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Citrate cycle (TCA cycle)

SourceIDPathway
KEGG00020 Map00020

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00026Isocitric acid
320-77-4
1-hydroxypropane-1,2,3-tricarboxylic acidC6H8O7
192.1235
Thumb
YMDB00086Citric acid
77-92-9
2-hydroxypropane-1,2,3-tricarboxylic acidC6H8O7
192.1235
Thumb
YMDB00101Fumaric acid
110-17-8
(2E)-but-2-enedioic acidC4H4O4
116.0722
Thumb
YMDB00153Oxoglutaric acid
328-50-7
2-oxopentanedioic acidC5H6O5
146.0981
Thumb
YMDB00175Pyruvic acid
127-17-3
2-oxopropanoic acidC3H4O3
88.0621
Thumb
YMDB00210Oxalosuccinic acid
1948-82-9
1-oxopropane-1,2,3-tricarboxylic acidC6H6O7
190.1076
Thumb
YMDB00235Oxalacetic acid
328-42-7
2-oxobutanedioic acidC4H4O5
132.0716
Thumb
YMDB00276Phosphoenolpyruvic acid
138-08-9
2-(phosphonooxy)prop-2-enoic acidC3H5O6P
168.042
Thumb
YMDB00280(S)-Malic acid
97-67-6
(2S)-2-hydroxybutanedioic acidC4H6O5
134.0874
Thumb
YMDB00312Acetyl-CoA
72-89-9
{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC23H38N7O17P3S
809.571
Thumb
YMDB00338Succinic acid
110-15-6
butanedioic acidC4H6O4
118.088
Thumb
YMDB00381Thiamine pyrophosphate
154-87-0
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-iumC12H19N4O7P2S
425.314
Thumb
YMDB00514Succinyl-CoA
604-98-8
4-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-4-oxobutanoic acidC25H40N7O19P3S
867.607
Thumb
YMDB00630cis-aconitic acid
585-84-2
(1Z)-prop-1-ene-1,2,3-tricarboxylic acidC6H6O6
174.1082
Thumb
YMDB01038fumarate(2-)
110-17-8
C4H2O4
114.0563
Thumb
YMDB01050phosphoenolpyruvate
138-08-9
C3H4O6P
167.034
Thumb
YMDB01053pyruvate
127-17-3
C3H3O3
87.0541
Thumb

Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P09624LPD1
YFL018C
Dihydrolipoyl dehydrogenase, mitochondrialEnzyme
P19414ACO1
YLR304C
Aconitate hydratase, mitochondrialEnzyme
P39533ACO2
YJL200C
Probable aconitate hydratase 2Enzyme
P28834IDH1
YNL037C
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrialEnzyme
P28241IDH2
YOR136W
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrialEnzyme
P53982IDP3
YNL009W
Isocitrate dehydrogenase [NADP]Enzyme
P21954IDP1
YDL066W
Isocitrate dehydrogenase [NADP], mitochondrialEnzyme
P41939IDP2
YLR174W
Isocitrate dehydrogenase [NADP] cytoplasmicEnzyme
P53598LSC1
YOR142W
Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrialEnzyme
P19262KGD2
YDR148C
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialEnzyme
P43635CIT3
YPR001W
Citrate synthase 3Enzyme
P53312LSC2
YGR244C
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrialEnzyme
P12695PDA2
YNL071W
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialEnzyme
P08679CIT2
YCR005C
Citrate synthase, peroxisomalEnzyme
P00890CIT1
YNR001C
Citrate synthase, mitochondrialEnzyme
Q00711SDH1
YKL148C
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialEnzyme
P47052
YJL045W
Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrialEnzyme
P21801SDH2
YLL041C
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialEnzyme
P08417FUM1
YPL262W
Fumarate hydratase, mitochondrialEnzyme
P11154PYC1
YGL062W
Pyruvate carboxylase 1Enzyme
P10963PCK1
YKR097W
Phosphoenolpyruvate carboxykinase [ATP]Enzyme
P32327PYC2
YBR218C
Pyruvate carboxylase 2Enzyme
P22133MDH2
YOL126C
Malate dehydrogenase, cytoplasmicEnzyme
P32419MDH3
YDL078C
Malate dehydrogenase, peroxisomalEnzyme
P20967KGD1
YIL125W
2-oxoglutarate dehydrogenase, mitochondrialEnzyme
P16387PDA1
YER178W
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrialEnzyme
P32473PDB1
YBR221C
Pyruvate dehydrogenase E1 component subunit beta, mitochondrialEnzyme
P17505MDH1
Malate dehydrogenase, mitochondrialEnzyme