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Histidine metabolism

SourceIDPathway
KEGG00340 Map00340

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00070Imidazole acetol-phosphate
99979-59-6
[3-(1H-imidazol-4-yl)-2-oxopropoxy]phosphonic acidC6H9N2O5P
220.1198
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YMDB00089D-Erythro-imidazole-glycerol-phosphate
36244-87-8
[(2R,3S)-2,3-dihydroxy-3-(1H-imidazol-4-yl)propoxy]phosphonic acidC6H11N2O6P
238.1351
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YMDB000925-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide{[(2R,3R)-5-{[({4-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazol-5-yl}amino)methylidene]amino}-2,3-dihydroxy-4-oxopentyl]oxy}phosphonic acidC15H25N5O15P2
577.331
Thumb
YMDB00123L-histidinol phosphate
25679-93-0
[(2S)-2-amino-3-(1H-imidazol-4-yl)propoxy]phosphonic acidC6H12N3O4P
221.1509
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YMDB00153Oxoglutaric acid
328-50-7
2-oxopentanedioic acidC5H6O5
146.0981
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YMDB00165Phosphoribosyl-ATP6-amino-9-[3,4-dihydroxy-5-({[hydroxy({[hydroxy(phosphonooxy)phosphoryl]oxy})phosphoryl]oxy}methyl)oxolan-2-yl]-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-9H-1λ⁵-purin-1-yliumC15H26N5O20P4
720.2835
Thumb
YMDB00271L-Glutamic acid
56-86-0
(2S)-2-aminopentanedioic acidC5H9NO4
147.1293
Thumb
YMDB00317Phosphoribosyl-AMP{[(2R,3S,4R,5R)-5-{1-[(2S,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-6-imino-6,9-dihydro-1H-purin-9-yl}-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC15H23N5O14P2
559.3157
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YMDB00369L-Histidine
71-00-1
(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acidC6H9N3O2
155.1546
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YMDB00402Phosphoribosyl pyrophosphate
7540-64-9
[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acidC5H13O14P3
390.0696
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YMDB004171-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide{[(2R,3S,4R,5R)-5-{4-carbamoyl-5-[(E)-({N-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]amino}methylidene)amino]-1H-imidazol-1-yl}-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC15H25N5O15P2
577.331
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YMDB005625-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
3031-94-5
{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC9H15N4O8P
338.2112
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YMDB00702L-histidinol
4836-52-6
(2S)-2-amino-3-(1H-imidazol-5-yl)propan-1-olC6H11N3O
141.171
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YMDB00703N(pros)-methyl-L-histidine
368-16-1
(2S)-2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acidC7H11N3O2
169.1811
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YMDB008681-(5-phosphoribosyl)-5'-AMP{[(2R,3S,4R,5R)-5-{1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-6-imino-6,9-dihydro-1H-purin-9-yl}-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC15H23N5O14P2
559.3157
Thumb
YMDB00896L-Aspartic acid
56-84-8
(2S)-2-aminobutanedioic acidC4H7NO4
133.1027
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YMDB009835-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide
36244-86-7
{[(2R,3R)-5-{[({4-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazol-5-yl}amino)methylidene]amino}-2,3-dihydroxy-4-oxopentyl]oxy}phosphonic acidC15H25N5O15P2
577.331
Thumb
YMDB01481Acadesine
3031-94-5
{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC9H15N4O8P
338.2112
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Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P47771ALD2
YMR170C
Aldehyde dehydrogenase [NAD(P)+] 1Enzyme
P46367ALD4
YOR374W
Potassium-activated aldehyde dehydrogenase, mitochondrialEnzyme
P54114ALD3
YMR169C
Aldehyde dehydrogenase [NAD(P)+] 2Enzyme
P54115ALD6
YPL061W
Magnesium-activated aldehyde dehydrogenase, cytosolicEnzyme
P07172HIS5
YIL116W
Histidinol-phosphate aminotransferaseEnzyme
P06633HIS3
YOR202W
Imidazoleglycerol-phosphate dehydrataseEnzyme
P40545HIS6
YIL020C
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseEnzyme
P00498HIS1
YER055C
ATP phosphoribosyltransferaseEnzyme
P22281ALD1
Aldehyde dehydrogenase 1, mitochondrialEnzyme
P00815HIS4
YCL030C
Histidine biosynthesis trifunctional proteinEnzyme
P38635HIS2
YFR025C
Histidinol-phosphataseEnzyme