Valine, leucine and isoleucine degradation

Source	ID	Pathway
KEGG	00280

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight	Structure
YMDB00038	L-Isoleucine 73-32-5	(2S,3S)-2-amino-3-methylpentanoic acid	C₆H₁₃NO₂ 131.1729
YMDB00053	(S)-3-Hydroxyisobutyryl-CoA 319440-43-2	{[5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({[hydroxy(3-hydroxy-3-{[2-({2-[(3-hydroxy-2-methylpropanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}-2,2-dimethylpropoxy)phosphoryl]oxy})phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid	C₂₅H₄₂N₇O₁₈P₃S 853.623
YMDB00152	L-Valine 72-18-4	(2S)-2-amino-3-methylbutanoic acid	C₅H₁₁NO₂ 117.1463
YMDB00168	(S)-3-methyl-2-oxovaleric acid 1460-34-0	(3S)-3-methyl-2-oxopentanoic acid	C₆H₁₀O₃ 130.1418
YMDB00312	Acetyl-CoA 72-89-9	{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₃H₃₈N₇O₁₇P₃S 809.571
YMDB00365	Alpha-Ketoisovaleric acid 759-05-7	3-methyl-2-oxobutanoic acid	C₅H₈O₃ 116.1152
YMDB00381	Thiamine pyrophosphate 154-87-0	3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium	C₁₂H₁₉N₄O₇P₂S 425.314
YMDB00387	L-Leucine 61-90-5	(2S)-2-amino-4-methylpentanoic acid	C₆H₁₃NO₂ 131.1729
YMDB00388	Ketoleucine 816-66-0	4-methyl-2-oxopentanoic acid	C₆H₁₀O₃ 130.1418
YMDB00446	propionyl-CoA 317-66-8	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-[(2-{[2-(propanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid	C₂₄H₄₀N₇O₁₇P₃S 823.597
YMDB00514	Succinyl-CoA 604-98-8	4-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-4-oxobutanoic acid	C₂₅H₄₀N₇O₁₉P₃S 867.607
YMDB00529	acetoacetyl-CoA 1420-36-6	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-{[2-({2-[(3-oxobutanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid	C₂₅H₄₀N₇O₁₈P₃S 851.607
YMDB00708	3-Hydroxy-3-methylglutaryl-CoA 1553-55-5	5-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-3-hydroxy-3-methyl-5-oxopentanoic acid	C₂₇H₄₄N₇O₂₀P₃S 911.659
YMDB00872	(S)-3-hydroxy-3-methylglutaryl-CoA 1553-55-5	(3S)-5-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-3-hydroxy-3-methyl-5-oxopentanoic acid	C₂₇H₄₄N₇O₂₀P₃S 911.659
YMDB01017	3-methyl-2-oxobutanoate 759-05-7		C₅H₇O₃ 115.1073
YMDB01020	(S)-3-methyl-2-oxovalerate 1460-34-0		C₆H₉O₃ 129.1339
YMDB01030	4-Methyl-2-oxopentanoate 816-66-0		C₆H₉O₃ 129.1339

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P09624	LPD1 YFL018C	Dihydrolipoyl dehydrogenase, mitochondrial	Enzyme	Glycine Coenzyme A NAD NADH Oxoglutaric acid Pyruvic acid Acetyl-CoA NAD(+) Ammonium 5,6,7,8-Tetrahydrofolic acid Succinyl-CoA S(8)-aminomethyldihydrolipoamide lipoamide S(8)-succinyldihydrolipoamide (6R)-5,10-methylenetetrahydrofolic acid hydron Dihydrolipoamide Carbon dioxide
P46367	ALD4 YOR374W	Potassium-activated aldehyde dehydrogenase, mitochondrial	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA gamma-Aminobutyric acid Indoleacetaldehyde NAD(+) NADPH NADP indole-3-acetate 4-aminobutanal hydron water
P54115	ALD6 YPL061W	Magnesium-activated aldehyde dehydrogenase, cytosolic	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA Indoleacetaldehyde NADPH NADP indole-3-acetate hydron water
P47176	BAT2 YJR148W	Branched-chain-amino-acid aminotransferase, cytosolic	Enzyme	L-Isoleucine L-Valine Oxoglutaric acid (S)-3-methyl-2-oxovaleric acid L-Glutamic acid Alpha-Ketoisovaleric acid L-Leucine Ketoleucine (2S)-2-Isopropyl-3-oxosuccinate hydron Carbon dioxide
P38891	BAT1 YHR208W	Branched-chain-amino-acid aminotransferase, mitochondrial	Enzyme	L-Isoleucine L-Valine Oxoglutaric acid (S)-3-methyl-2-oxovaleric acid L-Glutamic acid Alpha-Ketoisovaleric acid L-Leucine Ketoleucine (2S)-2-Isopropyl-3-oxosuccinate hydron Carbon dioxide
P41338	ERG10 YPL028W	Acetyl-CoA acetyltransferase	Enzyme	Coenzyme A Acetyl-CoA acetoacetyl-CoA
P28817	EHD3 YDR036C	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	Enzyme	Coenzyme A (S)-3-Hydroxyisobutyryl-CoA (2E)-Dodecenoyl-CoA (S)-3-Hydroxyisobutyric acid (S)-3-hydroxydecanoyl-CoA (S)-3-hydroxylauroyl-CoA (S)-3-hydroxypalmitoyl-CoA hexadec-2-enoyl-CoA (S)-3-hydroxytetradecanoyl-CoA water 3-Hydroxybutyryl-CoA Crotonoyl-CoA (S)-Hydroxyoctanoyl-CoA (S)-Hydroxyhexanoyl-CoA trans-2-Hexenoyl-CoA (2E)-Tetradecenoyl-CoA (2E)-Decenoyl-CoA (2E)-Octenoyl-CoA
P54839	ERG13 YML126C	Hydroxymethylglutaryl-CoA synthase	Enzyme	Coenzyme A Acetyl-CoA acetoacetyl-CoA 3-Hydroxy-3-methylglutaryl-CoA hydron (S)-3-hydroxy-3-methylglutaryl-CoA water
P27796	POT1 YIL160C	3-ketoacyl-CoA thiolase, peroxisomal	Enzyme	Coenzyme A Tetradecanoyl-CoA NAD NADH (2E)-Dodecenoyl-CoA Acetyl-CoA (S)-3-hydroxydecanoyl-CoA (S)-3-hydroxylauroyl-CoA (S)-3-hydroxypalmitoyl-CoA hexadec-2-enoyl-CoA (S)-3-hydroxytetradecanoyl-CoA 3-oxodecanoyl-CoA 3-oxolauroyl-CoA 3-oxopalmitoyl-CoA 3-oxooctadecanoyl-CoA 3-oxotetradecanoyl-CoA palmitoyl-CoA myristoyl-CoA acetoacetyl-CoA lauroyl-CoA
P22281	ALD1	Aldehyde dehydrogenase 1, mitochondrial	Enzyme	NAD NADH