13N5O3
251.2419
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YMDB005052'-Deoxyguanosine
2564-35-4
2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-oneC10H13N5O4
267.2413
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YMDB0051710-Formyltetrahydrofolic acid
2800-34-2
(2S)-2-{[4-(N-{[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)phenyl]formamido}pentanedioic acidC20H23N7O7
473.4393
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YMDB00558GTP
86-01-1
({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O14P3
523.1804
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YMDB00561(2S)-2-[5-Amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid
3031-95-6
2-({5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazol-4-yl}formamido)butanedioic acidC13H19N4O12P
454.2833
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YMDB005625-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
3031-94-5
{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC9H15N4O8P
338.2112
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YMDB00700dATP
1927-31-7
({[({[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O12P3
491.1816
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YMDB00716itaconic acid
97-65-4
2-methylidenebutanedioic acidC5H6O4
130.0987
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YMDB00717itaconyl-CoA
6008-93-1
4-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-2-methylidene-4-oxobutanoic acidC26H40N7O19P3S
879.618
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YMDB00744dGTP
2564-35-4
({[({[(2R,3S,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O13P3
507.181
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YMDB00745dTTP
365-08-2
{[hydroxy({[hydroxy({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphoryl]oxy})phosphoryl]oxy}phosphonic acidC10H17N2O14P3
482.1683
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YMDB007582-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine
6157-85-3
{[(2R,3S,4R)-3,4-dihydroxy-5-(2-formamidoethanimidamido)oxolan-2-yl]methoxy}phosphonic acidC8H16N3O8P
313.2017
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YMDB00759N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
349-34-8
{[(2R,3S,4R)-3,4-dihydroxy-5-(2-formamidoacetamido)oxolan-2-yl]methoxy}phosphonic acidC8H15N2O9P
314.1865
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YMDB00782potassium atompotassiumK
39.0983
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YMDB00844PPPi
10380-08-2
{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphonic acidH5O10P3
257.955
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YMDB00862hydron
12408-02-5
hydronH
1.00794
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YMDB00871N6-(1,2-Dicarboxyethyl)-AMP
19046-78-7
(2S)-2-({9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-9H-purin-6-yl}amino)butanedioic acidC14H18N5O11P
463.2934
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YMDB00890water
7732-18-5
waterH2O
18.0153
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YMDB00896L-Aspartic acid
56-84-8
(2S)-2-aminobutanedioic acidC4H7NO4
133.1027
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YMDB00898dGDP
3493-09-2
[({[(2R,3S,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acidC10H15N5O10P2
427.2011
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YMDB00901dADP
2793-06-8
[({[(2R,3S)-5-(6-amino-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acidC10H15N5O9P2
411.2017
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YMDB00907phosphate
14265-44-2
phosphoric acidO4P
94.9714
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YMDB00914ADP
58-64-0
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acidC10H15N5O10P2
427.2011
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YMDB01481Acadesine
3031-94-5
{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC9H15N4O8P
338.2112
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YMDB01520Magnesium
7439-95-4
magnesium(2+) ionMg
24.305
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YMDB01527Zinc
7440-66-6
zinc(2+) ionZn
65.409
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YMDB16117Potassiumpotassium(1+) ionK
39.0983
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YMDB16118Hydrogen carbonatecarbonic acidCHO3
61.0168
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YMDB16144AdenosylcobalaminThumb
YMDB16147Cobalamin(10S,12R,13S,17R,23R,24R,25R,30S,35S,36S,40S,41S,42R,46R)-30,35,40-tris(2-carbamoylethyl)-24,36,41-tris(carbamoylmethyl)-46-hydroxy-12-(hydroxymethyl)-5,6,17,23,28,31,31,36,38,41,42-undecamethyl-15,20-dioxo-11,14,16-trioxa-2lambda5,9,19,26,43lambda5,44lambda5,45lambda5-heptaaza-15lambda5-phospha-1-cobaltadodecacyclo[27.14.1.1^{1,34}.1^{2,9}.1^{10,13}.0^{1,26}.0^{3,8}.0^{23,27}.0^{25,42}.0^{32,44}.0^{39,43}.0^{37,45}]heptatetraconta-2(47),3,5,7,27,29(44),32,34(45),37,39(43)-decaene-2,43,44,45-tetrakis(ylium)-1,1-diuid-15-olateC62H88CoN13O14P
1329.3478
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YMDB16157Triphosphate{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphonic acidO10P3
252.9153
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YMDB16237N5-Carboxyaminoimidazole ribonucleotide(1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-1H-imidazol-5-yl)carbamic acidC9H14N3O9P
339.1959
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YMDB162524Fe-4Stetrakis(lambda1-iron(1+) ion) tetrasulfane tetrasulfanideFe4H12S8
491.96
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YMDB16256FAICAR{[5-(3-carbamoyl-4-formamido-1H-pyrazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC10H15N4O9P
366.223
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YMDB16281N1-(5-phospho-β-D-ribosyl)glycinamide[5-(2-azaniumylacetamido)-3,4-dihydroxyoxolan-2-yl]methyl phosphateC7H14N2O8P
285.169
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YMDB16284tetrahydropteroyl mono-L-glutamate2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioateC19H21N7O6
443.421
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Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P15454GUK1
YDR454C
Guanylate kinaseEnzyme
P00830ATP2
YJR121W
ATP synthase subunit beta, mitochondrialEnzyme
P39567IMD1
YAR073W
Putative inosine-5'-monophosphate dehydrogenase IMD1Enzyme
B3LG61
Adenylate kinase