You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Yeast Metabolome Database.

Pantothenate and CoA biosynthesis

SourceIDPathway
PathWhizPW002463 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG00770 Map00770

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00045Coenzyme A
85-61-0
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acidC21H36N7O16P3S
767.534
Thumb
YMDB00046L-Cysteine
52-90-4
(2R)-2-amino-3-sulfanylpropanoic acidC3H7NO2S
121.158
Thumb
YMDB000932-Dehydropantoic acid4-hydroxy-3,3-dimethyl-2-oxobutanoic acidC6H10O4
146.1412
Thumb
YMDB00097Adenosine monophosphate
61-19-8
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC10H14N5O7P
347.2212
Thumb
YMDB00098Uracil
66-22-8
1,2,3,4-tetrahydropyrimidine-2,4-dioneC4H4N2O2
112.0868
Thumb
YMDB00109Adenosine triphosphate
56-65-5
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O13P3
507.181
Thumb
YMDB00139Tetrahydrofolic acid
135-16-0
2-{[4-({[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acidC19H23N7O6
445.4292
Thumb
YMDB00152L-Valine
72-18-4
(2S)-2-amino-3-methylbutanoic acidC5H11NO2
117.1463
Thumb
YMDB00175Pyruvic acid
127-17-3
2-oxopropanoic acidC3H4O3
88.0621
Thumb
YMDB00195Beta-Alanine
107-95-9
3-aminopropanoic acidC3H7NO2
89.0932
Thumb
YMDB00203(R)-Pantothenic acid
79-83-4
3-[(2R)-2,4-dihydroxy-3,3-dimethylbutanamido]propanoic acidC9H17NO5
219.235
Thumb
YMDB00219Pyrophosphate
14000-31-8
(phosphonooxy)phosphonic acidH4O7P2
177.9751
Thumb
YMDB002605,10-Methylene-THF
31690-11-6
2-({4-[(6aR)-3-amino-1-oxo-1H,2H,5H,6H,6aH,7H,8H,9H-imidazolidino[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acidC20H23N7O6
457.4399
Thumb
YMDB00272D-4'-Phosphopantothenate3-{2-hydroxy-3-methyl-3-[(phosphonooxy)methyl]butanamido}propanoic acidC9H18NO8P
299.2149
Thumb
YMDB00279Cytidine triphosphate
65-47-4
({[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC9H16N3O14P3
483.1563
Thumb
YMDB00308Pantetheine 4'-phosphate
2226-71-3
[3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphonic acidC11H23N2O7PS
358.348
Thumb
YMDB00349Adenosine 3',5'-diphosphate
1053-73-2
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}phosphonic acidC10H15N5O10P2
427.2011
Thumb
YMDB00357Dephospho-CoA
3633-59-8
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy][3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphinic acidC21H35N7O13P2S
687.554
Thumb
YMDB00365Alpha-Ketoisovaleric acid
759-05-7
3-methyl-2-oxobutanoic acidC5H8O3
116.1152
Thumb
YMDB00376(R)-Pantoic acid
470-29-1
(2R)-2,4-dihydroxy-3,3-dimethylbutanoic acidC6H12O4
148.1571
Thumb
YMDB003942-Acetolactate 2-hydroxy-2-methyl-3-oxobutanoic acidC5H8O4
132.1146
Thumb
YMDB004004-Phosphopantothenoylcysteine
7196-09-0
(2R)-2-{3-[(2R)-2-hydroxy-3-methyl-3-[(phosphonooxy)methyl]butanamido]propanamido}-3-sulfanylpropanoic acidC12H23N2O9PS
402.358
Thumb
YMDB00406Cytidine monophosphate
63-37-6
{[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC9H14N3O8P
323.1965
Thumb
YMDB00426NADPH
53-57-6
{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC21H30N7O17P3
745.4209
Thumb
YMDB00427NADP
53-59-8
1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-yliumC21H29N7O17P3
744.4129
Thumb
YMDB004835,6,7,8-Tetrahydrofolic acid
135-16-0
(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acidC19H23N7O6
445.4292
Thumb
YMDB006643'-Dephospho-CoA
3633-59-8
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy][(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphinic acidC21H35N7O13P2S
687.554
Thumb
YMDB00749(R)-4'-phosphopantothenic acid3-[(2R)-2-hydroxy-3-methyl-3-[(phosphonooxy)methyl]butanamido]propanoic acidC9H18NO8P
299.2149
Thumb
YMDB00848(6R)-5,10-methylenetetrahydrofolic acid
3432-99-3
(2S)-2-({4-[(6aR)-3-amino-1-oxo-1H,2H,5H,6H,6aH,7H,8H,9H-imidazolidino[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acidC20H23N7O6
457.4399
Thumb
YMDB00862hydron
12408-02-5
hydronH
1.00794
Thumb
YMDB00887Adenine
73-24-5
7H-purin-6-amineC5H5N5
135.1267
Thumb
YMDB00890water
7732-18-5
waterH2O
18.0153
Thumb
YMDB00896L-Aspartic acid
56-84-8
(2S)-2-aminobutanedioic acidC4H7NO4
133.1027
Thumb
YMDB00912Carbon dioxide
124-38-9
methanedioneCO2
44.0095
Thumb
YMDB00914ADP
58-64-0
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acidC10H15N5O10P2
427.2011
Thumb
YMDB01009(R)-Pantothenate
79-83-4
C9H16NO5
218.227
Thumb
YMDB01012(R)-Pantoate
470-29-1
C6H11O4
147.1491
Thumb
YMDB010173-methyl-2-oxobutanoate
759-05-7
C5H7O3
115.1073
Thumb
YMDB01053pyruvate
127-17-3
C3H3O3
87.0541
Thumb
YMDB010582-DehydropantoateC6H9O4
145.1333
Thumb
YMDB01522Pantothenic acid
79-83-4
C9H17NO5
219.235
Thumb
YMDB162644'-phosphopantetheine2,3,3-trimethyl-4-(phosphonatooxy)-N-{2-[(2-sulfanylethyl)carbamoyl]ethyl}butanamideC12H23N2O6PS
354.36
Thumb
YMDB162692'-(5-Triphosphoribosyl)-3'-dephospho-CoA(2R)-4-({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-{[(2S,3R,4S,5R)-3,4-dihydroxy-5-({[hydroxy({[hydroxy(phosphonooxy)phosphoryl]oxy})phosphoryl]oxy}methyl)oxolan-2-yl]oxy}-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-2-hydroxy-3,3-dimethyl-N-{2-[(2-sulfanylethyl)-C-hydroxycarbonimidoyl]ethyl}butanimidic acidC26H46N7O26P5S
1059.609
Thumb
YMDB162862,3-Dihydroxyisovaleric acid2,3-dihydroxy-3-methylbutanoic acidC5H10O4
134.1305
Thumb

Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P47176BAT2
YJR148W
Branched-chain-amino-acid aminotransferase, cytosolicEnzyme
P38891BAT1
YHR208W
Branched-chain-amino-acid aminotransferase, mitochondrialEnzyme
P06168ILV5
YLR355C
Ketol-acid reductoisomerase, mitochondrialEnzyme
Q03941CAB5
YDR196C
Dephospho-CoA kinase CAB5Enzyme
Q12036PPT2
YPL148C
Mitochondrial holo-[acyl-carrier-protein] synthaseEnzyme
P40506
YIL083C
Uncharacterized protein YIL083CEnzyme
P25353NPP1
YCR026C
Ectonucleotide pyrophosphatase/phosphodiesterase 1Enzyme
P39997NPP2
YEL016C
Ectonucleotide pyrophosphatase/phosphodiesterase 2Enzyme
P38122ECM31
YBR176W
3-methyl-2-oxobutanoate hydroxymethyltransferaseEnzyme
Q04430
YDR531W
Pantothenate kinaseEnzyme
P07342ILV2
YMR108W
Acetolactate synthase catalytic subunit, mitochondrialEnzyme
P39522ILV3
YJR016C
Dihydroxy-acid dehydratase, mitochondrialEnzyme
P38787PAN5
YHR063C
2-dehydropantoate 2-reductaseEnzyme
P40459PAN6
YIL145C
Pantoate--beta-alanine ligaseEnzyme