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Valine, leucine and isoleucine degradation

SourceIDPathway
KEGG00280 Map00280

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00038L-Isoleucine
73-32-5
(2S,3S)-2-amino-3-methylpentanoic acidC6H13NO2
131.1729
Thumb
YMDB00053(S)-3-Hydroxyisobutyryl-CoA
319440-43-2
{[5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({[hydroxy(3-hydroxy-3-{[2-({2-[(3-hydroxy-2-methylpropanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}-2,2-dimethylpropoxy)phosphoryl]oxy})phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acidC25H42N7O18P3S
853.623
Thumb
YMDB00152L-Valine
72-18-4
(2S)-2-amino-3-methylbutanoic acidC5H11NO2
117.1463
Thumb
YMDB00168(S)-3-methyl-2-oxovaleric acid
1460-34-0
(3S)-3-methyl-2-oxopentanoic acidC6H10O3
130.1418
Thumb
YMDB00312Acetyl-CoA
72-89-9
{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC23H38N7O17P3S
809.571
Thumb
YMDB00365Alpha-Ketoisovaleric acid
759-05-7
3-methyl-2-oxobutanoic acidC5H8O3
116.1152
Thumb
YMDB00381Thiamine pyrophosphate
154-87-0
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-iumC12H19N4O7P2S
425.314
Thumb
YMDB00387L-Leucine
61-90-5
(2S)-2-amino-4-methylpentanoic acidC6H13NO2
131.1729
Thumb
YMDB00388Ketoleucine
816-66-0
4-methyl-2-oxopentanoic acidC6H10O3
130.1418
Thumb
YMDB00446propionyl-CoA
317-66-8
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-[(2-{[2-(propanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acidC24H40N7O17P3S
823.597
Thumb
YMDB00514Succinyl-CoA
604-98-8
4-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-4-oxobutanoic acidC25H40N7O19P3S
867.607
Thumb
YMDB00529acetoacetyl-CoA
1420-36-6
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-{[2-({2-[(3-oxobutanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acidC25H40N7O18P3S
851.607
Thumb
YMDB007083-Hydroxy-3-methylglutaryl-CoA
1553-55-5
5-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-3-hydroxy-3-methyl-5-oxopentanoic acidC27H44N7O20P3S
911.659
Thumb
YMDB00872(S)-3-hydroxy-3-methylglutaryl-CoA
1553-55-5
(3S)-5-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-3-hydroxy-3-methyl-5-oxopentanoic acidC27H44N7O20P3S
911.659
Thumb
YMDB010173-methyl-2-oxobutanoate
759-05-7
C5H7O3
115.1073
Thumb
YMDB01020(S)-3-methyl-2-oxovalerate
1460-34-0
C6H9O3
129.1339
Thumb
YMDB010304-Methyl-2-oxopentanoate
816-66-0
C6H9O3
129.1339
Thumb

Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P09624LPD1
YFL018C
Dihydrolipoyl dehydrogenase, mitochondrialEnzyme
P46367ALD4
YOR374W
Potassium-activated aldehyde dehydrogenase, mitochondrialEnzyme
P54115ALD6
YPL061W
Magnesium-activated aldehyde dehydrogenase, cytosolicEnzyme
P47176BAT2
YJR148W
Branched-chain-amino-acid aminotransferase, cytosolicEnzyme
P38891BAT1
YHR208W
Branched-chain-amino-acid aminotransferase, mitochondrialEnzyme
P41338ERG10
YPL028W
Acetyl-CoA acetyltransferaseEnzyme
P28817EHD3
YDR036C
3-hydroxyisobutyryl-CoA hydrolase, mitochondrialEnzyme
P54839ERG13
YML126C
Hydroxymethylglutaryl-CoA synthaseEnzyme
P27796POT1
YIL160C
3-ketoacyl-CoA thiolase, peroxisomalEnzyme
P22281ALD1
Aldehyde dehydrogenase 1, mitochondrialEnzyme