Synthesis and degradation of ketone bodies

Source	ID	Pathway
KEGG	00072

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00312	Acetyl-CoA 72-89-9	{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₃H₃₈N₇O₁₇P₃S 809.571
YMDB00529	acetoacetyl-CoA 1420-36-6	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-{[2-({2-[(3-oxobutanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid	C₂₅H₄₀N₇O₁₈P₃S 851.607
YMDB00708	3-Hydroxy-3-methylglutaryl-CoA 1553-55-5	5-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-3-hydroxy-3-methyl-5-oxopentanoic acid	C₂₇H₄₄N₇O₂₀P₃S 911.659
YMDB00872	(S)-3-hydroxy-3-methylglutaryl-CoA 1553-55-5	(3S)-5-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-3-hydroxy-3-methyl-5-oxopentanoic acid	C₂₇H₄₄N₇O₂₀P₃S 911.659

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P41338	ERG10 YPL028W	Acetyl-CoA acetyltransferase	Enzyme	Coenzyme A Acetyl-CoA acetoacetyl-CoA
P54839	ERG13 YML126C	Hydroxymethylglutaryl-CoA synthase	Enzyme	Coenzyme A Acetyl-CoA acetoacetyl-CoA 3-Hydroxy-3-methylglutaryl-CoA hydron (S)-3-hydroxy-3-methylglutaryl-CoA water